All Stories

  1. Synthesis of (2S,3S)-β-(trifluoromethyl)-α,β-diamino acid by Mannich addition of glycine Schiff base Ni(II) complexes to N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimine

    Article • Journal of Fluorine Chemistry, March 2015, Elsevier

    Dr Jose Luis Aceña

  2. Recent advances in the trifluoromethylation methodology and new CF3-containing drugs

    Article • Journal of Fluorine Chemistry, November 2014, Elsevier

    Dr Jose Luis Aceña

  3. Design and synthesis of (S)- and (R)-α-(phenyl)ethylamine-derived NH-type ligands and their application for the chemical resolution of α-amino acids

    Article • Organic & Biomolecular Chemistry, July 2014, Royal Society of Chemistry

    Dr Jose Luis Aceña

  4. Asymmetric Synthesis of α‐Amino Acids under Operationally Convenient Conditions

    Article • Advanced Synthesis & Catalysis, June 2014, Wiley

    Dr Jose Luis Aceña

  5. ChemInform Abstract: Asymmetric Mannich Reaction Between (S)‐N‐(tert‐Butanesulfinyl)‐3,3,3‐trifluoroacetaldimine and Malonic Acid Derivatives. Stereodivergent Synthesis of (R)‐ and (S)‐3‐Amino‐4,4,4‐trifluorobutanoic Acids.

    Article • ChemInform, June 2014, Wiley

    Dr Jose Luis Aceña

  6. Chemical Kinetic Resolution of Unprotected β‐Substituted β‐Amino Acids Using Recyclable Chiral Ligands

    Article • Angewandte Chemie, June 2014, Wiley

    Dr Jose Luis Aceña

  7. Chemical Kinetic Resolution of Unprotected β‐Substituted β‐Amino Acids Using Recyclable Chiral Ligands

    Article • Angewandte Chemie International Edition, June 2014, Wiley

    Dr Jose Luis Aceña

  8. Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 3: Michael addition reactions and miscellaneous transformations

    Article • Amino Acids, June 2014, Springer Science + Business Media

    Dr Jose Luis Aceña

  9. Chiral N(H)‐tBu and N(H)‐Ad NiII Complexes of Glycine Schiff Bases: Deduction of a Mode of Kinetic Diastereoselectivity

    Article • European Journal of Organic Chemistry, May 2014, Wiley

    Dr Jose Luis Aceña

  10. Biochemical quantitation of the eIF5A hypusination in Arabidopsis thaliana uncovers ABA-dependent regulation

    Article • Frontiers in Plant Science, May 2014, Frontiers

    Dr Jose Luis Aceña

  11. Synthesis and stereochemical assignments of diastereomeric Ni(II) complexes of glycine Schiff base with ( R )-2-( N -{2-[ N -alkyl- N -(1-phenylethyl)amino]acetyl}amino)benzophenone; a case of configurationally stable stereogenic nitrogen

    Article • Beilstein Journal of Organic Chemistry, February 2014, Beilstein Institut

    Dr Jose Luis Aceña

  12. Inexpensive chemical method for preparation of enantiomerically pure phenylalanine

    Article • Amino Acids, January 2014, Springer Science + Business Media

    Dr Jose Luis Aceña

  13. Asymmetric Mannich reaction between (S)-N-(tert-butanesulfinyl)-3,3,3-trifluoroacetaldimine and malonic acid derivatives. Stereodivergent synthesis of (R)- and (S)-3-amino-4,4,4-trifluorobutanoic acids

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Vadim Soloshonok, Dr Jose Luis Aceña, Professor Norio Shibata

  14. NH-type of chiral Ni(ii) complexes of glycine Schiff base: design, structural evaluation, reactivity and synthetic applications

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Vadim Soloshonok, Dr Jose Luis Aceña

  15. The self-disproportionation of the enantiomers (SDE) of methyl n-pentyl sulfoxide via achiral, gravity-driven column chromatography: a case study

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Vadim Soloshonok, Dr Jose Luis Aceña

  16. Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

    Article • Chemical Reviews, December 2013, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  17. ChemInform Abstract: Asymmetric Synthesis of α‐Amino Acids via Homologation of Ni(II) Complexes of Glycine Schiff Bases. Part 2. Aldol, Mannich Addition Reactions, Deracemization and (S) to (R) Interconversion of α‐Amino Acids

    Article • ChemInform, December 2013, Wiley

    Dr Jose Luis Aceña

  18. ChemInform Abstract: Synthesis of Fluorine‐Containing α‐Amino Acids in Enantiomerically Pure Form via Homologation of Ni(II) Complexes of Glycine and Alanine Schiff Bases

    Article • ChemInform, November 2013, Wiley

    Dr Jose Luis Aceña

  19. Synthesis of fluorine-containing α-amino acids in enantiomerically pure form via homologation of Ni(II) complexes of glycine and alanine Schiff bases

