All Stories

  1. Bridging the operational gap in population pharmacokinetic-pharmacodynamic analysis: an international perspective on the 2025 Chinese group standard
  2. Population Pharmacokinetics and Exposure–Response Analysis of Oral Pixavir Marboxil in Adults and Adolescents with Influenza
  3. Bayesian-Based Pharmacokinetic Framework Integrated with Therapeutic Drug Monitoring for Assessing Adherence to Antiseizure Medications: A Clinical Trial Simulation Study
  4. Model-informed precision pyrazinamide dosing: The establishment of a population pharmacokinetic model repository for clinical decision support
  5. Pharmacokinetic interactions of fruit juices with antihypertensive drugs in humans: A systematic review and meta-analysis
  6. Influential predictors of azithromycin pharmacokinetics: a systematic review of population pharmacokinetics
  7. Once‐ Versus Twice‐Daily Tacrolimus Therapy: Does Improved Adherence Lead to Better Efficacy?—A Pharmacokinetic Perspective
  8. Corrigendum to “External evaluation of tacrolimus population pharmacokinetic models in adult lung transplant patients: How to enhance the predictive ability of the model?” [Int. Immunopharmacol. 143 (2024) 113225]
  9. A tumor-conditional IL-15 safely synergizes with immunotherapy to enhance antitumor immune responses
  10. External evaluation of tacrolimus population pharmacokinetic models in adult lung transplant patients: How to enhance the predictive ability of the model?
  11. Handling delayed or missed direct oral anticoagulant doses: model-informed individual remedial dosing
  12. A small step toward precision dosing of caffeine in preterm infants: An external evaluation of published population pharmacokinetic models
  13. Do Chinese HIV-infected adult patients with altered renal function need to adjust tenofovir disoproxil fumarate dosage? A population pharmacokinetics analysis
  14. Evaluation of Population Pharmacokinetic Models of Micafungin: Implications for Dosing Regimen Optimization in Critically Ill Patients
  15. Development and application of a population pharmacokinetic model repository for caffeine dose tailoring in preterm infants
  16. Toward Model-Informed Precision Dosing for Remimazolam: A Population Pharmacokinetic–Pharmacodynamic Analysis
  17. Evaluation of Population Pharmacokinetic Models of Micafungin: Implications for Dosing Regimen Optimization in Critically Ill Patients
  18. Trilaciclib dosage in Chinese patients with extensive-stage small cell lung cancer: a pooled pharmacometrics analysis
  19. Corrigendum to “External evaluation of the predictive performance of published population pharmacokinetic models of linezolid in adult patients” [Journal of Global Antimicrobial Resistance 35 (2023) 347-353]
  20. Development and Evaluation of a Quantitative Systems Pharmacology Model for Mechanism Interpretation and Efficacy Prediction of Atezolizumab in Combination with Carboplatin and Nab-Paclitaxel in Patients with Non-Small-Cell Lung Cancer
  21. Population pharmacokinetics and pharmacodynamics of nirmatrelvir in Chinese patients with COVID‐19
  22. Safety of teriflunomide in Chinese adult patients with relapsing multiple sclerosis: A phase IV, 24-week multicenter study
  23. Effect of Voriconazole on Tacrolimus Blood Concentration in Renal Transplant Recipients after Voriconazole Discontinuation
  24. Insights into the population pharmacokinetics and pharmacodynamics of quetiapine: a systematic review
  25. External evaluation of the predictive performance of published population pharmacokinetic models of linezolid in adult patients
  26. Factors influencing methotrexate pharmacokinetics highlight the need for individualized dose adjustment: a systematic review
  27. Quantitative risk-benefit profiles of oral contraceptives, insulin sensitizers and antiandrogens for women with polycystic ovary syndrome: A model-based meta-analysis
  28. External evaluation and systematic review of population pharmacokinetic models for high-dose methotrexate in cancer patients
  29. Editorial: Model-informed drug development and precision dosing in clinical pharmacology practice
  30. Significant predictors for olanzapine pharmacokinetics: a systematic review of population pharmacokinetic studies
  31. Model Informed Development of SIM0295 in Patients with Gout and Hyperuricemia and Healthy Volunteers Using a Population Pharmacokinetics/ Pharmacodynamics Approach
  32. Pharmacokinetic Evaluation of Tacrolimus in Chinese Adult Patients during the Early Stages Post-Lung Transplantation
