All Stories

  1. New Latent Epitope Activation Mechanism

    Article • Frontiers in Immunology, October 2019, Frontiers

    Yuan-Ping Pang

  2. A pilot clinical trial testing topical resiquimod and a xenopeptide as immune adjuvants for a melanoma vaccine targeting MART-1

    Article • Melanoma Research, August 2019, Wolters Kluwer Health

    Yuan-Ping Pang

  3. Peptide-Binding Groove Contraction Linked to the Lack of T Cell Response: Using Complex Structure and Energy To Identify Neoantigens

    Article • ImmunoHorizons, August 2018, The American Association of Immunologists

    Yuan-Ping Pang

  4. How fast fast-folding proteins fold in silico

    Article • Biochemical and Biophysical Research Communications, August 2017, Elsevier

    Yuan-Ping Pang

  5. On the use of the experimentally determined enzyme inhibition constant as a measure of absolute binding affinity

    Article • Biochemical and Biophysical Research Communications, August 2017, Elsevier

    Yuan-Ping Pang

  6. Use of multiple picosecond high-mass molecular dynamics simulations to predict crystallographic B-factors of folded globular proteins

    Article • Heliyon, September 2016, Elsevier

    Yuan-Ping Pang

  7. FF12MC: A revised AMBER forcefield and new protein simulation protocol

    Article • Proteins Structure Function and Bioinformatics, July 2016, Wiley

    Yuan-Ping Pang

  8. Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size

    Article • Journal of Virology, February 2016, ASM Journals

    Yuan-Ping Pang

  9. Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis

    Article • Chemico-Biological Interactions, February 2016, Elsevier

    Yuan-Ping Pang

  10. Low-mass molecular dynamics simulation for configurational sampling enhancement: More evidence and theoretical explanation

    Article • Biochemistry and Biophysics Reports, December 2015, Elsevier

    Yuan-Ping Pang

  11. Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils

    Article • CNS Neuroscience & Therapeutics, October 2015, Wiley

    Yuan-Ping Pang

  12. Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1

    Article • Molecular Cell, October 2015, Elsevier

    Yuan-Ping Pang

  13. Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer’s Dimer

    Article • ACS Chemical Neuroscience, September 2015, American Chemical Society (ACS)

    Yuan-Ping Pang

  14. Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin

    Article • Scientific Reports, July 2015, Nature

    Yuan-Ping Pang

  15. Robust Neuritogenesis-Promoting Activity by Bis(heptyl)-Cognitin Through the Activation of alpha7-Nicotinic Acetylcholine Receptor/ERK Pathway

    Article • CNS Neuroscience & Therapeutics, April 2015, Wiley

    Yuan-Ping Pang

  16. Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

    Article • EBioMedicine, April 2015, Elsevier

    Yuan-Ping Pang

  17. At least 10% shorter C–H bonds in cryogenic protein crystal structures than in current AMBER forcefields

    Article • Biochemical and Biophysical Research Communications, March 2015, Elsevier

    Yuan-Ping Pang

  18. Plasma butyrylcholinesterase regulates ghrelin to control aggression

    Article • Proceedings of the National Academy of Sciences, February 2015, Proceedings of the National Academy of Sciences

    Yuan-Ping Pang

  19. Use of 1–4 interaction scaling factors to control the conformational equilibrium between α-helix and β-strand

    Article • Biochemical and Biophysical Research Communications, February 2015, Elsevier

    Yuan-Ping Pang

  20. Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

    Article • The Journal of Cell Biology, September 2014, Rockefeller University Press

    Yuan-Ping Pang

  21. Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

    Article • The Journal of Cell Biology, September 2014, Rockefeller University Press

    Yuan-Ping Pang

  22. Low-mass molecular dynamics simulation: A simple and generic technique to enhance configurational sampling

    Article • Biochemical and Biophysical Research Communications, September 2014, Elsevier

