All Stories

  1. Four pairs of proline-containing cyclic dipeptides from Nocardiopsis sp. HT88, an endophytic bacterium of Mallotus nudiflorus L
  2. Trinulactones A–D, New Dinorsesterterpenoids from Streptomyces sp. S006
  3. Indole-Induced Reversion of Intrinsic Multiantibiotic Resistance in Lysobacter enzymogenes
  4. In vitro and in vivo Evaluation of 17-phenylpropylamine/phenoxyethylamine- 17-demethoxygeldanamycins as Potent Hsp90 Inhibitors
  5. Heterologous expression of galbonolide biosynthetic genes in Streptomyces coelicolor
  6. Discovery of a series of 2-phenylnaphthalenes as firefly luciferase inhibitors
  7. Overexpression of hgc1 increases the production and diversity of hygrocins in Streptomyces sp. LZ35
  8. Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors
  9. ChemInform Abstract: Juanlimycins A (Ia) and B (Ib), Ansamycin Macrodilactams from Streptomyces sp.
  10. Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes
  11. Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIα and antitumor agents
  12. CS1 is a novel topoisomerase IIα inhibitor with favorable drug resistance profiles
  13. Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors
  14. Phomopsidone A, a novel depsidone metabolite from the mangrove endophytic fungus Phomopsis sp. A123
  15. Fusaric acid modulates Type Three Secretion System of Salmonella enterica serovar Typhimurium
  16. Discovery of Novel 17-Phenylethylaminegeldanamycin Derivatives as Potent Hsp90 Inhibitors
  17. Mycoepoxydiene induces apoptosis and inhibits TPA-induced invasion in human cholangiocarcinoma cells via blocking NF-κB pathway
  18. Synthesis of Aryl-Substituted Naphthalenoids as Potent Topoisomerase Inhibitors
  19. Iterative Assembly of Two Separate Polyketide Chains by the Same Single-Module Bacterial Polyketide Synthase in the Biosynthesis of HSAF
  20. Iterative Assembly of Two Separate Polyketide Chains by the Same Single-Module Bacterial Polyketide Synthase in the Biosynthesis of HSAF
  21. Juanlimycins A and B, Ansamycin Macrodilactams from Streptomyces sp.
  22. Para-Aminobenzoic Acid (PABA) Synthase Enhances Thermotolerance of Mushroom Agaricus bisporus
  23. ChemInform Abstract: A Novel p-Terphenyl Derivative Inducing Cell-Cycle Arrest and Apoptosis in MDA-MB-435 Cells Through Topoisomerase Inhibition.
  24. p-Terphenyl O-β-glucuronides, DNA topoisomerase inhibitors from Streptomyces sp. LZ35ΔgdmAI
  25. Mycoepoxydiene inhibits activation of BV2 microglia stimulated by lipopolysaccharide through suppressing NF-κB, ERK 1/2 and toll-like receptor pathways
  26. Crystallization and preliminary X-ray diffraction analysis of the diterpene cyclooctatin synthase (CYC) fromStreptomycessp. LZ35
  27. Guanacastane-type diterpenoids from Coprinus plicatilis
  28. Isotryptoquivaline F, a new quinazolinone derivative with anti TNF-α activity from Aspergillus sp. CM9a
  29. Synthesis and Antitumor Activity of Lycogarubin C and Lycogalic Acid
  30. Synthesis of Novel 17-[3,6-Dioxa-8-N-(substituted cinnamyol)- octanediamino]-17-demethoxygeldanamycin Derivatives
  31. Ligustrazine Derivatives. Part 8: Design, Synthesis, and Preliminary Biological Evaluation of Novel Ligustrazinyl Amides as Cardiovascular Agents
  32. Hygrocins C–G, Cytotoxic Naphthoquinone Ansamycins from gdmAI -Disrupted Streptomyces sp. LZ35
  33. Tricarballylic ester formation during biosynthesis of fumonisin mycotoxins inFusarium verticillioides
