All Stories

  1. Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1

    Article • Cardiovascular Research, November 2019, Oxford University Press (OUP)

    Dr Pawel Swietach

  2. Recovery from hypoxia-induced internalization of cardiac Na+ /H + exchanger 1 requires an adequate intracellular store of antioxidants

    Article • Journal of Cellular Physiology, September 2018, Wiley

    Dr Pawel Swietach

  3. Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2

    Article • British Journal of Pharmacology, April 2018, Wiley

    Dr Pawel Swietach

  4. Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes

    Article • Cardiovascular Research, April 2016, European Society of Cardiology

    Dr Pawel Swietach

  5. CrossTalk opposing view: Physiological CO2exchange does not normally depend on membrane channels

    Article • The Journal of Physiology, November 2015, Wiley

    Dr Pawel Swietach

  6. Rebuttal from Pawel Swietach, Richard D. Vaughan-Jones, Alzbeta Hulikova and Steven A. Niederer

    Article • The Journal of Physiology, November 2015, Wiley

    Dr Pawel Swietach

  7. Intracellular Carbonic Anhydrase Activity Sensitizes Cancer Cell pH Signaling to Dynamic Changes in CO 2 Partial Pressure

    Article • Journal of Biological Chemistry, July 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Pawel Swietach

  8. Rapid CO 2 permeation across biological membranes: implications for CO 2 venting from tissue

    Article • The FASEB Journal, March 2014, Wiley

    Dr Pawel Swietach

  9. Pumping Ca2+ up H+ gradients: a Ca2+–H+ exchanger without a membrane

    Article • The Journal of Physiology, March 2014, Wiley

    Dr Pawel Swietach

  10. The chemistry, physiology and pathology of pH in cancer

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, February 2014, Royal Society Publishing

    Dr Pawel Swietach

  11. Facilitation by intracellular carbonic anhydrase of Na+–HCO3− co‐transport but not Na+/H+ exchange activity in the mammalian ventricular myocyte

    Article • The Journal of Physiology, January 2014, Wiley

    Dr Pawel Swietach

  12. Antitumor Efficacy of a Monoclonal Antibody That Inhibits the Activity of Cancer-Associated Carbonic Anhydrase XII

    Article • Cancer Research, September 2013, American Association for Cancer Research (AACR)

    Dr Pawel Swietach

  13. H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH

    Article • Journal of Molecular and Cellular Cardiology, August 2013, Elsevier

    Dr Pawel Swietach

  14. Coupled Ca 2+ /H + transport by cytoplasmic buffers regulates local Ca 2+ and H + ion signaling

    Article • Proceedings of the National Academy of Sciences, May 2013, Proceedings of the National Academy of Sciences

    Dr Pawel Swietach

  15. Sarcolemmal localisation of Na+/H+exchange and Na+-HCO3−co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes

    Article • The Journal of Physiology, April 2013, Wiley

    Dr Pawel Swietach

  16. Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics

    Article • Proceedings of the National Academy of Sciences, February 2013, Proceedings of the National Academy of Sciences

    Dr Pawel Swietach

  17. Low and High pH Gating of Connexin43 Channels

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Pawel Swietach

  18. Intracellular Na+ Spatially Controls Ca2+ Signaling during Acidosis in the Ventricular Myocyte

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Pawel Swietach

  19. An Extra-Mitochondrial Domain Rich in Carbonic Anhydrase Activity Improves Myocardial Energetics

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Pawel Swietach, Prof. Kieran Clarke

  20. Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia

    Article • Journal of Cellular Physiology, December 2012, Wiley

    Dr Pawel Swietach

  21. Importance of Intracellular pH in Determining the Uptake and Efficacy of the Weakly Basic Chemotherapeutic Drug, Doxorubicin

    Article • PLoS ONE, April 2012, PLOS

    Dr Pawel Swietach

  22. Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy

    Article • Clinical Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Dr Pawel Swietach

  23. Acid-extrusion from Tissue: The Interplay Between Membrane Transporters and pH Buffers

    Article • Current Pharmaceutical Design, April 2012, Bentham Science Publishers

    Dr Pawel Swietach

  24. Spatial Localisation and Function of pH-Regulatory Transporters in the Rat Ventricular Myocyte

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Pawel Swietach

  25. Role of Cytoplasmic Buffers in Spatial H+-Ca2+ Interactions in Ventricular Myocytes

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Pawel Swietach

  26. Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX

    Article • European Journal of Pharmacology, April 2011, Elsevier

    Dr Pawel Swietach

  27. Dual Role of CO2/HCOFormula Buffer in the Regulation of Intracellular pH of Three-dimensional Tumor Growths

    Article • Journal of Biological Chemistry, February 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Pawel Swietach

  28. Hydrogen ion dynamics in human red blood cells

    Article • The Journal of Physiology, December 2010, Wiley

    Dr Pawel Swietach

  29. New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation

    Article • Oncogene, October 2010, Springer Science + Business Media

    Dr Pawel Swietach

  30. A mathematical model of the murine ventricular myocyte: a data-driven biophysically based approach applied to mice overexpressing the canine NCX isoform

    Article • AJP Heart and Circulatory Physiology, July 2010, American Physiological Society