    Yuan-Ping Pang

  23. Insect Acetylcholinesterase as a Target for Effective and Environmentally Safe Insecticides

    Article • January 2014, Elsevier

    Yuan-Ping Pang

  24. Common Pharmacophore of Structurally Distinct Small-Molecule Inhibitors of Intracellular Retrograde Trafficking of Ribosome Inactivating Proteins

    Article • Scientific Reports, December 2013, Nature

    Yuan-Ping Pang

  25. Evaluation of the BH3-only Protein Puma as a Direct Bak Activator

    Article • Journal of Biological Chemistry, November 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Yuan-Ping Pang

  26. Substantial Neuroprotection Against K+Deprivation-Induced Apoptosis in Primary Cerebellar Granule Neurons by Novel Dimer Bis(propyl)-Cognitin Via the Activation of VEGFR-2 Signaling Pathway

    Article • CNS Neuroscience & Therapeutics, July 2013, Wiley

    Yuan-Ping Pang

  27. Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways

    Article • Neurochemistry International, March 2013, Elsevier

    Yuan-Ping Pang

  28. Novel Selective and Irreversible Mosquito Acetylcholinesterase Inhibitors for Controlling Malaria and Other Mosquito-Borne Diseases

    Article • Scientific Reports, January 2013, Nature

    Yuan-Ping Pang

  29. Regulation of error-prone translesion synthesis by Spartan/C1orf124

    Article • Nucleic Acids Research, December 2012, Oxford University Press (OUP)

    Yuan-Ping Pang

  30. Chemical Structure of Retro-2, a Compound That Protects Cells against Ribosome-Inactivating Proteins

    Article • Scientific Reports, September 2012, Nature

    Yuan-Ping Pang

  31. Activation of Transcription Factor MEF2D by Bis(3)-cognitin Protects Dopaminergic Neurons and Ameliorates Parkinsonian Motor Defects

    Article • Journal of Biological Chemistry, August 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Yuan-Ping Pang

  32. Novel and Viable Acetylcholinesterase Target Site for Developing Effective and Environmentally Safe Insecticides

    Article • Current Drug Targets, April 2012, Bentham Science Publishers

    Yuan-Ping Pang

  33. Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum

    Article • Scientific Reports, February 2012, Nature

    Yuan-Ping Pang

  34. Genome Organization, Phylogenies, Expression Patterns, and Three-Dimensional Protein Models of Two Acetylcholinesterase Genes from the Red Flour Beetle

    Article • PLoS ONE, February 2012, PLOS

    Yuan-Ping Pang

  35. Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization

    Article • Scientific Reports, February 2012, Nature

    Yuan-Ping Pang

  36. Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

    Article • The Journal of Cell Biology, July 2011, Rockefeller University Press

    Yuan-Ping Pang

  37. Small-Molecule Inhibitor Leads of Ribosome-Inactivating Proteins Developed Using the Doorstop Approach

    Article • PLoS ONE, March 2011, PLOS

    Yuan-Ping Pang

  38. Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds

    Article • Biochemical Pharmacology, September 2010, Elsevier

    Yuan-Ping Pang

  39. Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle

    Article • Chemico-Biological Interactions, September 2010, Elsevier

    Yuan-Ping Pang

  40. ChemInform Abstract: Synthesis of Methoxy and Hydroxy Analogues of 1,2,3,4,4a,9a-Hexahydro-4a-fluorenamine: Rigid Phencyclidine Analogues as Probes of Phencyclidine Binding Site Topography.

    Article • ChemInform, August 2010, Wiley

    Yuan-Ping Pang

  41. ChemInform Abstract: Synthesis of Partial Nonpeptidic Peptide Mimetics as Potential Neurotensin Agonists and Antagonists.

