All Stories

  1. Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections

    Article • Communications Biology, October 2023, Springer Science + Business Media

    Winfried Hinrichs

  2. Structural Basis for (2R,3R)-Taxifolin Binding and Reaction Products to the Bacterial Chalcone Isomerase of Eubacterium ramulus

    Article • Molecules, November 2022, MDPI AG

    Winfried Hinrichs

  3. Crystal structures of free and ligand‐bound forms of the TetR/AcrR‐like regulator SCO3201 from Streptomyces coelicolor suggest a novel allosteric mechanism

    Article • European Journal of Biochemistry, September 2022, Wiley

    Winfried Hinrichs

  4. Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease

    Article • Communications Biology, August 2022, Springer Science + Business Media

    Winfried Hinrichs

  5. Hydrazones and Thiosemicarbazones Targeting Protein-Protein-Interactions of SARS-CoV-2 Papain-like Protease

    Article • Frontiers in Chemistry, April 2022, Frontiers

    Winfried Hinrichs

  6. Structural basis to repurpose boron-based proteasome inhibitors Bortezomib and Ixazomib as β-lactamase inhibitors

    Article • Scientific Reports, April 2022, Springer Science + Business Media

    Winfried Hinrichs

  7. The induction mechanism of the flavonoid‐responsive regulator FrrA

    Article • European Journal of Biochemistry, August 2021, Wiley

    Winfried Hinrichs

  8. The Komagataeibacter europaeus GqqA is the prototype of a novel bifunctional N-Acyl-homoserine lactone acylase with prephenate dehydratase activity

    Article • Scientific Reports, June 2021, Springer Science + Business Media

    Winfried Hinrichs

  9. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

    Article • Science, May 2021, American Association for the Advancement of Science

    Professor Henry N Chapman, Winfried Hinrichs

  10. Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, June 2020, Elsevier

    Winfried Hinrichs

  11. Structural and biochemical analysis of a phosin from Streptomyces chartreusis reveals a combined polyphosphate‐ and metal‐binding fold

    Article • FEBS Letters, June 2019, Wiley

    Winfried Hinrichs

  12. Protein binding to Tetracyclines: Inhibitor, Regulator, Substrate

    Article • Insights in Enzyme Research, January 2018, Scitechnol Biosoft Pvt. Ltd.

    Winfried Hinrichs

  13. Assemblins as maturational proteases in herpesviruses

    Article • Journal of General Virology, August 2017, Society for General Microbiology

    Winfried Hinrichs

  14. Blocking tetracycline destruction

    Article • Nature Chemical Biology, May 2017, Springer Science + Business Media

    Winfried Hinrichs

  15. Structural evidence of intramolecular propeptide inhibition of the aspzincin metalloendopeptidase AsaP1

    Article • FEBS Letters, September 2016, Wiley

    Winfried Hinrichs

  16. Modular organisation of inducer recognition and allostery in the tetracycline repressor

    Article • European Journal of Biochemistry, April 2016, Wiley

    Winfried Hinrichs

  17. Correction: Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease

    Article • PLoS Pathogens, March 2016, PLOS

    Winfried Hinrichs

  18. Structural analysis and knock-out of a Burkholderia pseudomallei homolog of the eukaryotic transcription coactivator PC4

    Article • Gene, February 2016, Elsevier

    Winfried Hinrichs

  19. A Quantitative Real-Time RT-PCR Assay for the Detection ofVenezuelan equine encephalitis virusUtilizing a Universal Alphavirus Control RNA

    Article • BioMed Research International, January 2016, Hindawi Publishing Corporation

    Winfried Hinrichs

  20. Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease

    Article • PLoS Pathogens, July 2015, PLOS

    Winfried Hinrichs

  21. Structure and catalytic mechanism of the evolutionarily unique bacterial chalcone isomerase

    Article • Acta Crystallographica Section D Biological Crystallography, March 2015, International Union of Crystallography

    Winfried Hinrichs

  22. Tetracycline Repressor Allostery Does Not Depend on Divalent Metal Recognition

    Article • Biochemistry, December 2014, American Chemical Society (ACS)

    Winfried Hinrichs

  23. Structural and biochemical characterization of the dual substrate recognition of the (R)-selective amine transaminase fromAspergillus fumigatus

