All Stories

  1. Neutron and time-resolved X-ray crystallography reveal the substrate recognition and catalytic mechanism of human Nudix hydrolase MTH1
  2. TIFAB regulates the TIFA–TRAF6 signaling pathway involved in innate immunity by forming a heterodimer complex with TIFA
  3. Polyrotaxane-based multi-step transformable materials for the delivery of Cas9 ribonucleoprotein
  4. Visualization of mutagenic nucleotide processing by Escherichia coli MutT, a Nudix hydrolase
  5. Isolation, Synthesis, and Structure–Activity Relationship Study on Daphnane and Tigliane Diterpenes as HIV Latency-Reversing Agents
  6. A Mannosylated, PEGylated Albumin as a Drug Delivery System for the Treatment of Cancer Stroma Cells
  7. Molecular recognition of a single-chain Fv antibody specific for GA-pyridine, an advanced glycation end-product (AGE), elucidated using biophysical techniques and synthetic antigen analogues
  8. Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer
  9. RAD18 mediates DNA double-strand break-induced ubiquitination of chromatin protein
  10. Lactose-appended β-cyclodextrin as an effective nanocarrier for brain delivery
  11. A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase Inhibitor
  12. Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity
  13. SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix
  14. Anammox Organism KSU-1 Expresses a Novel His/DOPA Ligated Cytochrome c
  15. Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
  16. C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir
  17. Impact of antibodies against amyloidogenic transthyretin (ATTR) on phenotypes of patients with familial amyloidotic polyneuropathy (FAP) ATTR Valine30Methionine
  18. Mechanism of the nucleotidyl-transfer reaction in DNA polymerase revealed by time-resolved protein crystallography
  19. Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus
  20. Watching DNA polymerase η make a phosphodiester bond
  21. Diverse substrate recognition and hydrolysis mechanisms of human NUDT5
  22. Structural Insights into Differences in Drug-binding Selectivity between Two Forms of Human α1-Acid Glycoprotein Genetic Variants, the A and F1*S Forms
  23. Solution of the Structure of the TNF-TNFR2 Complex
  24. The Crystal Structure of the Green Tea Polyphenol (−)-Epigallocatechin Gallate−Transthyretin Complex Reveals a Novel Binding Site Distinct from the Thyroxine Binding Site,
  25. Structural and Dynamic Features of the MutT Protein in the Recognition of Nucleotides with the Mutagenic 8-Oxoguanine Base
  26. Role of the Glutamic Acid 54 Residue in Transthyretin Stability and Thyroxine Binding,
  27. Fast Binding Kinetics and Conserved 3D Structure Underlie the Antagonistic Activity of Mutant TNF: Useful Information for Designing Artificial Proteo-Antagonists
  28. Crystallization and preliminary X-ray analysis of the tumour necrosis factor α–tumour necrosis factor receptor type 2 complex
  29. Structure–Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant
  30. Preparation, crystallization and preliminary X-ray diffraction analysis of the DNA-binding domain of the Ets transcription factor in complex with target DNA
  31. Creation and X-ray Structure Analysis of the Tumor Necrosis Factor Receptor-1-selective Mutant of a Tumor Necrosis Factor-α Antagonist
  32. Crystal structure of the IL-15–IL-15Rα complex, a cytokine-receptor unit presented in trans
  33. Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP
  34. Crystallization and preliminary X-ray analysis ofEscherichia coliMutT in binary and ternary complex forms