  33. Parametric population pharmacokinetics of isoniazid: a systematic review
  34. Physiologically based pharmacokinetic modeling to predict OAT3-mediated drug-drug interactions of meropenem in varying stages of chronic kidney disease
  35. Handling Delayed or Missed Dose of Antiseizure Medications
  36. Is a Lower Dose of Rivaroxaban Required for Asians? A Systematic Review of a Population Pharmacokinetics and Pharmacodynamics Analysis of Rivaroxaban
  37. Dose Regimen Optimization of PD-L1 Inhibitor and Nab-paclitaxel in Patients with NSCLC: a Quantitative Systems Pharmacology analysis
  38. Prospective population pharmacokinetic study of tacrolimus in adult recipients early after liver transplantation: A comparison of Michaelis-Menten and theory-based pharmacokinetic models
  39. Population pharmacokinetic modeling of caffeine in preterm infants with apnea of prematurity: New findings from concomitant erythromycin and AHR genetic polymorphisms
  40. Predicting drug-drug interactions with physiologically based pharmacokinetic/pharmacodynamic modelling and optimal dosing of apixaban and rivaroxaban with dronedarone co-administration
  41. Pharmacokinetic Evaluation of Tacrolimus in Chinese Adult Patients Receiving Voriconazole During the Early Stage Post-Lung Transplantation
  42. Effect of Meal Timings and Meal Content on the AUC 0‐12h of Mycophenolic Acid: A Simulation Study
  43. The Correlation Between Busulfan Exposure and Clinical Outcomes in Chinese Pediatric Patients: A Population Pharmacokinetic Study
  44. Parametric population pharmacokinetics of linezolid: A systematic review
  45. Application of Physiologically Based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs
  46. Population pharmacokinetics and model-informed precision dosing of lamivudine in Chinese HIV-infected patients with mild and moderate impaired renal function
  47. Application of physiologically-based pharmacokinetic and pharmacodynamics modeling to predict drug-drug interactions of dronedarone as a perpetrator with oral anti-coagulants
  48. Model Informed Development of SIM0295 in Gout Patients with Hyperuricemia and Healthy Volunteers Using a Population Pharmacokinetics/pharmacodynamics Approach
  49. Handling Delayed or Missed Dose of Antiepileptic Drugs: A Model-Informed Individual Remedial Dosing
  50. How to handle a delayed or missed dose of edoxaban in patients with non‐valvular atrial fibrillation? A model‐informed remedial strategy
  51. Interactions Between Meropenem and Renal Drug Transporters
  52. Population Pharmacokinetics of Oxcarbazepine: A Systematic Review
  53. Population pharmacokinetic and pharmacodynamic analysis of rivaroxaban in Chinese patients with non-valvular atrial fibrillation
  54. Population Pharmacokinetics of Linezolid: A Systematic Review
  55. Precision Cardio-Oncology: Use of Mechanistic Pharmacokinetic and Pharmacodynamic Modeling to Predict Cardiotoxicities of Anti-Cancer Drugs
  56. How to handle the delayed or the missed dose of edoxaban in patients with non-valvular atrial fibrillation: model-informed remedial strategy
  57. Model Based Identification of Linezolid Exposure–toxicity Thresholds in Hospitalized Patients
  58. Dose tailoring of tacrolimus based on a non-linear pharmacokinetic model in children with refractory nephrotic syndrome
  59. Wuzhi Capsule Dosage Affects Tacrolimus Elimination in Adult Kidney Transplant Recipients, as Determined by a Population Pharmacokinetics Analysis
  60. How to handle the delayed or missed dose of rivaroxaban in patients with non-valvular atrial fibrillation: model-informed remedial dosing
  61. Genetic polymorphisms in metabolic enzymes and transporters have no impact on mycophenolic acid pharmacokinetics in adult kidney transplant patients co‐treated with tacrolimus: A population analysis
  62. Population pharmacokinetics of oxcarbazepine: a systematic review
  63. Role of organic anion transporter 3 in the renal excretion of biapenem and potential drug-drug interactions
  64. Caspofungin pharmacokinetics and probability of target attainment in ICU patients in China
  65. Population Pharmacokinetics of Ropeginterferon Alfa-2b: A Comparison Between Healthy Caucasian and Chinese Subjects
  66. Establishment of a population pharmacokinetics model of vancomycin in 94 infants with septicemia and its application in individualized therapy
  67. Population pharmacokinetic modeling of pyrotinib in patients with HER2-positive advanced or metastatic breast cancer