    Article • ChemInform, August 2010, Wiley

    Yuan-Ping Pang

  42. ChemInform Abstract: Potent, Easily Synthesized Huperzine A-Tacrine Hybrid Acetylcholinesterase Inhibitors.

    Article • ChemInform, June 2010, Wiley

    Yuan-Ping Pang

  43. ChemInform Abstract: Successful Virtual Screening of a Chemical Database for Farnesyltransferase Inhibitor Leads.

    Article • ChemInform, June 2010, Wiley

    Yuan-Ping Pang

  44. Pathologically Activated Neuroprotection via Uncompetitive Blockade of N-Methyl-D-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin

    Article • Journal of Biological Chemistry, April 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Yuan-Ping Pang

  45. Small Molecules Showing Significant Protection of Mice against Botulinum Neurotoxin Serotype A

    Article • PLoS ONE, April 2010, PLOS

    Yuan-Ping Pang

  46. Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: Reactivation involving flipping of the His447 ring to form a reactive Glu334–His447–oxime triad

    Article • Biochemical Pharmacology, February 2010, Elsevier

    Yuan-Ping Pang

  47. One-Compound-Multi-Targets at Amyloid β Cascade Offered By Bis(7)-Cognitin, a Novel Anti-Alzheimer’s Dimer

    Article • January 2010, Springer Science + Business Media

    Yuan-Ping Pang

  48. Potent New Small-Molecule Inhibitor of Botulinum Neurotoxin Serotype A Endopeptidase Developed by Synthesis-Based Computer-Aided Molecular Design

    Article • PLoS ONE, November 2009, PLOS

    Yuan-Ping Pang

  49. Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of α-secretase and BACE-1 concurrently

    Article • European Journal of Pharmacology, November 2009, Elsevier

    Yuan-Ping Pang

  50. Selective and Irreversible Inhibitors of Mosquito Acetylcholinesterases for Controlling Malaria and Other Mosquito-Borne Diseases

    Article • PLoS ONE, August 2009, PLOS

    Yuan-Ping Pang

  51. Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons

    Article • Neuropharmacology, July 2009, Elsevier

    Yuan-Ping Pang

  52. Structure of HI-6•Sarin-Acetylcholinesterase Determined by X-Ray Crystallography and Molecular Dynamics Simulation: Reactivator Mechanism and Design

    Article • PLoS ONE, June 2009, PLOS

    Yuan-Ping Pang

  53. A selective small-molecule inhibitor of c-JunN-terminal kinase 1

    Article • FEBS Letters, June 2009, Wiley

    Yuan-Ping Pang

  54. Configurational Entropy in Protein–Peptide Binding:

    Article • Journal of Molecular Biology, June 2009, Elsevier

    Yuan-Ping Pang

  55. Structure-based discovery of dengue virus protease inhibitors

    Article • Antiviral Research, June 2009, Elsevier

    Yuan-Ping Pang

  56. Novel anti-Alzheimer’s dimer bis(7)-Cognitin: Cellular and molecular mechanisms of neuroprotection through multiple targets

    Article • Neurotherapeutics, January 2009, Springer Science + Business Media

    Yuan-Ping Pang

  57. Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry

    Article • Biomedical Chromatography, January 2009, Wiley

    Yuan-Ping Pang

  58. Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia

    Article • Neuroscience Letters, July 2008, Elsevier

    Yuan-Ping Pang

  59. Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine

    Article • International Journal of Pharmaceutics, June 2008, Elsevier

    Yuan-Ping Pang

  60. Inhibition of NMDA-gated ion channels by bis(7)-tacrine: Whole-cell and single-channel studies

    Article • Neuropharmacology, June 2008, Elsevier

    Yuan-Ping Pang

  61. Development of a Botulinum Neurotoxin animal inhalation model and evaluation of small molecule therapeutics for medical countermeasure

    Article • Toxicon, June 2008, Elsevier

    Yuan-Ping Pang

  62. The Impact of Structural Proteomics on Drug Design

    Article • May 2008, World Scientific Pub Co Pte Lt

    Yuan-Ping Pang

  63. Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors

    Article • Biochemical and Biophysical Research Communications, May 2008, Elsevier

    Yuan-Ping Pang

  64. Promising anti-Alzheimer’s dimer bis(7)-tacrine reduces β-amyloid generation by directly inhibiting BACE-1 activity

    Article • Biochemical and Biophysical Research Communications, February 2008, Elsevier

