All Stories

  1. Targeting tRNA-synthetase interactions towards novel therapeutic discovery against eukaryotic pathogens

    Article • PLoS Neglected Tropical Diseases, February 2020, PLOS

    Michael Ibba

  2. FARS2 mutations presenting with pure spastic paraplegia and lesions of the dentate nuclei

    Article • Annals of Clinical and Translational Neurology, August 2018, Wiley

    Dr John M Graham, Jr, Michael Ibba

  3. EF-P Posttranslational Modification Has Variable Impact on Polyproline Translation in Bacillus subtilis

    Article • mBio, April 2018, ASM Journals

    Michael Ibba

  4. Carbonyl reduction by YmfI in Bacillus subtilis prevents accumulation of an inhibitory EF-P modification state

    Article • Molecular Microbiology, August 2017, Wiley

    Michael Ibba

  5. Elongation Factor P Interactions with the Ribosome Are Independent of Pausing

    Article • mBio, August 2017, ASM Journals

    Michael Ibba

  6. Maintenance of Transcription-Translation Coupling by Elongation Factor P

    Article • mBio, September 2016, ASM Journals

    Michael Ibba

  7. Cyclic Rhamnosylated Elongation Factor P Establishes Antibiotic Resistance in Pseudomonas aeruginosa

    Article • mBio, June 2015, ASM Journals

    Michael Ibba

  8. Relaxed Substrate Specificity Leads to Extensive tRNA Mischarging by Streptococcus pneumoniae Class I and Class II Aminoacyl-tRNA Synthetases

    Article • mBio, September 2014, ASM Journals

    Michael Ibba

  9. tRNAs as regulators of biological processes

    Article • Frontiers in Genetics, June 2014, Frontiers

    Michael Ibba, Medha Raina

  10. Oxidation of cellular amino acid pools leads to cytotoxic mistranslation of the genetic code

    Article • eLife, June 2014, eLife

    Michael Ibba, Medha Raina

  11. LysPGS formation inListeria monocytogeneshas broad roles in maintaining membrane integrity beyond antimicrobial peptide resistance

    Article • Virulence, March 2014, Taylor & Francis

    Michael Ibba

  12. The ABCs of the ribosome

    Article • Nature Structural & Molecular Biology, February 2014, Springer Science + Business Media

    Michael Ibba

  13. Molecular evolution of protein-RNA mimicry as a mechanism for translational control

    Article • Nucleic Acids Research, December 2013, Oxford University Press (OUP)

    Michael Ibba

  14. Direction of aminoacylated transfer RNAs into antibiotic synthesis and peptidoglycan‐mediated antibiotic resistance

    Article • FEBS Letters, July 2013, Wiley

    Michael Ibba

  15. Lipid II-independent trans Editing of Mischarged tRNAs by the Penicillin Resistance Factor MurM

    Article • Journal of Biological Chemistry, July 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Ibba

  16. Spotlight on… Michael Ibba

    Article • FEBS Letters, July 2013, Wiley

    Michael Ibba

  17. Divergent Protein Motifs Direct Elongation Factor P-Mediated Translational Regulation in Salmonella enterica and Escherichia coli

    Article • mBio, April 2013, ASM Journals

    Michael Ibba

  18. Emergence and Evolution

    Article • January 2013, Springer Science + Business Media

    Michael Ibba

  19. Genetic Code

    Article • January 2013, Elsevier

    Michael Ibba

  20. Selection of tRNA charging quality control mechanisms that increase mistranslation of the genetic code

    Article • Nucleic Acids Research, December 2012, Oxford University Press (OUP)

