All Stories

  1. The Fungal Metabolite Eurochevalierine, a Sequiterpene Alkaloid, Displays Anti-Cancer Properties through Selective Sirtuin 1/2 Inhibition

    Article • Molecules, February 2018, MDPI AG

    Professor Marc Diederich, Dr Michael Schnekenburger

  2. Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in Cancer

    Article • Molecules, November 2016, MDPI AG

    Professor Marc Diederich, Dr Michael Schnekenburger

  3. Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells

    Article • Oncotarget, April 2016, Impact Journals, LLC

    Dr Michael Schnekenburger, Professor Marc Diederich

  4. 4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90α chaperone activity against prostate cancer

    Article • Biochemical Pharmacology, January 2016, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  5. Perspectives in Medicinal Chemistry: DNA Methylation and Demethylation Mechanisms as Therapeutic Targets?

    Article • Current Topics in Medicinal Chemistry, November 2015, Bentham Science Publishers

    Professor Marc Diederich, Dr Michael Schnekenburger

  6. Role of Histone Acetylation in Cell Cycle Regulation

    Article • Current Topics in Medicinal Chemistry, November 2015, Bentham Science Publishers

    Professor Marc Diederich, Dr Miglena Antonova Koprinarova, Dr Michael Schnekenburger

  7. Epigenetic alterations as a universal feature of cancer hallmarks and a promising target for personalized treatments

    Article • Current Topics in Medicinal Chemistry, November 2015, Bentham Science Publishers

    Professor Marc Diederich, Dr Michael Schnekenburger

  8. Editorial (Thematic Issue: Novel Pharmaceutical Approaches by Natural Compound-Derived Epigenetic Regulators: Epigenetic Readers, Writers and Erasers as Therapeutic Targets)

    Article • Current Topics in Medicinal Chemistry, November 2015, Bentham Science Publishers

    Professor Marc Diederich, Dr Michael Schnekenburger

  9. Dual Induction of Mitochondrial Apoptosis and Senescence in Chronic Myelogenous Leukemia by Myrtucommulone A

    Article • Anti-Cancer Agents in Medicinal Chemistry, March 2015, Bentham Science Publishers

    Professor Marc Diederich, Dr Michael Schnekenburger

  10. Histone deacetylase 6 in health and disease

    Article • Epigenomics, February 2015, Future Medicine

    Professor Marc Diederich, Dr Michael Schnekenburger

  11. Nutritional Epigenetic Regulators in the Field of Cancer

    Article • January 2015, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  12. Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and microRNA regulatory micro-networks

    Article • Biochemical Pharmacology, November 2014, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  13. Plant-derived epigenetic modulators for cancer treatment and prevention

    Article • Biotechnology Advances, November 2014, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  14. Epigenetic modulators from “The Big Blue”: A treasure to fight against cancer

    Article • Cancer Letters, September 2014, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  15. Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines

    Article • Bioorganic & Medicinal Chemistry Letters, August 2014, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  16. Regulation of epigenetic traits of the glutathione S-transferase P1 gene: from detoxification toward cancer prevention and diagnosis

    Article • Frontiers in Pharmacology, July 2014, Frontiers

    Professor Marc Diederich, Dr Michael Schnekenburger

  17. Bis(4-hydroxy-2H-chromen-2-one): Synthesis and effects on leukemic cell lines proliferation and NF-κB regulation

    Article • Bioorganic & Medicinal Chemistry, June 2014, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  18. 5-aza-2′-deoxycytidine-mediated c-myc Down-regulation Triggers Telomere-dependent Senescence by Regulating Human Telomerase Reverse Transcriptase in Chronic Myeloid Leukemia

    Article • Neoplasia, June 2014, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  19. Properly Substituted Analogues of BIX-01294 Lose Inhibition of G9a Histone Methyltransferase and Gain Selective Anti-DNA Methyltransferase 3A Activity

    Article • PLoS ONE, May 2014, PLOS

    Professor Marc Diederich, Dr Michael Schnekenburger

  20. The Ah Receptor Recruits IKK  to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation

    Article • Toxicological Sciences, February 2014, Oxford University Press (OUP)

