All Stories

  1. Soluble-microneedle enhance three T-cell activation signals as efficient tumor vaccines for melanoma prevention and treatment
  2. Discovery of Environment-Sensitive Near Infrared SHP2-Targeting Fluorescent Ligands for Living Cells and Tissue Section Imaging
  3. Discovery of environment-sensitive fluorescent ligands for SHP2 imaging in living cells and tumor sections
  4. Population pharmacokinetics and clinical assessment of linezolid in pediatric bacterial infections
  5. Efficacy and safety of ziresovir in hospitalised infants aged 6 months or younger with respiratory syncytial virus infection in China: findings from a phase 3 randomised trial with 24-month follow-up
  6. Machine learning approach for dosage individualization of azithromycin in children with community‐acquired pneumonia
  7. Pharmacokinetics, mass balance, and metabolism of [14C]PLB1004, a selective and irreversible EGFR-TKI in humans
  8. Drug-drug interactions of simnotrelvir/ritonavir: an open-label, fixed-sequence, two-period clinical trial
  9. Simultaneous inhibition of FLT3 and HDAC by novel 6-ethylpyrazine-2-Carboxamide derivatives provides therapeutic advantages in acute myelocytic leukemia
  10. Population Pharmacokinetics and Dose Optimization of Piperacillin in Infants and Children with Pneumonia
  11. Optimal dosing regimen of caspofungin in adolescents with allogeneic haematopoietic stem cell transplantation
  12. TEAD2 Promotes Hepatocellular Carcinoma Development and Sorafenib Resistance via TAK1 Transcriptional Activation
  13. Model-informed drug development in pediatric, pregnancy and geriatric drug development: States of the art and future
  14. Piperacillin/tazobactam treatment in children: evidence of subtherapeutic concentrations
  15. Machine Learning Approach in Dosage Individualization of Isoniazid for Tuberculosis
  16. Optimal use of β-lactams in neonates: machine learning-based clinical decision support system
  17. Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making
  18. Population pharmacokinetics of daptomycin in critically ill patients receiving extracorporeal membrane oxygenation
  19. Efficacy, Safety, and Population Pharmacokinetics of Eltrombopag in Children with Different Severities of Aplastic Anemia
  20. Population pharmacokinetics and dose optimization of levofloxacin in elderly patients with pneumonia
  21. Population pharmacokinetics of lenalidomide in Chinese patients with influence of genetic polymorphisms of ABCB1
  22. Population pharmacokinetics of antibacterial agents in the older population: a literature review
  23. Pharmacokinetics and bioavailability of a new long-acting insulin analog in healthy Chinese volunteers: an open, randomized, single-dose, two-period and two-sequence cross-over study
  24. Accuracy of antibiotic concentrations in drug dispensing in neonates: a laboratory-based study
  25. A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects
  26. Recombinant Klotho alleviates vancomycin-induced acute kidney injury by upregulating anti-oxidative capacity via JAK2/STAT3/GPx3 axis
  27. Individualized Use of 6‐Mercaptopurine in Chinese Children with ALL: A Multicenter Randomized Controlled Trial
  28. A first‐in‐human phase I study of SHR‐1906, a humanized monoclonal antibody against connective tissue growth factor, in healthy participants
  29. Machine Learning: A New Approach for Dose Individualization
  30. Meropenem Clearance in a Child With End-stage Renal Disease Undergoing Prolonged Intermittent Renal Replacement Therapy: A Case Report and Literature Review
  31. Editorial: Model-based evaluation of antimicrobial agents in children—volume II
  32. Use of Machine Learning for Dosage Individualization of Vancomycin in Neonates
  33. Regulatory considerations for paediatric drug evaluation in China
  34. Optimizing ganciclovir and valganciclovir dosing regimens in pediatric patients with cytomegalovirus infection: a spotlight on therapeutic drug monitoring
  35. Population pharmacokinetics and pharmacogenetics of apatinib in adult cancer patients
  36. A liquid chromatography-tandem mass spectrometry method for simultaneous quantification of thirty-nine tyrosine kinase inhibitors in human plasma
  37. Developmental Population Pharmacokinetics-Pharmacodynamics of Meropenem in Chinese Neonates and Young Infants: Dosing Recommendations for Late-Onset Sepsis
  38. Epithelial lining fluid concentrations of ceftriaxone in children with community‐acquired pneumonia
  39. Systematic review of efficacy, safety and pharmacokinetics of intravenous and intraventricular vancomycin for central nervous system infections
  40. General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimization of study protocols for small molecules and monoclonal antibodies in children