    Michael Ibba

  21. Taking AIM at the Start of Translation

    Article • Journal of Molecular Biology, November 2012, Elsevier

    Michael Ibba, Medha Raina

  22. A Pseudo-tRNA Modulates Antibiotic Resistance in Bacillus cereus

    Article • PLoS ONE, July 2012, PLOS

    Michael Ibba

  23. Association of a multi‐synthetase complex with translating ribosomes in the archaeon Thermococcus kodakarensis

    Article • FEBS Letters, June 2012, Wiley

    Michael Ibba, Medha Raina

  24. Cryo-EM Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6 and Implications for Ribosome Evolution

    Article • Journal of Molecular Biology, May 2012, Elsevier

    Michael Ibba

  25. The Cryo-EM Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6

    Article • February 2012, Protein Data Bank, Rutgers University

    Michael Ibba

  26. Roles of tRNA in cell wall biosynthesis

    Article • Wiley Interdisciplinary Reviews - RNA, January 2012, Wiley

    Michael Ibba

  27. Quality control in aminoacyl-tRNA synthesis

    Article • January 2012, Elsevier

    Michael Ibba

  28. β-Lysine discrimination by lysyl-tRNA synthetase

    Article • FEBS Letters, September 2011, Wiley

    Michael Ibba

  29. The tRNA synthetase paralog PoxA modifies elongation factor-P with (R)-β-lysine

    Article • Nature Chemical Biology, August 2011, Springer Science + Business Media

    Michael Ibba

  30. Mitochondrial Aminoacyl-tRNA Synthetase Single-Nucleotide Polymorphisms That Lead to Defects in Refolding but Not Aminoacylation

    Article • Journal of Molecular Biology, July 2011, Elsevier

    Michael Ibba

  31. Elongation factor P mediates a novel post-transcriptional regulatory pathway critical for bacterial virulence

    Article • Virulence, March 2011, Taylor & Francis

    Michael Ibba

  32. An Archaeal tRNA-Synthetase Complex that Enhances Aminoacylation under Extreme Conditions

    Article • Journal of Biological Chemistry, November 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Ibba

  33. Cellular mechanisms that control mistranslation

    Article • Nature Reviews Microbiology, November 2010, Springer Science + Business Media

    Michael Ibba

  34. New Roles for Codon Usage

    Article • Science, September 2010, American Association for the Advancement of Science

    Michael Ibba

  35. Transfer RNA's latest port of call

    Article • RNA Biology, September 2010, Taylor & Francis

    Michael Ibba

  36. Bridging the gap between ribosomal and nonribosomal protein synthesis

    Article • Proceedings of the National Academy of Sciences, August 2010, Proceedings of the National Academy of Sciences

    Michael Ibba

  37. Redox status affects the catalytic activity of glutamyl-tRNA synthetase

    Article • Biochemical and Biophysical Research Communications, July 2010, Elsevier

    Michael Ibba

  38. PoxA, YjeK, and Elongation Factor P Coordinately Modulate Virulence and Drug Resistance in Salmonella enterica

    Article • Molecular Cell, July 2010, Elsevier

    Michael Ibba, Professor Ferric C Fang

  39. Protein Evolution via Amino Acid and Codon Elimination

    Article • PLoS ONE, April 2010, PLOS

    Michael Ibba

  40. How the Sequence of a Gene Can Tune Its Translation

    Article • Cell, April 2010, Elsevier

    Michael Ibba

  41. Transfer RNA

    Article • FEBS Letters, November 2009, Wiley

    Michael Ibba

  42. tRNAs: Cellular barcodes for amino acids

    Article • FEBS Letters, November 2009, Wiley

    Michael Ibba, Medha Raina, Shawn Chen

  43. Aminoacyl-tRNA Synthesis and Translational Quality Control

    Article • Annual Review of Microbiology, October 2009, Annual Reviews

    Michael Ibba

  44. Large‐scale movement of functional domains facilitates aminoacylation by human mitochondrial phenylalanyl‐tRNA synthetase

    Article • FEBS Letters, September 2009, Wiley

    Michael Ibba, Dr Alexey V Zozulya

  45. Broad Range Amino Acid Specificity of RNA-dependent Lipid Remodeling by Multiple Peptide Resistance Factors

    Article • Journal of Biological Chemistry, September 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Ibba