    Yuan-Ping Pang

  65. Convenient synthesis of a library of discrete hydroxamic acids using the hydroxythiophenol (Marshall) resin

    Article • Tetrahedron Letters, February 2008, Elsevier

    Yuan-Ping Pang

  66. The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine

    Article • Journal of Pharmaceutical and Biomedical Analysis, January 2008, Elsevier

    Yuan-Ping Pang

  67. EUDOC on the IBM Blue Gene/L system: Accelerating the transfer of drug discoveries from laboratory to patient

    Article • IBM Journal of Research and Development, January 2008, IBM

    Yuan-Ping Pang

  68. Normal-Mode-Analysis–Monitored Energy Minimization Procedure for Generating Small–Molecule Bound Conformations

    Article • PLoS ONE, October 2007, PLOS

    Yuan-Ping Pang

  69. Preference of Small Molecules for Local Minimum Conformations when Binding to Proteins

    Article • PLoS ONE, September 2007, PLOS

    Yuan-Ping Pang

  70. East Meets West in the Search for Alzheimers Therapeutics - Novel Dimeric Inhibitors from Tacrine and Huperzine A

    Article • Current Alzheimer Research, September 2007, Bentham Science Publishers

    Yuan-Ping Pang

  71. Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents

    Article • Biochemical and Biophysical Research Communications, September 2007, Elsevier

    Yuan-Ping Pang

  72. Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood

    Article • Journal of Pharmaceutical and Biomedical Analysis, September 2007, Elsevier

    Yuan-Ping Pang

  73. Computer-Aided Lead Optimization: Improved Small-Molecule Inhibitor of the Zinc Endopeptidase of Botulinum Neurotoxin Serotype A

    Article • PLoS ONE, August 2007, PLOS

    Yuan-Ping Pang

  74. Mitochondrial Proteomic Analysis and Characterization of the Intracellular Mechanisms of Bis(7)-tacrine in Protecting against Glutamate-Induced Excitotoxicity in Primary Cultured Neurons

    Article • Journal of Proteome Research, July 2007, American Chemical Society (ACS)

    Yuan-Ping Pang

  75. Accurate Reproduction of 161 Small-Molecule Complex Crystal Structures using the EUDOC Program: Expanding the Use of EUDOC to Supramolecular Chemistry

    Article • PLoS ONE, June 2007, PLOS

    Yuan-Ping Pang

  76. Novel Nerve-Agent Antidote Design Based on Crystallographic and Mass Spectrometric Analyses of Tabun-Conjugated Acetylcholinesterase in Complex with Antidotes

    Article • Clinical Pharmacology & Therapeutics, April 2007, Nature

    Yuan-Ping Pang

  77. Cryptic proteolytic activity of dihydrolipoamide dehydrogenase

    Article • Proceedings of the National Academy of Sciences, April 2007, Proceedings of the National Academy of Sciences

    Yuan-Ping Pang

  78. Synergistic Neuroprotection by Bis(7)-tacrine via Concurrent Blockade of N-Methyl-d-aspartate Receptors and Neuronal Nitric-Oxide Synthase

    Article • Molecular Pharmacology, February 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Yuan-Ping Pang

  79. Alkylene tether-length dependent γ-aminobutyric acid type A receptor competitive antagonism by tacrine dimers

    Article • Neuropharmacology, February 2007, Elsevier

    Yuan-Ping Pang

  80. Inhibition of Mitochondrial Respiration as a Source of Adaphostin-induced Reactive Oxygen Species and Cytotoxicity

    Article • Journal of Biological Chemistry, January 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Yuan-Ping Pang

