All Stories

  1. Platinum resistance induces diverse evolutionary trajectories in high grade serous ovarian cancer

    Article • July 2020, Cold Spring Harbor Laboratory Press

    Dr Trevor A Graham

  2. Navigating the path to distant metastasis

    Article • Nature Genetics, July 2020, Springer Science + Business Media

    Dr Trevor A Graham

  3. Author Correction: The effects of mutational processes and selection on driver mutations across cancer types

    Article • Nature Communications, April 2020, Springer Science + Business Media

    Dr Trevor A Graham

  4. Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios

    Article • eLife, March 2020, eLife

    Dr Trevor A Graham

  5. Measuring single cell divisions in human tissues from multi-region sequencing data

    Article • Nature Communications, February 2020, Springer Science + Business Media

    Dr Trevor A Graham

  6. A novel use of random priming-based single-strand library preparation for whole genome sequencing of formalin-fixed paraffin-embedded tissue samples

    Article • NAR Genomics and Bioinformatics, December 2019, Oxford University Press (OUP)

    Dr Trevor A Graham

  7. Author Correction: Resolving genetic heterogeneity in cancer

    Article • Nature Reviews Genetics, October 2019, Springer Science + Business Media

    Dr Trevor A Graham

  8. Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data

    Article • PLoS Computational Biology, July 2019, PLOS

    Dr Trevor A Graham

  9. Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios

    Article • June 2019, Cold Spring Harbor Laboratory Press

    Dr Trevor A Graham

  10. Niche engineering drives early passage through an immune bottleneck in progression to colorectal cancer

    Article • May 2019, Cold Spring Harbor Laboratory Press

    Dr Trevor A Graham

  11. Resolving genetic heterogeneity in cancer

    Article • Nature Reviews Genetics, March 2019, Springer Science + Business Media

    Dr Trevor A Graham

  12. Model-based tumor subclonal reconstruction

    Article • March 2019, Cold Spring Harbor Laboratory Press

    Dr Trevor A Graham

  13. Crypt fusion as a homeostatic mechanism in the human colon

    Article • Gut, March 2019, BMJ

    Biancastella Cereser, Dr Trevor A Graham

  14. Measuring single cell divisions in human cancers from multi-region sequencing data

    Article • February 2019, Cold Spring Harbor Laboratory Press

    Dr Trevor A Graham

  15. Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data

    Article • February 2019, Cold Spring Harbor Laboratory Press

    Dr Trevor A Graham

  16. Evolutionary dynamics of neoantigens in growing tumours

    Article • January 2019, Cold Spring Harbor Laboratory Press

    Dr Trevor A Graham

  17. NeoPredPipe: High-Throughput Neoantigen Prediction and Recognition Potential Pipeline

    Article • December 2018, Cold Spring Harbor Laboratory Press

    Dr Trevor A Graham

  18. Reply to ‘Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution’

    Article • Nature Genetics, October 2018, Springer Science + Business Media

    Dr Trevor A Graham

  19. Reply to ‘Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data’

    Article • Nature Genetics, September 2018, Springer Science + Business Media

    Dr Trevor A Graham

  20. Detecting repeated cancer evolution from multi-region tumor sequencing data

    Article • Nature Methods, August 2018, Springer Science + Business Media

    Dr Trevor A Graham

  21. The evolutionary landscape of colorectal tumorigenesis

    Article • Nature Ecology & Evolution, August 2018, Springer Science + Business Media

    Dr Trevor A Graham

  22. Author Correction: Quantification of subclonal selection in cancer from bulk sequencing data

    Article • Nature Genetics, July 2018, Springer Science + Business Media

    Dr Trevor A Graham

  23. Evolutionary history of human colitis-associated colorectal cancer

    Article • Gut, July 2018, BMJ

    Dr Trevor A Graham

  24. Quantification of subclonal selection in cancer from bulk sequencing data

    Article • Nature Genetics, May 2018, Springer Science + Business Media

    Dr Trevor A Graham

  25. The effects of mutational processes and selection on driver mutations across cancer types

    Article • Nature Communications, May 2018, Springer Science + Business Media

    Dr Trevor A Graham

  26. Reply: Neutral tumor evolution?

    Article • March 2018, Cold Spring Harbor Laboratory Press

    Dr Trevor A Graham

  27. Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels

    Article • Nature Communications, February 2018, Nature

    Dr Trevor A Graham

  28. Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution

    Article • Nature Communications, December 2017, Springer Science + Business Media