  34. Biosynthesis of Hygrocins, Antitumor Naphthoquinone Ansamycins Produced byStreptomycessp. LZ35
  35. Facile Method for Site-specific Gene Integration in Lysobacter enzymogenes for Yield Improvement of the Anti-MRSA Antibiotics WAP-8294A and the Antifungal Antibiotic HSAF
  36. A new polyketide fromDiaporthesp. SXZ-19, an endophytic fungal strain ofCamptotheca acuminate
  37. A novel p-terphenyl derivative inducing cell-cycle arrest and apoptosis in MDA-MB-435 cells through topoisomerase inhibition
  38. Parenteral nanosuspension of a novel synthesized antitumor candidate: Investigation of tissue biodistributions and plasma pharmacokinetics
  39. Arylazolylthioacetanilide. Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-triazole Thioacetanilide Derivatives as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors
  40. Nanosuspension for parenteral delivery of a p-terphenyl derivative: Preparation, characteristics and pharmacokinetic studies
  41. Identification and Characterization of the Cuevaene A Biosynthetic Gene Cluster inStreptomycessp. LZ35
  42. Biosynthetic Mechanism for Sunscreens of the Biocontrol Agent Lysobacter enzymogenes
  43. Cytosporone B, an Inhibitor of the Type III Secretion System of Salmonella enterica Serovar Typhimurium
  44. Four natural epothilone derivatives isolated from Sorangium cellulosum strain So0157-2
  45. Discovery of a pair of diastereomers as potent HDACs inhibitors: determination of absolute configuration, biological activity comparison and computational study
  46. Chemical Components of Some Microorganisms Isolated from Specific Habitats and Their Antitumor Activities
  47. Two New Pimarane-Type Diterpenes from the Metabolites of Xylaria sp. 290
  48. ChemInform Abstract: Guanacastane-Type Diterpenoids with Cytotoxic Activity from Coprinus plicatilis.
  49. Correction: Mycoepoxydiene Inhibits Lipopolysaccharide-Induced Inflammatory Responses through the of TRAF6 Polyubiquitination
  50. Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-κB pathways
  51. Mycoepoxydiene Inhibits Lipopolysaccharide-Induced Inflammatory Responses through the of TRAF6 Polyubiquitination
  52. Ligustrazine Derivatives. Part 6: Design, Synthesis and Evaluation of Novel Ligustrazinyl Acylguanidine Derivatives as Potential Cardiovascular Agents
  53. Guanacastane-type diterpenoids with cytotoxic activity from Coprinus plicatilis
  54. Spiroindimicins A–D: New Bisindole Alkaloids from a Deep-Sea-Derived Actinomycete
  55. Gambogic acid activates AMP-activated protein kinase in mammalian cells
  56. Mycoepoxydiene suppresses RANKL-induced osteoclast differentiation and reduces ovariectomy-induced bone loss in mice
  57. The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation
  58. Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids
  59. Unusual Activities of the Thioesterase Domain for the Biosynthesis of the Polycyclic Tetramate Macrolactam HSAF in Lysobacter enzymogenes C3
  60. 3-Hydroxylation of the polycyclic tetramate macrolactam in the biosynthesis of antifungal HSAF from Lysobacter enzymogenes C3
  61. Bioactive natural products from Lysobacter
  62. Biosynthesis of 3,5-AHBA-derived natural products
  63. Recent advances in the boric acid/boronate-based fluorescent probes for detection of hydrogen peroxide
  64. A rapid and sensitive LC–MS/MS assay for the quantitation of deacetyl mycoepoxydiene in rat plasma with application to preclinical pharmacokinetics studies