  81. Species marker for developing novel and safe pesticides

    Article • Bioorganic & Medicinal Chemistry Letters, January 2007, Elsevier

    Yuan-Ping Pang

  82. Inhibition by bis(7)-tacrine of native delayed rectifier and KV1.2 encoded potassium channels

    Article • Neuroscience Letters, January 2007, Elsevier

    Yuan-Ping Pang

  83. In Silico Drug Discovery: Solving the “Target-rich and Lead-poor” Imbalance Using the Genome-to-drug-lead Paradigm

    Article • Clinical Pharmacology & Therapeutics, January 2007, Nature

    Yuan-Ping Pang

  84. Novel Acetylcholinesterase Target Site for Malaria Mosquito Control

    Article • PLoS ONE, December 2006, PLOS

    Yuan-Ping Pang

  85. Critical role of the FERM domain in Pyk2 stimulated glioma cell migration

    Article • Biochemical and Biophysical Research Communications, October 2006, Elsevier

    Yuan-Ping Pang

  86. Complexes of Alkylene-Linked Tacrine Dimers with Torpedo c alifornica Acetylcholinesterase:  Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge

    Article • Journal of Medicinal Chemistry, September 2006, American Chemical Society (ACS)

    Yuan-Ping Pang

  87. Bis(7)-tacrine attenuates β amyloid-induced neuronal apoptosis by regulating L-type calcium channels

    Article • Journal of Neurochemistry, September 2006, Wiley

    Yuan-Ping Pang

  88. Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: Structural basis for differences in the ability to reactivate tabun conjugates

    Article • Biochemical Pharmacology, August 2006, Elsevier

    Yuan-Ping Pang

  89. Bis-imidazoles as molecular probes for peripheral sites of the zinc endopeptidase of botulinum neurotoxin serotype A

    Article • Bioorganic & Medicinal Chemistry, May 2006, Elsevier

    Yuan-Ping Pang

  90. From Genome to Drug Lead: Identification of a Small-Molecule Inhibitor (I) of the SARS Virus.

    Article • ChemInform, April 2006, Wiley

    Yuan-Ping Pang

  91. Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine

    Article • Neuroreport, April 2006, Wolters Kluwer Health

    Yuan-Ping Pang

  92. From genome to drug lead: Identification of a small-molecule inhibitor of the SARS virus

    Article • Bioorganic & Medicinal Chemistry Letters, February 2006, Elsevier

    Yuan-Ping Pang

  93. 3D model of a substrate-bound SARS chymotrypsin-like cysteine proteinase predicted by multiple molecular dynamics simulations: Catalytic efficiency regulated by substrate binding

    Article • Proteins Structure Function and Bioinformatics, February 2006, Wiley

    Yuan-Ping Pang

  94. Pyrrole-Based Partial Peptidic Mimic of Neurotensin (8-13): Design and Synthesis (Experimental Section)

    Article • Letters in Organic Chemistry, January 2006, Bentham Science Publishers

    Yuan-Ping Pang

  95. Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A

    Article • Bioorganic & Medicinal Chemistry, January 2006, Elsevier

    Yuan-Ping Pang, Assoc. Prof. Alfonso T. Garcia-Sosa

  96. Poster reception---Optimizing EUDOC for the IBM eServer Blue Gene supercomputer

    Article • January 2006, Institute of Electrical & Electronics Engineers (IEEE)

    Yuan-Ping Pang

  97. Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase

    Article • Journal of the American Chemical Society, August 2005, American Chemical Society (ACS)

    Yuan-Ping Pang

  98. Novel Dimeric Acetylcholinesterase Inhibitor Bis(7)-tacrine, but Not Donepezil, Prevents Glutamate-induced Neuronal Apoptosis by Blocking N-Methyl-D-aspartate Receptors

    Article • Journal of Biological Chemistry, February 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Yuan-Ping Pang

  99. A Potent and Selective Tacrine Analog—Biomembrane Permeation and Physicochemical Characterization

    Article • Pharmaceutical Development and Technology, January 2005, Taylor & Francis