    Dr Trevor A Graham

  29. Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study

    Article • Gut, November 2017, BMJ

    Dr Trevor A Graham

  30. Insights Into the Pathophysiology of Esophageal Adenocarcinoma

    Article • Gastroenterology, October 2017, Elsevier

    Dr Trevor A Graham

  31. Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures

    Article • Nature Genetics, August 2017, Nature

    Dr Trevor A Graham

  32. Detecting repeated cancer evolution in human tumours from multi-region sequencing data

    Article • June 2017, Cold Spring Harbor Laboratory Press

    Dr Trevor A Graham

  33. Quantification of within-sample genetic heterogeneity from SNP-array data

    Article • Scientific Reports, June 2017, Nature

    Dr Trevor A Graham

  34. Between-region genetic divergence reflects the mode and tempo of tumor evolution

    Article • Nature Genetics, June 2017, Nature

    Dr Trevor A Graham

  35. Catch my drift? Making sense of genomic intra-tumour heterogeneity

    Article • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, January 2017, Elsevier

    Dr Trevor A Graham

  36. Quantification of subclonal selection in cancer from bulk sequencing data

    Article • December 2016, Cold Spring Harbor Laboratory Press

    Dr Trevor A Graham

  37. Measuring cancer evolution from the genome

    Article • The Journal of Pathology, November 2016, Wiley

    Dr Trevor A Graham

  38. New paradigms in clonal evolution: punctuated equilibrium in cancer

    Article • The Journal of Pathology, August 2016, Wiley

    Dr Trevor A Graham

  39. Tumour Cell Heterogeneity

    Article • F1000Research, February 2016, Faculty of 1000, Ltd.

    Dr Trevor A Graham

  40. Identification of neutral tumor evolution across cancer types

    Article • Nature Genetics, January 2016, Nature

    Dr Trevor A Graham

  41. Pan-cancer analysis of the extent and consequences of intratumor heterogeneity

    Article • Nature Medicine, November 2015, Nature

    Dr Trevor A Graham

  42. Derivation of genetic biomarkers for cancer risk stratification in Barrett’s oesophagus: a prospective cohort study

    Article • Gut, June 2015, BMJ

    Dr Trevor A Graham

  43. Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, June 2015, Royal Society Publishing

    Dr Trevor A Graham

  44. Krt19+/Lgr5− Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine

    Article • Cell Stem Cell, June 2015, Elsevier

    Dr Trevor A Graham

  45. Forty-Year Analysis of Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis: An Updated Overview

    Article • The American Journal of Gastroenterology, March 2015, Nature

    Dr Trevor A Graham

  46. Characterization of LGR5 stem cells in colorectal adenomas and carcinomas

    Article • Scientific Reports, March 2015, Springer Science + Business Media

    Dr Trevor A Graham

  47. A pan-cancer signature of neutral tumor evolution

    Article • February 2015, Cold Spring Harbor Laboratory Press

    Dr Trevor A Graham

  48. A Big Bang model of human colorectal tumor growth

    Article • Nature Genetics, February 2015, Springer Science + Business Media

    Dr Trevor A Graham

  49. Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

    Article • Cell, January 2015, Elsevier

    Dr Trevor A Graham

  50. Location, location, location! The reality of life for an intestinal stem cell in the crypt

    Article • The Journal of Pathology, August 2014, Wiley

    Dr Trevor A Graham

  51. Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon

    Article • Cell Reports, August 2014, Elsevier

    Dr Stuart A McDonald, Dr Trevor A Graham, Biancastella Cereser

  52. Cell migration leads to spatially distinct but clonally related airway cancer precursors

    Article • Thorax, February 2014, BMJ

    Dr Trevor A Graham

  53. Re: Mitochondria and Tumor Progression in Ulcerative Colitis

    Article • JNCI Journal of the National Cancer Institute, January 2014, Oxford University Press (OUP)

    Dr Trevor A Graham

  54. Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors

    Article • eLife, October 2013, eLife

    Dr Stuart A McDonald, Dr Trevor A Graham

  55. Clonal Selection and Persistence in Dysplastic Barrettʼs Esophagus and Intramucosal Cancers After Failed Radiofrequency Ablation

    Article • The American Journal of Gastroenterology, October 2013, Wolters Kluwer Health

    Dr Stuart A McDonald, Dr Trevor A Graham

  56. Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells

    Article • The Journal of Pathology, August 2013, Wiley

    Dr Stuart A McDonald, Dr Trevor A Graham

  57. Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution

    Article • Proceedings of the National Academy of Sciences, June 2013, Proceedings of the National Academy of Sciences

    Dr Trevor A Graham, Biancastella Cereser

  58. What Can Be Learnt about Disease Progression in Breast Cancer Dormancy from Relapse Data?

    Article • PLoS ONE, May 2013, PLOS

    Dr Trevor A Graham

  59. Pre-tumour clones, periodic selection and clonal interference in the origin and progression of gastrointestinal cancer: potential for biomarker development