  46. The CCA anticodon specifies separate functions inside and outside translation inBacillus cereus

    Article • RNA Biology, September 2009, Taylor & Francis

    Michael Ibba

  47. Characterization of Two Seryl-tRNA Synthetases in Albomycin-Producing Streptomyces sp. Strain ATCC 700974

    Article • Antimicrobial Agents and Chemotherapy, August 2009, ASM Journals

    Michael Ibba, Shawn Chen

  48. Resampling and Editing of Mischarged tRNA Prior to Translation Elongation

    Article • Molecular Cell, March 2009, Elsevier

    Michael Ibba

  49. Adaptation of the bacterial membrane to changing environments using aminoacylated phospholipids

    Article • Molecular Microbiology, January 2009, Wiley

    Michael Ibba

  50. Errors rectified in retrospect

    Article • Nature, January 2009, Springer Science + Business Media

    Michael Ibba

  51. The return of pretransfer editing in protein synthesis

    Article • Proceedings of the National Academy of Sciences, December 2008, Proceedings of the National Academy of Sciences

    Michael Ibba

  52. Aminoacyl-tRNA synthetase complexes: molecular multitasking revealed

    Article • FEMS Microbiology Reviews, July 2008, Oxford University Press (OUP)

    Michael Ibba

  53. Structural and functional mapping of the archaeal multi‐aminoacyl‐tRNA synthetase complex

    Article • FEBS Letters, June 2008, Wiley

    Michael Ibba

  54. RNA-dependent lipid remodeling by bacterial multiple peptide resistance factors

    Article • Proceedings of the National Academy of Sciences, March 2008, Proceedings of the National Academy of Sciences

    Michael Ibba

  55. Methods for studying aminoacyl-tRNA

    Article • Methods, February 2008, Elsevier

    Michael Ibba

  56. Monitoring Lys-tRNALys phosphatidylglycerol transferase activity

    Article • Methods, February 2008, Elsevier

    Michael Ibba

  57. Correction: Mechanisms of Resistance to an Amino Acid Antibiotic That Targets Translation

    Article • ACS Chemical Biology, February 2008, American Chemical Society (ACS)

    Michael Ibba

  58. Mechanisms of Resistance to an Amino Acid Antibiotic That Targets Translation

    Article • ACS Chemical Biology, December 2007, American Chemical Society (ACS)

    Michael Ibba

  59. Phenylalanyl-tRNA synthetase editing defects result in efficient mistranslation of phenylalanine codons as tyrosine

    Article • RNA, September 2007, Cold Spring Harbor Laboratory Press

    Michael Ibba

  60. Anticodon Recognition and Discrimination by the α-Helix Cage Domain of Class I Lysyl-tRNA Synthetase

    Article • Biochemistry, August 2007, American Chemical Society (ACS)

    Michael Ibba

  61. An aminoacyl-tRNA synthetase:elongation factor complex for substrate channeling in archaeal translation

    Article • Nucleic Acids Research, August 2007, Oxford University Press (OUP)

    Michael Ibba

  62. Peroxin Pex21p interacts with the C‐terminal noncatalytic domain of yeast seryl‐tRNA synthetase and forms a specific ternary complex with tRNASer

    Article • FEBS Journal, April 2007, Wiley

    Michael Ibba

  63. The unnatural culture of amino acids

    Article • Nature Methods, March 2007, Springer Science + Business Media

    Michael Ibba

  64. Mechanism of tRNA-dependent editing in translational quality control

    Article • Proceedings of the National Academy of Sciences, January 2007, Proceedings of the National Academy of Sciences

    Michael Ibba

  65. Functional Association between Three Archaeal Aminoacyl-tRNA Synthetases

    Article • Journal of Biological Chemistry, November 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Ibba

