All Stories

  1. PHYFUM: Phylogenetic Reconstruction of Normal and Pre-malignant Tissue Evolution Using Fluctuating Methylation
  2. Inference of Cancer Drug Cross Resistance Using Only Single-Drug Exposure Data
  3. Classpose: foundation model-driven whole slide image-scale cell phenotyping in H&E
  4. Data from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  5. Figure 1 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  6. Figure 2 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  7. Figure 3 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  8. Figure 4 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  9. Figure 5 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  10. Figure 6 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  11. Figure 7 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  12. Figure 8 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  13. Supplementary Figure 1 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  14. Supplementary Figure 2 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  15. Supplementary Figure 3 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  16. Supplementary Figure 4 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  17. Supplementary Figure 5 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  18. Supplementary Figure 6 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  19. Supplementary Figure 7 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  20. Supplementary Figure 8 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  21. Supplementary Figure 9 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  22. Supplementary Table 1 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  23. Supplementary Table 2 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  24. Mathematical modelling of cancer cell evolution and plasticity
  25. Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding
  26. Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
  27. Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding
  28. Deep Learning for Biomarker Discovery in Cancer Genomes
  29. Phenotypic noise and plasticity in cancer evolution
  30. Gene mutant dosage determines prognosis and metastatic tropism in 60,000 clinical cancer samples
  31. Contribution of pks+ E. coli mutations to colorectal carcinogenesis
  32. Adaptive therapy achieves long-term control of chemotherapy resistance in high grade ovarian cancer
  33. Bridging clinic and wildlife care with AI-powered pan-species computational pathology
  34. First passage time analysis of spatial mutation patterns reveals sub-clonal evolutionary dynamics in colorectal cancer
  35. Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactions
  36. Cell Competition in Carcinogenesis
  37. The mutational signatures of formalin fixation on the human genome
  38. Lineage tracing in human tissues
  39. AI-powered pan-species computational pathology: bridging clinic and wildlife care
  40. CNETML: Maximum likelihood inference of phylogeny from copy number profiles of spatio-temporal samples
  41. AI-powered pan-species computational pathology: bridging clinic and wildlife care
  42. First passage time analysis of spatial mutation patterns reveals evolutionary dynamics of pre-existing resistance in colorectal cancer
  43. Evolutionary dynamics in Barrett oesophagus: implications for surveillance, risk stratification and therapy
  44. LiquidCNA: Tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations
  45. Predicting Colorectal Cancer Occurrence in IBD
  46. The mutational signatures of formalin fixation on the human genome
  47. LiquidCNA: tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations
  48. Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology
  49. Platinum resistance induces diverse evolutionary trajectories in high grade serous ovarian cancer
  50. Navigating the path to distant metastasis
  51. Author Correction: The effects of mutational processes and selection on driver mutations across cancer types
  52. Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios
  53. Measuring single cell divisions in human tissues from multi-region sequencing data
  54. A novel use of random priming-based single-strand library preparation for whole genome sequencing of formalin-fixed paraffin-embedded tissue samples
