All Stories

  1. The N-terminus of Apolipoprotein B mediates the interaction of atherogenic lipoproteins with endothelial cells

    Article • Journal of Clinical Investigation, April 2026, American Society for Clinical Investigation

    Warren Lee

  2. Preventing ARDS, Not Treating It—Lessons From Sivelestat After Cardiopulmonary Bypass

    Article • JAMA Network Open, March 2026, American Medical Association (AMA)

    Warren Lee

  3. Non-remnant triglyceride-rich lipoproteins due to lipoprotein lipase deficiency increase atherosclerosis in mice

    Article • Nature Communications, January 2026, Springer Science + Business Media

    Warren Lee

  4. Correction for Jang et al., Lipid raft proteomics identify endothelial myosin-9 (MYH9) as a regulator of low-density lipoprotein transcytosis and atherosclerosis

    Article • Proceedings of the National Academy of Sciences, December 2025, Proceedings of the National Academy of Sciences

    Warren Lee

  5. Human diamine oxidase undergoes transcytosis and colocalizes with the plasma membrane monoamine transporter indicating intracellular histamine degradation

    Article • European Journal of Cell Biology, December 2025, Elsevier

    Warren Lee

  6. The protein MYH9 helps cholesterol build up in the wall of arteries to start heart disease.

    Article • Proceedings of the National Academy of Sciences, October 2025, Proceedings of the National Academy of Sciences

    Warren Lee

  7. LDL transcytosis passes through the trans-Golgi network and requires Rab10

    Article • Journal of Lipid Research, October 2025, Elsevier

    Warren Lee

  8. Purpura post-transfusionnel chez une femme de 36 ans

    Article • Canadian Medical Association Journal, September 2025, Canadian Medical Association (CMA)

    Warren Lee

  9. Cigarette smoke exposure sets up a pro-inflammatory circuit in the lung that induces the hyper-activation of myelin-specific T helper cells

    Article • August 2025, Cold Spring Harbor Laboratory Press

    Dr. Nuria Álvarez-Sánchez, Warren Lee

  10. Phenotypic screening in influenza-infected zebrafish identifies Nrf2-mediated compound protective against ischemia-reperfusion injury

    Article • iScience, August 2025, Elsevier

    Warren Lee

  11. Post-transfusion purpura in a 36-year-old woman

    Article • Canadian Medical Association Journal, June 2025, Canadian Medical Association (CMA)

    Warren Lee

  12. Abstract Or132: The N-terminus of Apolipoprotein B mediates the interaction of atherogenic lipoproteins with endothelial cells

    Article • Arteriosclerosis Thrombosis and Vascular Biology, April 2025, Wolters Kluwer Health

    Warren Lee

  13. Improving the Efficiency of Ultrasound and Microbubble Mediated Gene Delivery by Manipulation of Microbubble Lipid Composition

    Article • ACS Applied Bio Materials, March 2025, American Chemical Society (ACS)

    Warren Lee

  14. Hyperchylomicronemia causes endothelial cell inflammation and increases atherosclerosis

    Article • November 2024, Springer Science + Business Media

    Warren Lee

  15. Alternative Strategies for Delivering Immunotherapeutics Targeting the PD-1/PD-L1 Immune Checkpoint in Cancer

    Article • Pharmaceutics, September 2024, MDPI AG

    Warren Lee

  16. IL-1β Induces LDL Transcytosis by a Novel Pathway Involving LDLR and Rab27a

    Article • Arteriosclerosis Thrombosis and Vascular Biology, September 2024, Wolters Kluwer Health

    Warren Lee

  17. Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis

    Article • Circulation Research, July 2024, Wolters Kluwer Health

    Warren Lee

  18. ATPSpin: A Single Microfluidic Platform that Produces Diversified ATPS-Alginate Microfibers

    Article • ACS Biomaterials Science & Engineering, May 2024, American Chemical Society (ACS)

