All Stories

  1. Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping

    Article • Nature Biotechnology, August 2014, Springer Science + Business Media

    Professor Wouter de Laat

  2. Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling

    Article • Molecular Systems Biology, April 2014, EMBO

    Professor Wouter de Laat

  3. A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia

    Article • Cell, April 2014, Elsevier

    Professor Wouter de Laat

  4. A common genetic variant within SCN10A modulates cardiac SCN5A expression

    Article • Journal of Clinical Investigation, March 2014, American Society for Clinical Investigation

    Professor Wouter de Laat

  5. Long-Range Chromatin Contacts in Embryonic Stem Cells Reveal a Role for Pluripotency Factors and Polycomb Proteins in Genome Organization

    Article • Cell Stem Cell, November 2013, Elsevier

    Professor Wouter de Laat

  6. Topology of mammalian developmental enhancers and their regulatory landscapes

    Article • Nature, October 2013, Springer Science + Business Media

    Professor Wouter de Laat

  7. For Genomes to Stay in Shape, Insulators Must Be up to PAR

    Article • Cell, September 2013, Elsevier

    Professor Wouter de Laat

  8. Flexible Long-Range Loops in the VH Gene Region of the Igh Locus Facilitate the Generation of a Diverse Antibody Repertoire

    Article • Immunity, August 2013, Elsevier

    Professor Wouter de Laat

  9. The pluripotent genome in three dimensions is shaped around pluripotency factors

    Article • Nature, July 2013, Springer Science + Business Media

    Professor Wouter de Laat

  10. Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells

    Article • Nucleic Acids Research, June 2013, Oxford University Press (OUP)

    Professor Wouter de Laat

  11. CTCF: the protein, the binding partners, the binding sites and their chromatin loops

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, May 2013, Royal Society Publishing

    Professor Wouter de Laat

  12. Identical cells with different 3D genomes; cause and consequences?

    Article • Current Opinion in Genetics & Development, April 2013, Elsevier

    Professor Wouter de Laat

  13. eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription

    Article • Molecular Cell, February 2013, Elsevier

    Professor Wouter de Laat

  14. DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

    Article • Genome Biology, January 2013, Springer Science + Business Media

    Professor Wouter de Laat

  15. 3C-based technologies to study the shape of the genome

    Article • Methods, November 2012, Elsevier

    Professor Wouter de Laat

  16. Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: From fixation to computation

    Article • Methods, November 2012, Elsevier

    Professor Wouter de Laat

  17. Robust 4C-seq data analysis to screen for regulatory DNA interactions

    Article • Nature Methods, September 2012, Springer Science + Business Media

    Professor Wouter de Laat

  18. Chromatin loops, gene positioning, and gene expression

    Article • Frontiers in Genetics, January 2012, Frontiers

    Professor Wouter de Laat

  19. 4C Technology: Protocols and Data Analysis

    Article • January 2012, Elsevier

    Professor Wouter de Laat

  20. A decade of 3C technologies: insights into nuclear organization

    Article • Genes & Development, January 2012, Cold Spring Harbor Laboratory Press

    Professor Wouter de Laat

  21. A Regulatory Archipelago Controls Hox Genes Transcription in Digits

    Article • Cell, November 2011, Elsevier

    Professor Wouter de Laat

  22. The Dynamic Architecture of Hox Gene Clusters

    Article • Science, October 2011, American Association for the Advancement of Science

