All Stories

  1. Weight Loss Results in Increased Expression of Anti‐Inflammatory Protein CRISPLD2 in Mouse Adipose Tissue
  2. Early-life DNA methylation profiles are indicative of age-related transcriptome changes
  3. Tamoxifen induction of Cre recombinase does not cause long-lasting or sexually divergent responses in the CNS epigenome or transcriptome: implications for the design of aging studies
  4. Short-term Calorie Restriction and 17α-Estradiol Administration Elicit Divergent Effects on Proteostatic Processes and Protein Content in Metabolically Active Tissues
  5. Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching
  6. Revisiting the genomic hypomethylation hypothesis of aging
  7. Analysis of DNA modifications in aging research
  8. 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior
  9. Functional changes in the neural retina occur in the absence of mitochondrial dysfunction in a rodent model of diabetic retinopathy
  10. Sexually divergent DNA methylation patterns with hippocampal aging
  11. Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging
  12. Sexually divergent DNA methylation programs with hippocampal aging
  13. Role of DNA methylation in the dietary restriction mediated cellular memory
  14. Isolation of Neuronal Synaptic Membranes by Sucrose Gradient Centrifugation
  15. Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle
  16. Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice
  17. Assessment of individual differences in the rat nucleus accumbens transcriptome following taste-heroin extended access
  18. Reward devaluation and heroin escalation is associated with differential expression of CRF signaling genes
  19. Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation
  20. CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging
  21. Detrimental effects of duplicate reads and low complexity regions on RNA- and ChIP-seq data
  22. Recent Developments in Understanding Brain Aging: Implications for Alzheimer’s Disease and Vascular Cognitive Impairment
  23. Targeted DNA Methylation Analysis by Next-generation Sequencing
  24. Insulin treatment normalizes retinal neuroinflammation but not markers of synapse loss in diabetic rats
  25. Hippocampal Subregions Exhibit Both Distinct and Shared Transcriptomic Responses to Aging and Nonneurodegenerative Cognitive Decline
  26. Integrative transcriptomic and proteomic analysis of osteocytic cells exposed to fluid flow reveals novel mechano-sensitive signaling pathways
  27. Effect of cold perfusion and perfluorocarbons on liver graft ischemia in a donation after cardiac death model
  28. Expression of NgR1-Antagonizing Proteins Decreases with Aging and Cognitive Decline in Rat Hippocampus
  29. Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition
  30. Focused, high accuracy 5-methylcytosine quantitation with base resolution by benchtop next-generation sequencing
  31. Nanoliposomal minocycline for ocular drug delivery
  32. Protein biomarkers of alcohol abuse
  33. Differential Gene Expression in Tamoxifen-Resistant Breast Cancer Cells Revealed by a New Analytical Model of RNA-Seq Data
  34. Quantification of Hepatic UDP Glucuronosyltransferase 1A Splice Variant Expression and Correlation of UDP Glucuronosyltransferase 1A1 Variant Expression with Glucuronidation Activity
  35. Neuroglial Expression of the MHCI Pathway and PirB Receptor Is Upregulated in the Hippocampus with Advanced Aging
  36. Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory
  37. The Kinetics of Cardiopulmonary Bypass: A Dual-Platform Proteomics Study of Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass
  38. A Longitudinal Analysis of Circulating Stress-Related Proteins and Chronic Ethanol Self-Administration in Cynomolgus Macaques
  39. Plasma proteomic alterations in non-human primates and humans after chronic alcohol self-administration
  40. Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence
  41. Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline
  42. Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome
  43. TPH2 in the ventral tegmental area of the male rat brain
  44. Multi-Modal Proteomic Analysis of Retinal Protein Expression Alterations in a Rat Model of Diabetic Retinopathy
  45. Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment
  46. The Hippocampal Neuroproteome with Aging and Cognitive Decline: Past Progress and Future Directions
  47. Individual Differences in Hyperlipidemia and Vitamin E Status in Response to Chronic Alcohol Self-Administration in Cynomolgus Monkeys
  48. Effects of Ischemic Preconditioning and Bevacizumab on Apoptosis and Vascular Permeability Following Retinal Ischemia–Reperfusion Injury