  68. Population pharmacokinetic analysis and dosing guidelines for tacrolimus co‐administration with Wuzhi capsule in Chinese renal transplant recipients
  69. External Evaluation of Vancomycin Population Pharmacokinetic Models at Two Clinical Centers
  70. External evaluation of the predictive performance of seven population pharmacokinetic models for phenobarbital in neonates
  71. Determination of vancomycin exposure target and individualised dosing recommendations for neonates: model-informed precision dosing
  72. Population Pharmacokinetics of Oxcarbazepine: A Systematic Review
  73. Population Pharmacokinetics of Levetiracetam: A Systematic Review
  74. Population pharmacokinetics of unbound valproic acid in pediatric epilepsy patients in China: a protein binding model
  75. Investigating the interaction between nifedipine‐ and ritonavir‐containing antiviral regimens: a physiologically‐based pharmacokinetic/pharmacodynamic analysis
  76. Population pharmacokinetics of azathioprine active metabolite in patients with inflammatory bowel disease and dosage regimens optimisation
  77. Evidence-based Guideline for Therapeutic Drug Monitoring of Vancomycin: 2020 Update by the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society
  78. Population pharmacokinetics of the anti-PD-1 antibody camrelizumab in patients with multiple tumor types and model-informed dosing strategy
  79. Population pharmacokinetic and optimization of polymyxin B dosing in adult patients with various renal functions
  80. Remedial dosing regimens for delayed or missed rivaroxaban doses in patients with non-valvular atrial fibrillation based on Monte Carlo simulation
  81. Population Pharmacokinetics of Vancomycin in Kidney Transplant Recipients: Model Building and Parameter Optimization
  82. Remedial dosing recommendations for delayed or missed doses of valproic acid in patients with epilepsy based on Monte Carlo simulations
  83. Incorporating nonlinear kinetics to improve predictive performance of population pharmacokinetic models for ciclosporin in adult renal transplant recipients: A comparison of modelling strategies
  84. Can Population Pharmacokinetics of Antibiotics be Extrapolated? Implications of External Evaluations
  85. External validation of the predictive performance of population pharmacokinetic models for phenobarbital in pediatric patients
  86. Population pharmacokinetics and dosing regimen optimization of tacrolimus in Chinese lung transplant recipients
  87. Evaluation of the Impacts of Formulation Parameters on the Pharmacokinetics and Bioequivalence of Risperidone Orodispersible Film: a Physiologically Based Pharmacokinetic Modeling Approach
  88. Population pharmacokinetic modeling of pyrotinib in patients with HER2-positive advanced or metastatic breast cancer
  89. Remedial dosing recommendation for delayed or missed rivaroxaban doses for patients with non-valvular atrial fibrillation based on Monte Carlo simulation
  90. A Review of Population Pharmacokinetic Studies of Levetiracetam
  91. TDM-guided medication of polymyxin B in a patient with CRKP-induced bloodstream infection: a case report
  92. Population Pharmacokinetics of an Anti-PD-1 Antibody Camrelizumab in Patients with Multiple tumor types and model informed dosing strategy
  93. Probable Drug Interaction Between Etanercept and Cyclosporine Resulting in Clinically Unexpected Low Trough Concentrations: First Case Report
  94. Investigation on the interaction between nifedipine and ritonavir containing antivirus regimens: a physiologically-based pharmacokinetic/pharmacodynamic analysis
  95. Population pharmacokinetics of vancomycin in Chinese elderly patients and its application for dose individualisation
  96. Pharmacokinetics and pharmacogenetics of high-dose methotrexate in Chinese adult patients with non-Hodgkin lymphoma: a population analysis
  97. Determination of vancomycin exposure target and individualized dosing recommendations for ICU neonates: model informed precision dosing
  98. Effect of Protein Binding on Exposure of Unbound and Total Mycophenolic Acid: A Population Pharmacokinetic Analysis in Chinese Adult Kidney Transplant Recipients
  99. Population Pharmacokinetic Analysis of Tacrolimus in Adult Chinese Patients with Myasthenia Gravis: A Prospective Study
  100. Systematic external evaluation of published population pharmacokinetic models for tacrolimus in adult liver transplant recipients