    Yuan-Ping Pang

  100. Proteomics shows Hsp70 does not bind peptide sequences indiscriminately in vivo

    Article • Experimental Cell Research, July 2004, Elsevier

    Yuan-Ping Pang

  101. Nonbonded bivalence approach to cell-permeable molecules that target DNA sequences

    Article • Bioorganic & Medicinal Chemistry, June 2004, Elsevier

    Yuan-Ping Pang

  102. Improved Loading and Cleavage Methods for Solid-Phase Synthesis Using Chlorotrityl Resins:  Synthesis and Testing of a Library of 144 Discrete Chemicals as Potential Farnesyltransferase Inhibitors

    Article • Journal of Combinatorial Chemistry, May 2004, American Chemical Society (ACS)

    Yuan-Ping Pang

  103. ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating

    Article • Nature Genetics, March 2004, Nature

    Yuan-Ping Pang

  104. Three-dimensional model of a substrate-bound SARS chymotrypsin-like cysteine proteinase predicted by multiple molecular dynamics simulations: Catalytic efficiency regulated by substrate binding

    Article • Proteins Structure Function and Bioinformatics, January 2004, Wiley

    Yuan-Ping Pang

  105. Cholinesterase Reactivation in Vivo with a Novel Bis-Oxime Optimized by Computer-Aided Design

    Article • Journal of Pharmacology and Experimental Therapeutics, July 2003, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Yuan-Ping Pang

  106. Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A

    Article • FEBS Letters, July 2003, Wiley

    Yuan-Ping Pang

  107. Rational Design of Alkylene-Linked Bis-Pyridiniumaldoximes as Improved Acetylcholinesterase Reactivators

    Article • Chemistry & Biology, June 2003, Elsevier

    Yuan-Ping Pang

  108. Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A:  Experimental Evidence for Species-Dependent Protein−Ligand Complementarity

    Article • Journal of the American Chemical Society, January 2003, American Chemical Society (ACS)

    Yuan-Ping Pang

  109. The antiangiogenic activity of cleaved high molecular weight kininogen is mediated through binding to endothelial cell tropomyosin

    Article • Proceedings of the National Academy of Sciences, August 2002, Proceedings of the National Academy of Sciences

    Yuan-Ping Pang

  110. Re-engineering Butyrylcholinesterase as a Cocaine Hydrolase

    Article • Molecular Pharmacology, August 2002, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Yuan-Ping Pang

  111. Cocaine Metabolism Accelerated by a Re-Engineered Human Butyrylcholinesterase

    Article • Journal of Pharmacology and Experimental Therapeutics, August 2002, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Yuan-Ping Pang

  112. Schisandrin B Protects Against Tacrine- and Bis(7)-tacrine-Induced Hepatotoxicity and Enhances Cognitive Function in Mice

    Article • Planta Medica, March 2002, Thieme Publishing Group

    Yuan-Ping Pang

  113. Theoretical 3D Model of Histamine N-Methyltransferase: Insights into the Effects of a Genetic Polymorphism on Enzymatic Activity and Thermal Stability

    Article • Biochemical and Biophysical Research Communications, September 2001, Elsevier

    Yuan-Ping Pang

  114. Rabbit indolethylamine N -methyltransferase three-dimensional structure prediction: a model approach to bridge sequence to function in pharmacogenomic studies

    Article • Journal of Molecular Modeling, September 2001, Springer Science + Business Media

    Yuan-Ping Pang

  115. Discovery of a new inhibitor lead of adenovirus proteinase: steps toward selective, irreversible inhibitors of cysteine proteinases

    Article • FEBS Letters, August 2001, Wiley

    Yuan-Ping Pang

  116. Comparison of DFT, Møller–Plesset, and coupled cluster calculations of the proton dissociation energies of imidazole and N-methylacetamide in the presence of zinc(II)

    Article • Journal of Molecular Structure THEOCHEM, July 2001, Elsevier

    Yuan-Ping Pang

  117. Successful molecular dynamics simulation of two zinc complexes bridged by a hydroxide in phosphotriesterase using the cationic dummy atom method

    Article • Proteins Structure Function and Bioinformatics, January 2001, Wiley

    Yuan-Ping Pang

  118. EUDOC: a computer program for identification of drug interaction sites in macromolecules and drug leads from chemical databases

