All Stories

  1. Increased Libido Following Brivaracetam Initiation: A Case Report of Temporal Lobe Epilepsy
  2. Reduced plasma C‐mannosyl tryptophan in major depressive disorder
  3. Transcriptomic signatures associated with mania-to-depression and depression-to-mania transitions in bipolar disorder: a case report using induced microglia-like (iMG) cells
  4. Examining the Causal Relationship Between Hikikomori and Psychological Features of New-Type Depression: A Longitudinal Study on Male Individuals With Hikikomori Condition
  5. Mind the gap: quantifying population–individual gap in depressive symptom dynamics through energy landscapes
  6. CAT‐Hokkaido: A tablet‐based assessment of cognitive impairment in schizophrenia
  7. Beyond Diagnosis: Transdiagnostic Cognitive Subgroups in Mood Disorders Linked to Work‐Related Disability
  8. Parental bonding and attachment in the hikikomori trajectory
  9. Avatar Representation and Subsequent Social Experience: Longitudinal and Multimethod Evidence from Online Social Support and Online Social Activity
  10. Association between higher cerebrospinal fluid levels of phosphorylated tau and reduced depressive symptoms in patients with cognitive decline
  11. Psychosis induced by invocation presenting as possession state: A case of Kitousei‐Seishinbyo still emerging in modern Japan
  12. Improvement of Game Users’ Depressive Symptoms via Behavioral Activation in a Massive Multiplayer Online Game: Randomized Controlled Trial
  13. Clozapine‐induced slowing in quantitative EEG: Delta–theta amplification and alpha peak shift in TRS patients
  14. Norman Sartorius: A true legend in psychiatry, renowned for inspiring and mentoring early‐career psychiatrists across the globe
  15. Leveraging machine learning to uncover the hidden links between trusting behavior and biological markers
  16. Hikikomori Diagnostic Evaluation‐Screening Form (HiDE‐S): A validation study
  17. Depression, Gaming Disorder, and Internet Addiction in Adolescents with Autism Spectrum Disorder
  18. Predicting social anxiety disorder based on communication logs and social network data from a massively multiplayer online game: Using a graph neural network
  19. Avatar Communication Provides More Efficient Online Social Support Than Text Communication
  20. Improving social anxiety in lesbian, gay, bisexual, transgender, questioning, intersex and asexual individuals through avatar customization and communication
  21. Human monocyte‐derived microglia‐like (iMG) cells: A tool to explore microglial dynamics
  22. Unexpected risk factors of pathological hikikomori during the COVID‐19 pandemic among working adults initially without social isolation: A longitudinal online survey
  23. Could the Construct of Modern-Type Depression Predict Internet Gaming Disorder in Italian Video Gamers? A Case–Control Study
  24. Youth hikikomori-like social withdrawal in Italy: Two clinical cases
  25. Development of depression assessment tools using humanoid robots -Can tele-operated robots talk with depressive persons like humans?
  26. Heterogeneity of gaming disorder: A clinically-based typology for developing personalized interventions
  27. Hikikomori and gaming disorder tendency: A case‐control online survey for non‐working adults
  28. TRPV4‐mediated Ca2+ deregulation causes mitochondrial dysfunction via the AKT/α‐synuclein pathway in dopaminergic neurons
  29. Analyzing changes in help-seeking from mental and physical health professionals during COVID-19 in Japan
  30. Holiday Internet Usage Time and the Risk of Internet Addiction Tendency among Working Adults in their 30s in Japan
  31. Hikikomori‐Like Social Withdrawal: An Italian Case Report
  32. High‐sensitivity C‐reactive protein and bilirubin as possible biomarkers for hikikomori in depression: a case–control study
  33. Clinical Usefulness of a Short Version of the Internet Addiction Test to Screen for Probable Internet Addiction in Adolescents with Autism Spectrum Disorder
  34. Preliminary analysis of hippocampus synaptic apoptosis and microglial phagocytosis induced by severe restraint stress
  35. A case of bipolar disorder with AIF1 (coding gene of Iba‐1) deletion: a pilot in vitro analysis using blood‐derived microglia‐like (iMG) cells