  101. Development of a Physiologically Based Pharmacokinetic Model for Prediction of Pramipexole Pharmacokinetics in Parkinson's Disease Patients With Renal Impairment
  102. Physiologically Based Pharmacokinetic Modeling to Understand the Absorption of Risperidone Orodispersible Film
  103. Incorporating Nonlinear Kinetics to Improve the Predictive Performance of Population Pharmacokinetic Models for Ciclosporin in Adult Renal Transplant Recipients: A Comparison of Modelling Strategies
  104. A reappraisal of polymyxin B dosing based on population pharmacokinetic model in patient with renal insufficiency
  105. How to Handle Delayed or Missed Doses: A Population Pharmacokinetic Perspective
  106. Population Pharmacokinetic Study of Tacrolimus in Pediatric Patients with Primary Nephrotic Syndrome: A Comparison of Linear and Nonlinear Michaelis–Menten Pharmacokinetic Model
  107. Prediction of pharmacokinetic drug-drug interactions causing atorvastatin-induced rhabdomyolysis using physiologically based pharmacokinetic modelling
  108. Glomerular Filtration Rate Is a Major Predictor of Clearance of Oxcarbazepine Active Metabolite in Adult Chinese Epileptic Patients: A Population Pharmacokinetic Analysis
  109. Clinical Evaluation of the Tolerability and Pharmacokinetics of Azilsartan, a Potent Angiotensin Receptor Blocker, in Healthy Chinese Subjects
  110. Myasthenia gravis and specific immunotherapy: monoclonal antibodies
  111. Prediction of Ticagrelor and its Active Metabolite in Liver Cirrhosis Populations Using a Physiologically Based Pharmacokinetic Model Involving Pharmacodynamics
  112. Remedial dosing recommendations for delayed or missed doses of lamotrigine in pediatric patients with epilepsy using Monte Carlo simulations
  113. Clinical Evaluation of the Tolerability, Pharmacokinetics, and Inhibition of Platelet Aggregation of Eptifibatide in Healthy Chinese Subjects
  114. Lower clearance of sodium tanshinone IIA sulfonate in coronary heart disease patients and the effect of total bilirubin: a population pharmacokinetics analysis
  115. Population pharmacokinetic and pharmacogenetics of imatinib in Chinese patients with chronic myeloid leukemia
  116. Systematic external evaluation of published population pharmacokinetic models of mycophenolate mofetil in adult kidney transplant recipients co‐administered with tacrolimus
  117. Population pharmacokinetics and dosing regimen optimisation of lopinavir in Chinese adults infected with HIV
  118. Population pharmacokinetics of oxcarbazepine active metabolite in Chinese paediatric epilepsy patients and its application in individualised dosage regimens
  119. Optimization and application of an HPLC method for quantification of inosine-5′-monophosphate dehydrogenase activity as a pharmacodynamic biomarker of mycophenolic acid in Chinese renal transplant patients
  120. Pharmacokinetics Evaluation of Mycophenolic Acid and Its Glucuronide Metabolite in Chinese Renal Transplant Recipients Receiving Enteric-Coated Mycophenolate Sodium and Tacrolimus
  121. FKBP1A rs6041749 polymorphism is associated with allograft function in renal transplant patients
  122. Population Pharmacokinetics of Vancomycin in Chinese ICU Neonates: Initial Dosage Recommendations
  123. FOXP3 rs3761549 polymorphism predicts long-term renal allograft function in patients receiving cyclosporine-based immunosuppressive regimen
  124. A mechanism-based pharmacokinetic model of fenofibrate for explaining increased drug absorption after food consumption
  125. External evaluation of population pharmacokinetic models for ciclosporin in adult renal transplant recipients
  126. Prediction of Drug-Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically-Based Pharmacokinetic Modelling
  127. NFATC1genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients
  128. Chemical profiling of San-Huang decoction by UPLC–ESI-Q-TOF-MS
  129. FOXP3 rs3761548 polymorphism is associated with tacrolimus-induced acute nephrotoxicity in renal transplant patients
  130. External evaluation of published population pharmacokinetic models of tacrolimus in adult renal transplant recipients
  131. Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics
  132. Effect of long-term coadministration of compound glycyrrhizin tablets on the pharmacokinetics of mycophenolic acid in rats
  133. Population pharmacokinetics of vancomycin in adult Chinese patients with post-craniotomy meningitis and its application in individualised dosage regimens
  134. Association between PK/PD-involved gene polymorphisms and carbamazepine-individualized therapy
