All Stories

  1. Oropouche virus infection induces pyroptosis in human THP-1 macrophages

    Article • Virology, October 2025, Elsevier

    Dr Tetsuro Ikegami

  2. Oropouche virus NSs protein suppresses host transcription by targeting the RNA polymerase II RPB1 protein

    Article • Journal of Virology, September 2025, ASM Journals

    Dr Tetsuro Ikegami

  3. Distinct Pathological Changes in Preweaning Mice Infected with Live-Attenuated Rift Valley Fever Virus Strains

    Article • Viruses, June 2024, MDPI AG

    Dr Tetsuro Ikegami

  4. Computer-Selected Antiviral Compounds: Assessing In Vitro Efficacies against Rift Valley Fever Virus

    Article • Viruses, January 2024, MDPI AG

    Dr Tetsuro Ikegami

  5. Advancements in Rift Valley fever vaccines: a historical overview and prospects for next generation candidates

    Article • npj Vaccines, November 2023, Springer Science + Business Media

    Dr Tetsuro Ikegami

  6. Perspectives of Next-Generation Live-Attenuated Rift Valley Fever Vaccines for Animal and Human Use

    Article • Vaccines, March 2023, MDPI AG

    Dr Tetsuro Ikegami

  7. Nipah Virus Bangladesh Infection Elicits Organ-Specific Innate and Inflammatory Responses in the Marmoset Model

    Article • The Journal of Infectious Diseases, March 2023, Oxford University Press (OUP)

    Dr Tetsuro Ikegami

  8. Evaluations of rationally designed rift valley fever vaccine candidate RVax-1 in mosquito and rodent models

    Article • npj Vaccines, September 2022, Springer Science + Business Media

    Dr Tetsuro Ikegami

  9. Tilorone-Dihydrochloride Protects against Rift Valley Fever Virus Infection and Disease in the Mouse Model

    Article • Microorganisms, December 2021, MDPI AG

    Dr Tetsuro Ikegami, Dr Alexander N Freiberg

  10. STAT-1 Knockout Mice as a Model for Wild-Type Sudan Virus (SUDV)

    Article • Viruses, July 2021, MDPI AG

    Dr Tetsuro Ikegami, Dr Alexander N Freiberg

  11. Development of a Simian RNA Polymerase I Promoter-Driven Reverse Genetics System for the Rescue of Recombinant Rift Valley Fever Virus from Vero Cells

    Article • Journal of Virology, March 2021, ASM Journals

    Dr Tetsuro Ikegami

  12. Rift Valley Fever Virus and Other Phleboviruses (Phenuiviridae)

    Article • January 2021, Elsevier

    Dr Tetsuro Ikegami

  13. Rescue of infectious Arumowot virus from cloned cDNA: Posttranslational degradation of Arumowot virus NSs protein in human cells

    Article • PLoS Neglected Tropical Diseases, November 2019, PLOS

    Dr Tetsuro Ikegami

  14. Candidate vaccines for human Rift Valley fever

    Article • Expert Opinion on Biological Therapy, September 2019, Taylor & Francis

    Dr Tetsuro Ikegami

  15. Favipiravir (T-705) protects against Nipah virus infection in the hamster model

    Article • Scientific Reports, May 2018, Springer Science + Business Media

    Dr Tetsuro Ikegami, Dr Alexander N Freiberg

  16. Rift Valley fever vaccines: current and future needs

    Article • Current Opinion in Virology, April 2018, Elsevier

    Dr Tetsuro Ikegami

  17. Distinct virulence of Rift Valley fever phlebovirus strains from different genetic lineages in a mouse model

    Article • PLOS One, December 2017, PLOS

    Dr Tetsuro Ikegami, Dr Alexander N Freiberg

  18. Risk analysis of inter-species reassortment through a Rift Valley fever phlebovirus MP-12 vaccine strain

    Article • PLOS One, September 2017, PLOS

    Dr Tetsuro Ikegami

  19. Genetic stability of Rift Valley fever virus MP-12 vaccine during serial passages in culture cells

    Article • npj Vaccines, July 2017, Springer Science + Business Media

    Dr Tetsuro Ikegami

  20. Rift Valley fever vaccines: an overview of the safety and efficacy of the live-attenuated MP-12 vaccine candidate

    Article • Expert Review of Vaccines, May 2017, Taylor & Francis

    Dr Tetsuro Ikegami

  21. Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins

    Article • Virology Journal, July 2016, Springer Science + Business Media

    Dr Tetsuro Ikegami

  22. Attenuation of pathogenic Rift Valley fever virus strain through the chimeric S-segment encoding sandfly fever phlebovirus NSs or a dominant-negative PKR