  65. A new cyclic peptide from the marine fungal strain Aspergillus sp. AF119
  66. Secondary metabolites ofPyrenochaetasp. B36, an endophytic fungus fromAnnona squamosaL.
  67. Effect of salinity on the growth, biological activity and secondary metabolites of some marine fungi
  68. Development and in vitro evaluation of deacety mycoepoxydiene nanosuspension
  69. Transformation of Fusarium verticillioides with a polyketide gene cluster isolated from a fungal endophyte activates the biosynthesis of fusaric acid
  70. Biosynthesis of HSAF, a Tetramic Acid-Containing Macrolactam from Lysobacter enzymogenes
  71. ChemInform Abstract: Macrolides of the Bafilomycin Family Produced by Streptomyces sp. CS
  72. Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS
  73. ChemInform Abstract: Two 18-Membered Epothilones from Sorangium cellulosum So0157-2
  74. Mycoepoxydiene, a fungal polyketide, induces cell cycle arrest at the G2/M phase and apoptosis in HeLa cells
  75. Species Diversity, Distribution, and Genetic Structure of Endophytic and Epiphytic Trichoderma Associated with Banana Roots
  76. Macrolides of the bafilomycin family produced by Streptomyces sp. CS
  77. Two 18-membered epothilones from Sorangium cellulosum So0157-2
  78. Chemical constitutes from endophytic Streptomyces sp. W5 isolated from Trewia nudiflora L.
  79. Protoplast Mutation and Genome Shuffling Induce the Endophytic Fungus Tubercularia sp. TF5 to Produce New Compounds
  80. ChemInform Abstract: First Total Syntheses of (.+-.)-Isopiline (IIIa), (.+-.)-Preocoteine (IIIb), (.+-.)-Oureguattidine (IIIc) and (.+-.)-3-Methoxynordomesticine (IIId) and the Biological Activities of (.+-.)-3-Methoxynordomesticine.
  81. Diversities Within Genotypes, Bioactivity and Biosynthetic Genes of Endophytic Actinomycetes Isolated from Three Pharmaceutical Plants
  82. Introduction of the AAL-Toxin Polyketide Synthase Gene ALT1 into FUM1 -disrupted Fusarium verticillioides Produces Metabolites with the Fumonisin Methylation Pattern
  83. Secondary Metabolites ofPhomopsissp. XZ-26, an Endophytic Fungus fromCamptothecaacuminate
  84. ChemInform Abstract: Clavicorolides A and B, Sesquiterpenoids from the Fermentation Products of Edible Fungus Clavicorona pyxidata
  85. Structure–antibacterial relationship of nigericin derivatives
  86. Spiraeosides A and B, Two New Diterpenoid Glucosides from Spiraea japonica var. ovalifolia
  87. Secondary metabolites ofAspergillussp. F1, a commensal fungal strain ofTrewia nudiflora
  88. Secondary metabolites ofTuberculariasp. TF5, an endophytic fungal strain ofTaxus mairei
  89. Clavicorolides A and B, Sesquiterpenoids from the Fermentation Products of Edible Fungus Clavicorona pyxidata
  90. First Total Syntheses of (±)-Isopiline, (±)-Preocoteine, (±)-Oureguattidine and (±)-3-Methoxynordomesticine and the Biological Activities of (±)-3-Methoxynordomesticine
  91. Selective Isolation and Ansamycin-Targeted Screenings of Commensal Actinomycetes from the “Maytansinoids-Producing” Arboreal Trewia nudiflora