  135. SCN1A, ABCC2 and UGT2B7 gene polymorphisms in association with individualized oxcarbazepine therapy
  136. Population Pharmacokinetics of Valproic Acid in Adult Chinese Epileptic Patients and its Application in an Individualized Dosage Regimen
  137. Vincristine drug safety administration survey: results from hospitals in Shanghai, China
  138. Application of modeling and simulation techniques in research on medication compliance
  139. A Population Pharmacokinetic Model of Valproic Acid in Pediatric Patients with Epilepsy: A Non-Linear Pharmacokinetic Model Based on Protein-Binding Saturation
  140. Population pharmacokinetics of mycophenolic acid and its main glucuronide metabolite: a comparison between healthy Chinese and Caucasian subjects receiving mycophenolate mofetil
  141. The effects of medication education and behavioral intervention on Chinese patients with epilepsy
  142. Association of SCN1A , SCN2A and ABCC2 Gene Polymorphisms with the Response to Antiepileptic Drugs in Chinese Han Patients with Epilepsy
  143. Validation of Chinese version of the Morisky Medication Adherence Scale in patients with epilepsy
  144. Pharmacokinetic comparisons of berberine and palmatine in normal and metabolic syndrome rats
  145. Citrate Pharmacokinetics in Critically Ill Patients with Acute Kidney Injury
  146. Self-reported adherence in patients with epilepsy who missed their medications and reasons for nonadherence in China
  147. The effect of poor compliance on the pharmacokinetics of carbamazepine and its epoxide metabolite using Monte Carlo simulation
  148. Genetic association of FOXP3 gene polymorphisms with allograft rejection in renal transplant patients
  149. The Impact of Sulfonylureas on Tacrolimus Apparent Clearance Revealed by a Population Pharmacokinetics Analysis in Chinese Adult Liver-Transplant Patients
  150. The association of the UGT1A8, SLCO1B3 and ABCC2/ABCG2 genetic polymorphisms with the pharmacokinetics of mycophenolic acid and its phenolic glucuronide metabolite in Chinese individuals
  151. The Pharmacokinetics of Ropivacaine in Elderly Patients Undergoing Nerve Stimulator–Guided Thoracic Paravertebral Block
  152. Association of ABCB1, CYP3A4*18B and CYP3A5*3 genotypes with the pharmacokinetics of tacrolimus in healthy Chinese subjects: a population pharmacokinetic analysis
  153. Simultaneous determination of procaine, lidocaine, ropivacaine, tetracaine and bupivacaine in human plasma by high-performance liquid chromatography
  154. Simple and Sensitive Determination of Metformin in Human Plasma Using an Ion-Pair LC Method
  155. Population pharmacokinetics of sirolimus inde novoChinese adult renal transplant patients
  156. Association of MDR1, CYP3A4*18B, and CYP3A5*3 polymorphisms with cyclosporine pharmacokinetics in Chinese renal transplant recipients
  157. Population pharmacokinetic modelling for enterohepatic circulation of mycophenolic acid in healthy Chinese and the influence of polymorphisms in UGT1A9
  158. Simultaneous determination of aciclovir, ganciclovir, and penciclovir in human plasma by high-performance liquid chromatography with fluorescence detection
  159. Isocratic Reversed-Phase HPLC for Simultaneous Separation and Determination of Seven Antiepileptic Drugs and Two of their Active Metabolites in Human Plasma
  160. Quantification of Teicoplanin in Human Plasma by Liquid Chromatography with Ultraviolet Detection
  161. Clinical Trial Simulation
  162. Total and free mycophenolic acid and its 7-O-glucuronide metabolite in Chinese adult renal transplant patients: pharmacokinetics and application of limited sampling strategies
  163. Simultaneous determination of mycophenolic acid and valproic acid based on derivatization by high-performance liquid chromatography with fluorescence detection
  164. Errata
  165. Simple High-Performance Liquid Chromatographic Assay, with Post-Column Derivatization, for Simultaneous Determination of Mycophenolic Acid and its Glucuronide Metabolite in Human Plasma and Urine
  166. Quantification of total and free mycophenolic acid in human plasma by liquid chromatography with fluorescence detection
  167. The Validation of an LC-MS Method for the Determination of Risperidone and its Active Metabolite 9-Hydroxyrisperidone in Human Plasma
  168. Population pharmacokinetic modeling of steady state clearance of carbamazepine and its epoxide metabolite from sparse routine clinical data
  169. Population Pharmacokinetics of Carbamazepine in Chinese Epilepsy Patients