  66. Sticky end in protein synthesis

    Article • Nature, August 2006, Springer Science + Business Media

    Michael Ibba

  67. Phenylalanyl-tRNA Synthetase Contains a Dispensable RNA-Binding Domain that Contributes to the Editing of Noncognate Aminoacyl-tRNA

    Article • Biochemistry, July 2006, American Chemical Society (ACS)

    Michael Ibba

  68. Small Molecules: Big Players in the Evolution of Protein Synthesis

    Article • ACS Chemical Biology, June 2006, American Chemical Society (ACS)

    Michael Ibba

  69. Aspartyl-tRNA Synthetase Is the Target of Peptide Nucleotide Antibiotic Microcin C

    Article • Journal of Biological Chemistry, March 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Ibba

  70. Stationary-phase expression and aminoacylation of a transfer-RNA-like small RNA

    Article • EMBO Reports, August 2005, EMBO

    Michael Ibba

  71. Association between Archaeal Prolyl- and Leucyl-tRNA Synthetases Enhances tRNAPro Aminoacylation

    Article • Journal of Biological Chemistry, April 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Ibba

  72. Transfer RNA recognition by class I lysyl‐tRNA synthetase from the Lyme disease pathogen Borrelia burgdorferi

    Article • FEBS Letters, April 2005, Wiley

    Michael Ibba

  73. Post-transfer editing in vitro and in vivo by the β subunit of phenylalanyl-tRNA synthetase

    Article • The EMBO Journal, November 2004, Springer Science + Business Media

    Michael Ibba

  74. Discrimination of Cognate and Noncognate Substrates at the Active Site of Class II Lysyl-tRNA Synthetase

    Article • Biochemistry, August 2004, American Chemical Society (ACS)

    Michael Ibba

  75. Turning tRNA upside down: When aminoacylation is not a prerequisite to protein synthesis

    Article • Proceedings of the National Academy of Sciences, May 2004, Proceedings of the National Academy of Sciences

    Michael Ibba

  76. Photoreactive Bicyclic Amino Acids as Substrates for Mutant Escherichia coli Phenylalanyl-tRNA Synthetases

    Article • Journal of Biological Chemistry, March 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Ibba

  77. Divergence in Noncognate Amino Acid Recognition between Class I and Class II Lysyl-tRNA Synthetases

    Article • Journal of Biological Chemistry, January 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Michael Ibba

  78. Trans-editing of mischarged tRNAs

    Article • Proceedings of the National Academy of Sciences, December 2003, Proceedings of the National Academy of Sciences

    Michael Ibba

  79. Activation of the Pyrrolysine Suppressor tRNA Requires Formation of a Ternary Complex with Class I and Class II Lysyl-tRNA Synthetases

    Article • Molecular Cell, August 2003, Elsevier

    Michael Ibba

  80. Aminoacyl‐tRNA synthesis in archaea: different but not unique

    Article • Molecular Microbiology, April 2003, Wiley

    Michael Ibba

  81. Elongating without arms

    Article • Trends in Biochemical Sciences, November 2002, Elsevier

    Michael Ibba

  82. aDEAD-end job for RNA chaperone

    Article • Trends in Biochemical Sciences, September 2002, Elsevier

    Michael Ibba

  83. Functional Annotation of Class I Lysyl-tRNA Synthetase Phylogeny Indicates a Limited Role for Gene Transfer

    Article • Journal of Bacteriology, August 2002, ASM Journals

    Michael Ibba

  84. Genetic Code: Introducing Pyrrolysine

    Article • Current Biology, July 2002, Elsevier

    Michael Ibba

  85. mRNA decay: the big picture

    Article • Trends in Biochemical Sciences, July 2002, Elsevier

    Michael Ibba

  86. Eyeing up tryptophanyl-tRNA synthetase

    Article • Trends in Biochemical Sciences, May 2002, Elsevier

    Michael Ibba

  87. Antibody Detection in Human Serum Using a Versatile Protein Chip Platform Constructed by Applying Nanoscale Self-Assembled Architectures on Gold

    Article • Journal of Proteome Research, April 2002, American Chemical Society (ACS)

    Michael Ibba, Dr Michael Schäferling

  88. Functional convergence of two lysyl-tRNA synthetases with unrelated topologies

    Article • Nature Structural Biology, March 2002, Springer Science + Business Media

    Michael Ibba

  89. Biochemistry and bioinformatics: when worlds collide

    Article • Trends in Biotechnology, February 2002, Elsevier

    Michael Ibba

  90. Biochemistry and bioinformatics: when worlds collide

    Article • Trends in Biochemical Sciences, February 2002, Elsevier

    Michael Ibba

  91. Nonsense suppression in Archaea

    Article • Trends in Biochemical Sciences, November 2001, Elsevier

    Michael Ibba

  92. PROTEIN SYNTHESIS: Enhanced: Discriminating Right from Wrong

    Article • Science, October 2001, American Association for the Advancement of Science

    Michael Ibba

  93. Nuclear translation: keeping a lookout for nonsense

    Article • Trends in Biochemical Sciences, September 2001, Elsevier

    Michael Ibba

  94. Protein synthesis: Twenty three amino acids and counting

    Article • Current Biology, July 2001, Elsevier

    Michael Ibba

  95. The renaissance of aminoacyl-tRNA synthesis

    Article • EMBO Reports, May 2001, Wiley

    Michael Ibba

  96. ChemInform Abstract: Development of Strategies for the Site‐Specific in vivo Incorporation of Photoreactive Amino Acids: p‐Azidophenylalanine, p‐Acetylphenylalanine and Benzofuranylalanine.

    Article • ChemInform, March 2001, Wiley

    Michael Ibba

  97. Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use

    Article • Toxicology, March 2001, Elsevier

    Michael Ibba

  98. Context-dependent anticodon recognition by class I lysyl-tRNA synthetases

    Article • Proceedings of the National Academy of Sciences, December 2000, Proceedings of the National Academy of Sciences

    Michael Ibba

  99. Development of Strategies for the Site-Specific In Vivo Incorporation of Photoreactive Amino Acids: p-Azidophenylalanine, p-Acetylphenylalanine and Benzofuranylalanine

    Article • Tetrahedron, November 2000, Elsevier

    Michael Ibba

  100. Author Correction

    Article • Trends in Biochemical Sciences, August 2000, Elsevier

    Michael Ibba

  101. The Adaptor hypothesis revisited

    Article • Trends in Biochemical Sciences, July 2000, Elsevier

    Michael Ibba

  102. Aminoacyl-tRNA Synthesis

    Article • Annual Review of Biochemistry, June 2000, Annual Reviews

    Michael Ibba

  103. Aminoacyl-tRNA Synthetases, the Genetic Code, and the Evolutionary Process

    Article • Microbiology and Molecular Biology Reviews, March 2000, ASM Journals

    Michael Ibba

  104. Quality Control Mechanisms During Translation

    Article • Science, December 1999, American Association for the Advancement of Science

    Michael Ibba

  105. Transfer RNA identity contributes to transition state stabilization during aminoacyl-tRNA synthesis

    Article • Nucleic Acids Research, September 1999, Oxford University Press (OUP)

    Michael Ibba

  106. Archaeal Aminoacyl-tRNA Synthesis: Unique Determinants of a Universal Genetic Code?

    Article • Biological Bulletin, June 1999, JSTOR

    Michael Ibba

  107. tRNA recognition and evolution of determinants in seryl-tRNA synthesis

    Article • Nucleic Acids Research, February 1999, Oxford University Press (OUP)