  49. Phosphorimager
  50. Classification of Alcohol Abuse by Plasma Protein Biomarkers
  51. Dual-Platform Proteomics Study of Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass
  52. Future Prospects for Biomarkers of Alcohol Consumption and Alcohol-Induced Disorders
  53. Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome
  54. The use of neuroproteomics in drug abuse research
  55. Clinical application for the preservation of phospho-proteins through in-situ tissue stabilization
  56. Differences in the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice
  57. FOXO3a elicits a pro-apoptotic transcription program and cellular response to human lung carcinogen nicotine-derived nitrosaminoketone (NNK)
  58. Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration
  59. Circulating Cytokines as Biomarkers of Alcohol Abuse and Alcoholism
  60. A multistep validation process of biomarkers for preclinical drug development
  61. Transcriptomic comparison of the retina in two mouse models of diabetes
  62. Penn State Hershey—Center for Pediatric Cardiovascular Research
  63. Improved membrane protein solubilization and clean-up for optimum two-dimensional electrophoresis utilizing GLUT-1 as a classic integral membrane protein
  64. Down-Regulation of 14-3-3 Isoforms and Annexin A5 Proteins in Lung Adenocarcinoma Induced by the Tobacco-Specific Nitrosamine NNK in the A/J Mouse Revealed by Proteomic Analysis
  65. Human Embryonic and Mesenchymal Stem Cells Express Different Nuclear Proteomes
  66. 2-D DIGE identification of differentially expressed heterogeneous nuclear ribonucleoproteins and transcription factors during neural differentiation of human embryonic stem cells
  67. Persistent proteomic alterations in the medial prefrontal cortex with abstinence from cocaine self-administration
  68. Cognitive performance and age-related changes in the hippocampal proteome
  69. Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
  70. Gene expression changes following extinction testing in a heroin behavioral incubation model
  71. The impact of surfactant protein-A on ozone-induced changes in the mouse bronchoalveolar lavage proteome
  72. The Retinal Proteome in Experimental Diabetic Retinopathy
  73. A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis
  74. Age-related changes in the expression and oxidation of bronchoalveolar lavage proteins in the rat
  75. Correlating Human and Animal Studies of Cocaine Abuse and Gene Expression
  76. Heroin self-administration: II. CNS gene expression following withdrawal and cue-induced drug-seeking behavior
  77. Diabetes downregulates presynaptic proteins and reduces basal synapsin I phosphorylation in rat retina
  78. Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass
  79. Twenty-five years of quantitative PCR for gene expression analysis
  80. CNS Genes Implicated in Relapse
  81. Persistent Alterations in Mesolimbic Gene Expression with Abstinence from Cocaine Self-Administration
  82. A threshold neurotoxic amphetamine exposure inhibits parietal cortex expression of synaptic plasticity-related genes
  83. Diabetic Retinopathy
  84. Depletion of abundant proteins from non-human primate serum for biomarker studies
  85. APO-AII IS AN ELEVATED BIOMARKER OF CHRONIC NON-HUMAN PRIMATE ETHANOL SELF-ADMINISTRATION
  86. Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats
  87. Distinct proteomic profiles of amphetamine self-administration transitional states
  88. cDNA Arrays in Alcohol-Related Pathology: Methods and Approaches
  89. Manganese-Induced Cytotoxicity in Dopamine-Producing Cells
  90. Proteomics for Protein Expression Profiling in Neuroscience
  91. Alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats
  92. Use of Microarray Technologies in Toxicology Research
  93. Induction of GADD45 and GADD153 in Neuroblastoma Cells by Dopamine-Induced Toxicity
  94. Changes in rat frontal cortex gene expression following chronic cocaine
  95. Experimental Design for Hybridization Array Analysis of Gene Expression
  96. Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression
  97. Cocaine-responsive gene expression changes in rat hippocampus
  98. Phosphorimager
  99. A cocaine analog, 2β-propanoyl-3β-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway
  100. Panning for molecular gold
  101. The maturation of nucleic acid technologies
  102. PCR-based apolipoprotein E genotype analysis from archival fixed brain
  103. Tyrosine mRNA is expressed in human substantia nigra
  104. Functional Genomic Analysis in Pain Research Using Hybridization Arrays
  105. Systematic Screening of Gene Expression Using a cDNA Macroarray