    Article • European Journal of Biochemistry, December 2014, Wiley

    Winfried Hinrichs, Prof. Uwe T Bornscheuer

  24. Post-translational modification and extended glycosylation pattern of a plant latex peroxidase of native source characterized by X-ray crystallography

    Article • European Journal of Biochemistry, August 2014, Wiley

    Winfried Hinrichs, Dr. Santosh Panjikar

  25. Structure and regulatory targets of SCO3201, a highly promiscuous TetR-like regulator of Streptomyces coelicolor M145

    Article • Biochemical and Biophysical Research Communications, July 2014, Elsevier

    Winfried Hinrichs

  26. Crystallographic characterization of the (R)-selective amine transaminase fromAspergillus fumigatus

    Article • Acta Crystallographica Section D Biological Crystallography, March 2014, International Union of Crystallography

    Winfried Hinrichs, Prof. Uwe T Bornscheuer

  27. Enzymatic Conversion of Flavonoids using Bacterial Chalcone Isomerase and Enoate Reductase

    Article • Angewandte Chemie, December 2013, Wiley

    Prof. Uwe T Bornscheuer, Winfried Hinrichs

  28. Crystallization and preliminary X-ray diffraction studies of the (R)-selective amine transaminase fromAspergillus fumigatus

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2013, International Union of Crystallography

    Prof. Uwe T Bornscheuer, Winfried Hinrichs

  29. Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX

    Article • Acta Crystallographica Section D Biological Crystallography, August 2013, International Union of Crystallography

    Winfried Hinrichs, Dr. Santosh Panjikar

  30. Toxoid construction of AsaP1, a lethal toxic aspzincin metalloendopeptidase of Aeromonas salmonicida subsp. achromogenes, and studies of its activity and processing

    Article • Veterinary Microbiology, March 2013, Elsevier

    Prof. Uwe T Bornscheuer, Winfried Hinrichs

  31. A FRET Enzyme-Based Probe for Monitoring Hydrogen Sulfide

    Article • Inorganic Chemistry, October 2012, American Chemical Society (ACS)

    Winfried Hinrichs

  32. Purification, crystallization and preliminary crystallographic analysis of banyan peroxidase

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, July 2012, International Union of Crystallography

    Dr. Santosh Panjikar, Winfried Hinrichs

  33. Humanes α2-Makroglobulin - eine Variation der Venusfliegenfalle

    Article • Angewandte Chemie, April 2012, Wiley

    Winfried Hinrichs

  34. Human α2‐Macroglobulin—Another Variation on the Venus Flytrap

    Article • Angewandte Chemie, April 2012, Wiley

    Winfried Hinrichs

  35. Structural insights into the redox-switch mechanism of the MarR/DUF24-type regulator HypR

    Article • Nucleic Acids Research, January 2012, Oxford University Press (OUP)

    Winfried Hinrichs

  36. Recognition of Drug Degradation Products by Target Proteins: Isotetracycline Binding to Tet Repressor

    Article • Journal of Medicinal Chemistry, July 2011, American Chemical Society (ACS)

    Winfried Hinrichs

  37. The crystal structure of an esterase from the hyperthermophilic microorganism Pyrobaculum calidifontis VA1 explains its enantioselectivity

    Article • Applied Microbiology and Biotechnology, May 2011, Springer Science + Business Media

    Prof. Uwe T Bornscheuer, Winfried Hinrichs

  38. Cloning, functional expression, biochemical characterization, and structural analysis of a haloalkane dehalogenase from Plesiocystis pacifica SIR-1

    Article • Applied Microbiology and Biotechnology, May 2011, Springer Science + Business Media

    Prof. Uwe T Bornscheuer, Winfried Hinrichs

  39. Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase

    Article • FEBS Letters, March 2011, Wiley

    Winfried Hinrichs

  40. Influence of temperature during crystallization setup on precipitate formation and crystal shape of a metalloendopeptidase

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, February 2011, International Union of Crystallography

    Winfried Hinrichs

  41. The growth of single crystal silver wires at the nitrobenzene|water interface

    Article • Physical Chemistry Chemical Physics, January 2011, Royal Society of Chemistry

    Winfried Hinrichs

  42. Crystallization and preliminary X-ray diffraction studies of the putative haloalkane dehalogenase DppA fromPlesiocystis pacificaSIR-I

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, June 2010, International Union of Crystallography

