All Stories

  1. Progress of CDK4/6 Inhibitor Palbociclib in the Treatment of Cancer
  2. JAK/STAT Signal Transduction: Promising Attractive Targets for Immune, Inflammatory and Hematopoietic Diseases
  3. Design, Synthesis and Biological Evaluation of Novel Tamibarotene Derivative as Multitarget Anticancer Agent
  4. Discovery of Multi-target Anticancer Agents Based on HDAC Inhibitor MS-275 and 5-FU
  5. Design, synthesis, and antitumor evaluation of histone deacetylase inhibitors with L-phenylglycine scaffold
  6. Synthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase
  7. Development of N-hydroxybenzamide derivatives with indole-containing cap group as histone deacetylases inhibitors
  8. Discovery of a series of novel compounds with moderate anti-hepatitis C virus NS3 protease activity in vitro
  9. Correction to Design, Synthesis, and Antitumor Evaluation of Novel Histone Deacetylase Inhibitors Equipped with a Phenylsulfonylfuroxan Module as a Nitric Oxide Donor
  10. Synthesis and biological evaluation of novel histone deacetylases inhibitors with nitric oxide releasing activity
  11. Design, Synthesis, and Antitumor Evaluation of Novel Histone Deacetylase Inhibitors Equipped with a Phenylsulfonylfuroxan Module as a Nitric Oxide Donor
  12. Isoform-selective histone deacetylase inhibitors: the trend and promise of disease treatment
  13. Histone deacetylase inhibitors merged with protein tyrosine kinase inhibitors
  14. Enhanced anticancer activity of 5-FU in combination with Bestatin: Evidence in human tumor-derived cell lines and an H22 tumor-bearing mouse
  15. Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity
  16. Discovery of N-Substituted Oseltamivir Derivatives as Potent and Selective Inhibitors of H5N1 Influenza Neuraminidase
  17. Superior activity of a new histone deacetylase inhibitor (ZYJ-34c) in inhibiting growth of human leukemia cells by inducing p21WAF1 expression and cell cycle arrest
  18. Design, synthesis and preliminary evaluation of α-sulfonyl γ-(glycinyl-amino)proline peptidomimetics as matrix metalloproteinase inhibitors
  19. Discovery of the First N -Hydroxycinnamamide-Based Histone Deacetylase 1/3 Dual Inhibitors with Potent Oral Antitumor Activity
  20. Progress of HDAC Inhibitor Panobinostat in the Treatment of Cancer
  21. VEGF Signal System: The Application of Antiangiogenesis
  22. Discovery of N-(3-((7H-purin-6-yl)thio)-4-hydroxynaphthalen-1-yl)-sulfonamide derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: Synthesis and biological evaluation. Part III
  23. Developments of Polo-like Kinase 1 (Plk1) Inhibitors as Anti-Cancer Agents
  24. Histone Deacetylase Inhibitors with Enhanced Enzymatic Inhibition Effects and Potent in vitro and in vivo Antitumor Activities
  25. Discovery of 4-amino-2-(thio)phenol derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: Synthesis and biological evaluation. Part II
  26. 3D QSAR and docking studies of a series of histone deacetylase inhibitors
  27. Design and Synthesis of a Tetrahydroisoquinoline-Based Hydroxamate Derivative (ZYJ-34v), An Oral Active Histone Deacetylase Inhibitor with Potent Antitumor Activity
  28. Progress Review on Kinesin Spindle Protein Inhibitors as Anti- Cancer Agents
  29. Synthesis and biological evaluation of N-(4-hydroxy-3-mercaptonaphthalen-1-yl)amides as inhibitors of angiogenesis and tumor growth
  30. Development of N -Hydroxycinnamamide-Based Histone Deacetylase Inhibitors with an Indole-Containing Cap Group
  31. Discovery of a pair of diastereomers as potent HDACs inhibitors: determination of absolute configuration, biological activity comparison and computational study
  32. Design, synthesis and primary activity assay of tripeptidomimetics as histone deacetylase inhibitors with linear linker and branched cap group
  33. Discovery of a Tetrahydroisoquinoline-Based Hydroxamic Acid Derivative (ZYJ-34c) as Histone Deacetylase Inhibitor with Potent Oral Antitumor Activities
  34. Design, synthesis and biological evaluation of tyrosine-based hydroxamic acid analogs as novel histone deacetylases (HDACs) inhibitors
  35. Development of Tetrahydroisoquinoline-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities
  36. Applications and Modifications of 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid (Tic) in Peptides and Peptidomimetics Design and Discovery
  37. Design, synthesis and preliminary activity assay of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as novel Histone deacetylases (HDACs) inhibitors
  38. The Structure and Function of Histone Deacetylases: The Target for Anti-cancer Therapy
  39. Progress on Kinesin Spindle Protein Inhibitors as Anti-Cancer Agents
  40. Progress on Kinesin Spindle Protein Inhibitors as Anti-Cancer Agents