All Stories

  1. Nuclear Myosin VI cooperates with actin to promote transcriptional cluster formation at androgen receptors
  2. Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney disease
  3. SDF2 and SDF2L1 are essential co-factors of DNAJB11 for Polycystin-1 processing
  4. Signatures of the systemic effects of a snake venom and antivenom: multiomics profiling of the kidney pathology
  5. A Noncatalytic Cysteine Residue Modulates Cobalamin Reactivity in the Human B12 Processing Enzyme CblC
  6. Proteomic analysis of non‐muscle invasive and muscle invasive bladder cancer highlights distinct subgroups with metabolic, matrisomal, and immune hallmarks and emphasizes importance of the stromal compartment
  7. Data-Independent Acquisition: A Milestone and Prospect in Clinical Mass Spectrometry–Based Proteomics
  8. Mass Spectrometry-Based Proteomics of Poly(methylmethacrylate)-Embedded Bone
  9. Mass spectrometry‐based proteomic applications in dental implants research
  10. Proteometabolomics of initial and recurrent glioblastoma highlights an increased immune cell signature with altered lipid metabolism
  11. Alternative mRNA Splicing Controls the Functions of the Histone H3K27 Demethylase UTX/KDM6A
  12. An EOMES induced epigenetic deflection initiates lineage commitment at mammalian gastrulation
  13. Neoadjuvant Chemotherapy or Combined Chemo-Radiation Therapy of Pancreatic Ductal Adenocarcinoma Differentially Shift Immune Activation, ECM Composition, Energy Metabolism, and Ribosomal Proteins of the Residual Tumor Mass
  14. Characterization of Spatial Heterogeneity in Metastasized Colorectal Cancer by MALDI Imaging
  15. Targeted and explorative profiling of kallikrein proteases and global proteome biology of pancreatic ductal adenocarcinoma, chronic pancreatitis, and normal pancreas highlights disease-specific proteome remodelling
  16. Proteome-Wide Identification of RNA-Dependent Proteins in Lung Cancer Cells
  17. Targeted and Explorative Profiling of Kallikrein Proteases and Global Proteome Biology of Pancreatic Ductal Adenocarcinoma, Chronic Pancreatitis, and Normal Pancreas Highlights Disease-Specific Proteome Remodelling
  18. Proteome alterations during clonal isolation of established human pancreatic cancer cell lines
  19. Addition of Chromosome 17 Polysomy and HER2 Amplification Status Improves the Accuracy of Clinicopathological Factor-Based Progression Risk Stratification and Tumor Grading of Non-Muscle-Invasive Bladder Cancer
  20. MaxQuant and MSstats in Galaxy Enable Reproducible Cloud-Based Analysis of Quantitative Proteomics Experiments for Everyone
  21. NUP133 Controls Nuclear Pore Assembly, Transcriptome Composition, and Cytoskeleton Regulation in Podocytes
  22. MaxQuant and MSstats in Galaxy enable reproducible cloud-based analysis of quantitative proteomics experiments for everyone
  23. An adapted passive model of anti-MPO dependent crescentic glomerulonephritis reveals matrix dysregulation and is amenable to modulation by CXCR4 inhibition
  24. Democratizing data-independent acquisition proteomics analysis on public cloud infrastructures via the Galaxy framework
  25. Proteome biology of primary colorectal carcinoma and corresponding liver metastases
  26. Proteome biology of primary colorectal carcinoma and corresponding liver metastases
  27. Moving translational mass spectrometry imaging towards transparent and reproducible data analyses: A case study of an urothelial cancer cohort analyzed in the Galaxy framework
  28. Democratizing Data-Independent Acquisition Proteomics Analysis on Public Cloud Infrastructures Via The Galaxy Framework
  29. A Systematic Evaluation of Semispecific Peptide Search Parameter Enables Identification of Previously Undescribed N-Terminal Peptides and Conserved Proteolytic Processing in Cancer Cell Lines
  30. EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission
  31. Impact of DJ-1 and Helix 8 on the Proteome and Degradome of Neuron-Like Cells
  32. Origin and Expansion of the Serine Protease Repertoire in the Myelomonocyte Lineage
  33. Automation of peptide desalting for proteomic liquid chromatography – tandem mass spectrometry by centrifugal microfluidics
  34. Discovery of a novel small protein factor involved in the coordinated degradation of phycobilisomes in cyanobacteria
  35. Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death
  36. Accessible and reproducible mass spectrometry imaging data analysis in Galaxy
  37. Targeted Metabolic Profiling of Methionine Cycle Metabolites and Redox Thiol Pools in Mammalian Plasma, Cells and Urine
  38. Impact of left ventricular assist device therapy on the cardiac proteome and metabolome composition in ischemic cardiomyopathy
  39. Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100
  40. A human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins
  41. Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome
  42. Detection and Characterization of a Mycobacterial L-Arabinofuranose ABC Transporter Identified with a Rapid Lipoproteomics Protocol
  43. Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer
  44. Accessible and reproducible mass spectrometry imaging data analysis in Galaxy
  45. Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics
  46. ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma
  47. Infection of HeLa cells with Chlamydia trachomatis inhibits protein synthesis and causes multiple changes to host cell pathways
  48. Radiomic features from PSMA PET for non-invasive intraprostatic tumor discrimination and characterization in patients with intermediate- and high-risk prostate cancer - a comparison study with histology reference
