All Stories

  1. Microbiological evidence for the trisubstituted benzimidazoles targeting MmpL3 in Mycobacterium tuberculosis

    Article • Antimicrobial Agents and Chemotherapy, October 2025, ASM Journals

    Shawn Chen

  2. GenVS-TBDB: An Open AI-Generated and Virtual-Screened Small-Molecule Database for Tuberculosis Drug Discovery

    Article • May 2025, Cold Spring Harbor Laboratory Press

    Shawn Chen

  3. Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria

    Article • mLife, April 2025, Wiley

    Shawn Chen

  4. TamGen: drug design with target-aware molecule generation through a chemical language model

    Article • Nature Communications, October 2024, Springer Science + Business Media

    Shawn Chen

  5. Assessing Boron-Pleuromutilin AN11251 for the Development of Antibacterial Agents

    Article • Molecules, June 2023, MDPI AG

    Shawn Chen

  6. A streamlined process for discovery and characterization of inhibitors against phenylalanyl-tRNA synthetase of Mycobacterium tuberculosis

    Article • January 2023, Elsevier

    Shawn Chen

  7. Human Kinase IGF1R/IR Inhibitor Linsitinib Controls the In Vitro and Intracellular Growth of Mycobacterium tuberculosis

    Article • ACS Infectious Diseases, September 2022, American Chemical Society (ACS)

    Shawn Chen

  8. Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents

    Article • ACS Chemical Biology, December 2021, American Chemical Society (ACS)

    Shawn Chen

  9. Rediscovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis

    Article • Journal of Biological Chemistry, January 2021, Elsevier

    Shawn Chen

  10. Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens

    Article • Nature Communications, September 2018, Springer Science + Business Media

    Shawn Chen

  11. Systematic and functional identification of small non-coding RNAs associated with exogenous biofuel stress in cyanobacterium Synechocystis sp. PCC 6803

    Article • Biotechnology for Biofuels, March 2017, Springer Science + Business Media

    Shawn Chen

  12. Nature’s combinatorial biosynthesis and recently engineered production of nucleoside antibiotics in Streptomyces

    Article • World Journal of Microbiology and Biotechnology, March 2017, Springer Science + Business Media

    Shawn Chen

  13. A Branch Point of Streptomyces Sulfur Amino Acid Metabolism Controls the Production of Albomycin

    Article • Applied and Environmental Microbiology, October 2015, ASM Journals

    Shawn Chen

  14. Analysis of the biosynthesis of antibacterial cyclic dipeptides in Nocardiopsis alba

    Article • Archives of Microbiology, July 2014, Springer Science + Business Media

    Shawn Chen

  15. Whole-Genome Sequence of Nocardiopsis alba Strain ATCC BAA-2165, Associated with Honeybees

    Article • Journal of Bacteriology, October 2012, ASM Journals

    Shawn Chen

  16. Biosynthesis of Albomycin δ 2 Provides a Template for Assembling Siderophore and Aminoacyl-tRNA Synthetase Inhibitor Conjugates

    Article • ACS Chemical Biology, September 2012, American Chemical Society (ACS)

    Professor Steven G Van Lanen, Shawn Chen

  17. Inhibition of selenocysteine tRNA[Ser]Sec aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA

    Article • Biochemical and Biophysical Research Communications, June 2011, Elsevier

    Shawn Chen

  18. Isolation and characterization of a Nocardiopsis sp. from honeybee guts

    Article • FEMS Microbiology Letters, September 2010, Oxford University Press (OUP)

    Shawn Chen

  19. tRNAs: Cellular barcodes for amino acids

    Article • FEBS Letters, November 2009, Wiley

    Michael Ibba, Medha Raina, Shawn Chen

  20. Characterization of Two Seryl-tRNA Synthetases in Albomycin-Producing Streptomyces sp. Strain ATCC 700974

    Article • Antimicrobial Agents and Chemotherapy, August 2009, ASM Journals

    Michael Ibba, Shawn Chen

  21. Identification of Human Kinases Involved in Hepatitis C Virus Replication by Small Interference RNA Library Screening

    Article • Journal of Biological Chemistry, January 2008, Elsevier

    Shawn Chen

  22. An Improved System for the Generation and Analysis of Mutant Proteins Containing Unnatural Amino Acids in Saccharomyces cerevisiae

    Article • Journal of Molecular Biology, August 2007, Elsevier

    Shawn Chen

  23. Genetic incorporation of unnatural amino acids into proteins in mammalian cells

    Article • Nature Chemical Biology, February 2007, Springer Science + Business Media

    Shawn Chen

  24. A genetically encoded fluorescent amino acid

    Article • Proceedings of the National Academy of Sciences, June 2006, Proceedings of the National Academy of Sciences

    Shawn Chen

  25. High throughput drug discovery with ESI-FTICR

    Article • International Journal of Mass Spectrometry, November 2004, Elsevier

    Shawn Chen

  26. MicC, a Second Small-RNA Regulator of Omp Protein Expression in Escherichia coli

    Article • Journal of Bacteriology, October 2004, ASM Journals

    Shawn Chen

  27. Multitarget Affinity/Specificity Screening of Natural Products:  Finding and Characterizing High-Affinity Ligands from Complex Mixtures by Using High-Performance Mass Spectrometry

    Article • Journal of Natural Products, August 2003, American Chemical Society (ACS)

    Shawn Chen

  28. A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome

    Article • Biosystems, March 2002, Elsevier

    Shawn Chen

  29. Genetic approaches for controlling ratios of related polyketide products in fermentation processes

    Article • Journal of Industrial Microbiology & Biotechnology, December 2001, Oxford University Press (OUP)

    Shawn Chen

  30. The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide

    Article • Gene, January 2001, Elsevier

    Shawn Chen

  31. Mechanisms of molecular recognition in the pikromycin polyketide synthase

    Article • Chemistry & Biology, December 2000, Elsevier

    Shawn Chen

  32. Biosynthesis of ansatrienin (mycotrienin) and naphthomycin

    Article • European Journal of Biochemistry, March 1999, Wiley

    Shawn Chen