    Dr Michael Schnekenburger

  21. Antiproliferative and proapoptotic activities of 4-hydroxybenzoic acid-based inhibitors of histone deacetylases

    Article • Cancer Letters, February 2014, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  22. Protein Kinase and HDAC Inhibitors from the Endophytic Fungus Epicoccum nigrum

    Article • Journal of Natural Products, January 2014, American Chemical Society (ACS)

    Professor Marc Diederich, Dr Michael Schnekenburger

  23. Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells

    Article • Journal of Medicinal Chemistry, January 2014, American Chemical Society (ACS)

    Dr Hideharu Hashimoto, Professor Marc Diederich, Dr Michael Schnekenburger

  24. The DNA hypomethylating agent, 5‐aza‐2′‐deoxycytidine, enhances tumor cell invasion through a transcription‐dependent modulation of MMP‐1 expression in human fibrosarcoma cells

    Article • Molecular Carcinogenesis, September 2013, Wiley

    Professor Marc Diederich, Dr Michael Schnekenburger

  25. Epigenetically induced changes in nuclear textural patterns and gelatinase expression in human fibrosarcoma cells

    Article • Cell Proliferation, March 2013, Wiley

    Dr Michael Schnekenburger, Professor Marc Diederich

  26. Chromatin-modifying agents in anti-cancer therapy

    Article • Biochimie, November 2012, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  27. Natural chalcones as dual inhibitors of HDACs and NF-κB

    Article • Oncology Reports, June 2012, Spandidos Publications

    Dr Michael Schnekenburger, Professor Marc Diederich

  28. MicroRNAs in cancer management and their modulation by dietary agents

    Article • Biochemical Pharmacology, June 2012, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  29. DNA demethylation increases sensitivity of neuroblastoma cells to chemotherapeutic drugs

    Article • Biochemical Pharmacology, April 2012, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  30. Histone deacetylase modulators provided by Mother Nature

    Article • Genes & Nutrition, February 2012, Springer Science + Business Media

    Professor Marc Diederich, Dr Michael Schnekenburger

  31. Epigenetics Offer New Horizons for Colorectal Cancer Prevention

    Article • Current Colorectal Cancer Reports, January 2012, Springer Science + Business Media

    Professor Marc Diederich, Dr Michael Schnekenburger

  32. COX-2 inhibitors block chemotherapeutic agent-induced apoptosis prior to commitment in hematopoietic cancer cells

    Article • Biochemical Pharmacology, November 2011, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  33. Epigenomics of leukemia: from mechanisms to therapeutic applications

    Article • Epigenomics, October 2011, Future Medicine

    Professor Marc Diederich, Dr Michael Schnekenburger

  34. Conference Scene: Omic technologies in human disease: extending the network of epigenetic control

    Article • Epigenomics, October 2011, Future Medicine

    Professor Marc Diederich, Dr Michael Schnekenburger

  35. Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines

    Article • Biochemical Pharmacology, June 2011, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  36. Natural compounds as inflammation inhibitors

    Article • Genes & Nutrition, May 2011, Springer Science + Business Media

    Professor Marc Diederich, Dr Michael Schnekenburger

  37. Aryl Hydrocarbon Receptor Ligands of Widely Different Toxic Equivalency Factors Induce Similar Histone Marks in Target Gene Chromatin

    Article • Toxicological Sciences, February 2011, Oxford University Press (OUP)

    Dr Michael Schnekenburger

  38. Valproic acid perturbs hematopoietic homeostasis by inhibition of erythroid differentiation and activation of the myelo-monocytic pathway

    Article • Biochemical Pharmacology, February 2011, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  39. Sustained exposure to the DNA demethylating agent, 2′-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy

    Article • Biochemical Pharmacology, February 2011, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  40. UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

    Article • Biochemical Pharmacology, January 2011, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  41. Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression ofCYP46A1gene transcription