  55. Author Correction: Resolving genetic heterogeneity in cancer
  56. Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data
  57. Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios
  58. Niche engineering drives early passage through an immune bottleneck in progression to colorectal cancer
  59. Resolving genetic heterogeneity in cancer
  60. Model-based tumor subclonal reconstruction
  61. Crypt fusion as a homeostatic mechanism in the human colon
  62. Measuring single cell divisions in human cancers from multi-region sequencing data
  63. Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data
  64. Evolutionary dynamics of neoantigens in growing tumours
  65. NeoPredPipe: High-Throughput Neoantigen Prediction and Recognition Potential Pipeline
  66. Reply to ‘Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution’
  67. Reply to ‘Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data’
  68. Detecting repeated cancer evolution from multi-region tumor sequencing data
  69. The evolutionary landscape of colorectal tumorigenesis
  70. Author Correction: Quantification of subclonal selection in cancer from bulk sequencing data
  71. Evolutionary history of human colitis-associated colorectal cancer
  72. Quantification of subclonal selection in cancer from bulk sequencing data
  73. The effects of mutational processes and selection on driver mutations across cancer types
  74. Reply: Neutral tumor evolution?
  75. Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
  76. Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution
  77. Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study
  78. Insights Into the Pathophysiology of Esophageal Adenocarcinoma
  79. Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures
  80. Detecting repeated cancer evolution in human tumours from multi-region sequencing data
  81. Quantification of within-sample genetic heterogeneity from SNP-array data
  82. Between-region genetic divergence reflects the mode and tempo of tumor evolution
  83. Catch my drift? Making sense of genomic intra-tumour heterogeneity
  84. Quantification of subclonal selection in cancer from bulk sequencing data
  85. Measuring cancer evolution from the genome
  86. New paradigms in clonal evolution: punctuated equilibrium in cancer
  87. Tumour Cell Heterogeneity
  88. Identification of neutral tumor evolution across cancer types
  89. Pan-cancer analysis of the extent and consequences of intratumor heterogeneity
  90. Derivation of genetic biomarkers for cancer risk stratification in Barrett’s oesophagus: a prospective cohort study
  91. Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis
  92. Krt19+/Lgr5− Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine
  93. Forty-Year Analysis of Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis: An Updated Overview
  94. Characterization of LGR5 stem cells in colorectal adenomas and carcinomas
  95. A pan-cancer signature of neutral tumor evolution
  96. A Big Bang model of human colorectal tumor growth
  97. Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential
  98. Location, location, location! The reality of life for an intestinal stem cell in the crypt
  99. Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon
  100. Cell migration leads to spatially distinct but clonally related airway cancer precursors
  101. Re: Mitochondria and Tumor Progression in Ulcerative Colitis
  102. Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors
  103. Clonal Selection and Persistence in Dysplastic Barrettʼs Esophagus and Intramucosal Cancers After Failed Radiofrequency Ablation
  104. Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells
  105. Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution
  106. What Can Be Learnt about Disease Progression in Breast Cancer Dormancy from Relapse Data?
  107. Pre-tumour clones, periodic selection and clonal interference in the origin and progression of gastrointestinal cancer: potential for biomarker development
  108. LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development
  109. Modelling the evolution of genetic instability during tumour progression
  110. Resolving the stem-cell debate
  111. Field Cancerization in the Intestinal Epithelium of Patients With Crohn's Ileocolitis
  112. A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts
  113. Utilizing DNA Mutations to Trace Epithelial Cell Lineages in Human Tissues
  114. Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor
  115. Clonal architecture of human prostatic epithelium in benign and malignant conditions
  116. Field cancerization in the GI tract
  117. The human urothelium consists of multiple clonal units, each maintained by a stem cell
  118. Use of Methylation Patterns to Determine Expansion of Stem Cell Clones in Human Colon Tissue
  119. The Clonal Origins of Dysplasia From Intestinal Metaplasia in the Human Stomach
  120. Stem cells and their implications for colorectal cancer
  121. Stem Cells and Inflammation in the Intestine
  122. Field defects in DNA repair: is loss of MGMT an initial event in colorectal carcinogenesis?
  123. Breast Cancer Dormancy Can Be Maintained by Small Numbers of Micrometastases
  124. Spindles losing their bearings: Does disruption of orientation in stem cells predict the onset of cancer?
  125. Clonality Assessment and Clonal Ordering of Individual Neoplastic Crypts Shows Polyclonality of Colorectal Adenomas
  126. Genetic diversity during the development of Barrett's oesophagus-associated adenocarcinoma: how, when and why?
  127. Long-term proton pump induced hypergastrinaemia does induce lineage-specific restitution but not clonal expansion in benign Barrett's oesophagus in vivo
  128. Stem cells and solid cancers
  129. Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis–Associated Neoplasia
  130. Investigating the fixation and spread of mutations in the gastrointestinal epithelium
  131. A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence
  132. Most low-level microsatellite instability in colorectal cancers can be explained without an elevated slippage rate
  133. Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas