All Stories

  1. Assessing Boron-Pleuromutilin AN11251 for the Development of Antibacterial Agents

    Article • Molecules, June 2023, MDPI AG

    Shawn Chen

  2. A streamlined process for discovery and characterization of inhibitors against phenylalanyl-tRNA synthetase of Mycobacterium tuberculosis

    Article • January 2023, Elsevier

    Shawn Chen

  3. Human Kinase IGF1R/IR Inhibitor Linsitinib Controls the In Vitro and Intracellular Growth of Mycobacterium tuberculosis

    Article • ACS Infectious Diseases, September 2022, American Chemical Society (ACS)

    Shawn Chen

  4. Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents

    Article • ACS Chemical Biology, December 2021, American Chemical Society (ACS)

    Shawn Chen

  5. Rediscovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis

    Article • Journal of Biological Chemistry, January 2021, Elsevier

    Shawn Chen

  6. Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens

    Article • Nature Communications, September 2018, Springer Science + Business Media

    Shawn Chen

  7. Nature’s combinatorial biosynthesis and recently engineered production of nucleoside antibiotics in Streptomyces

    Article • World Journal of Microbiology and Biotechnology, March 2017, Springer Science + Business Media

    Shawn Chen

  8. A Branch Point of Streptomyces Sulfur Amino Acid Metabolism Controls the Production of Albomycin

    Article • Applied and Environmental Microbiology, October 2015, ASM Journals

    Shawn Chen

  9. Analysis of the biosynthesis of antibacterial cyclic dipeptides in Nocardiopsis alba

    Article • Archives of Microbiology, July 2014, Springer Science + Business Media

    Shawn Chen

  10. Whole-Genome Sequence of Nocardiopsis alba Strain ATCC BAA-2165, Associated with Honeybees

    Article • Journal of Bacteriology, October 2012, ASM Journals

    Shawn Chen

  11. Biosynthesis of Albomycin δ 2 Provides a Template for Assembling Siderophore and Aminoacyl-tRNA Synthetase Inhibitor Conjugates

    Article • ACS Chemical Biology, September 2012, American Chemical Society (ACS)

    Professor Steven G Van Lanen, Shawn Chen

  12. Isolation and characterization of a Nocardiopsis sp. from honeybee guts

    Article • FEMS Microbiology Letters, September 2010, Oxford University Press (OUP)

    Shawn Chen

  13. tRNAs: Cellular barcodes for amino acids

    Article • FEBS Letters, November 2009, Wiley

    Michael Ibba, Medha Raina, Shawn Chen

  14. Characterization of Two Seryl-tRNA Synthetases in Albomycin-Producing Streptomyces sp. Strain ATCC 700974

    Article • Antimicrobial Agents and Chemotherapy, August 2009, ASM Journals

    Michael Ibba, Shawn Chen

  15. An Improved System for the Generation and Analysis of Mutant Proteins Containing Unnatural Amino Acids in Saccharomyces cerevisiae

    Article • Journal of Molecular Biology, August 2007, Elsevier

    Shawn Chen

  16. Genetic incorporation of unnatural amino acids into proteins in mammalian cells

    Article • Nature Methods, February 2007, Springer Science + Business Media

    Shawn Chen

  17. A genetically encoded fluorescent amino acid

    Article • Proceedings of the National Academy of Sciences, June 2006, Proceedings of the National Academy of Sciences

    Shawn Chen

  18. MicC, a Second Small-RNA Regulator of Omp Protein Expression in Escherichia coli

    Article • Journal of Bacteriology, October 2004, ASM Journals

    Shawn Chen

  19. Multitarget Affinity/Specificity Screening of Natural Products:  Finding and Characterizing High-Affinity Ligands from Complex Mixtures by Using High-Performance Mass Spectrometry

    Article • Journal of Natural Products, August 2003, American Chemical Society (ACS)

    Shawn Chen

  20. A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome

    Article • Biosystems, March 2002, Elsevier

    Shawn Chen

  21. The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide

    Article • Gene, January 2001, Elsevier

    Shawn Chen

  22. Mechanisms of molecular recognition in the pikromycin polyketide synthase

    Article • Chemistry & Biology, December 2000, Elsevier

    Shawn Chen

  23. Biosynthesis of ansatrienin (mycotrienin) and naphthomycin

    Article • European Journal of Biochemistry, March 1999, Wiley

    Shawn Chen