    Article • The Journal of Pathology, February 2013, Wiley

    Dr Trevor A Graham

  60. LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development

    Article • The Journal of Pathology, February 2013, Wiley

    Dr Trevor A Graham, Professor Fiona M Watt

  61. Modelling the evolution of genetic instability during tumour progression

    Article • Evolutionary Applications, November 2012, Wiley

    Dr Trevor A Graham

  62. Resolving the stem-cell debate

    Article • Nature, August 2012, Springer Science + Business Media

    Dr Trevor A Graham

  63. Field Cancerization in the Intestinal Epithelium of Patients With Crohn's Ileocolitis

    Article • Gastroenterology, April 2012, Elsevier

    Dr Stuart A McDonald, Dr Trevor A Graham

  64. A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

    Article • Gut, January 2012, BMJ

    Dr Trevor A Graham

  65. Utilizing DNA Mutations to Trace Epithelial Cell Lineages in Human Tissues

    Article • January 2012, Springer Science + Business Media

    Dr Trevor A Graham

  66. Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor

    Article • Gut, December 2011, BMJ

    Dr Stuart A McDonald, Dr Trevor A Graham, Professor Janusz Antoni Jankowski

  67. Clonal architecture of human prostatic epithelium in benign and malignant conditions

    Article • The Journal of Pathology, August 2011, Wiley

    Dr Stuart A McDonald, Dr Trevor A Graham

  68. Field cancerization in the GI tract

    Article • Future Oncology, August 2011, Future Medicine

    Dr Stuart A McDonald, Dr Trevor A Graham

  69. The human urothelium consists of multiple clonal units, each maintained by a stem cell

    Article • The Journal of Pathology, July 2011, Wiley

    Dr Stuart A McDonald, Dr Trevor A Graham

  70. Use of Methylation Patterns to Determine Expansion of Stem Cell Clones in Human Colon Tissue

    Article • Gastroenterology, April 2011, Elsevier

    Dr Stuart A McDonald, Dr Trevor A Graham

  71. The Clonal Origins of Dysplasia From Intestinal Metaplasia in the Human Stomach

    Article • Gastroenterology, April 2011, Elsevier

    Dr Stuart A McDonald, Dr Trevor A Graham, Professor Janusz Antoni Jankowski

  72. Stem cells and their implications for colorectal cancer

    Article • Nature Reviews Gastroenterology & Hepatology, February 2011, Springer Science + Business Media

    Dr Trevor A Graham

  73. Stem Cells and Inflammation in the Intestine

    Article • January 2011, Springer Science + Business Media

    Dr Trevor A Graham

  74. Field defects in DNA repair: is loss of MGMT an initial event in colorectal carcinogenesis?

    Article • Gut, October 2010, BMJ

    Dr Trevor A Graham

  75. Breast Cancer Dormancy Can Be Maintained by Small Numbers of Micrometastases

    Article • Cancer Research, May 2010, American Association for Cancer Research (AACR)

    Dr Trevor A Graham

  76. Spindles losing their bearings: Does disruption of orientation in stem cells predict the onset of cancer?

    Article • BioEssays, May 2010, Wiley

    Dr Trevor A Graham

  77. Clonality Assessment and Clonal Ordering of Individual Neoplastic Crypts Shows Polyclonality of Colorectal Adenomas

    Article • Gastroenterology, April 2010, Elsevier

    Dr Stuart A McDonald, Dr Trevor A Graham, Professor Janusz Antoni Jankowski

  78. Genetic diversity during the development of Barrett's oesophagus-associated adenocarcinoma: how, when and why?

    Article • Biochemical Society Transactions, April 2010, Portland Press Ltd.

    Dr Trevor A Graham

  79. Long-term proton pump induced hypergastrinaemia does induce lineage-specific restitution but not clonal expansion in benign Barrett's oesophagus in vivo

    Article • Gut, August 2009, BMJ

    Dr Trevor A Graham, Professor Janusz Antoni Jankowski

  80. Stem cells and solid cancers

    Article • Virchows Archiv, June 2009, Springer Science + Business Media

    Dr Stuart A McDonald, Dr Trevor A Graham

  81. Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis–Associated Neoplasia

    Article • Gastroenterology, February 2009, Elsevier

    Dr Stuart A McDonald, Dr Trevor A Graham, Professor Janusz Antoni Jankowski

  82. Investigating the fixation and spread of mutations in the gastrointestinal epithelium

    Article • Future Oncology, December 2008, Future Medicine

    Dr Trevor A Graham

  83. A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence

    Article • The Journal of Pathology, January 2008, Wiley

    Dr Trevor A Graham

  84. Most low-level microsatellite instability in colorectal cancers can be explained without an elevated slippage rate

    Article • The Journal of Pathology, January 2008, Wiley

    Dr Trevor A Graham

  85. Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas

    Article • The Journal of Pathology, January 2007, Wiley

    Dr Trevor A Graham