  36. One month version of Hikikomori Questionnaire‐25 ( HQ‐25M ): Development and initial validation
  37. Personality traits of female vocational school students in Japan with smartphone addiction with comorbid modern type depression traits
  38. Risk factors of hikikomori among office workers during the COVID-19 pandemic: A prospective online survey
  39. Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insufficiency
  40. Machine Learning Algorithm-Based Prediction Model for the Augmented Use of Clozapine with Electroconvulsive Therapy in Patients with Schizophrenia
  41. Low-Density Lipoprotein Cholesterol Is a Possible Blood Biomarker of Schizoid Personality Traits among Females
  42. Network Analysis-Based Disentanglement of the Symptom Heterogeneity in Asian Patients with Schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics
  43. Effects of COVID-19 on Mental Health in Business: Increasing the Hikikomori-Like Workers in Japan
  44. Psychodynamic group psychotherapy for hikikomori: The case of a socially withdrawn male with schizoaffective disorder
  45. Hyperbaric Oxygen Therapy for Carbon Monoxide-Induced Delayed Neuropsychiatric Sequelae: Case Report of Two Cases and Relevant Literature Review
  46. Blood metabolic signatures of hikikomori, pathological social withdrawal
  47. Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder
  48. Autism Spectrum Conditions in Hikikomori: A Pilot Case–Control Study
  49. Forced social isolation due to COVID ‐19 and consequent mental health problems: lessons from hikikomori
  50. Network Analysis of the Depressive Symptom Profiles in Asian Patients with Depressive Disorders: Findings from the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP‐AD)
  51. Improvement Of Frontal Lobe Dysfunction And White Matter Integrity By rTMS In Treatment-Resistant Depression
  52. Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress
  53. Cuprizone-treated mice, a possible model of schizophrenia, highlighting the simultaneous abnormalities of GABA, serine and glycine in hippocampus
  54. Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia
  55. Establishing the cut-off score for aggression on the Brief Psychiatric Rating Scale-Excited Component (BPRS-EC) in schizophrenia patients
  56. Hikikomori: Multidimensional understanding, assessment and future international perspectives
  57. Development and validation of the 22‐item Tarumi's modern‐type depression trait scale; Avoidance of social roles, Complaint and low Self‐esteem (TACS‐22)
  58. Development and validation of the 25-item Hikikomori Questionnaire (HQ-25)
  59. Prevalence rate of Internet addiction among Japanese college students: Two cross-sectional studies and reconsideration of cut-off points of Young's Internet Addiction Test in Japan
  60. Does LINE addiction exist? Potential concerns about Japan's most popular form of social media on smartphones
  61. Harnessing Social Media to Explore Youth Social Withdrawal in Three Major Cities in China: Cross-Sectional Web Survey
  62. Is a Socio-Cultural Analysis of Depressive Disorders a Matter of Concern? Response to Kaiya
  63. Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study
  64. p66Shc Signaling Mediates Diabetes-Related Cognitive Decline
  65. Blood biomarkers of Hikikomori, a severe social withdrawal syndrome
  66. Hikikomori: experience in Japan and international relevance
  67. Development of a 2-h suicide prevention program for medical staff including nurses and medical residents: A two-center pilot trial
  68. Does hikikomori (severe social withdrawal) exist among young people in urban areas of China?
  69. Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia
  70. Early-onset epileptic encephalopathy and severe developmental delay in an association with de novo double mutations in NF1 and MAGEL2
  71. Modern-Type Depression as an “Adjustment” Disorder in Japan
  72. Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study
  73. Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells
  74. Suicidal ideation and burnout among psychiatric trainees in Japan
  75. Harnessing Social Media to Explore Youth Social Withdrawal in Three Major Cities in China: Cross-Sectional Web Survey (Preprint)
