All Stories

  1. The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease

    Article • Translational Neurodegeneration, August 2019, Springer Science + Business Media

    Dr Philip Wing-Lok Ho

  2. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)

    Article • Autophagy, April 2019, Taylor & Francis

    Dr Philip Wing-Lok Ho

  3. Role of Nurr1 in the regulation of Synaptogyrin 3 (SYNGR3)

    Article • Endocrine Abstracts, November 2018, Bioscientifica

    Dr Philip Wing-Lok Ho

  4. Activation of hypothalamic RIP‐Cre neurons promotes beiging of WAT via sympathetic nervous system

    Article • EMBO Reports, February 2018, EMBO

    Dr Philip Wing-Lok Ho

  5. Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase

    Article • Biochemical Journal, January 2018, Portland Press Ltd.

    Dr Philip Wing-Lok Ho

  6. Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease

    Article • Scientific Reports, January 2017, Springer Science + Business Media

    Dr Philip Wing-Lok Ho

  7. Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice

    Article • Molecular Neurodegeneration, November 2016, Springer Science + Business Media

    Dr Philip Wing-Lok Ho

  8. Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates

    Article • Cerebral Cortex, November 2016, Oxford University Press (OUP)

    Dr Philip Wing-Lok Ho

  9. Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

    Article • Biochemical Journal, August 2016, Portland Press Ltd.

    Dr Philip Wing-Lok Ho

  10. Revealing ecological risks of priority endocrine disrupting chemicals in four marine protected areas in Hong Kong through an integrative approach

    Article • Environmental Pollution, August 2016, Elsevier

    Dr Philip Wing-Lok Ho

  11. Efficient attenuation of Friedreich's ataxia (FRDA) cardiomyopathy by modulation of iron homeostasis-human induced pluripotent stem cell (hiPSC) as a drug screening platform for FRDA

    Article • International Journal of Cardiology, January 2016, Elsevier

    Dr Philip Wing-Lok Ho

  12. PMCA 4 ( ATP 2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion

    Article • Brain and Behavior, February 2015, Wiley

    Dr Philip Wing-Lok Ho

  13. PMCA4 (ATP2B4) Mutation in Familial Spastic Paraplegia

    Article • PLoS ONE, August 2014, PLOS

    Dr Philip Wing-Lok Ho

  14. LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity

    Article • Annals of Clinical and Translational Neurology, March 2014, Wiley

    Dr Philip Wing-Lok Ho

  15. Modeling of Friedreich ataxia-related iron overloading cardiomyopathy using patient-specific-induced pluripotent stem cells

    Article • Pflügers Archiv - European Journal of Physiology, December 2013, Springer Science + Business Media

    Dr Philip Wing-Lok Ho

  16. Assessment of Cellular Estrogenic Activity Based on Estrogen Receptor-Mediated Reduction of Soluble-Form Catechol-O-Methyltransferase (COMT) Expression in an ELISA-Based System

    Article • PLoS ONE, September 2013, PLOS

    Dr Philip Wing-Lok Ho

  17. Central nervous system inflammatory demyelinating disorders among Hong Kong Chinese

    Article • Journal of Neuroimmunology, September 2013, Elsevier

    Dr Philip Wing-Lok Ho

  18. Modeling of Friedreich Ataxia related iron overloading cardiomyopathy using patient-specific induced pluripotent stem cellsCellp

    Article • European Heart Journal, August 2013, European Society of Cardiology

    Dr Philip Wing-Lok Ho

  19. Human Mesenchymal Stem Cells Upregulate CD1dhighCD5+Regulatory B Cells in Experimental Autoimmune Encephalomyelitis

    Article • NeuroImmunoModulation, January 2013, Karger Publishers

    Dr Philip Wing-Lok Ho

  20. Adiponectin is Protective against Oxidative Stress Induced Cytotoxicity in Amyloid-Beta Neurotoxicity

    Article • PLoS ONE, December 2012, PLOS

    Dr Philip Wing-Lok Ho

  21. UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress

    Article • Free Radical Biology and Medicine, July 2012, Elsevier

    Dr Philip Wing-Lok Ho

  22. Plasma amyloid-β oligomers level is a biomarker for Alzheimer’s disease diagnosis

    Article • Biochemical and Biophysical Research Communications, July 2012, Elsevier

    Dr Philip Wing-Lok Ho

  23. Human neuronal uncoupling proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation, and physiological role in protection against oxidative stress and mitochondrial dysfunction