    Article • Journal of Computational Chemistry, January 2001, Wiley

    Yuan-Ping Pang

  119. Predicted Michaelis-Menten Complexes of Cocaine-Butyrylcholinesterase: ENGINEERING EFFECTIVE BUTYRYLCHOLINESTERASE MUTANTS FOR COCAINE DETOXICATION

    Article • Journal of Biological Chemistry, December 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Yuan-Ping Pang

  120. Protonation States of the Chromophore of Denatured Green Fluorescent Proteins Predicted by ab Initio Calculations

    Article • Journal of the American Chemical Society, November 2000, American Chemical Society (ACS)

    Yuan-Ping Pang

  121. Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine

    Article • Neuroscience Letters, September 2000, Elsevier

    Yuan-Ping Pang

  122. A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist

    Article • Biochemical Pharmacology, September 2000, Elsevier

    Yuan-Ping Pang

  123. Corrigendum to 'Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor' [Neurosci. Lett. 288 (2000) 95–98]

    Article • Neuroscience Letters, August 2000, Elsevier

    Yuan-Ping Pang

  124. Protection against ischemic injury in primary cultured astrocytes of mouse cerebral cortex by bis(7)-tacrine, a novel anti-Alzheimer's agent

    Article • Neuroscience Letters, July 2000, Elsevier

    Yuan-Ping Pang

  125. Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats

    Article • Neuroscience Letters, March 2000, Elsevier

    Yuan-Ping Pang, Dr Philip Wing-Lok Ho

  126. Successful Virtual Screening of a Chemical Database for Farnesyltransferase Inhibitor Leads

    Article • Journal of Medicinal Chemistry, February 2000, American Chemical Society (ACS)

    Yuan-Ping Pang

  127. Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities

    Article • Bioorganic & Medicinal Chemistry, November 1999, Elsevier

    Yuan-Ping Pang

  128. Novel Zinc Protein Molecular Dynamics Simulations: Steps Toward Antiangiogenesis for Cancer Treatment

    Article • Journal of Molecular Modeling, October 1999, Springer Science + Business Media

    Yuan-Ping Pang

  129. Heterodimeric Tacrine-Based Acetylcholinesterase Inhibitors:  Investigating Ligand−Peripheral Site Interactions

    Article • Journal of Medicinal Chemistry, October 1999, American Chemical Society (ACS)

    Yuan-Ping Pang

  130. Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, August 1999, Elsevier

    Yuan-Ping Pang

  131. Atomic levers control pyranose ring conformations

    Article • Proceedings of the National Academy of Sciences, July 1999, Proceedings of the National Academy of Sciences

    Yuan-Ping Pang

  132. In vitro binding and CNS effects of novel neurotensin agonists that cross the blood–brain barrier

    Article • Neuropharmacology, July 1999, Elsevier

    Yuan-Ping Pang

  133. Zinc′s Exclusive Tetrahedral Coordination Governed by Its Electronic Structure

    Article • Journal of Molecular Modeling, July 1999, Springer Science + Business Media

    Yuan-Ping Pang

  134. Computational and Experimental Studies of (2,2)-Bis(indol-1-yl-methyl)acetate Suggest the Importance of the Hydrophobic Effect in Aromatic Stacking Interactions

    Article • Journal of the American Chemical Society, March 1999, American Chemical Society (ACS)

    Yuan-Ping Pang

  135. Evaluation of short-tether Bis-THA AChE inhibitors. A further test of the dual binding site hypothesis

    Article • Bioorganic & Medicinal Chemistry, February 1999, Elsevier

    Yuan-Ping Pang

  136. Article • Nature, December 1998, Nature

    Yuan-Ping Pang

  137. Synthesis of (2S)-2-amino-3-(1H-4-indolyl)propanoic acid, a novel tryptophan analog for structural modification of bioactive peptides