    Prof. Uwe T Bornscheuer, Winfried Hinrichs

  43. Crystallization and preliminary X-ray crystallographic analysis of the tetracycline-degrading monooxygenase TetX2 fromBacteroides thetaiotaomicron

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, April 2010, International Union of Crystallography

    Winfried Hinrichs

  44. Nonantibiotic Properties of Tetracyclines: Structural Basis for Inhibition of Secretory Phospholipase A2

    Article • Journal of Molecular Biology, April 2010, Elsevier

    Winfried Hinrichs

  45. Tetracycline-Tet Repressor Binding Specificity: Insights from Experiments and Simulations

    Article • Biophysical Journal, November 2009, Elsevier

    Winfried Hinrichs

  46. Structure of the Ni(II) complex of Escherichia coli peptide deformylase and suggestions on deformylase activities depending on different metal(II) centres

    Article • JBIC Journal of Biological Inorganic Chemistry, September 2009, Springer Science + Business Media

    Winfried Hinrichs

  47. Prion Protein Misfolding

    Article • Current Molecular Medicine, September 2009, Bentham Science Publishers

    Winfried Hinrichs

  48. Crystallization and preliminary X-ray diffraction studies of AsaP1_E294A and AsaP1_E294Q, two inactive mutants of the toxic zinc metallopeptidase AsaP1 fromAeromonas salmonicidasubsp.achromogenes

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, June 2009, International Union of Crystallography

    Winfried Hinrichs

  49. Tryptophan π-Electron System Capping a Copper(I) Binding Site-A New Organometallic Bonding Mode in Proteins

    Article • ChemBioChem, August 2008, Wiley

    Winfried Hinrichs

  50. Tryptophan π‐Electron System Capping a Copper(I) Binding Site—A New Organometallic Bonding Mode in Proteins

    Article • ChemBioChem, July 2008, Wiley

    Winfried Hinrichs

  51. Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex

    Article • JBIC Journal of Biological Inorganic Chemistry, June 2008, Springer Science + Business Media

    Winfried Hinrichs

  52. Tet Repressor Induction by Tetracycline: A Molecular Dynamics, Continuum Electrostatics, and Crystallographic Study

    Article • Journal of Molecular Biology, May 2008, Elsevier

    Winfried Hinrichs

  53. Protonation Patterns in Tetracycline:Tet Repressor Recognition: Simulations and Experiments

    Article • ChemBioChem, April 2007, Wiley

    Winfried Hinrichs

  54. Structure of the apo form of the catabolite control protein A (CcpA) fromBacillus megateriumwith a DNA-binding domain

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, March 2007, International Union of Crystallography

    Dr. Santosh Panjikar, Winfried Hinrichs

  55. Synergistic and strain-specific effects of bovine spongiform encephalopathy and scrapie prions in the cell-free conversion of recombinant prion protein

    Article • Journal of General Virology, December 2006, Society for General Microbiology

    Winfried Hinrichs

  56. Old Codons, New Amino Acids

    Article • ChemInform, June 2004, Wiley

    Winfried Hinrichs

  57. Alte Codons– neue Aminosäuren

    Article • Angewandte Chemie, February 2004, Wiley

    Winfried Hinrichs

  58. Old Codons, New Amino Acids

    Article • Angewandte Chemie, February 2004, Wiley

    Winfried Hinrichs

  59. How Unique Is the Genetic Code

    Article • ChemInform, May 2003, Wiley

    Winfried Hinrichs

  60. Wie eindeutig ist der genetische Code?

    Article • Angewandte Chemie, February 2003, Wiley

    Winfried Hinrichs

  61. How Unique Is the Genetic Code?

    Article • Angewandte Chemie, February 2003, Wiley

    Winfried Hinrichs

  62. Gene regulation by the tetracycline-inducible Tet repressor-operator system — molecular mechanisms at atomic resolution

    Article • January 2001, Springer Science + Business Media

    Winfried Hinrichs

  63. ChemInform Abstract: The Tetracycline Repressor - A Paradigm for a Biological Switch

    Article • ChemInform, September 2000, Wiley

    Winfried Hinrichs

  64. Der Tetracyclin-Repressor – das Musterbeispiel für einen biologischen Schalter

    Article • Angewandte Chemie, June 2000, Wiley

    Winfried Hinrichs

  65. Article • Nature Structural Biology, March 2000, Springer Science + Business Media

    Winfried Hinrichs

  66. Crystallization and preliminary X-ray analyses of catabolite control protein A, free and in complex with its DNA-binding site