    Warren Lee

  19. Apolipoprotein A1 and high-density lipoprotein limit low-density lipoprotein transcytosis by binding SR-B1

    Article • Journal of Lipid Research, April 2024, Elsevier

    Warren Lee

  20. Circulating small extracellular vesicles mediate vascular hyperpermeability in diabetes

    Article • Diabetologia, March 2024, Springer Science + Business Media

    Warren Lee

  21. Directional Endothelial Communication by Polarized Extracellular Vesicle Release

    Article • Circulation Research, February 2024, Wolters Kluwer Health

    Warren Lee

  22. Unexpected Antiatherogenic Effect: Myeloid-Derived Growth Factor Inhibits LDL Transcytosis

    Article • Arteriosclerosis Thrombosis and Vascular Biology, November 2023, Wolters Kluwer Health

    Warren Lee

  23. The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus

    Article • eLife, September 2023, eLife

    Warren Lee

  24. A negative trial for vasoactive intestinal peptide in COVID-19-associated acute hypoxaemic respiratory failure

    Article • The Lancet Respiratory Medicine, September 2023, Elsevier

    Warren Lee

  25. Ultrasound-guided transfection of claudin-5 improves lung endothelial barrier function in lung injury without impairing innate immunity

    Article • AJP Lung Cellular and Molecular Physiology, August 2023, American Physiological Society

    Warren Lee

  26. Modulation of the Host Response as a Therapeutic Strategy in Severe Lung Infections

    Article • Viruses, June 2023, MDPI AG

    Warren Lee

  27. LDL Transcytosis by the Arterial Endothelium—Atherosclerosis by a Thousand Cuts?

    Article • Current Atherosclerosis Reports, June 2023, Springer Science + Business Media

    Warren Lee

  28. Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice

    Article • Nature Cardiovascular Research, May 2023, Springer Science + Business Media

    Warren Lee

  29. Abstract 336: Endothelial Cells Communicate with Surrounding Vascular Cells Via Bidirectional and Polarized Secretion of Extracellular Vesicular Cargo: Implications for Atherosclerotic Plaque Development

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 2023, Wolters Kluwer Health

    Warren Lee

  30. Endothelial cells secrete small extracellular vesicles bidirectionally containing distinct cargo to uniquely reprogram vascular cells in the circulation and vessel wall

    Article • April 2023, openRxiv

    Warren Lee

  31. Endothelial ACKR1 is induced by neutrophil contact and down-regulated by secretion in extracellular vesicles

    Article • Frontiers in Immunology, April 2023, Frontiers

    Warren Lee

  32. Plug and Pop: A 3D-Printed, Modular Platform for Drug Delivery Using Clinical Ultrasound and Microbubbles

    Article • Pharmaceutics, November 2022, MDPI AG

    Warren Lee

  33. FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses

    Article • Journal of Lipid Research, September 2022, Elsevier

    Warren Lee

  34. Apolipoprotein A1 and high-density lipoprotein limit low-density lipoprotein transcytosis by binding scavenger receptor B1

    Article • August 2022, openRxiv

    Warren Lee

  35. Cigarette smoke augments CSF3 expression in neutrophils to compromise alveolar–capillary barrier function during influenza infection

    Article • European Respiratory Journal, January 2022, European Respiratory Society (ERS)

    Warren Lee

  36. Quantifying Endothelial Transcytosis with Total Internal Reflection Fluorescence Microscopy (TIRF)

    Article • January 2022, Springer Science + Business Media

    Warren Lee

  37. Ultrasound and Microbubbles for Targeted Drug Delivery to the Lung Endothelium in ARDS: Cellular Mechanisms and Therapeutic Opportunities

    Article • Biomedicines, July 2021, MDPI AG

    Warren Lee

  38. Radiation Impacts Early Atherosclerosis by Suppressing Intimal LDL Accumulation

    Article • Circulation Research, February 2021, Wolters Kluwer Health

    Warren Lee

  39. Interactions of Influenza and SARS-CoV-2 with the Lung Endothelium: Similarities, Differences, and Implications for Therapy

    Article • Viruses, January 2021, MDPI AG

    Warren Lee

  40. Endothelial HMGB1 Is a Critical Regulator of LDL Transcytosis via an SREBP2–SR-BI Axis

    Article • Arteriosclerosis Thrombosis and Vascular Biology, January 2021, Wolters Kluwer Health

