All Stories

  1. The Neonatal Myeloid Hypoxia Response Promotes a Cardiac Regenerative Response through Insulin-Like Growth Factor

    Article • April 2026, openRxiv

    Professor Zhi-Dong Ge

  2. Machine Learning Identifies Distinct Treg-Mediated Remodeling in HFpEF Hearts Treated with Neonatal Mesenchymal Stem Cells and Their Secretome

    Article • January 2026, openRxiv

    Professor Zhi-Dong Ge

  3. Correction to: Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction

    Article • Circulation, January 2026, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  4. LncRNA H19 Upregulation Links Hypoplastic Left Heart Syndrome to Impaired PINK1/Parkin-Mediated Mitophagy and Ischemic Vulnerability

    Article • December 2025, openRxiv

    Professor Zhi-Dong Ge

  5. Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction

    Article • Circulation, May 2025, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  6. Early-age efferocytosis directs macrophage arachidonic acid metabolism for tissue regeneration

    Article • Immunity, February 2025, Elsevier

    Professor Zhi-Dong Ge

  7. Mechanical regulation of macrophage metabolism by allograft inflammatory factor 1 leads to adverse remodeling after cardiac injury

    Article • Nature Cardiovascular Research, January 2025, Springer Science + Business Media

    Professor Zhi-Dong Ge

  8. Leukocyte-lymphatic intersections during cardiac inflammation

    Article • Journal of Molecular and Cellular Cardiology, January 2025, Elsevier

    Professor Zhi-Dong Ge

  9. Hypoxia-inducible factor-2α enhances neutrophil survival to promote cardiac injury following myocardial infarction

    Article • AJP Heart and Circulatory Physiology, November 2024, American Physiological Society

    Professor Zhi-Dong Ge

  10. FOXC1 and FOXC2 Ablation Causes Abnormal Valvular Endothelial Cell Junctions and Lymphatic Vessel Formation in Myxomatous Mitral Valve Degeneration

    Article • Arteriosclerosis Thrombosis and Vascular Biology, September 2024, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  11. Genetic deletion or pharmacologic inhibition of histone deacetylase 6 protects the heart against ischaemia/reperfusion injury by limiting tumour necrosis factor alpha–induced mitochondrial injury in experimental diabetes

    Article • Cardiovascular Research, July 2024, Oxford University Press (OUP)

    Professor Zhi-Dong Ge

  12. Neonatal Cardiac Mesenchymal Stromal Cells Promote Recovery of Infarcted Myocardium through CD44 Mediated FoxP3+ T-Regulatory Cells after Vascular Infusion

    Article • Stem Cell Reviews and Reports, June 2024, Springer Science + Business Media

    Professor Zhi-Dong Ge

  13. In Vivo Mapping of Myocardial Injury Outside the Infarct Zone: Tissue at an Intermediate Pathological State

    Article • Journal of the American Heart Association, May 2024, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  14. HSF-1 enhances cardioprotective potential of stem cells via exosome biogenesis and their miRNA cargo enrichment

    Article • Stem Cell Reviews and Reports, June 2023, Springer Science + Business Media

    Professor Zhi-Dong Ge

  15. Augmentation of Histone Deacetylase 6 Activity Impairs Mitochondrial Respiratory Complex I in Ischemic/Reperfused Diabetic Hearts

    Article • February 2023, Cold Spring Harbor Laboratory Press

    Professor Zhi-Dong Ge

  16. Cardio-omentopexy requires a cardioprotective innate immune response to promote myocardial angiogenesis in mice

    Article • JTCVS Open, June 2022, Elsevier

    Professor Zhi-Dong Ge

  17. Wireless, implantable catheter-type oximeter designed for cardiac oxygen saturation

    Article • Science Advances, February 2021, American Association for the Advancement of Science

    Professor Zhi-Dong Ge

  18. Identification and analysis of circulating long non-coding RNAs with high significance in diabetic cardiomyopathy

    Article • Scientific Reports, January 2021, Springer Science + Business Media

    Professor Zhi-Dong Ge

  19. Genome-wide differential expression profiling of lncRNAs and mRNAs associated with early diabetic cardiomyopathy

    Article • Scientific Reports, October 2019, Springer Science + Business Media

    Professor Zhi-Dong Ge

  20. Current Status and Challenges of NRF2 as a Potential Therapeutic Target for Diabetic Cardiomyopathy

    Article • International Heart Journal, May 2019, International Heart Journal (Japanese Heart Journal)

    Professor Zhi-Dong Ge

  21. Microarray analysis of long non-coding RNA and mRNA expression profiles in diabetic cardiomyopathy using human induced pluripotent stem cell–derived cardiomyocytes

    Article • Diabetes and Vascular Disease Research, November 2018, SAGE Publications

    Professor Zhi-Dong Ge

  22. Current status and strategies of long noncoding RNA research for diabetic cardiomyopathy

    Article • BMC Cardiovascular Disorders, October 2018, Springer Science + Business Media