    Article • Virulence, June 2016, Taylor & Francis

    Dr Tetsuro Ikegami, Dr Alexander N Freiberg

  23. Mutational Analysis of the Rift Valley Fever Virus Glycoprotein Precursor Proteins for Gn Protein Expression

    Article • Viruses, May 2016, MDPI AG

    Dr Tetsuro Ikegami

  24. N-Glycans on the Rift Valley Fever Virus Envelope Glycoproteins Gn and Gc Redundantly Support Viral Infection via DC-SIGN

    Article • Viruses, May 2016, MDPI AG

    Dr Tetsuro Ikegami, Dr Alexander N Freiberg

  25. Optimized P2A for reporter gene insertion into Nipah virus results in efficient ribosomal skipping and wild-type lethality

    Article • Journal of General Virology, April 2016, Society for General Microbiology

    Dr Tetsuro Ikegami, Dr Alexander N Freiberg

  26. The L, M, and S Segments of Rift Valley Fever Virus MP-12 Vaccine Independently Contribute to a Temperature-Sensitive Phenotype

    Article • Journal of Virology, January 2016, ASM Journals

    Dr Tetsuro Ikegami

  27. Application of Droplet Digital PCR to Validate Rift Valley Fever Vaccines

    Article • January 2016, Springer Science + Business Media

    Dr Tetsuro Ikegami

  28. Pathogenesis of Rift Valley Fever in Humans

    Article • November 2015, Wiley

    Dr Tetsuro Ikegami

  29. Temperature-sensitive mutations for live-attenuated Rift Valley fever vaccines: implications from other RNA viruses

    Article • Frontiers in Microbiology, August 2015, Frontiers

    Dr Tetsuro Ikegami

  30. MP-12 virus containing the clone 13 deletion in the NSs gene prevents lethal disease when administered after Rift Valley fever virus infection in hamsters

    Article • Frontiers in Microbiology, June 2015, Frontiers

    Dr Tetsuro Ikegami

  31. Rift Valley Fever Virus MP-12 Vaccine Is Fully Attenuated by a Combination of Partial Attenuations in the S, M, and L Segments

    Article • Journal of Virology, May 2015, ASM Journals

    Dr Tetsuro Ikegami, Dr Alexander N Freiberg

  32. Countermeasure development for Rift Valley fever: deletion, modification or targeting of major virulence factor NSs

    Article • Future Virology, January 2014, Future Medicine

    Dr Tetsuro Ikegami

  33. The Dominant-Negative Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR Increases the Efficacy of Rift Valley Fever Virus MP-12 Vaccine

    Article • Journal of Virology, October 2013, ASM Journals

    Dr Tetsuro Ikegami

  34. Using Click Chemistry to Measure the Effect of Viral Infection on Host-Cell RNA Synthesis

    Article • Journal of Visualized Experiments, August 2013, MyJove Corporation

    Dr Tetsuro Ikegami

  35. Using Click Chemistry to Measure the Effect of Viral Infection on Host-Cell RNA Synthesis

    Article • Journal of Visualized Experiments, August 2013, MyJove Corporation

    Dr Tetsuro Ikegami

  36. Rift Valley fever virus MP-12 vaccine encoding Toscana virus NSs retains neuroinvasiveness in mice

    Article • Journal of General Virology, July 2013, Society for General Microbiology

    Dr Tetsuro Ikegami, Dr Alexander N Freiberg

  37. Post-exposure vaccination with MP-12 lacking NSs protects mice against lethal Rift Valley fever virus challenge

    Article • Antiviral Research, May 2013, Elsevier

    Dr Tetsuro Ikegami

  38. Characterization of Rift Valley Fever Virus MP-12 Strain Encoding NSs of Punta Toro Virus or Sandfly Fever Sicilian Virus

    Article • PLoS Neglected Tropical Diseases, April 2013, PLOS

    Dr Alexander N Freiberg, Dr Tetsuro Ikegami

  39. Toscana Virus NSs Protein Promotes Degradation of Double-Stranded RNA-Dependent Protein Kinase

    Article • Journal of Virology, January 2013, ASM Journals

    Dr Tetsuro Ikegami

  40. Rift Valley fever virus NSs inhibits host transcription independently of the degradation of dsRNA-dependent protein kinase PKR