    Article • Journal of Fluorine Chemistry, November 2013, Elsevier

    Dr Jose Luis Aceña

  20. ChemInform Abstract: Asymmetric Synthesis of α‐Amino Acids via Homologation of Ni(II) Complexes of Glycine Schiff Bases. Part 1. Alkyl Halide Alkylations

    Article • ChemInform, October 2013, Wiley

    Dr Jose Luis Aceña

  21. Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 2: Aldol, Mannich addition reactions, deracemization and (S) to (R) interconversion of α-amino acids

    Article • Amino Acids, September 2013, Springer Science + Business Media

    Dr Jose Luis Aceña

  22. Preface

    Article • Journal of Fluorine Chemistry, August 2013, Elsevier

    Dr Jose Luis Aceña

  23. Chemical deracemization and (S) to (R) interconversion of some fluorine-containing α-amino acids

    Article • Journal of Fluorine Chemistry, August 2013, Elsevier

    Dr Jose Luis Aceña

  24. ChemInform Abstract: Recent Advances in the Synthesis of Fluorinated Aminophosphonates and Aminophosphonic Acids

    Article • ChemInform, July 2013, Wiley

    Dr Jose Luis Aceña

  25. Note

    Article • Chirality, July 2013, Wiley

    Dr Jose Luis Aceña

  26. Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases; Part 1: alkyl halide alkylations

    Article • Amino Acids, July 2013, Springer Science + Business Media

    Dr Jose Luis Aceña

  27. Optical Purifications via Self‐Disproportionation of Enantiomers by Achiral Chromatography: Case Study of a Series of α‐CF3‐containing Secondary Alcohols

    Article • Chirality, May 2013, Wiley

    Dr Jose Luis Aceña

  28. ChemInform Abstract: Self‐Disproportionation of Enantiomers of Chiral, Non‐Racemic Fluoroorganic Compounds: Role of Fluorine as Enabling Element

    Article • ChemInform, March 2013, Wiley

    Dr Jose Luis Aceña

  29. Unconventional preparation of racemic crystals of isopropyl 3,3,3-trifluoro-2-hydroxypropanoate and their unusual crystallographic structure: the ultimate preference for homochiral intermolecular interactions

    Article • Chemical Communications, January 2013, Royal Society of Chemistry

    Dr Jose Luis Aceña

  30. Chemical approach for interconversion of (S)- and (R)-α-amino acids

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Dr Jose Luis Aceña

  31. Synthesis of bis-α,α′-amino acids through diastereoselective bis-alkylations of chiral Ni(ii)-complexes of glycine

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Dr Jose Luis Aceña

  32. Recent advances in the synthesis of fluorinated aminophosphonates and aminophosphonic acids

    Article • RSC Advances, January 2013, Royal Society of Chemistry

    Dr Jose Luis Aceña

  33. Alkylations of Chiral Nickel(II) Complexes of Glycine under Phase‐Transfer Conditions

    Article • Helvetica Chimica Acta, December 2012, Wiley

    Dr Jose Luis Aceña

  34. Design and synthesis of quasi-diastereomeric molecules with unchanging central, regenerating axial and switchable helical chirality via cleavage and formation of Ni(II)–O and Ni(II)–N coordination bonds

    Article • Beilstein Journal of Organic Chemistry, November 2012, Beilstein Institut

    Dr Jose Luis Aceña

  35. Synthesis of polysubstituted β-amino cyclohexane carboxylic acids via Diels–Alder reaction using Ni(II)-complex stabilized β-alanine derived dienes

    Article • Amino Acids, September 2012, Springer Science + Business Media

    Dr Jose Luis Aceña

  36. ChemInform Abstract: Recent Advances in the Asymmetric Synthesis of α‐(Trifluoromethyl)‐Containing α‐Amino Acids

    Article • ChemInform, July 2012, Wiley

    Dr Jose Luis Aceña

  37. Self-disproportionation of enantiomers of non-racemic chiral amine derivatives through achiral chromatography

    Article • Tetrahedron, May 2012, Elsevier

    Dr Jose Luis Aceña

  38. Stereoselective Access to Fluorinated and Non‐fluorinated Quaternary Piperidines: Synthesis of Pipecolic Acid and Iminosugar Derivatives

    Article • Chemistry - A European Journal, February 2012, Wiley

    Dr Jose Luis Aceña

  39. ChemInform Abstract: Synthesis of Fluorinated β‐Amino Acids

    Article • ChemInform, December 2011, Wiley

    Dr Jose Luis Aceña

  40. Synthesis of Fluorinated β-Amino Acids

    Article • Synthesis, August 2011, Thieme Publishing Group

    Dr Jose Luis Aceña

  41. Synthetic and Biological Applications of Fluorous Reagents as Phase Tags

    Article • January 2011, Springer Science + Business Media

    Dr Jose Luis Aceña

  42. ChemInform Abstract: Diastereoselective Intramolecular Additions of Allyl‐ and Propargylsilanes to Iminium Ions: Synthesis of Cyclic and Bicyclic Quaternary Amino Acids.

