All Stories

  1. Developmental Expression of the Cell Cycle Regulator p16INK4a in Retinal Glial Cells: A Novel Marker for Immature Ocular Astrocytes?

    Article • Journal of Histochemistry & Cytochemistry, June 2023, SAGE Publications

    Thomas Burgoyne

  2. Axonemal structures reveal mechanoregulatory and disease mechanisms

    Article • Nature, May 2023, Springer Science + Business Media

    Thomas Burgoyne

  3. Changes in Mitochondrial Size and Morphology in the RPE and Photoreceptors of the Developing and Ageing Zebrafish

    Article • Cells, November 2022, MDPI AG

    Thomas Burgoyne

  4. SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules

    Article • Proceedings of the National Academy of Sciences, October 2022, Proceedings of the National Academy of Sciences

    Thomas Burgoyne

  5. Functional Changes Within the Rod Inner Segment Ellipsoid in Wildtype Mice: An Optical Coherence Tomography and Electron Microscopy Study

    Article • Investigative Ophthalmology & Visual Science, July 2022, Association for Research in Vision and Ophthalmology (ARVO)

    Thomas Burgoyne

  6. Disruption of CFAP418 interaction with lipids causes abnormal membrane-associated cellular processes in retinal degenerations

    Article • June 2022, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  7. Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium

    Article • Nature Communications, March 2022, Springer Science + Business Media

    Thomas Burgoyne

  8. A persistent neutrophil-associated immune signature characterises post-COVID19 pulmonary sequelae

    Article • February 2022, Research Square

    Thomas Burgoyne

  9. Fission of megamitochondria into multiple smaller well-defined mitochondria in the ageing zebrafish retina

    Article • December 2021, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  10. Zebrafish Motile Cilia as a Model for Primary Ciliary Dyskinesia

    Article • International Journal of Molecular Sciences, August 2021, MDPI AG

    Thomas Burgoyne

  11. Glucose-dependent miR-125b is a negative regulator of β-cell function

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  12. Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity

    Article • Journal of Extracellular Vesicles, April 2021, Wiley

    Thomas Burgoyne

  13. Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P‐GI.2) from Lagomorpha to Eurasian badger

    Article • Transboundary and Emerging Diseases, March 2021, Hindawi Publishing Corporation

    Thomas Burgoyne

  14. Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic

    Article • January 2021, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  15. PCD Detect: enhancing ciliary features through image averaging and classification

    Article • AJP Lung Cellular and Molecular Physiology, December 2020, American Physiological Society

    Thomas Burgoyne

  16. Improving Primary Ciliary Dyskinesia diagnosis using Artificial Intelligence

    Article • September 2020, European Respiratory Society (ERS)

    Thomas Burgoyne

  17. Membrane trafficking in the retinal pigment epithelium at a glance

    Article • Journal of Cell Science, August 2020, The Company of Biologists

    Thomas Burgoyne

  18. Ciliary Feature Counter: A program for the Quantitative Assessment of Cilia to Diagnose Primary Ciliary Dyskinesia

    Article • Diagnostics, July 2020, MDPI AG

    Thomas Burgoyne

  19. Physiological and Pathophysiological Aspects of Primary Cilia—A Literature Review with View on Functional and Structural Relationships in Cartilage

    Article • International Journal of Molecular Sciences, July 2020, MDPI AG

    Thomas Burgoyne

  20. Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1

    Article • Proceedings of the National Academy of Sciences, June 2020, Proceedings of the National Academy of Sciences

    Thomas Burgoyne

  21. NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

    Article • Nature Communications, September 2019, Springer Science + Business Media

    Thomas Burgoyne

  22. Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells

    Article • PLoS Biology, August 2019, PLOS

    Thomas Burgoyne

  23. Three-dimensional structure of the basketweave Z-band in midshipman fish sonic muscle

    Article • Proceedings of the National Academy of Sciences, July 2019, Proceedings of the National Academy of Sciences

    Professor Kenneth A. Taylor, Thomas Burgoyne

  24. Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1

    Article • May 2019, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  25. Phagosomal and mitochondrial alterations in RPE may contribute to KCNJ13 retinopathy

    Article • Scientific Reports, March 2019, Springer Science + Business Media

    Thomas Burgoyne

  26. Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration

    Article • Investigative Ophthalmology & Visual Science, January 2019, Association for Research in Vision and Ophthalmology (ARVO)

    Thomas Burgoyne

  27. Agonist binding affinity determines palmitoylation of the glucagon-like peptide-1 receptor and its functional interaction with plasma membrane nanodomains in pancreatic beta cells

    Article • December 2018, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  28. Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus

    Article • The American Journal of Human Genetics, December 2018, Elsevier

    Thomas Burgoyne

  29. ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation

    Article • Cell Reports, July 2018, Elsevier

    Thomas Burgoyne

  30. Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer

    Article • Cell Reports, June 2018, Elsevier

    Thomas Burgoyne

  31. Primary ciliary dyskinesia with normal ultrastructure: three-dimensional tomography detects absence of DNAH11

    Article • European Respiratory Journal, February 2018, European Respiratory Society (ERS)