    Article • Journal of Neurochemistry, April 2010, Wiley

    Professor Marc Diederich, Dr Michael Schnekenburger

  42. Naturally Occurring Regulators of Histone Acetylation/Deacetylation

    Article • Current Nutrition & Food Science, February 2010, Bentham Science Publishers

    Professor Marc Diederich, Dr Michael Schnekenburger

  43. Genomewide Analysis of Aryl Hydrocarbon Receptor Binding Targets Reveals an Extensive Array of Gene Clusters that Control Morphogenetic and Developmental Programs

    Article • Environmental Health Perspectives, March 2009, Environmental Health Perspectives

    Dr Michael Schnekenburger

  44. Tumor necrosis factor α induces γ-glutamyltransferase expression via nuclear factor-κB in cooperation with Sp1

    Article • Biochemical Pharmacology, February 2009, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  45. Repression of Ah receptor and induction of transforming growth factor-β genes in DEN-induced mouse liver tumors

    Article • Toxicology, April 2008, Elsevier

    Dr Michael Schnekenburger

  46. HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation

    Article • Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, September 2007, Elsevier

    Dr Michael Schnekenburger

  47. Chromium Cross-Links Histone Deacetylase 1-DNA Methyltransferase 1 Complexes to Chromatin, Inhibiting Histone-Remodeling Marks Critical for Transcriptional Activation

    Article • Molecular and Cellular Biology, August 2007, ASM Journals

    Dr Michael Schnekenburger

  48. Long term low-dose arsenic exposure induces loss of DNA methylation

    Article • Biochemical and Biophysical Research Communications, January 2007, Elsevier

    Dr Michael Schnekenburger

  49. Tumor necrosis factor alpha inhibits aclacinomycin A-induced erythroid differentiation of K562 cells via GATA-1

    Article • Cancer Letters, August 2006, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  50. Transcriptional and post-transcriptional regulation of glutathione S-transferase P1 expression during butyric acid-induced differentiation of K562 cells

    Article • Leukemia Research, May 2006, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  51. Chemopreventive and therapeutic effects of curcumin

    Article • Cancer Letters, June 2005, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  52. GATA-1: Friends, Brothers, and Coworkers

    Article • Annals of the New York Academy of Sciences, December 2004, Wiley

    Professor Marc Diederich, Dr Michael Schnekenburger

  53. Curcumin Stability and Its Effect on GlutathioneS-Transferase P1-1 mRNA Expression in K562 Cells

    Article • Annals of the New York Academy of Sciences, December 2004, Wiley

    Professor Marc Diederich, Dr Michael Schnekenburger

  54. Expression of glutathione S-transferase P1-1 in leukemic cells is regulated by inducible AP-1 binding

    Article • Cancer Letters, December 2004, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  55. Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor kappaB inhibition

    Article • Biochemical Pharmacology, September 2004, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  56. Increased glutathione S-transferase P1-1 expression by mRNA stabilization in hemin-induced differentiation of K562 cells

    Article • Biochemical Pharmacology, September 2004, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  57. Regulation of glutathione S-transferase P1-1 gene expression by NF-kappaB in tumor necrosis factor alpha-treated K562 leukemia cells

    Article • Biochemical Pharmacology, April 2004, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  58. An Introduction to the Molecular Mechanisms of Apoptosis

    Article • Annals of the New York Academy of Sciences, December 2003, Wiley

    Professor Marc Diederich, Dr Michael Schnekenburger

  59. Curcumin-Induced Cell Death in Two Leukemia Cell Lines: K562 and Jurkat

    Article • Annals of the New York Academy of Sciences, December 2003, Wiley

    Dr Michael Schnekenburger, Professor Marc Diederich

  60. Expression of glutathione S-transferase P1-1 in differentiating K562: role of GATA-1

    Article • Biochemical and Biophysical Research Communications, November 2003, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  61. Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1-1 inhibition

    Article • Biochemical Pharmacology, October 2003, Elsevier

    Professor Marc Diederich, Dr Michael Schnekenburger

  62. Transcriptional regulation of glutathione S-transferase P1-1 in human leukemia

    Article • BioFactors, January 2003, Wiley

    Dr Michael Schnekenburger