    Article • ChemInform, October 2010, Wiley

    Dr Jose Luis Aceña

  43. ChemInform Abstract: Recent Developments in the Synthesis of Fluorinated β‐Amino Acids

    Article • ChemInform, August 2010, Wiley

    Dr Jose Luis Aceña

  44. Diastereoselective Intramolecular Additions of Allyl- and Propargylsilanes to Iminium Ions: Synthesis of Cyclic and Bicyclic Quaternary Amino Acids

    Article • Organic Letters, June 2010, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  45. Recent Developments in the Synthesis of Fluorinated β-Amino Acids

    Article • Current Organic Chemistry, May 2010, Bentham Science Publishers

    Dr Jose Luis Aceña

  46. ChemInform Abstract: A New Strategy for the Synthesis of Fluorinated 3,4‐Dihydropyrimidinones.

    Article • ChemInform, April 2010, Wiley

    Dr Jose Luis Aceña

  47. ChemInform Abstract: Organocatalytic anti‐Selective Mannich Reactions with Fluorinated Aldimines: Synthesis of anti‐γ‐Fluoroalkyl‐γ‐amino Alcohols.

    Article • ChemInform, January 2010, Wiley

    Dr Jose Luis Aceña

  48. ChemInform Abstract: Fluorous TBAF: A Convenient and Selective Reagent for Fluoride‐Mediated Deprotections.

    Article • ChemInform, December 2009, Wiley

    Dr Jose Luis Aceña

  49. A new strategy for the synthesis of fluorinated 3,4-dihydropyrimidinones

    Article • Journal of Fluorine Chemistry, December 2009, Elsevier

    Dr Jose Luis Aceña

  50. Organocatalytic anti‐Selective Mannich Reactions with Fluorinated Aldimines: Synthesis of anti‐γ‐Fluoroalkyl‐γ‐amino Alcohols

    Article • European Journal of Organic Chemistry, October 2009, Wiley

    Dr Jose Luis Aceña

  51. Fluorous TBAF: A Convenient and Selective Reagent for Fluoride-Mediated Deprotections

    Article • The Journal of Organic Chemistry, August 2009, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  52. ChemInform Abstract: Cross‐Metathesis Reactions as an Efficient Tool in the Synthesis of Fluorinated Cyclic β‐Amino Acids.

    Article • ChemInform, August 2009, Wiley

    Dr Jose Luis Aceña

  53. ChemInform Abstract: A New Strategy for the Synthesis of Optically Pure β‐Fluoroalkyl β‐Amino Acid Derivatives.

    Article • ChemInform, June 2009, Wiley

    Dr Jose Luis Aceña

  54. ChemInform Abstract: Nitrogen‐Containing Organofluorine Derivatives: An Overview

    Article • ChemInform, May 2009, Wiley

    Dr Jose Luis Aceña

  55. Straightforward Stereoselective Access to Cyclic Peptidomimetics

    Article • The Journal of Organic Chemistry, May 2009, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  56. Cross-Metathesis Reactions as an Efficient Tool in the Synthesis of Fluorinated Cyclic β-Amino Acids

    Article • The Journal of Organic Chemistry, April 2009, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  57. Nitrogen-Containing Organofluorine Derivatives: An Overview

    Article • Synlett, February 2009, Thieme Publishing Group

    Dr Jose Luis Aceña

  58. Tiratricol Neutralizes Bacterial Endotoxins and Reduces Lipopolysaccharide‐Induced TNF‐α Production in the Cell

    Article • Chemical Biology & Drug Design, September 2008, Wiley

    Dr Jose Luis Aceña

  59. ChemInform Abstract: An Efficient Entry to Optically Active anti‐ and syn‐β‐Amino‐α‐trifluoromethyl Alcohols.

    Article • ChemInform, July 2008, Wiley

    Dr Jose Luis Aceña

  60. An Efficient Entry to Optically Active anti- and syn-β-Amino-α-trifluoromethyl Alcohols

    Article • Organic Letters, January 2008, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  61. Nitrogen‐Containing Organofluorine Compounds Through Metathesis Reactions

    Article • ChemInform, June 2007, Wiley

    Dr Jose Luis Aceña

  62. Asymmetric Synthesis of Fluorinated Cyclic β-Αmino Acid Derivatives through Cross Metathesis

    Article • Organic Letters, March 2007, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  63. First Fluorous Synthesis of Fluorinated Uracils.