    Article • Virology, January 2013, Elsevier

    Dr Tetsuro Ikegami

  41. Modifying theNSsgene to improve live-attenuated vaccine for Rift Valley fever

    Article • Expert Review of Vaccines, November 2012, Informa Healthcare

    Dr Tetsuro Ikegami

  42. Genetic Subpopulations of Rift Valley Fever Virus Strains ZH548 and MP-12 and Recombinant MP-12 Strains

    Article • Journal of Virology, October 2012, ASM Journals

    Dr Tetsuro Ikegami, Dr Alexander N Freiberg

  43. Rift Valley Fever Virus Strain MP-12 Enters Mammalian Host Cells via Caveola-Mediated Endocytosis

    Article • Journal of Virology, September 2012, ASM Journals

    Dr Tetsuro Ikegami

  44. Functional Analysis of Rift Valley Fever Virus NSs Encoding a Partial Truncation

    Article • PLOS One, September 2012, PLOS

    Dr Tetsuro Ikegami

  45. Molecular biology and genetic diversity of Rift Valley fever virus

    Article • Antiviral Research, September 2012, Elsevier

    Dr Tetsuro Ikegami

  46. The Dominant-Negative Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR Increases the Efficacy of Rift Valley Fever Virus MP-12 Vaccine

    Article • Journal of Virology, May 2012, ASM Journals

    Dr Tetsuro Ikegami, Dr Alexander N Freiberg

  47. Analysis of the humoral immune responses among cynomolgus macaque naturally infected with Reston virus during the 1996 outbreak in the Philippines

    Article • BMC Veterinary Research, January 2012, Springer Science + Business Media

    Dr Masayuki Saijo, Dr Tetsuro Ikegami

  48. Novel approaches to develop Rift Valley fever vaccines

    Article • Frontiers in Cellular and Infection Microbiology, January 2012, Frontiers

    Dr Tetsuro Ikegami

  49. Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

    Article • Journal of Visualized Experiments, November 2011, MyJove Corporation

    Dr Tetsuro Ikegami

  50. Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

    Article • Journal of Visualized Experiments, November 2011, MyJove Corporation

    Dr Tetsuro Ikegami

  51. The Pathogenesis of Rift Valley Fever

    Article • Viruses, May 2011, MDPI AG

    Dr Tetsuro Ikegami

  52. NSs Protein of Rift Valley Fever Virus Promotes Posttranslational Downregulation of the TFIIH Subunit p62

    Article • Journal of Virology, May 2011, ASM Journals

    Dr Tetsuro Ikegami

  53. Correction: Rapid Accumulation of Virulent Rift Valley Fever Virus in Mice from an Attenuated Virus Carrying a Single Nucleotide Substitution in the M RNA

    Article • PLOS One, April 2010, PLOS

    Dr Tetsuro Ikegami

  54. Rapid Accumulation of Virulent Rift Valley Fever Virus in Mice from an Attenuated Virus Carrying a Single Nucleotide Substitution in the M RNA

    Article • PLOS One, April 2010, PLOS

    Dr Tetsuro Ikegami

  55. Rift Valley fever vaccines

    Article • Vaccine, November 2009, Elsevier

    Dr Tetsuro Ikegami

  56. Rift Valley Fever Virus L Protein Forms a Biologically Active Oligomer

    Article • Journal of Virology, October 2009, ASM Journals

    Dr Tetsuro Ikegami

  57. Dual Functions of Rift Valley Fever Virus NSs Protein: Inhibition of Host mRNA Transcription and Post-transcriptional Downregulation of Protein Kinase PKR

    Article • Annals of the New York Academy of Sciences, September 2009, Wiley

    Dr Tetsuro Ikegami

  58. Rift Valley Fever Virus NSs Protein Promotes Post-Transcriptional Downregulation of Protein Kinase PKR and Inhibits eIF2α Phosphorylation

    Article • PLoS Pathogens, February 2009, PLOS

    Dr Tetsuro Ikegami

  59. Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

    Article • Journal of Virology, February 2008, ASM Journals

    Dr Tetsuro Ikegami

  60. NSm Protein of Rift Valley Fever Virus Suppresses Virus-Induced Apoptosis

    Article • Journal of Virology, October 2007, ASM Journals

    Dr Tetsuro Ikegami

  61. Characterization of Rift Valley Fever Virus Transcriptional Terminations

    Article • Journal of Virology, May 2007, ASM Journals

    Dr Tetsuro Ikegami

  62. Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation

    Article • Proceedings of the National Academy of Sciences, August 2006, Proceedings of the National Academy of Sciences

    Dr Tetsuro Ikegami

  63. NSm and 78-Kilodalton Proteins of Rift Valley Fever Virus Are Nonessential for Viral Replication in Cell Culture

    Article • Journal of Virology, August 2006, ASM Journals

    Dr Tetsuro Ikegami

  64. Laboratory Diagnostic Systems for Ebola and Marburg Hemorrhagic Fevers Developed with Recombinant Proteins

    Article • Clinical and Vaccine Immunology, April 2006, ASM Journals

    Dr Tetsuro Ikegami

  65. Rescue of Infectious Rift Valley Fever Virus Entirely from cDNA, Analysis of Virus Lacking the NSs Gene, and Expression of a Foreign Gene