  49. FOXG1 Regulates PRKAR2B Transcriptionally and Posttranscriptionally via miR200 in the Adult Hippocampus
  50. Proteome Profiling of Primary Pancreatic Ductal Adenocarcinomas Undergoing Additive Chemoradiation Link ALDH1A1 to Early Local Recurrence and Chemoradiation Resistance
  51. Dreidimensionale Rekonstruktion solider Tumoren
  52. Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer
  53. Multimodal imaging for radiation therapy planning in patients with primary prostate cancer
  54. Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics
  55. The two cathepsin B-like proteases of Arabidopsis thaliana are closely related enzymes with discrete endopeptidase and carboxydipeptidase activities
  56. Specificity profiling of human trypsin-isoenzymes
  57. N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration
  58. Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin
  59. Proteomic distinction of renal oncocytomas and chromophobe renal cell carcinomas
  60. Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin
  61. Nanoparticle decoration impacts airborne fungal pathobiology
  62. Morphology of Immunomodulation in Breast Cancer Tumor Draining Lymph Nodes Depends on Stage and Intrinsic Subtype
  63. The pleiotropic roles of ADAM9 in the biology of solid tumors
  64. Reproducible proteomics sample preparation for single FFPE tissue slices using acid-labile surfactant and direct trypsinization
  65. Identification of tissue damage, extracellular matrix remodeling and bacterial challenge as common mechanisms associated with high-risk cutaneous squamous cell carcinomas
  66. Proteomic Characterization of Prostate Cancer to Distinguish Nonmetastasizing and Metastasizing Primary Tumors and Lymph Node Metastases
  67. HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
  68. The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton
  69. HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication
  70. OpenMS – A platform for reproducible analysis of mass spectrometry data
  71. Proteome profiling of clear cell renal cell carcinoma in von Hippel-Lindau patients highlights upregulation of Xaa-Pro aminopeptidase-1, an anti-proliferative and anti-migratory exoprotease
  72. Differential effect of TGFβ on the proteome of cancer associated fibroblasts and cancer epithelial cells in a co-culture approach - a short report
  73. Determinants of Macromolecular Specificity from Proteomics-De rived Peptide Substrate Data
  74. Form follows function: Morphological and immunohistological insights into epithelial–mesenchymal transition characteristics of tumor buds
  75. The papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B
  76. Proteomics highlights decrease of matricellular proteins in left ventricular assist device therapy†
  77. Identification of Protease Cleavage Sites by Charge-Based Enrichment of Protein N-Termini
  78. Profiling of Protease Cleavage Sites by Proteome-Derived Peptide Libraries and Quantitative Proteomics
  79. Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression
  80. System-Wide Profiling of Protein Amino Termini from Formalin-Fixed, Paraffin-Embedded Tissue Specimens for the Identification of Novel Substrates
  81. The Prognostic Impact of the Carcinoembryonic Antigen in Ampullary Cancer - A Retrospective Single Center Study
  82. Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro- and Anti-angiogenic Signaling
  83. Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality
  84. Yeast membrane proteomics using leucine metabolic labelling: Bioinformatic data processing and exemplary application to the ER-intramembrane protease Ypf1
  85. OpenMS: a flexible open-source software platform for mass spectrometry data analysis
  86. The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity
  87. Proteomic Profiling of Cardiomyocyte-Specific Cathepsin A Overexpression Links Cathepsin A to the Oxidative Stress Response
  88. Comprehensive Proteomic Analysis of Nitrogen-Starved Mycobacterium smegmatis Δpup Reveals the Impact of Pupylation on Nitrogen Stress Response
  89. Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14
  90. Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels
  91. Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics
  92. Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR Are Based on Highly Similar Proteome and Degradome Alterations
  93. Formalin-Fixed, Paraffin-Embedded Tissues (FFPE) as a Robust Source for the Profiling of Native and Protease-Generated Protein Amino Termini
  94. Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses
  95. Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers
  96. Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses
  97. Mesopancreatic Stromal Clearance Defines Curative Resection of Pancreatic Head Cancer and Can Be Predicted Preoperatively by Radiologic Parameters
  98. Pregnancy Specific β-1 Glycoprotein 1 is Expressed in Pancreatic Ductal Adenocarcinoma and its Subcellular Localization Correlates with Overall Survival
  99. Taspase1: a 'misunderstood' protease with translational cancer relevance
  100. A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity
  101. An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation
  102. The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia
  103. Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations
  104. Quantitative proteomic analysis of formalin–fixed, paraffin–embedded clear cell renal cell carcinoma tissue using stable isotopic dimethylation of primary amines