    Article • Acta Crystallographica Section D Biological Crystallography, January 2000, International Union of Crystallography

    Winfried Hinrichs

  67. Effect of the ionic environment on the molecular structure of bacteriophage SPP1 portal protein

    Article • European Journal of Biochemistry, September 1999, Wiley

    Dr Paulo Tavares, Winfried Hinrichs

  68. Crystal structure of the tet repressor in complex with a novel tetracycline, 9-( N , N -dimethylglycylamido)-6-demethyl-6-deoxy-tetracycline 1 1Edited by R. Huber

    Article • Journal of Molecular Biology, January 1999, Elsevier

    Winfried Hinrichs

  69. Tetracycline-Chelated Mg2+ Ion Initiates Helix Unwinding in Tet Repressor Induction,

    Article • Biochemistry, December 1998, American Chemical Society (ACS)

    Winfried Hinrichs

  70. Crystallization and preliminary X-ray crystallographic studies of the 13-fold symmetric portal protein of bacteriophage SPP1

    Article • Acta Crystallographica Section D Biological Crystallography, September 1998, International Union of Crystallography

    Dr Paulo Tavares, Winfried Hinrichs

  71. Conformational changes of the Tet repressor induced by tetracycline trapping

    Article • Journal of Molecular Biology, June 1998, Elsevier

    Winfried Hinrichs

  72. Crystallization and preliminary X-ray analysis of the Tet-repressor/operator complex

    Article • Acta Crystallographica Section D Biological Crystallography, January 1998, International Union of Crystallography

    Winfried Hinrichs

  73. Ligand-Field Control and Hydrogen Bonding as Design Elements in the Assembly and Crystallization of Poly(azolyl)borate-Metal Complexes: Chelate Complexes Versus Coordination Polymers and Symmetrical Versus Distorted Grid Sheets

    Article • Chemistry - A European Journal, December 1995, Wiley

    Professor Christoph Janiak, Winfried Hinrichs

  74. Characterization of non-inducible Tet repressor mutants suggests conformational changes necessary for induction

    Article • Nature Structural Biology, August 1995, Springer Science + Business Media

    Winfried Hinrichs

  75. SELFSTACKING SYSTEMS, PART 6.1HOST LATTICE FUNCTION OF 2,3,8,9-TETRAMETHOXYDIBENZO[c,e][1,2]-DICHALCOGENINS IN THEIR ELECTRICALLY CONDUCTING IODINE COMPLEXES

    Article • Phosphorus Sulfur and Silicon and the Related Elements, April 1995, Taylor & Francis

    Winfried Hinrichs

  76. Structure of the Tet Repressor-tetracycline Complex and Regulation of Antibiotic Resistance

    Article • Science, April 1994, American Association for the Advancement of Science

    Winfried Hinrichs

  77. The structure of the left-handed antiparallel amylose double helix: Theoretical studies

    Article • Biopolymers, March 1993, Wiley

    Winfried Hinrichs

  78. Three-dimensional structure of system I of photosynthesis at 6 Å resolution

    Article • Nature, January 1993, Springer Science + Business Media

    Winfried Hinrichs

  79. Crystal structures of linear and cyclic oligosaccharides: An overview

    Article • Pure and Applied Chemistry, January 1993, De Gruyter

    Winfried Hinrichs

  80. Cyclic ligands with fixed coordination geometry. Part 7 Cationic copper(I) complexes of composition [Cu(Vn3S3)L]+-CF3SO 3 - (Vn3S3=5,10, 15-trithia-cyclo-triveratrylene, L=CO, CH3OH)

    Article • Transition Metal Chemistry, February 1991, Springer Science + Business Media

    Winfried Hinrichs

  81. Crystallization of proteins under microgravity

    Article • FEBS Letters, December 1989, Wiley

    Winfried Hinrichs

  82. A side chain of diastereomeric iloprost protrudes from the cage in the complex with cyclomaltoheptaose (β-cyclodextrin): Crystal structure of (β-cyclodextrin)2 iloprost·20.5 H2O