    Article • Brain and Behavior, June 2012, Wiley

    Dr Philip Wing-Lok Ho

  24. Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse

    Article • Journal of Neuroimmunology, April 2012, Elsevier

    Dr Philip Wing-Lok Ho

  25. Detection of endocrine disruptors - from simple assays to whole genome scanning

    Article • International Journal of Andrology, March 2012, Wiley

    Dr Philip Wing-Lok Ho

  26. Uncoupling Protein-4 (UCP4) Increases ATP Supply by Interacting with Mitochondrial Complex II in Neuroblastoma Cells

    Article • PLoS ONE, February 2012, PLOS

    Dr Philip Wing-Lok Ho

  27. Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease

    Article • Translational Neurodegeneration, January 2012, Springer Science + Business Media

    Dr Philip Wing-Lok Ho

  28. Brain Involvement in Neuromyelitis Optica Spectrum Disorders

    Article • Archives of Neurology, November 2011, American Medical Association (AMA)

    Dr Philip Wing-Lok Ho

  29. Clinical outcome of relapsing remitting multiple sclerosis among Hong Kong Chinese

    Article • Clinical Neurology and Neurosurgery, October 2011, Elsevier

    Dr Philip Wing-Lok Ho

  30. Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis

    Article • Journal of Neuroimmunology, October 2010, Elsevier

    Dr Philip Wing-Lok Ho

  31. Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity

    Article • Free Radical Biology and Medicine, September 2010, Elsevier

    Dr Philip Wing-Lok Ho

  32. Transcriptional regulation of UCP4 by NF-κB and its role in mediating protection against MPP+ toxicity

    Article • Free Radical Biology and Medicine, July 2010, Elsevier

    Dr Philip Wing-Lok Ho

  33. Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays

    Article • Journal of Neuroinflammation, January 2010, Springer Science + Business Media

    Dr Philip Wing-Lok Ho

  34. Mitochondrial Uncoupling Protein-2 (UCP2) Mediates Leptin Protection Against MPP+ Toxicity in Neuronal Cells

    Article • Neurotoxicity Research, September 2009, Springer Science + Business Media

    Dr Philip Wing-Lok Ho

  35. Mitochondrial UCP4 attenuates MPP+- and dopamine-induced oxidative stress, mitochondrial depolarization, and ATP deficiency in neurons and is interlinked with UCP2 expression

    Article • Free Radical Biology and Medicine, March 2009, Elsevier

    Dr Philip Wing-Lok Ho

  36. −459C>T point mutation in 5′ non-coding region of humanGJB1gene is linked to X-linked Charcot-Marie-Tooth neuropathy

    Article • Journal of the Peripheral Nervous System, March 2009, Wiley

    Dr Philip Wing-Lok Ho

  37. Effects of Plasticisers and Related Compounds on the Expression of the Soluble Form of Catechol-O-Methyltransferase in MCF-7 Cells

    Article • Current Drug Metabolism, May 2008, Bentham Science Publishers

    Dr Philip Wing-Lok Ho

  38. Estrogenic Phenol and Catechol Metabolites of PCBs Modulate Catechol-Omethyltransferase Expression Via the Estrogen Receptor: Potential Contribution to Cancer Risk

    Article • Current Drug Metabolism, May 2008, Bentham Science Publishers

    Dr Philip Wing-Lok Ho

  39. Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation

    Article • Journal of Magnetic Resonance Imaging, January 2007, Wiley

    Dr Philip Wing-Lok Ho

  40. Knockdown of uncoupling protein-5 in neuronal SH-SY5Y cells: Effects on MPP+-induced mitochondrial membrane depolarization, ATP deficiency, and oxidative cytotoxicity

    Article • Journal of Neuroscience Research, January 2006, Wiley

    Dr Philip Wing-Lok Ho

  41. Clinical phenotypes of a large Chinese multigenerational kindred with autosomal dominant familial ALS due to Ile149Thr SOD1 gene mutation

    Article • Amyotrophic Lateral Sclerosis, January 2006, Taylor & Francis

    Dr Philip Wing-Lok Ho

  42. Uncoupling proteins: Targets of endocrine disruptors?

    Article • Molecular and Cellular Endocrinology, December 2005, Elsevier

    Dr Philip Wing-Lok Ho

  43. Methyl-4-phenylpyridinium ion modulates expression of mitochondrial uncoupling proteins 2, 4, and 5 in catecholaminergic (SK-N-SH) cells

    Article • Journal of Neuroscience Research, January 2005, Wiley

    Dr Philip Wing-Lok Ho

  44. Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats

    Article • Neuroscience Letters, March 2000, Elsevier

    Yuan-Ping Pang, Dr Philip Wing-Lok Ho

  45. Effects of bis(7)-tacrine, a novel anti-Alzheimerʼs agent, on rat brain AChE

    Article • Neuroreport, March 1999, Wolters Kluwer Health

    Dr Philip Wing-Lok Ho