    Warren Lee

  41. Fatty Acid Synthase inhibitor TVB-3166 prevents S-acylation of the Spike protein of human coronaviruses

    Article • December 2020, openRxiv

    Warren Lee

  42. Transendothelial transport of lipoproteins

    Article • Atherosclerosis, December 2020, Elsevier

    Warren Lee

  43. BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells

    Article • Journal of Biological Chemistry, December 2020, Elsevier

    Warren Lee

  44. Photoacoustic imaging of kidney fibrosis for assessing pretransplant organ quality

    Article • JCI Insight, May 2020, American Society for Clinical Investigation

    Warren Lee

  45. Reply to Mehmood: Adrenomedullin: A Double-edged Sword in Septic Shock and Heart Failure Therapeutics?

    Article • American Review of Respiratory Disease, May 2020, American Thoracic Society

    Warren Lee

  46. Induction And Regulation of Endogenous DARC Expression in Primary Human Endothelial Cells

    Article • The FASEB Journal, April 2020, Wiley

    Warren Lee

  47. Inhibition of Low density Lipoprotein Internalization and Transcytosis by HDL; an alternative role for “good” cholesterol

    Article • The FASEB Journal, April 2020, Wiley

    Warren Lee

  48. The Endothelial Barrier Is not Rate-limiting to Insulin Action in the Myocardium of Male Mice

    Article • Endocrinology, February 2020, Endocrine Society

    Warren Lee

  49. Long noncoding RNA SNHG12 integrates a DNA-PK–mediated DNA damage response and vascular senescence

    Article • Science Translational Medicine, February 2020, American Association for the Advancement of Science

    Warren Lee

  50. Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α

    Article • Journal of Clinical Investigation, January 2020, American Society for Clinical Investigation

    Warren Lee

  51. Inflammation without Vascular Leakage. Science Fiction No Longer?

    Article • American Review of Respiratory Disease, December 2019, American Thoracic Society

    Warren Lee

  52. Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation

    Article • Circulation, July 2019, Wolters Kluwer Health

    Warren Lee

  53. CD36 mediates albumin transcytosis by dermal but not lung microvascular endothelial cells: role in fatty acid delivery

    Article • AJP Lung Cellular and Molecular Physiology, May 2019, American Physiological Society

    Warren Lee

  54. Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice

    Article • Cell Host & Microbe, March 2019, Elsevier

    Warren Lee

  55. Estrogen Inhibits LDL (Low-Density Lipoprotein) Transcytosis by Human Coronary Artery Endothelial Cells via GPER (G-Protein–Coupled Estrogen Receptor) and SR-BI (Scavenger Receptor Class B Type 1)

    Article • Arteriosclerosis Thrombosis and Vascular Biology, October 2018, Wolters Kluwer Health

    Warren Lee

  56. Lung Ultrasound and Microbubbles Enhance Aminoglycoside Efficacy and Delivery to the Lung in Escherichia coli–induced Pneumonia and Acute Respiratory Distress Syndrome

    Article • American Review of Respiratory Disease, August 2018, American Thoracic Society

    Warren Lee

  57. Immunotherapy for Sepsis

    Article • Anesthesiology, July 2018, Wolters Kluwer Health

    Warren Lee

  58. Physiological Concentrations of Estrogen Decrease LDL Transcytosis by Coronary Artery Endothelial Cells – Elucidation of Molecular Mechanisms

    Article • Atherosclerosis Supplements, June 2018, Elsevier

    Warren Lee

  59. Abstract 452: Estrogen Inhibits LDL Transcytosis by Coronary Artery Endothelial Cells via GPER and SR-BI

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 2018, Wolters Kluwer Health

    Warren Lee

  60. Should basic science matter to clinicians?

    Article • The Lancet, February 2018, Elsevier

    Warren Lee

  61. Transcellular vesicular transport in epithelial and endothelial cells: Challenges and opportunities

    Article • Traffic, November 2017, Wiley

    Warren Lee

  62. SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1

    Article • Frontiers in Physiology, October 2017, Frontiers

    Warren Lee

  63. Development of a Zebrafish Sepsis Model for High-Throughput Drug Discovery

    Article • Extremophiles, January 2017, Springer Science + Business Media

    Warren Lee

  64. Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells

    Article • Nature Communications, November 2016, Springer Science + Business Media