  41. ‘Population pharmacokinetics and dosing optimization of mezlocillin in neonates and young infants’–authors’ response
  42. Improving the efficacy for meropenem therapy requires a high probability of target attainment in critically ill infants and children
  43. BMJ Paediatrics Openand the Global South: an open call towards editorial diversity and inclusion
  44. Clinical utility of a model‐based amoxicillin dosage regimen in neonates with early‐onset sepsis
  45. Optimal dose of cefotaxime in neonates with early-onset sepsis: A developmental pharmacokinetic model-based evaluation
  46. Relationship Between Linezolid Exposure and the Typical Clinical Laboratory Safety and Bacterial Clearance in Chinese Pediatric Patients
  47. Guideline for the management of pediatric off-label use of drugs in China (2021)
  48. Population pharmacokinetics and dosing optimization of mezlocillin in neonates and young infants
  49. Predictive Performance of Pharmacokinetic Model-Based Virtual Trials of Vancomycin in Neonates: Mathematics Matches Clinical Observation
  50. Optimal dose of meropenem for the treatment of neonatal sepsis: Dosing guideline variations and clinical practice deviations
  51. Optimal Sample Size for Use in Neonatal Pharmacokinetic Studies
  52. Clinical utiliy of a model‐based piperacillin dose in neonates with early‐onset sepsis
  53. Population Pharmacokinetics and Dosing Optimization of Vancomycin in Infants, Children, and Adolescents with Augmented Renal Clearance
  54. A simplified method for bortezomib determination using dried blood spots in combination with liquid chromatography/tandem mass spectrometry
  55. Editorial: Model-Based Evaluation of Antimicrobial Agents in Children
  56. LPS-Induced Inflammation Affects Midazolam Clearance in Juvenile Mice in an Age-Dependent Manner
  57. Population pharmacokinetics-pharmacodynamics of ceftazidime in neonates and young infants: Dosing optimization for neonatal sepsis
  58. A Validated LC-MS/MS Method for the Determination of Mezlocillin in Plasma: An Adapted Method for Therapeutic Drug Monitoring in Children
  59. Current knowledge, challenges and innovations in developmental pharmacology: A combined conect4children Expert Group and European Society for Developmental, Perinatal and Paediatric Pharmacology White Paper
  60. Population Pharmacokinetics and Safety of Dasatinib in Chinese Children with Core-Binding Factor Acute Myeloid Leukemia
  61. Developmental Pharmacogenetics of CYP2D6 in Chinese Children: Loratadine as a Substrate Drug
  62. CYP3A5 Genotype-Dependent Drug-Drug Interaction Between Tacrolimus and Nifedipine in Chinese Renal Transplant Patients
  63. Latamoxef for Neonates With Early-Onset Neonatal Sepsis: A Study Protocol for a Randomized Controlled Trial
  64. Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction
  65. Downregulation of Renal MRPs Transporters in Acute Lymphoblastic Leukemia Mediated by the IL-6/STAT3/PXR Signaling Pathway
  66. Population Pharmacokinetics and Safety of Oral Tetra-Arsenic Tetra-Sulfide Formula in Pediatric Acute Promyelocytic Leukemia
  67. Serum Creatinine and Serum Cystatin C are Both Relevant Renal Markers to Estimate Vancomycin Clearance in Critically Ill Neonates
  68. Population Pharmacokinetic Study of Cefathiamidine in Infants With Augmented Renal Clearance
  69. Off‐label use of letrozole in Chinese short pubertal boys: Effectiveness, safety, and exposure–response analysis
  70. Pharmacokinetics and safety of pegylated recombinant human granulocyte colony‐stimulating factor in children with acute leukaemia
  71. Effects of continuous venovenous hemofiltration on vancomycin trough concentrations in critically ill children
  72. Prediction of Unbound Ceftriaxone Concentration in Children: Simple Bioanalysis Method and Basic Mathematical Equation
  73. Oral drugs used to treat persistent pulmonary hypertension of the newborn
  74. Evidence-based Guideline for Therapeutic Drug Monitoring of Vancomycin: 2020 Update by the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society
  75. Population pharmacokinetics and dosing optimization of azlocillin in neonates with early-onset sepsis: a real-world study
  76. Population pharmacokinetics and dosing optimization of metformin in Chinese patients with type 2 diabetes mellitus
  77. Optimal Dosing of Ceftriaxone in Infants Based on a Developmental Population Pharmacokinetic-Pharmacodynamic Analysis
  78. Cefotiam Treatment in Children: Evidence of Subtherapeutic Levels
  79. Population Pharmacokinetics and Dosing Optimization of Amoxicillin in Chinese Infants
  80. Carbapenem-Resistant Enterobacteriaceae Bloodstream Infection Treated Successfully With High-Dose Meropenem in a Preterm Neonate