  76. Progressive brain atrophy and cognitive decline along with multiple episodes of delirium
  77. Microglia-derived neuregulin expression in psychiatric disorders
  78. Editorial: Minding Glial Cells in the Novel Understandings of Mental Illness
  79. Comparison of treatment patterns in schizophrenia between China and Japan (2001-2009)
  80. Microglial CD206 Gene Has Potential as a State Marker of Bipolar Disorder
  81. Effect of Excessive Coffee Consumption on the Clinical Course of a Patient With Bipolar Disorder
  82. Can Pokémon GO rescue shut-ins (hikikomori) from their isolated world?
  83. Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis
  84. Aripiprazole inhibits polyI:C-induced microglial activation possibly via TRPM7
  85. New game software (Pokémon Go) may help youth with severe social withdrawal, hikikomori
  86. Directly Induced Glial/Neuronal Cells from Human Peripheral Tissues: A Novel Translational Research Tool for Neuropsychiatric Disorders
  87. Internet addiction and self-evaluated attention-deficit hyperactivity disorder traits among Japanese college students
  88. TNF-α from hippocampal microglia induces working memory deficits by acute stress in mice
  89. A 39-Year-Old “Adultolescent”: Understanding Social Withdrawal in Japan
  90. Boundless syndromes in modern society: An interconnected world producing novel psychopathology in the 21st century
  91. Neurocognitive Disorders in Chronic Kidney Disease: A Case Report and Literature Review
  92. Multidimensional anatomy of ‘modern type depression’ in Japan: A proposal for a different diagnostic approach to depression beyond the DSM-5
  93. Effectiveness of suicide prevention gatekeeper-training for university administrative staff in Japan
  94. Abnormal behaviours during pramipexole treatment for Cotard's syndrome: a case report
  95. A patient with Alzheimer's disease complicated by elderly-onset Cushing's syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia
  96. Psychopathology associated with social withdrawal: Idiopathic and comorbid presentations
  97. Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: a novel translational research tool for psychiatric disorders
  98. MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia
  99. Relationship between Trusting Behaviors and Psychometrics Associated with Social Network and Depression among Young Generation: A Pilot Study
  100. Mania occurring during systemic lupus erythematosus relapse and its amelioration on clinical and neuroimaging follow-up
  101. Microglial intracellular Ca2+ signaling as a target of antipsychotic actions for the treatment of schizophrenia
  102. The prevalence and correlates of severe social withdrawal in Hong Kong
  103. Anti-allergic mechanisms of Japanese herbal medicine,yokukansanon mast cells
  104. Identification of the hikikomori syndrome of social withdrawal: Psychosocial features and treatment preferences in four countries
  105. Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease
  106. Brain-derived Neurotrophic Factor (BDNF) Induces Sustained Intracellular Ca2+Elevation through the Up-regulation of Surface Transient Receptor Potential 3 (TRPC3) Channels in Rodent Microglia
  107. Minocycline, a Microglial Inhibitor, Diminishes Terminal Patients' Delirium?
  108. Why medical students choose psychiatry - a 20 country cross-sectional survey
  109. Neurodevelopmental and Neuropsychiatric Disorders
  110. Pretreatment of aripiprazole and minocycline, but not haloperidol, suppresses oligodendrocyte damage from interferon-γ-stimulated microglia in co-culture model
  111. Suicide Intervention Skills Among Japanese Medical Residents
  112. Undergraduate medical students’ attitudes towards psychiatry: An international cross-sectional survey between India and Japan
  113. Emerging devices for epilepsy
  114. Effectiveness of brief suicide management training programme for medical residents in Japan: a cluster randomized controlled trial
  115. Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange
  116. Neuroinflammation in schizophrenia especially focused on the role of microglia
  117. Nationwide Survey of Work Environment, Work-Life Balance and Burnout among Psychiatrists in Japan
  118. Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia
  119. Neuron-Glia Interaction as a Possible Glue to Translate the Mind-Brain Gap: A Novel Multi-Dimensional Approach Toward Psychology and Psychiatry (R1)
  120. Hikikomori as a possible clinical term in psychiatry: a questionnaire survey
  121. Minocycline Modulates Human Social Decision-Making: Possible Impact of Microglia on Personality-Oriented Social Behaviors
  122. Introducing the concept of modern depression in Japan; an international case vignette survey
  123. Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction?
  124. Are Japan's hikikomori and depression in young people spreading abroad?
  125. Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: Implication for antioxidative psychotropic actions via microglia
  126. Does the ‘hikikomori’ syndrome of social withdrawal exist outside Japan? A preliminary international investigation
  127. Anti-Inflammatory Properties of Antipsychotics Via Microglia Modulations: Are Antipsychotics a ‘Fire Extinguisher’ in the Brain of Schizophrenia?
  128. Possible Role of BDNF-Induced Microglial Intracellular Ca2+ Elevation in the Pathophysiology of Neuropsychiatric Disorders
  129. Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium
  130. Successful treatment of chronic urticaria with a Japanese herbal medicine, yokukansan
  131. Impact of biopsychosocial factors on psychiatric training in Japan and overseas: Are psychiatrists oriented to mind, brain, or sociocultural issues?
  132. Development of 2-hour suicide intervention program among medical residents: First pilot trial
  133. Differences in the preferred antipsychotics for acute schizophrenia among young psychiatrists in two regions of Japan
  134. Attitudes of early-career psychiatrists in Japan toward child and adolescent psychiatry and their career decision
  135. Brain-Derived Neurotrophic Factor Induces Sustained Elevation of Intracellular Ca2+ in Rodent Microglia
  136. Cytokines and schizophrenia: Microglia hypothesis of schizophrenia
  137. Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease
  138. Attitude of young psychiatrists toward coercive measures in psychiatry: a case vignette study in Japan
  139. Inhibitory effects of aripiprazole on interferon--induced microglial activation via intracellular Ca2+regulationin vitro
  140. The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-γ
  141. Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide
  142. Risperidone significantly inhibits interferon-γ-induced microglial activation in vitro
  143. Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid β and interferon-γ-induced microglial activation
  144. Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia
  145. Interictal Psychosis After Stroke With Forced Normalization
  146. Different SPECT findings before and after Capgras’ syndrome in interictal psychosis
  147. Laminin and its Related Peptides for the Treatment of Alzheimers Disease