    Warren Lee

  65. Endothelial Transcytosis of Insulin: Does It Contribute to Insulin Resistance?

    Article • Physiology, September 2016, American Physiological Society

    Warren Lee

  66. Tsr Chemoreceptor Interacts With IL-8 Provoking E. coli Transmigration Across Human Lung Epithelial Cells

    Article • Scientific Reports, August 2016, Springer Science + Business Media

    Warren Lee

  67. Thrombin stimulates albumin transcytosis in lung microvascular endothelial cells via activation of acid sphingomyelinase

    Article • AJP Lung Cellular and Molecular Physiology, April 2016, American Physiological Society

    Warren Lee

  68. Adhesion Molecules: Master Controllers of the Circulatory System

    Article • March 2016, Wiley

    Warren Lee

  69. Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury

    Article • American Journal of Respiratory Cell and Molecular Biology, March 2016, American Thoracic Society

    Dr Wolfgang M. Kuebler, Warren Lee

  70. Prostaglandin I2 Receptor Agonism Preserves β-Cell Function and Attenuates Albuminuria Through Nephrin-Dependent Mechanisms

    Article • Diabetes, February 2016, American Diabetes Association

    Warren Lee

  71. Influenza Virus Infection Induces Platelet-Endothelial Adhesion Which Contributes to Lung Injury

    Article • Journal of Virology, February 2016, ASM Journals

    Warren Lee

  72. Is basic science disappearing from medicine? The decline of biomedical research in the medical literature

    Article • The FASEB Journal, October 2015, Wiley

    Warren Lee

  73. Influenza-Induced Priming and Leak of Human Lung Microvascular Endothelium upon Exposure to Staphylococcus aureus

    Article • American Journal of Respiratory Cell and Molecular Biology, October 2015, American Thoracic Society

    Warren Lee

  74. A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis

    Article • Cardiovascular Research, September 2015, European Society of Cardiology

    Warren Lee

  75. Is strengthening the endothelial barrier a therapeutic strategy for Ebola?

    Article • International Journal of Infectious Diseases, July 2015, Elsevier

    Warren Lee

  76. Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis

    Article • AJP Endocrinology and Metabolism, July 2015, American Physiological Society

    Warren Lee

  77. The Tie2-agonist Vasculotide rescues mice from influenza virus infection

    Article • Scientific Reports, June 2015, Springer Science + Business Media

    Warren Lee

  78. Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells

    Article • Molecular Biology of the Cell, February 2015, American Society for Cell Biology (ASCB)

    Warren Lee

  79. In Reply

    Article • Anesthesiology, February 2015, Wolters Kluwer Health

    Dr BRIAN P KAVANAGH, Warren Lee

  80. Is nosocomial infection really the major cause of death in sepsis?

    Article • Critical Care, October 2014, Springer Science + Business Media

    Dr Arthur Slutsky, Warren Lee

  81. Lung-protective Ventilation in the Operating Room

    Article • Anesthesiology, July 2014, Wolters Kluwer Health

    Dr BRIAN P KAVANAGH, Warren Lee

  82. Endothelial activation and dysfunction in the pathogenesis of influenza A virus infection

    Article • Virulence, August 2013, Taylor & Francis

    Warren Lee

  83. Slit2 Prevents Neutrophil Recruitment and Renal Ischemia-Reperfusion Injury

    Article • Journal of the American Society of Nephrology, August 2013, Wolters Kluwer Health

    Warren Lee

  84. The lung microvascular endothelium as a therapeutic target in severe influenza

    Article • Antiviral Research, August 2013, Elsevier

    Warren Lee

  85. Influenza Infects Lung Microvascular Endothelium Leading to Microvascular Leak: Role of Apoptosis and Claudin-5

    Article • PLOS One, October 2012, PLOS

    Warren Lee

  86. Shuttling glucose across brain microvessels, with a little help from GLUT1 and AMP kinase. Focus on “AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress”