    Professor Zhi-Dong Ge

  23. Vascular endothelial growth factor regulation of endothelial nitric oxide synthase phosphorylation is involved in isoflurane cardiac preconditioning

    Article • Cardiovascular Research, June 2018, Oxford University Press (OUP)

    Professor Michael Garnet Irwin, Professor Zhi-Dong Ge

  24. Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury

    Article • Mediators of Inflammation, June 2018, Hindawi Publishing Corporation

    Professor Zhi-Dong Ge

  25. Failure of Isoflurane Cardiac Preconditioning in Obese Type 2 Diabetic Mice Involves Aberrant Regulation of MicroRNA-21, Endothelial Nitric-oxide Synthase, and Mitochondrial Complex I

    Article • Anesthesiology, January 2018, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  26. The application of remote ischemic conditioning in heart surgery

    Article • F1000Research, June 2017, Faculty of 1000, Ltd.

    Professor Zhi-Dong Ge

  27. Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling

    Article • Scientific Reports, June 2017, Springer Science + Business Media

    Professor Zhi-Dong Ge

  28. Nicorandil, a Nitric Oxide Donor and ATP-Sensitive Potassium Channel Opener, Protects Against Dystrophin-Deficient Cardiomyopathy

    Article • Journal of Cardiovascular Pharmacology and Therapeutics, July 2016, SAGE Publications

    Professor Zhi-Dong Ge

  29. Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy

    Article • Scientific Reports, June 2016, Nature

    Professor Zhi-Dong Ge

  30. Chronic Co-Administration of Sepiapterin and l -Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice

    Article • Circulation Heart Failure, January 2016, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  31. MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia–Reperfusion Injury via Akt/Nitric Oxide Synthase/Mitochondrial Permeability Transition Pore Pathway

    Article • Anesthesiology, October 2015, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  32. Isoflurane Favorably Modulates Guanosine Triphosphate Cyclohydrolase-1 and Endothelial Nitric Oxide Synthase during Myocardial Ischemia and Reperfusion Injury in Rats

    Article • Anesthesiology, September 2015, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  33. Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling

    Article • Clinical Science, May 2015, Portland Press Ltd.

    Professor Michael Garnet Irwin, Professor Zhi-Dong Ge

  34. Up-regulation of MicroRNA-21 Mediates Isoflurane-induced Protection of Cardiomyocytes

    Article • Anesthesiology, April 2015, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  35. Far red/near infrared light-induced protection against cardiac ischemia and reperfusion injury remains intact under diabetic conditions and is independent of nitric oxide synthase

    Article • Frontiers in Physiology, August 2014, Frontiers

    Professor Zhi-Dong Ge

  36. Rap1b in Smooth Muscle and Endothelium Is Required for Maintenance of Vascular Tone and Normal Blood Pressure

    Article • Arteriosclerosis Thrombosis and Vascular Biology, July 2014, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  37. Impairment of Endothelial-Myocardial Interaction Increases the Susceptibility of Cardiomyocytes to Ischemia/Reperfusion Injury

    Article • PLOS One, July 2013, PLOS

    Professor Zhi-Dong Ge

  38. Apolipoprotein A-1 mimetic D-4F enhances isoflurane-induced eNOS signaling and cardioprotection during acute hyperglycemia

    Article • AJP Heart and Circulatory Physiology, July 2013, American Physiological Society

    Professor Zhi-Dong Ge

  39. 4F Decreases IRF5 Expression and Activation in Hearts of Tight Skin Mice

    Article • PLOS One, December 2012, PLOS

    Professor Zhi-Dong Ge

  40. Stress-Induced Cell-Cycle Activation in Tip60 Haploinsufficient Adult Cardiomyocytes

    Article • PLOS One, February 2012, PLOS

    Professor Zhi-Dong Ge

  41. Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning

    Article • AJP Heart and Circulatory Physiology, November 2011, American Physiological Society

    Professor Zhi-Dong Ge

  42. Characterization of a critical role for CFTR chloride channels in cardioprotection against ischemia/reperfusion injury

    Article • Acta Pharmacologica Sinica, June 2011, Springer Science + Business Media

    Professor Zhi-Dong Ge

  43. Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia

    Article • Cardiovascular Research, March 2011, European Society of Cardiology

    Professor Zhi-Dong Ge

  44. A3 adenosine receptor activation during reperfusion reduces infarct size through actions on bone marrow-derived cells

    Article • Journal of Molecular and Cellular Cardiology, August 2010, Elsevier

    Professor Zhi-Dong Ge

  45. Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection

    Article • AJP Heart and Circulatory Physiology, July 2010, American Physiological Society

    Professor Zhi-Dong Ge

  46. Isoflurane Postconditioning Protects against Reperfusion Injury by Preventing Mitochondrial Permeability Transition by an Endothelial Nitric Oxide Synthase–dependent Mechanism