    Article • Carbohydrate Research, October 1989, Elsevier

    Winfried Hinrichs

  83. Binding of vanadate (V) to ribonuclease-T1 and inosine, investigated by 15V NMR spectroscopy

    Article • Journal of Inorganic Biochemistry, October 1989, Elsevier

    Winfried Hinrichs

  84. Long-range structural changes in proteinase K triggered by calcium ion removal

    Article • Nature, February 1989, Springer Science + Business Media

    Winfried Hinrichs

  85. The first crystallization of a vanadium‐dependent peroxidase

    Article • FEBS Letters, November 1988, Wiley

    Winfried Hinrichs

  86. The enzymatic activity of proteinase K is controlled by calcium

    Article • European Journal of Biochemistry, September 1988, Wiley

    Winfried Hinrichs

  87. A Novel Tetranuclear Copper(I) Cluster with Alternate Bridging Halide and Triazolopyrimidine Ligands

    Article • Angewandte Chemie International Edition in English, June 1988, Wiley

    Winfried Hinrichs

  88. Cyclic ligands with fixed co-ordination geometry. Part 6(1). Chalcogenanthrenes as bridging ligands in dinuclear complexes of rhenium(I) and platinum(IV)-X-ray crystal structure of di(?-chloro) (?-2, 3, 7, 8-tetramethoxyselenanthrene) hexamethyl diplat...

    Article • Transition Metal Chemistry, December 1987, Springer Science + Business Media

    Winfried Hinrichs

  89. An Amylose Antiparallel Double Helix at Atomic Resolution

    Article • Science, October 1987, American Association for the Advancement of Science

    Winfried Hinrichs

  90. Structure and electrical conductivity of TCNQ-2,3,7,8-tetramethoxychalcogenanthrene complexes

    Article • Synthetic Metals, July 1987, Elsevier

    Winfried Hinrichs

  91. Selbststapelnde Systeme, IV 2,3,7,8-Tetramethoxythianthreniumsalze/Selfstacking Systems, Part IV 2.3.7.8-Tetramethoxythianthrenium Salts

    Article • Zeitschrift für Naturforschung B, February 1987, De Gruyter

    Winfried Hinrichs

  92. Absolute configuration ofRp-uridine 3′,5′-cyclic phosphorothioate

    Article • Nucleic Acids Research, January 1987, Oxford University Press (OUP)

    Winfried Hinrichs

  93. Koordinationsverhältnisse in basenfreien tricyclopentadienyl-lanthanoid(III)-komplexen

    Article • Journal of Organometallic Chemistry, September 1986, Elsevier

    Winfried Hinrichs

  94. Elementorganische Verbindungen mit ö-Phenylenresten, XI [1] 3:l-Komplexe von Hexachlor-dibenzo-p-dioxin-2,3-chinon mit 2,3,7,8-Tetramethoxythianthren und -selenanthren / Organometallic Compounds with o-Phenylene Substituents, Part XI [1] 3:1 Complexes ...

    Article • Zeitschrift für Naturforschung B, September 1986, De Gruyter

    Winfried Hinrichs

  95. Structure, spectroscopy and magnetism of di-iodo-bridged tetrahedral cobalt(II) compounds. The crystal and molecular structures of di-μ-iodo-bis[iodotriphenylphosphinecobalt(II)] bis(benzene) and di-μ-iodo-bis[iodotriphenylphosphineoxidecobalt(II)] bis...

    Article • Inorganica Chimica Acta, December 1985, Elsevier

    Winfried Hinrichs

  96. Koordinationsverhältnisse in basenfreien tricyclopentadienyl-lanthanoid(III)-komplexen

    Article • Journal of Organometallic Chemistry, August 1983, Elsevier

    Winfried Hinrichs

  97. Acyclische Liganden mit fixierter Koordinationsgeometrie, 1:2-Komplexe von Cobalt(II) mit den Anionen von 2.2′-Dihydroxydiphenyloxid und -sulfid -Kristall-und Molekülstruktur von Natrium-bis[diphenylsulfid-2.2′ -diolato(2-)]cobaltat(II>- Aceton-Wass...

    Article • Zeitschrift für Naturforschung B, March 1982, De Gruyter

    Winfried Hinrichs

  98. Nitrosolates and related compounds—IX

    Article • Polyhedron, January 1982, Elsevier

    Winfried Hinrichs