    Article • Tetrahedron Asymmetry, December 1998, Elsevier

    Yuan-Ping Pang

  138. Supercomputing-based dimeric analog approach for drug optimization

    Article • Parallel Computing, September 1998, Elsevier

    Yuan-Ping Pang

  139. Structure of acetylcholinesterase complexed with the nootropic alkaloid, (–)-huperzine A

    Article • Nature Structural Biology, January 1997, Nature

    Yuan-Ping Pang

  140. Highly Potent, Selective, and Low Cost Bis-tetrahydroaminacrine Inhibitors of Acetylcholinesterase. STEPS TOWARD NOVEL DRUGS FOR TREATING ALZHEIMER'S DISEASE

    Article • Journal of Biological Chemistry, September 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Yuan-Ping Pang

  141. Proposed Ligand Binding Site of the Transmembrane Receptor for Neurotensin(8-13)

    Article • Journal of Biological Chemistry, June 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Yuan-Ping Pang

  142. Chimeric Rat/Human Neurotensin Receptors Localize a Region of the Receptor Sensitive to Binding of a Novel, Species-specific, Picomolar Affinity Peptide

    Article • Journal of Biological Chemistry, June 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Yuan-Ping Pang

  143. Applications of free energy derivatives to analog design

    Article • Perspectives in Drug Discovery and Design, December 1995, Springer Science + Business Media

    Yuan-Ping Pang

  144. Pharmacological and Biochemical Profiles of Unique Neurotensin 8-13 Analogs Exhibiting Species Selectivity, Stereoselectivity, and Superagonism

    Article • Journal of Biological Chemistry, August 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Yuan-Ping Pang

  145. Synthesis of partial nonpeptidic peptide mimetics as potential neurotensin agonists and antagonists

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1995, Royal Society of Chemistry

    Yuan-Ping Pang

  146. Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies

    Article • Journal of Computer-Aided Molecular Design, December 1994, Springer Science + Business Media

    Yuan-Ping Pang

  147. Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program

    Article • Journal of Computer-Aided Molecular Design, December 1994, Springer Science + Business Media

    Yuan-Ping Pang

  148. Rational design of novel neurotensin mimetics: Discovery of a pharmacologically unprecedented agent exhibiting concentration-dependent dual effects as antagonist and full agonist

    Article • Journal of Computer-Aided Molecular Design, August 1994, Springer Science + Business Media

    Yuan-Ping Pang

  149. Synthesis, molecular modeling, 2-D NMR, and biological evaluation of ILV mimics as potential modulators of protein kinase C

    Article • Journal of the American Chemical Society, May 1993, American Chemical Society (ACS)

    Yuan-Ping Pang

  150. Topography of the huperzine A binding site in AChE: Ab initio docking of reversible inhibitors of AChE into the dynamic enzyme

    Article • January 1993, Springer Science + Business Media

    Yuan-Ping Pang

  151. Synthesis and 2D NMR analysis of a cyclopropane containing analogue of huperzine A

    Article • Tetrahedron Letters, May 1992, Elsevier

    Yuan-Ping Pang

  152. Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency

    Article • Journal of Medicinal Chemistry, May 1992, American Chemical Society (ACS)

    Yuan-Ping Pang

  153. Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity

    Article • Journal of Medicinal Chemistry, December 1991, American Chemical Society (ACS)

    Yuan-Ping Pang

  154. Synthesis of methoxy and hydroxy analogs of 1,2,3,4,4a,9a-hexahydro-4a-fluorenamine: rigid phencyclidine analogs as probes of phencyclidine binding site topography

    Article • The Journal of Organic Chemistry, July 1991, American Chemical Society (ACS)

    Yuan-Ping Pang

  155. A route to optically pure (-)-huperzine A; molecular modeling and in vitro pharmacology

    Article • Journal of the American Chemical Society, June 1991, American Chemical Society (ACS)

    Yuan-Ping Pang

  156. Synthesis and Chemical Resolution of a Novel Class of Rigid 1-(1-Phenylcyclohexyl)-iperidine(PCP) Analogues

    Article • Synlett, January 1990, Thieme Publishing Group

    Yuan-Ping Pang