    Article • Anesthesiology, January 2010, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  47. Transient Receptor Potential Vanilloid Type 4–Deficient Mice Exhibit Impaired Endothelium-Dependent Relaxation Induced by Acetylcholine In Vitro and In Vivo

    Article • Hypertension, March 2009, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  48. The A3 Adenosine Receptor Agonist CP-532,903 [N6-(2,5-Dichlorobenzyl)-3′-aminoadenosine-5′-N-methylcarboxamide] Protects against Myocardial Ischemia/Reperfusion Injury via the Sarcolemmal ATP-Sensitive Potassium Channel

    Article • Journal of Pharmacology and Experimental Therapeutics, January 2008, Elsevier

    Professor Zhi-Dong Ge

  49. Cl-IB-MECA [2-Chloro-N6-(3-iodobenzyl)adenosine-5′-N-methylcarboxamide] Reduces Ischemia/Reperfusion Injury in Mice by Activating the A Adenosine Receptor

    Article • Journal of Pharmacology and Experimental Therapeutics, December 2006, Elsevier

    Professor Zhi-Dong Ge

  50. Improved cardiac function in infarcted mice after treatment with pluripotent embryonic stem cells

    Article • The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology, September 2006, Wiley

    Professor Zhi-Dong Ge

  51. Adenosine Inhibits Tumor Necrosis Factor-α Release from Mouse Peritoneal Macrophages via A2A and A2B but Not the A3 Adenosine Receptor

    Article • Journal of Pharmacology and Experimental Therapeutics, April 2006, Elsevier

    Professor Zhi-Dong Ge

  52. Electrophysiologic and mechanical evidence of superiority of hyperpolarizing versus depolarizing cardioplegia in protection of endothelium-derived hyperpolarizing factor–mediated endothelial function: a study in coronary resistance arteries

    Article • Journal of Thoracic and Cardiovascular Surgery, June 2004, Elsevier

    Professor Zhi-Dong Ge

  53. Comparison of Three Different A1 Adenosine Receptor Antagonists on Infarct Size and Multiple Cycle Ischemic Preconditioning in Anesthetized Dogs

    Article • Journal of Pharmacology and Experimental Therapeutics, November 2003, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Zhi-Dong Ge

  54. A3adenosine receptor agonist IB-MECA reduces myocardial ischemia-reperfusion injury in dogs

    Article • AJP Heart and Circulatory Physiology, August 2003, American Physiological Society

    Professor Zhi-Dong Ge

  55. Comparison of Cardioprotective Efficacy of Two Thromboxane A2 Receptor Antagonists

    Article • Journal of Cardiovascular Pharmacology, March 2003, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  56. Cyclic ADP-Ribose Contributes to Contraction and Ca<sup>2+</sup> Release by M<sub>1</sub> Muscarinic Receptor Activation in Coronary Arterial Smooth Muscle

    Article • Journal of Vascular Research, January 2003, Karger Publishers

    Professor Zhi-Dong Ge

  57. Gene Dosage-Dependent Effects of Cardiac-Specific Overexpression of the A 3 Adenosine Receptor

    Article • Circulation Research, July 2002, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  58. Myocardial ischemia and reperfusion reduce the levels of cyclic ADP-ribose in rat myocardium

    Article • Basic Research in Cardiology, July 2002, Springer Science + Business Media

    Professor Zhi-Dong Ge

  59. Role of ADP-ribose in 11,12-EET-induced activation of KCachannels in coronary arterial smooth muscle cells

    Article • AJP Heart and Circulatory Physiology, April 2002, American Physiological Society

    Professor Zhi-Dong Ge

  60. Difference in Endothelium-Derived Hyperpolarizing Factor–Mediated Hyperpolarization and Nitric Oxide Release Between Human Internal Mammary Artery and Saphenous Vein

    Article • Circulation, November 2000, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  61. Difference in Endothelium-Derived Hyperpolarizing Factor-Mediated Hyperpolarization and Nitric Oxide Release Between Human Internal Mammary Artery and Saphenous Vein

    Article • Circulation, November 2000, Wolters Kluwer Health

    Professor Zhi-Dong Ge

  62. Effect of nitric oxide on calcium-induced calcium release in coronary arterial smooth muscle

    Article • General Pharmacology The Vascular System, July 2000, Elsevier

    Professor Zhi-Dong Ge

  63. Endothelium-dependent hyperpolarization and relaxation resistance to NG-nitro-?-arginine and indomethacin in coronary circulation

    Article • Cardiovascular Research, June 2000, European Society of Cardiology

    Professor Zhi-Dong Ge

  64. Altered endothelium-derived hyperpolarizing factor–mediated endothelial function in coronary microarteries by St Thomas' hospital solution

    Article • Journal of Thoracic and Cardiovascular Surgery, July 1999, Elsevier

    Professor Zhi-Dong Ge