    Dr Pawel Swietach

  31. The importance of carbonic anhydrase II in red blood cells during exposure of chicken embryos to CO2

    Article • Respiratory Physiology & Neurobiology, July 2010, Elsevier

    Dr Pawel Swietach

  32. The Tumor Microenvironment: New Insights into Regulation of Tumor pH by Carbonic Anhydrases

    Article • January 2010, Springer Science + Business Media

    Dr Pawel Swietach

  33. Modeling calcium waves in cardiac myocytes: importance of calcium diffusion

    Article • Frontiers in Bioscience, January 2010, Frontiers in Bioscience

    Dr Pawel Swietach

  34. Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study

    Article • Cardiovascular Research, December 2009, European Society of Cardiology

    Dr Pawel Swietach

  35. Spatial regulation of intracellular pH in multicellular strands of neonatal rat cardiomyocytes

    Article • Cardiovascular Research, October 2009, European Society of Cardiology

    Dr Pawel Swietach

  36. The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths

    Article • Journal of Biological Chemistry, May 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Pawel Swietach

  37. Differentiation impairs low pH-induced Ca2+ signaling and ERK phosphorylation in granule precursor tumour cells

    Article • Cell Calcium, April 2009, Elsevier

    Dr Pawel Swietach

  38. Intracellular pH regulation in heart

    Article • Journal of Molecular and Cellular Cardiology, March 2009, Elsevier

    Dr Pawel Swietach

  39. Confocal Imaging Of Extracellular pH With Fluorescein Derivatives

    Article • Biophysical Journal, February 2009, Elsevier

    Dr Pawel Swietach

  40. Modulation Of Cardiac Na+/H+ Exchange Activity By Muscarinic Agonists, Nitric Oxide and Cyclic GMP

    Article • Biophysical Journal, February 2009, Elsevier

    Dr Pawel Swietach

  41. Comparison of pH-dependence of Carbonic Anhydrase Activity in vitro and in Living Cells

    Article • Biophysical Journal, February 2009, Elsevier

    Dr Pawel Swietach

  42. Pushing and Pulling the Cardiac Sodium/Hydrogen Exchanger

    Article • Circulation Research, October 2008, Wolters Kluwer Health

    Dr Pawel Swietach

  43. Ca2+-Mobility in the Sarcoplasmic Reticulum of Ventricular Myocytes Is Low

    Article • Biophysical Journal, August 2008, Elsevier

    Dr Pawel Swietach

  44. Cancer-associated, hypoxia-inducible carbonic anhydrase IX facilitates CO2diffusion

    Article • BJU International, June 2008, Wiley

    Dr Pawel Swietach

  45. Extracellular Acidification Elicits Spatially and Temporally Distinct Ca 2+ Signals

    Article • Current Biology, May 2008, Elsevier

    Dr Pawel Swietach

  46. Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths

    Article • Journal of Biological Chemistry, April 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Pawel Swietach

  47. Measuring and Modeling Chloride-Hydroxyl Exchange in the Guinea-Pig Ventricular Myocyte

    Article • Biophysical Journal, March 2008, Elsevier

    Dr Pawel Swietach

  48. S0859, an N -cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart

    Article • British Journal of Pharmacology, March 2008, Wiley

    Dr Pawel Swietach

  49. H + Ion Activation and Inactivation of the Ventricular Gap Junction

    Article • Circulation Research, April 2007, Wolters Kluwer Health

    Dr Pawel Swietach

  50. Regulation of tumor pH and the role of carbonic anhydrase 9

    Article • Cancer and Metastasis Reviews, April 2007, Springer Science + Business Media

    Dr Pawel Swietach

  51. pH-Dependence of Extrinsic and Intrinsic H+-Ion Mobility in the Rat Ventricular Myocyte, Investigated Using Flash Photolysis of a Caged-H+ Compound

    Article • Biophysical Journal, January 2007, Elsevier

    Dr Pawel Swietach

  52. pH-Regulated Na+ Influx into the Mammalian Ventricular Myocyte: The Relative Role of Na+-H+ Exchange and Na+-HCO3- Co-Transport

    Article • Journal of Cardiovascular Electrophysiology, May 2006, Wiley

    Dr Pawel Swietach

  53. Spatial aspects of intracellular pH regulation in heart muscle

    Article • Progress in Biophysics and Molecular Biology, January 2006, Elsevier

    Dr Pawel Swietach

  54. Relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes

    Article • The Journal of Physiology, July 2005, Wiley

    Dr Pawel Swietach

  55. Spatial Regulation of Intracellular pH in the Ventricular Myocyte

    Article • Annals of the New York Academy of Sciences, June 2005, Wiley

    Dr Pawel Swietach

  56. Experimental Generation and Computational Modeling of Intracellular pH Gradients in Cardiac Myocytes

    Article • Biophysical Journal, April 2005, Elsevier

    Dr Pawel Swietach

  57. Functional diversity of electrogenic Na+-HCO3−cotransport in ventricular myocytes from rat, rabbit and guinea pig

    Article • The Journal of Physiology, January 2005, Wiley

    Dr Pawel Swietach

  58. Novel method for measuring junctional proton permeation in isolated ventricular myocyte cell pairs

    Article • AJP Heart and Circulatory Physiology, July 2004, American Physiological Society

    Dr Pawel Swietach

  59. Modelling intracellular H+ ion diffusion

    Article • Progress in Biophysics and Molecular Biology, October 2003, Elsevier

    Dr Pawel Swietach

  60. Amino Acid Transport

    Article • January 2003, Springer Science + Business Media

    Dr Pawel Swietach

  61. Functional and molecular determination of carbonic anhydrase levels in bovine and cultured human chondrocytes

    Article • Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology, November 2002, Elsevier

    Dr Pawel Swietach