    Article • AJP Cell Physiology, October 2012, American Physiological Society

    Warren Lee

  87. Co-Regulation of Transcellular and Paracellular Leak Across Microvascular Endothelium by Dynamin and Rac

    Article • American Journal Of Pathology, March 2012, Elsevier

    Warren Lee

  88. The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin–associated hemolytic uremic syndrome in humans and mice

    Article • Journal of Clinical Investigation, February 2012, American Society for Clinical Investigation

    Warren Lee

  89. Do viral infections mimic bacterial sepsis? The role of microvascular permeability: A review of mechanisms and methods

    Article • Antiviral Research, January 2012, Elsevier

    Warren Lee

  90. On, Around, and Through: Neutrophil-Endothelial Interactions in Innate Immunity

    Article • Physiology, October 2011, American Physiological Society

    Warren Lee

  91. Broken Barriers: A New Take on Sepsis Pathogenesis

    Article • Science Translational Medicine, June 2011, American Association for the Advancement of Science

    Warren Lee

  92. Endothelial activation, dysfunction and permeability during severe infections

    Article • Current Opinion in Hematology, May 2011, Wolters Kluwer Health

    Warren Lee

  93. Sepsis and Endothelial Permeability

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, August 2010, New England Journal of Medicine (NEJM/MMS)

    Dr Arthur Slutsky, Warren Lee

  94. Update in Critical Care 2008

    Article • American Review of Respiratory Disease, May 2009, American Thoracic Society

    Warren Lee

  95. Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite

    Article • Molecular Microbiology, January 2009, Wiley

    Warren Lee

  96. Update in Critical Care 2007

    Article • American Review of Respiratory Disease, April 2008, American Thoracic Society

    Warren Lee

  97. Quantitative Analysis of Membrane Remodeling at the Phagocytic Cup

    Article • Molecular Biology of the Cell, August 2007, American Society for Cell Biology (ASCB)

    Warren Lee

  98. Role of CrkII in Fcγ Receptor-mediated Phagocytosis

    Article • Journal of Biological Chemistry, April 2007, Elsevier

    Warren Lee

  99. The ESAT-6/CFP-10 secretion system of Mycobacterium marinum modulates phagosome maturation

    Article • Cellular Microbiology, September 2006, Hindawi Publishing Corporation

    Warren Lee

  100. SOAP and sepsis—Analyzing what comes out in the wash*

    Article • Critical Care Medicine, February 2006, Wolters Kluwer Health

    Warren Lee

  101. Role of Ubiquitin and Proteasomes in Phagosome Maturation

    Article • Molecular Biology of the Cell, April 2005, American Society for Cell Biology (ASCB)

    Warren Lee

  102. The Tangled Webs That Neutrophils Weave

    Article • Science, March 2004, American Association for the Advancement of Science

    Warren Lee

  103. Phagocytosis by neutrophils

    Article • Microbes and Infection, November 2003, Elsevier

    Warren Lee

  104. Contrast Echocardiography Remains Positive After Treatment of Pulmonary Arteriovenous Malformations*

    Article • CHEST Journal, February 2003, Elsevier

    Warren Lee

  105. Safety of Pressure-Volume Curve Measurement in Acute Lung Injury and ARDS Using a Syringe Technique

    Article • CHEST Journal, May 2002, Elsevier

    Warren Lee

  106. Leukocyte Elastase

    Article • American Review of Respiratory Disease, September 2001, American Thoracic Society

    Warren Lee

  107. Neutrophil activation and acute lung injury

    Article • Current Opinion in Critical Care, February 2001, Wolters Kluwer Health

    Warren Lee

  108. Ventilator-Induced Lung Injury and Recommendations for Mechanical Ventilation of Patients with ARDS

    Article • Seminars in Respiratory and Critical Care Medicine, January 2001, Thieme Publishing Group

    Dr Arthur Slutsky, Warren Lee

  109. Coagulation inhibitors in sepsis and disseminated intravascular coagulation

    Article • Intensive Care Medicine, October 2000, Springer Science + Business Media

    Warren Lee

  110. Lung-protective mechanical ventilation strategies in ARDS

    Article • Intensive Care Medicine, August 2000, Springer Science + Business Media

    Warren Lee

  111. Impact of diabetes on coronary artery disease in women and men: a meta-analysis of prospective studies.

    Article • Diabetes Care, July 2000, American Diabetes Association

    Warren Lee