    Thomas Burgoyne

  32. Correlative light and immuno-electron microscopy of retinal tissue cryostat sections

    Article • PLoS ONE, January 2018, PLOS

    Thomas Burgoyne

  33. Oxidation of Atg3 and Atg7 mediates inhibition of autophagy

    Article • Nature Communications, January 2018, Springer Science + Business Media

    Thomas Burgoyne

  34. HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model

    Article • EBioMedicine, January 2018, Elsevier

    Dr Oliver Schilling, Thomas Burgoyne

  35. Use of electron tomography to confirm the diagnosis of primary ciliary dyskinesia

    Article • September 2017, European Respiratory Society (ERS)

    Thomas Burgoyne

  36. Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer

    Article • August 2017, Cold Spring Harbor Laboratory Press

    Thomas Burgoyne

  37. Endothelial MAPKs Direct ICAM-1 Signaling to Divergent Inflammatory Functions

    Article • The Journal of Immunology, May 2017, The American Association of Immunologists

    Thomas Burgoyne

  38. REEP6 deficiency leads to retinal degeneration through disruption of ER homeostasis and protein trafficking

    Article • Human Molecular Genetics, May 2017, Oxford University Press (OUP)

    Thomas Burgoyne

  39. Mutations in REEP6 Cause Autosomal-Recessive Retinitis Pigmentosa

    Article • The American Journal of Human Genetics, December 2016, Elsevier

    Thomas Burgoyne

  40. Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-resolution Microscopy

    Article • ACS Nano, November 2016, American Chemical Society (ACS)

    Thomas Burgoyne

  41. Multivesicular Bodies: Roles in Intracellular and Intercellular Signaling

    Article • August 2016, Wiley

    Thomas Burgoyne

  42. New light on photoreceptor renewal

    Article • Cell Cycle, May 2016, Taylor & Francis

    Thomas Burgoyne

  43. Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment

    Article • Proceedings of the National Academy of Sciences, December 2015, Proceedings of the National Academy of Sciences

    Thomas Burgoyne

  44. Three-Dimensional Structure of Vertebrate Muscle Z-Band: The Small-Square Lattice Z-Band in Rat Cardiac Muscle

    Article • Journal of Molecular Biology, November 2015, Elsevier

    Thomas Burgoyne

  45. Retinal Pigment Epithelial Cells Mitigate the Effects of Complement Attack by Endocytosis of C5b-9

    Article • The Journal of Immunology, October 2015, The American Association of Immunologists

    Thomas Burgoyne

  46. Erratum to: Arum Palaestinum with isovanillin, linolenic acid and β-sitosterol inhibits prostate cancer spheroids and reduces the growth rate of prostate tumors in mice

    Article • BMC Complementary and Alternative Medicine, September 2015, Springer Science + Business Media

    Thomas Burgoyne

  47. Calcium signaling at ER membrane contact sites

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, September 2015, Elsevier

    Thomas Burgoyne

  48. WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway

    Article • Nature Communications, June 2015, Springer Science + Business Media

    Thomas Burgoyne

  49. Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL

    Article • Journal of Cell Science, April 2015, The Company of Biologists

    Thomas Burgoyne

  50. CCDC151 Mutations Cause Primary Ciliary Dyskinesia by Disruption of the Outer Dynein Arm Docking Complex Formation

    Article • The American Journal of Human Genetics, September 2014, Elsevier

    Thomas Burgoyne

  51. Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers

    Article • Developmental Cell, September 2014, Elsevier

    Thomas Burgoyne

  52. Characterizing the ultrastructure of primary ciliary dyskinesia transposition defect using electron tomography

    Article • Cytoskeleton, March 2014, Wiley

    Amelia Shoemark, Thomas Burgoyne

  53. Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects

    Article • Human Molecular Genetics, February 2014, Oxford University Press (OUP)

    Thomas Burgoyne

  54. Methamphetamine-induced nitric oxide promotes vesicular transport in blood–brain barrier endothelial cells

    Article • Neuropharmacology, February 2013, Elsevier

    Thomas Burgoyne

  55. Expression of OA1 limits the fusion of a subset of MVBs with lysosomes; a mechanism likely involved in the initial biogenesis of melanosomes

    Article • Journal of Cell Science, January 2013, The Company of Biologists

    Thomas Burgoyne

  56. Generation of a Three-Dimensional Ultrastructural Model of Human Respiratory Cilia

    Article • American Journal of Respiratory Cell and Molecular Biology, December 2012, American Thoracic Society

    Amelia Shoemark, Thomas Burgoyne

  57. Recessive HYDIN Mutations Cause Primary Ciliary Dyskinesia without Randomization of Left-Right Body Asymmetry

    Article • The American Journal of Human Genetics, October 2012, Elsevier

    Thomas Burgoyne

  58. The relationship between ER–multivesicular body membrane contacts and the ESCRT machinery

    Article • Biochemical Society Transactions, March 2012, Portland Press Ltd.

    Thomas Burgoyne

  59. A Comparison Between Chlamydomonas Flagella And Human Cilia By Electron Tomography

    Article • May 2010, American Thoracic Society

    Amelia Shoemark, Thomas Burgoyne

  60. The Study Of Primary Ciliary Dyskinesia In Difficult Cases Using Electron Tomography

    Article • May 2010, American Thoracic Society

    Amelia Shoemark, Thomas Burgoyne

  61. Visualization of cardiac muscle thin filaments and measurement of their lengths by electron tomography

    Article • Cardiovascular Research, January 2008, European Society of Cardiology

    Thomas Burgoyne