  92. ChemInform Abstract: Three New Antimicrobial Metabolites of Phomopsis sp.
  93. Five unusual natural carbohydrates from Actinosynnema pretiosum
  94. A new dihydroisocoumarin from the strain Aspergillus sp. CMM, an endophytic fungus of Cephalotaxus mannii
  95. Cytosporone B is an agonist for nuclear orphan receptor Nur77
  96. Amide N-Glycosylation by Asm25, an N-Glycosyltransferase of Ansamitocins
  97. ChemInform Abstract: A Novel Ansamycin, Naphthomycin K from Streptomyces sp.
  98. Three New Antimicrobial Metabolites of Phomopsis sp.
  99. Synergistic Activities of 4-Arylcoumarins Against Phytopathogenic Fungi
  100. 3-Acetonyl-3-hydroxyoxindole: a new inducer of systemic acquired resistance in plants
  101. Chemical Constituents and Diversity of Ligularia lankongensis in Yunnan Province of China
  102. Chemical and genetic diversity of Ligularia vellerea in Yunnan, China
  103. Biological Activity of Chemical Constituents Isolated from Streptomyces sp. Tc052, an Endophyte in Alpinia galanga
  104. High Diversity ofLigularia dictyoneura in Chemical Composition and DNA Sequence
  105. A Novel Ansamycin, Naphthomycin K from Streptomyces sp.
  106. In vitroanti-inflammatory activity of 4-arylcoumarins from endophyticStreptomyces aureofaciensCMUAc130 in murine macrophage RAW 264.7 cells
  107. Chemical Constituents of the Endophytic Fungal StrainPhomopsis sp. NXZ-05 ofCamptotheca acuminata
  108. Chemical and Genetic Diversity ofLigularia latihastata andLigularia villosa in Yunnan Province of China
  109. 4-arylcoumarin inhibits immediate-type allergy
  110. Chemical and Genetic Differentiation ofLigularia tsangchanensis in Yunnan and Sichuan Provinces of China
  111. Antitumor activity of 4-Arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130
  112. RETRACTED: Anti-inflammatory Activity of 4-Arylcoumarins from EndophyticStreptomyces aureofaciensCMUAc130 in Murine Macrophage RAW 264.7 Cells
  113. Chemical constituents of Ligularia virgaurea and its diversity in southwestern Sichuan of China
  114. Isoflavone Diglycosides from Glycosmis pentaphylla
  115. Enzymatic cyclization of linear peptide to plant cyclopeptide heterophyllin B
  116. Anti-inflammatory Effects of 4-Arylcoumarins in LPS-induced Murine Macrophage RAW 264.7 Cells
  117. Chemical and Genetic Differentiation of Ligularia pleurocaulis in Northwestern Yunnan and Southwestern Sichuan Provinces of China
  118. Two New Macrolides Produced by Streptomyces sp. CS.
  119. Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities
  120. Norsesquiterpenoid and Sesquiterpenoid Glycosides from Evodia austrosinensis
  121. Sulfur-containing and dimeric flavanols from Glycosmis montana
  122. Chemical and Genetic Study of Ligularia tongolensis, Ligularia cymbulifera, and Ligularia atroviolacea in the Hengduan Mountains of China
  123. A Novel Amide N-Glycoside of Ansamitocins from Actinosynnema pretiosum.
  124. Five new C21 steroidal glycosides from Cynanchum komarovii Al.Iljinski
  125. Harnessing the potential of chemical defenses from antimicrobial activities
  126. Two New Macrolides Produced by Streptomyces sp. CS
  127. A Novel Amide N-Glycoside of Ansamitocins from Actinosynnema pretiosum
  128. Five diterpene alkaloids from Spiraea japonica (Rosaceae)
  129. The Chemistry and Biochemistry of Spiraea japonica Complex
  130. A New Macrolide Antibiotic with Antitumor Activity Produced by Streptomyces sp. CS, a Commensal Microbe of Maytenus hookeri.
  131. A New Macrolide Antibiotic with Antitumor Activity Produced by Streptomyces sp. CS, a Commensal Microbe of Maytenus hookeri
  132. Four diterpenes from Callicarpa pedunculata
  133. ChemInform Abstract: Six New O-Terpenoidal Coumarins, Excavacoumarins B-G from Clausena excavata
  134. O-Terpenoidal Coumarins from Clausena excavata
  135. Six New O-Terpenoidal Coumarins, Excavacoumarins B-G from Clausena excavata
  136. Engineered Biosynthesis of Novel Polyketides from Streptomyces Spore Pigment Polyketide Synthases