  81. Extremely low dose of 6‐mercaptopurine in a Chinese child with acute lymphoblastic leukaemia and multiple pharmacogenetic mutations
  82. Determination of Loratadine and Its Active Metabolite in Plasma by LC/MS/MS: An Adapted Method for Children
  83. Drug Elimination Alteration in Acute Lymphoblastic Leukemia Mediated by Renal Transporters and Glomerular Filtration
  84. Developmental population pharmacokinetics of caffeine in Chinese premature infants with apnoea of prematurity: A post‐marketing study to support paediatric labelling in China
  85. Reappraisal of the Optimal Dose of Meropenem in Critically Ill Infants and Children: a Developmental Pharmacokinetic-Pharmacodynamic Analysis
  86. Population pharmacokinetics and dose optimization of ceftriaxone for children with community-acquired pneumonia
  87. First dose in neonates: pharmacokinetic bridging study from juvenile mice to neonates for drugs metabolized by CYP3A
  88. An adapted LC-MS/MS method for the determination of free plasma concentration of cefoperazone in children: Age-dependent protein binding
  89. PK/PD modeling of 5‐hydroxytryptophan (5‐HTP) challenge test with cortisol measurement in serum and saliva
  90. Developmental population pharmacokinetics–pharmacodynamics and dosing optimization of cefoperazone in children
  91. Paediatric drugs trials in China
  92. Precision therapy of 6‐mercaptopurine in Chinese children with acute lymphoblastic leukemia
  93. Developmental Population Pharmacokinetics and Dosing Optimization of Cefepime in Neonates and Young Infants
  94. Population Pharmacokinetic Analysis of Isoniazid among Pulmonary Tuberculosis Patients from China
  95. Off-label use of medicines in neonates, infants, children, and adolescents: a joint policy statement by the European Academy of Paediatrics and the European society for Developmental Perinatal and Pediatric Pharmacology
  96. Developmental Pharmacogenetics of SLCO2B1 on Montelukast Pharmacokinetics in Chinese Children
  97. Off‐label use of tacrolimus in children with glomerular disease: Effectiveness, Safety and Pharmacokinetics
  98. Population Pharmacokinetics of Ganciclovir after Valganciclovir Treatment in Children with Renal Transplant
  99. Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants
  100. Optimisation of vancomycin exposure in neonates based on the best level of evidence
  101. Body Surface Area-Based Dosing Regimen of Caspofungin in Children: a Population Pharmacokinetics Confirmatory Study
  102. Population Pharmacokinetics and Dosing Optimization of Imipenem in Children with Hematological Malignancies
  103. Population Pharmacokinetics and Dosing Optimization of Amoxicillin in Neonates and Young Infants
  104. Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants
  105. Early target attainment of azithromycin therapy in children with lower respiratory tract infections
  106. Population Pharmacokinetics and Dosing Optimization of Azithromycin in Children with Community-Acquired Pneumonia
  107. Pharmacokinetics and safety of fluconazole and micafungin in neonates with systemic candidiasis: a randomized, open-label clinical trial
  108. A Sensitive Microscale HPLC-UV Method for the Determination of Doxofylline and its Metabolites in Plasma: An Adapted Method for Therapeutic Drug Monitoring in Children
  109. Aciclovir CSF concentration in children with viral encephalitis: is it adequate?
  110. Population pharmacokinetics of tacrolimus in children with nephrotic syndrome
  111. A microscale HPLC-UV method for the determination of latamoxef in plasma: An adapted method for therapeutic drug monitoring in neonates
  112. Population pharmacokinetics and dosing optimization of cefathiamidine in children with hematologic infection
  113. Principles and applications of pharmacometrics in drug evaluation in children
  114. Off-label use of tacrolimus in children with Henoch-Schönlein purpura nephritis: a pilot study
  115. Developmental pharmacogenetics of CYP2C19 in neonates and young infants: omeprazole as a probe drug
  116. Pilot Study of Model-Based Dosage Individualization of Ganciclovir in Neonates and Young Infants with Congenital Cytomegalovirus Infection
  117. Penetration of Cefotaxime into Cerebrospinal Fluid in Neonates and Young Infants
  118. Pharmacogenetics of post-transplant diabetes mellitus in children with renal transplantation treated with tacrolimus
  119. Population Pharmacokinetics of Cefotaxime and Dosage Recommendations in Children with Sickle Cell Disease
  120. Population Pharmacokinetics and Dosing Optimization of Ceftazidime in Infants
  121. Determination of cefoperazone and sulbactam in serum by HPLC-MS/MS: An adapted method for therapeutic drug monitoring in children