    Article • ChemInform, December 2006, Wiley

    Dr Jose Luis Aceña

  64. Synthesis and Biological Evaluation of New Bicyclic Fluorinated Uracils Through Ring‐Closing Metathesis.

    Article • ChemInform, September 2006, Wiley

    Dr Jose Luis Aceña

  65. First Fluorous Synthesis of Fluorinated Uracils

    Article • QSAR & Combinatorial Science, September 2006, Wiley

    Dr Jose Luis Aceña

  66. Asymmetric Synthesis of Fluorinated Cyclic β-Amino Acid Derivatives through Cross Metathesis

    Article • Organic Letters, August 2006, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  67. Role of the gem‐Difluoro Moiety in the Tandem Ring‐Closing Metathesis—Olefin Isomerization: Regioselective Preparation of Unsaturated Lactams.

    Article • ChemInform, August 2006, Wiley

    Dr Jose Luis Aceña

  68. New Fluorinated 1,3‐Vinylogous Amidines as Versatile Intermediates: Synthesis of Fluorinated Pyrimidin‐2(1H)‐ones.

    Article • ChemInform, May 2006, Wiley

    Dr Jose Luis Aceña

  69. Synthesis and Biological Evaluation of New Bicyclic Fluorinated Uracils through Ring-Closing Metathesis

    Article • The Journal of Organic Chemistry, April 2006, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  70. Fluorous (Trimethylsilyl)ethanol:  A New Reagent for Carboxylic Acid Tagging and Protection in Peptide Synthesis

    Article • The Journal of Organic Chemistry, March 2006, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  71. Role of the gem-Difluoro Moiety in the Tandem Ring-Closing Metathesis−Olefin Isomerization:  Regioselective Preparation of Unsaturated Lactams

    Article • The Journal of Organic Chemistry, March 2006, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  72. New fluorinated 1,3-vinylogous amidines as versatile intermediates: synthesis of fluorinated pyrimidin-2(1H)-ones

    Article • Tetrahedron, February 2006, Elsevier

    Dr Jose Luis Aceña

  73. ChemInform Abstract: Total Synthesis of (+)‐7‐Deoxypancratistatin from Furan.

    Article • ChemInform, April 2001, Wiley

    Dr Jose Luis Aceña

  74. Total Synthesis of (+)-7-Deoxypancratistatin from Furan

    Article • Organic Letters, October 2000, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  75. ChemInform Abstract: Marine Polypropionate Synthesis: Total Synthesis of (‐)‐Baconipyrone C.

    Article • ChemInform, September 2000, Wiley

    Dr Jose Luis Aceña

  76. ChemInform Abstract: Unexpected One‐Pot Epoxy Sulfone—Enaminone Transformation. Synthesis of 5a‐Carba‐β‐mannopyranosylamine.

    Article • ChemInform, August 2000, Wiley

    Dr Jose Luis Aceña

  77. Studies in Marine Polypropionate Synthesis:  Total Synthesis of (−)-Baconipyrone C

    Article • Organic Letters, May 2000, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  78. A new and expeditious entry to 7-oxabicyclo[3.2.1]octan-8-ol and 2-oxabicyclo[3.3.1]nonan-9-ol skeletons via intramolecular Michael addition–SN2′ ring opening of 7-oxabicyclic sulfones

    Article • Tetrahedron Letters, April 2000, Elsevier

    Dr Jose Luis Aceña

  79. Unexpected One-Pot Epoxy Sulfone−Enaminone Transformation. Synthesis of 5a-Carba-β-mannopyranosylamine

    Article • The Journal of Organic Chemistry, March 2000, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  80. Total Syntheses of (±)-Cyclophellitol and (1R*,6S*)-Cyclophellitol

    Article • The Journal of Organic Chemistry, May 1997, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  81. Polypropionates from 7-oxanorbornene derivatives. A stereoselective and divergent synthesis of fragments with four contiguous chiral centers

    Article • Tetrahedron Letters, December 1996, Elsevier

    Dr Jose Luis Aceña

  82. A Stereodivergent Access to Naturally Occurring Aminocarba Sugars from (Phenylsulfonyl)-7-oxabicyclo[2.2.1]heptane Derivatives. Total Synthesis of Penta-N,O-Acetyl-(.+-.)-Validamine and Its C1 and C2 Stereoisomers

    Article • The Journal of Organic Chemistry, October 1994, American Chemical Society (ACS)

    Dr Jose Luis Aceña

  83. Strain-directed bridge cleavage of (phenylsulfonyl)-7-oxabicyclo[2.2.1]heptane derivatives: application to the total synthesis of carba-.alpha.-DL-glucopyranose

    Article • The Journal of Organic Chemistry, March 1992, American Chemical Society (ACS)

    Dr Jose Luis Aceña