    Michael Ibba

  108. Recognition of One tRNA by Two Classes of Aminoacyl-tRNA Synthetase

    Article • January 1999, Springer Science + Business Media

    Michael Ibba

  109. Retracing the evolution of amino acid specificity in glutaminyl‐tRNA synthetase

    Article • FEBS Letters, August 1998, Wiley

    Michael Ibba

  110. A Euryarchaeal Lysyl-tRNA Synthetase: Resemblance to Class I Synthetases

    Article • Science, November 1997, American Association for the Advancement of Science

    Michael Ibba

  111. Aminoacyl-tRNA synthesis: divergent routes to a common goal

    Article • Trends in Biochemical Sciences, February 1997, Elsevier

    Michael Ibba

  112. 'Distorted' RNA helix recognition

    Article • Nature, December 1996, Springer Science + Business Media

    Michael Ibba

  113. Strategies forin vitroandin vivotranslation with non-natural amino acids

    Article • Biotechnology and Genetic Engineering Reviews, December 1996, Taylor & Francis

    Michael Ibba

  114. Genetic analysis of functional connectivity between substrate recognition domains ofEscherichia coli glutaminyl-tRNA synthetase

    Article • October 1996

    Michael Ibba

  115. tRNA-dependent asparagine formation

    Article • Nature, August 1996, Springer Science + Business Media

    Michael Ibba

  116. Protein-RNA molecular recognition

    Article • Nature, June 1996, Springer Science + Business Media

    Michael Ibba

  117. Glutaminyl‐tRNA synthetase: from genetics to molecular recognition

    Article • Genes to Cells, May 1996, Wiley

    Michael Ibba

  118. Homologous Expression and Purification of Mutants of an Essential Protein by Reverse Epitope-Tagging

    Article • Nature Biotechnology, January 1996, Springer Science + Business Media

    Michael Ibba

  119. Genetic analysis of functional connectivity between substrate recognition domains of

    Article • MGG Molecular & General Genetics, January 1996, Springer Science + Business Media

    Michael Ibba

  120. Relaxing the substrate specificity of an aminoacyl‐tRNA synthetase allows in vitro and in vivo synthesis of proteins containing unnatural amino acids

    Article • FEBS Letters, May 1995, Wiley

    Michael Ibba

  121. Increased rates of tRNA charging through modification of the enzyme‐aminoacyl‐adenylate complex of phenylalanyl‐tRNA synthetase

    Article • FEBS Letters, January 1995, Wiley

    Michael Ibba

  122. A broadly applicable continuous spectrophotometric assay for measuring aminoacyl-tRNA synthetase activity

    Article • Nucleic Acids Research, January 1995, Oxford University Press (OUP)

    Michael Ibba

  123. Towards Engineering Proteins by Site-Directed Incorporation In Vivo of Non-Natural Amino Acids

    Article • Nature Biotechnology, July 1994, Springer Science + Business Media

    Michael Ibba

  124. Substrate Specificity Is Determined by Amino Acid Binding Pocket Size in Escherichia coli Phenylalanyl-tRNA Synthetase

    Article • Biochemistry, June 1994, American Chemical Society (ACS)

    Michael Ibba

  125. Stable continuous constitutive expression of a heterologous protein in Saccharomyces cerevisiae without selection pressure

    Article • Applied Microbiology and Biotechnology, July 1993, Springer Science + Business Media

    Michael Ibba

  126. Mode of cultivation is critical for the optimal expression of recombinant Hirudin bySaccharomyces cerevisiae

    Article • Biotechnology Letters, July 1993, Springer Science + Business Media

    Michael Ibba

  127. Two stage methanogenesis of glucose byAcetogenium kivui and acetoclastic methanogenic Sp.

    Article • Biotechnology Letters, September 1991, Springer Science + Business Media

    Michael Ibba

  128. Submerged Fermentation of Penicillium paxilli Biosynthesizing Paxilline, a Process Inhibited by Calcium-induced Sporulation

    Article • Microbiology, November 1987, Society for General Microbiology

    Michael Ibba