  105. Toward improved peptide feature detection in quantitative proteomics using stable isotope labeling
  106. miR-200c dampens cancer cell migration via regulation of protein kinase A subunits
  107. Enrichment of protein N-termini by charge reversal of internal peptides
  108. The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells
  109. The emerging role of the peptidome in biomarker discovery and degradome profiling
  110. Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma
  111. Protein amino-terminal modifications and proteomic approaches for N-terminal profiling
  112. Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells
  113. Evolutionary divergence of Threonine Aspartase1 leads to species-specific substrate recognition
  114. The Yeast ER-Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance
  115. Carboxyterminal Protein Processing in Health and Disease: Key Actors and Emerging Technologies
  116. Cancer cell invasion and EMT marker expression: a three-dimensional study of the human cancer-host interface
  117. Septins Arrange F-Actin-Containing Fibers on the Chlamydia trachomatis Inclusion and Are Required for Normal Release of the Inclusion by Extrusion
  118. Impact of routinely employed procedures for tissue processing on the proteomic analysis of formalin-fixed paraffin-embedded tissue
  119. Prognostic significance of Zinc finger E-box binding homeobox 1 (ZEB1) expression in cancer cells and cancer-associated fibroblasts in pancreatic head cancer
  120. Proteases and Disease
  121. Global remodelling of cellular microenvironment due to loss of collagen VII
  122. Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy
  123. Transmembrane Collagen XVII Modulates Integrin Dependent Keratinocyte Migration via PI3K/Rac1 Signaling
  124. Automated peptide mapping and protein-topographical annotation of proteomics data
  125. Proteomic identification of protease cleavage sites: cell-biological and biomedical applications
  126. Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells
  127. Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis
  128. Glycocapture-based proteomics for secretome analysis
  129. Limited and Degradative Proteolysis in the Context of Posttranslational Regulatory Networks: Current Technical and Conceptional Advances
  130. Deletion of Cysteine Cathepsins B or L Yields Differential Impacts on Murine Skin Proteome and Degradome
  131. Enhanced identification of peptides lacking basic residues by LC-ESI-MS/MS analysis of singly charged peptides
  132. NSP4, an elastase-related protease in human neutrophils with arginine specificity
  133. Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S
  134. Correction to Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S
  135. Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites
  136. Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts
  137. Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts
  138. Proteomic Analyses Reveal an Acidic Prime Side Specificity for the Astacin Metalloprotease Family Reflected by Physiological Substrates
  139. Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragmentsin Vivo
  140. Protease Specificity Profiling by Tandem Mass Spectrometry Using Proteome-Derived Peptide Libraries
  141. Identification and Relative Quantification of Native and Proteolytically Generated Protein C-Termini from Complex Proteomes: C-Terminome Analysis
  142. Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry
  143. Biological role of matrix metalloproteinases: a critical balance
  144. Proteomic techniques and activity-based probes for the system-wide study of proteolysis
  145. Proteome-wide analysis of protein carboxy termini: C terminomics
  146. Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products
  147. Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites
  148. Protease subsite profiling with proteome-derived peptide libraries (PICS)
  149. Metal Requirements and Phosphodiesterase Activity of tRNase Z Enzymes †
  150. Proteomic discovery of protease substrates
  151. The Crystal Structure of the Zinc Phosphodiesterase from Escherichia coli Provides Insight into Function and Cooperativity of tRNase Z-Family Proteins
  152. Exosite Modules Guide Substrate Recognition in the ZiPD/ElaC Protein Family
  153. Erratum to “Characterization of an Escherichia coli elaC deletion mutant” [Biochem. Biophys. Res. Commun. 320 (2004) 1365–1373]
  154. The tRNase Z family of proteins: physiological functions, substrate specificity and structural properties
  155. Zinc- and iron-dependent cytosolic metallo-β-lactamase domain proteins exhibit similar zinc-binding affinities, independent of an atypical glutamate at the metal-binding site
  156. Functional diversity and metal selectivity of proteins sharing the metallo-β-lactamase fold
  157. Characterization of an Escherichia coli elaC deletion mutant
  158. Identification of Metal Binding Residues for the Binuclear Zinc Phosphodiesterase Reveals Identical Coordination as Glyoxalase II
  159. The binding of iron and zinc to glyoxalase II occurs exclusively as di-metal centers and is unique within the metallo-β-lactamase family
  160. Flexible Metal Binding of the Metallo-β-lactamase Domain:  Glyoxalase II Incorporates Iron, Manganese, and Zinc in Vivo †
  161. Activation Mechanism of Pro-astacin: Role of the Pro-peptide, Tryptic and Autoproteolytic Cleavage and Importance of Precise Amino-terminal Processing
  162. The GCM domain is a Zn-coordinating DNA-binding domain
  163. ElaCEncodes a Novel Binuclear Zinc Phosphodiesterase