All Stories

  1. Claudin 5-binding small molecule transiently opens the blood-brain barrier and safely enhances brain drug delivery

    Article • Journal of Controlled Release, December 2025, Elsevier

    Yoshiaki Okada

  2. Vascular Molecules Suppress Inflammatory Disease

    Article • Communications Biology, May 2024, Springer Science + Business Media

    Yoshiaki Okada

  3. A drug reduces vascular permeability and mortality in severe infectious diseases

    Article • Proceedings of the National Academy of Sciences, January 2023, Proceedings of the National Academy of Sciences

    Yoshiaki Okada

  4. SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression.

    Article • Science Advances, September 2022, American Association for the Advancement of Science

    Yoshiaki Okada

  5. HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells

    Article • Tissue Barriers, May 2021, Taylor & Francis

    Yoshiaki Okada

  6. ETV2-TET1/TET2 Complexes Induce Endothelial Cell-Specific Robo4 Expression via Promoter Demethylation

    Article • Scientific Reports, April 2018, Springer Science + Business Media

    Yoshiaki Okada

  7. Endothelial Robo4 regulates IL-6 production by endothelial cells and monocytes via a crosstalk mechanism in inflammation

    Article • Biochemical and Biophysical Research Communications, January 2018, Elsevier

    Yoshiaki Okada

  8. The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation

    Article • Journal of Cell Science, January 2018, The Company of Biologists

    Yoshiaki Okada

  9. Endothelial Cell–Specific Expression of Roundabout 4 Is Regulated by Differential DNA Methylation of the Proximal Promoter

    Article • Arteriosclerosis Thrombosis and Vascular Biology, July 2014, Wolters Kluwer Health

    Yoshiaki Okada

  10. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

    Article • Nature, May 2009, Springer Science + Business Media

    Yoshiaki Okada

  11. Elevated levels of placental growth factor represent an adaptive host response in sepsis

    Article • Journal of Experimental Medicine, October 2008, Rockefeller University Press

    Yoshiaki Okada

  12. A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo

    Article • Blood, September 2008, American Society of Hematology

    Yoshiaki Okada

  13. A Three-Kilobase Fragment of the Human Robo4 Promoter Directs Cell Type–Specific Expression in Endothelium

    Article • Circulation Research, June 2007, Wolters Kluwer Health

    Yoshiaki Okada