    Article • Journal of Virology, March 2006, ASM Journals

    Dr Tetsuro Ikegami

  66. Rift Valley Fever Virus NSs mRNA Is Transcribed from an Incoming Anti-Viral-Sense S RNA Segment

    Article • Journal of Virology, September 2005, ASM Journals

    Dr Tetsuro Ikegami

  67. Rift Valley Fever Virus Nonstructural Protein NSs Promotes Viral RNA Replication and Transcription in a Minigenome System

    Article • Journal of Virology, May 2005, ASM Journals

    Dr Tetsuro Ikegami

  68. Modification of endothelial cell functions by Hantaan virus infection: prolonged hyper-permeability induced by TNF-alpha of hantaan virus-infected endothelial cell monolayers

    Article • Archives of Virology, March 2004, Springer Science + Business Media

    Dr Masayuki Saijo, Dr Tetsuro Ikegami

  69. 'Notable virus Infectim around Japan' Rift Valley fever virus

    Article • Uirusu, January 2004, Japanese Association of Virology

    Dr Tetsuro Ikegami

  70. Antigen Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Reston Ebola Virus Nucleoprotein

    Article • Clinical and Diagnostic Laboratory Immunology, July 2003, ASM Journals

    Dr Masayuki Saijo, Dr Tetsuro Ikegami

  71. Detection of immunoglobulin G to Crimean-Congo hemorrhagic fever virus in sheep sera by recombinant nucleoprotein-based enzyme-linked immunosorbent and immunofluorescence assays

    Article • Journal of Virological Methods, March 2003, Elsevier

    Dr Masayuki Saijo, Dr Tetsuro Ikegami

  72. Analysis of Linear B-Cell Epitopes of the Nucleoprotein of Ebola Virus That Distinguish Ebola Virus Subtypes

    Article • Clinical and Vaccine Immunology, January 2003, ASM Journals

    Dr Masayuki Saijo, Dr Tetsuro Ikegami

  73. Development of an Immunofluorescence Method for the Detection of Antibodies to Ebola Virus Subtype Reston by the Use of Recombinant Nucleoprotein-Expressing HeLa Cells

    Article • Microbiology and Immunology, September 2002, Wiley

    Dr Masayuki Saijo, Dr Tetsuro Ikegami

  74. Recombinant Nucleoprotein-Based Enzyme-Linked Immunosorbent Assay for Detection of Immunoglobulin G Antibodies to Crimean-Congo Hemorrhagic Fever Virus

    Article • Journal of Clinical Microbiology, May 2002, ASM Journals

    Dr Masayuki Saijo, Dr Tetsuro Ikegami

  75. Immunofluorescence Technique Using HeLa Cells Expressing Recombinant Nucleoprotein for Detection of Immunoglobulin G Antibodies to Crimean-Congo Hemorrhagic Fever Virus

    Article • Journal of Clinical Microbiology, February 2002, ASM Journals

    Dr Masayuki Saijo, Dr Tetsuro Ikegami

  76. Histopathology of Natural Ebola Virus Subtype Reston Infection in Cynomolgus Macaques during the Philippine Outbreak in 1996.

    Article • EXPERIMENTAL ANIMALS, January 2002, Japanese Association for Laboratory Animal Science

    Dr Masayuki Saijo, Dr Tetsuro Ikegami

  77. Chronological and Spatial Analysis of the 1996 Ebola Reston Virus Outbreak in a Monkey Breeding Facility in the Philippines.

    Article • EXPERIMENTAL ANIMALS, January 2002, Japanese Association for Laboratory Animal Science

    Dr Tetsuro Ikegami

  78. Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes

    Article • Archives of Virology, October 2001, Springer Science + Business Media

    Dr Masayuki Saijo, Dr Tetsuro Ikegami

  79. Detection of Ebola Viral Antigen by Enzyme-Linked Immunosorbent Assay Using a Novel Monoclonal Antibody to Nucleoprotein

    Article • Journal of Clinical Microbiology, September 2001, ASM Journals

    Dr Tetsuro Ikegami

  80. Enterocolitis Associated with Dual Infection by Clostridium piliforme and Feline Panleukopenia Virus in Three Kittens

    Article • Veterinary Pathology, November 1999, SAGE Publications

    Dr Tetsuro Ikegami

  81. Naturally Occurring Tyzzer's Disease in a Calf

    Article • Veterinary Pathology, May 1999, SAGE Publications

    Dr Tetsuro Ikegami