  122. Commentary on the MID3 Good Practices Paper
  123. Posologie des antibiotiques chez le nouveau-né : variations des pratiques et comment y remédier ?
  124. A Population and Developmental Pharmacokinetic Analysis To Evaluate and Optimize Cefotaxime Dosing Regimen in Neonates and Young Infants
  125. Safety study of Ciprofloxacin in newborn mice
  126. Clinical Utility and Safety of a Model-Based Patient-Tailored Dose of Vancomycin in Neonates
  127. Pharmacodynamics of vancomycin for CoNS infection: experimental basis for optimal use of vancomycin in neonates
  128. Author’s Reply to Standing et al. Pharmacokinetic Studies in Neonates: The Utility of an Opportunistic Sampling Design
  129. Population pharmacokinetics and dosing optimization of teicoplanin in children with malignant haematological disease
  130. How to use vancomycin optimally in neonates: remaining questions
  131. Pharmacokinetic Studies in Neonates: The Utility of an Opportunistic Sampling Design
  132. Cystatin C as a potential biomarker for dosing of renally excreted drugs
  133. Therapeutic guidelines for prescribing antibiotics in neonates should be evidence-based: a French national survey
  134. Impact of Glutathione S-Transferase M1 and T1 on Anti-Tuberculosis Drug–Induced Hepatotoxicity in Chinese Pediatric Patients
  135. Pilot Phase II study of mazindol in children with attention deficit/hyperactivity disorder
  136. Choosing the right dose of tacrolimus
  137. First Dose in Neonates: Are Juvenile Mice, Adults and In Vitro–In Silico Data Predictive of Neonatal Pharmacokinetics of Fluconazole
  138. Population Pharmacokinetics of Ciprofloxacin in Neonates and Young Infants Less than Three Months of Age
  139. Dosage individualization in children: integration of pharmacometrics in clinical practice
  140. A model‐based approach for the evaluation of once daily dosing of lamivudine in HIV‐infected children
  141. Covariate effects and population pharmacokinetics of lamivudine in HIV‐infected children
  142. Population Pharmacokinetics and Dosing Optimization of Vancomycin in Children with Malignant Hematological Disease
  143. Pharmacokinetics and dosage individualization of ganciclovir and valganciclovir in an infant with nephrotic syndrome associated with cytomegalovirus infection
  144. Amikacin Maturation Model as a Marker of Renal Maturation to Predict Glomerular Filtration Rate and Vancomycin Clearance in Neonates
  145. The Importance of Knowing How Vancomycin is Measured When Interpreting Its Pharmacokinetic Results
  146. Population pharmacokinetics of abacavir in infants, toddlers and children
  147. Population pharmacokinetics of ciclosporin in Chinese children with aplastic anemia: effects of weight, renal function and stanozolol administration
  148. External evaluation of population pharmacokinetic models of vancomycin in neonates: the transferability of published models to different clinical settings
  149. Use of antibacterial agents in the neonate: 50 years of experience with vancomycin administration
  150. Vancomycin continuous infusion in neonates: dosing optimisation and therapeutic drug monitoring
  151. Limited sampling strategy using Bayesian estimation for estimating individual exposure of the once-daily prolonged-release formulation of tacrolimus in kidney transplant children
  152. Pharmacogenetic Determinant of the Drug Interaction Between Tacrolimus and Omeprazole
  153. Optimizing Micafungin Dosing in Children
  154. Population pharmacokinetics and pharmacogenetics of once daily prolonged-release formulation of tacrolimus in pediatric and adolescent kidney transplant recipients
  155. Individualization of Valganciclovir Prophylaxis for Cytomegalovirus Infection in Pediatric Kidney Transplant Patients
  156. Pharmacokinetic Interaction Between Tacrolimus and Amlodipine in a Renal Transplant Child
  157. Population pharmacokinetics and maximum a posteriori probability Bayesian estimator of abacavir: application of individualized therapy in HIV‐infected infants and toddlers
  158. Limited Sampling Strategy for Estimating Individual Exposure of Tacrolimus in Pediatric Kidney Transplant Patients
  159. Paediatric drug development: are population models predictive of pharmacokinetics across paediatric populations?
  160. Principles of Therapeutic Drug Monitoring
  161. Developmental Pharmacogenetics of Immunosuppressants in Pediatric Organ Transplantation
  162. Population Pharmacokinetics and Pharmacogenetics of Mycophenolic Acid Following Administration of Mycophenolate Mofetil in De Novo Pediatric Renal-Transplant Patients
  163. Determination of ciprofloxacin in plasma by micro-liquid chromatography-mass spectrometry: An adapted method for neonates
  164. Population pharmacokinetics and Bayesian estimator of mycophenolic acid in children with idiopathic nephrotic syndrome
  165. Pharmacokinetic study of once-daily versus twice-daily abacavir and lamivudine in HIV type-1-infected children aged 3-<36 months
  166. Population Pharmacokinetics and Pharmacogenetics of Tacrolimus in De Novo Pediatric Kidney Transplant Recipients
  167. Population Pharmacokinetics of Ganciclovir Following Administration of Valganciclovir in Paediatric Renal Transplant Patients