    Professor Wouter de Laat

  23. The complex transcription regulatory landscape of our genome: control in three dimensions

    Article • The EMBO Journal, September 2011, Springer Science + Business Media

    Professor Wouter de Laat

  24. Variegated gene expression caused by cell-specific long-range DNA interactions

    Article • Nature Cell Biology, June 2011, Springer Science + Business Media

    Professor Wouter de Laat

  25. The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA

    Article • Genes & Development, June 2011, Cold Spring Harbor Laboratory Press

    Professor Wouter de Laat, Dr ir Wilfred van IJcken

  26. An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation

    Article • Nature Communications, May 2011, Springer Science + Business Media

    Professor Wouter de Laat

  27. Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements

    Article • Genome Research, April 2011, Cold Spring Harbor Laboratory Press

    Professor Wouter de Laat

  28. Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia

    Article • Cancer Cell, April 2011, Elsevier

    Professor Wouter de Laat

  29. Interactions among Polycomb Domains Are Guided by Chromosome Architecture

    Article • PLoS Genetics, March 2011, PLOS

    Professor Wouter de Laat

  30. Genome organization influences partner selection for chromosomal rearrangements

    Article • Trends in Genetics, February 2011, Elsevier

    Professor Wouter de Laat

  31. High-resolution identification of balanced and complex chromosomal rearrangements by 4C technology

    Article • Nature Methods, October 2009, Springer Science + Business Media

    Professor Wouter de Laat

  32. Studying physical chromatin interactions in plants using Chromosome Conformation Capture (3C)

    Article • Nature Protocols, July 2009, Springer Science + Business Media

    Professor Wouter de Laat

  33. FISH-eyed and genome-wide views on the spatial organisation of gene expression

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, November 2008, Elsevier

    Professor Wouter de Laat

  34. Joining the loops: β‐Globin gene regulation

    Article • IUBMB Life, September 2008, Wiley

    Professor Wouter de Laat

  35. Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

    Article • Nature, May 2008, Springer Science + Business Media

    Professor Wouter de Laat

  36. Transcription and Chromatin Organization of a Housekeeping Gene Cluster Containing an Integrated β-Globin Locus Control Region

    Article • PLoS Genetics, March 2008, PLOS

    Professor Wouter de Laat, Dr ir Wilfred van IJcken

  37. Maintenance of Long-Range DNA Interactions after Inhibition of Ongoing RNA Polymerase II Transcription

    Article • PLoS ONE, February 2008, PLOS

    Professor Wouter de Laat

  38. Chapter 5 Three‐Dimensional Organization of Gene Expression in Erythroid Cells

    Article • January 2008, Elsevier

    Professor Wouter de Laat

  39. Chapter 4 β‐Globin Regulation and Long‐Range Interactions

    Article • January 2008, Elsevier

    Professor Wouter de Laat

  40. An evaluation of 3C-based methods to capture DNA interactions

    Article • Nature Methods, October 2007, Springer Science + Business Media

    Professor Wouter de Laat

  41. Inter-chromosomal gene regulation in the mammalian cell nucleus

    Article • Current Opinion in Genetics & Development, October 2007, Elsevier

    Professor Wouter de Laat

  42. Quantitative analysis of chromosome conformation capture assays (3C-qPCR)

    Article • Nature Protocols, July 2007, Springer Science + Business Media

    Professor Wouter de Laat

  43. Long-range DNA contacts: romance in the nucleus?

    Article • Current Opinion in Cell Biology, June 2007, Elsevier

    Professor Wouter de Laat

  44. beta-Globin Active Chromatin Hub Formation in Differentiating Erythroid Cells and in p45 NF-E2 Knock-out Mice

    Article • Journal of Biological Chemistry, April 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Wouter de Laat

  45. Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes

    Article • Nature Immunology, March 2007, Springer Science + Business Media

    Professor Wouter de Laat

  46. Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)

    Article • Nature Genetics, October 2006, Springer Science + Business Media

    Professor Wouter de Laat

  47. The β-globin nuclear compartment in development and erythroid differentiation

    Article • Nature Genetics, September 2003, Springer Science + Business Media

    Professor Wouter de Laat

  48. 3C Technology: Analyzing the Spatial Organization of Genomic Loci In Vivo

    Article • January 2003, Elsevier

    Professor Wouter de Laat

  49. Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus

    Article • Molecular Cell, December 2002, Elsevier

    Professor Wouter de Laat

  50. Novel Functional Interactions between Nucleotide Excision DNA Repair Proteins Influencing the Enzymatic Activities of TFIIH, XPG, and ERCC1-XPF

    Article • Biochemistry, December 2000, American Chemical Society (ACS)

    Professor Wouter de Laat

  51. Molecular mechanism of nucleotide excision repair

    Article • Genes & Development, April 1999, Cold Spring Harbor Laboratory Press

    Professor Wouter de Laat

  52. Mapping of interaction domains between human repair proteins ERCC1 and XPF

    Article • Nucleic Acids Research, September 1998, Oxford University Press (OUP)

    Professor Wouter de Laat

  53. DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair

    Article • Genes & Development, August 1998, Cold Spring Harbor Laboratory Press

    Professor Wouter de Laat

  54. DNA Structural Elements Required for ERCC1-XPF Endonuclease Activity

    Article • Journal of Biological Chemistry, April 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Wouter de Laat

  55. Recombining DNA Damage Repair, Basal Transcription, and Human Syndromes

    Article • January 1997, Springer Science + Business Media

    Professor Wouter de Laat

  56. Xeroderma Pigmentosum Group F Caused by a Defect in a Structure-Specific DNA Repair Endonuclease

    Article • Cell, September 1996, Elsevier

    Professor Wouter de Laat