All Stories

  1. Beyond Diagnosis: Transdiagnostic Cognitive Subgroups in Mood Disorders Linked to Work‐Related Disability
  2. Parental bonding and attachment in the hikikomori trajectory
  3. Association between higher cerebrospinal fluid levels of phosphorylated tau and reduced depressive symptoms in patients with cognitive decline
  4. Psychosis induced by invocation presenting as possession state: A case of Kitousei‐Seishinbyo still emerging in modern Japan
  5. Improvement of Game Users’ Depressive Symptoms via Behavioral Activation in a Massive Multiplayer Online Game: Randomized Controlled Trial
  6. Clozapine‐induced slowing in quantitative EEG: Delta–theta amplification and alpha peak shift in TRS patients
  7. Norman Sartorius: A true legend in psychiatry, renowned for inspiring and mentoring early‐career psychiatrists across the globe
  8. Leveraging machine learning to uncover the hidden links between trusting behavior and biological markers
  9. Hikikomori Diagnostic Evaluation‐Screening Form (HiDE‐S): A validation study
  10. Depression, Gaming Disorder, and Internet Addiction in Adolescents with Autism Spectrum Disorder
  11. Predicting social anxiety disorder based on communication logs and social network data from a massively multiplayer online game: Using a graph neural network
  12. Improving social anxiety in lesbian, gay, bisexual, transgender, questioning, intersex and asexual individuals through avatar customization and communication
  13. Human monocyte‐derived microglia‐like (iMG) cells: A tool to explore microglial dynamics
  14. Unexpected risk factors of pathological hikikomori during the COVID‐19 pandemic among working adults initially without social isolation: A longitudinal online survey
  15. Could the Construct of Modern-Type Depression Predict Internet Gaming Disorder in Italian Video Gamers? A Case–Control Study
  16. Youth hikikomori-like social withdrawal in Italy: Two clinical cases
  17. Development of depression assessment tools using humanoid robots -Can tele-operated robots talk with depressive persons like humans?
  18. Heterogeneity of gaming disorder: A clinically-based typology for developing personalized interventions
  19. Hikikomori and gaming disorder tendency: A case‐control online survey for non‐working adults
  20. TRPV4‐mediated Ca2+ deregulation causes mitochondrial dysfunction via the AKT/α‐synuclein pathway in dopaminergic neurons
  21. Analyzing changes in help-seeking from mental and physical health professionals during COVID-19 in Japan
  22. Holiday Internet Usage Time and the Risk of Internet Addiction Tendency among Working Adults in their 30s in Japan
  23. Hikikomori‐Like Social Withdrawal: An Italian Case Report
  24. High‐sensitivity C‐reactive protein and bilirubin as possible biomarkers for hikikomori in depression: a case–control study
  25. Clinical Usefulness of a Short Version of the Internet Addiction Test to Screen for Probable Internet Addiction in Adolescents with Autism Spectrum Disorder
  26. Preliminary analysis of hippocampus synaptic apoptosis and microglial phagocytosis induced by severe restraint stress
  27. A case of bipolar disorder with AIF1 (coding gene of Iba‐1) deletion: a pilot in vitro analysis using blood‐derived microglia‐like (iMG) cells
  28. One month version of Hikikomori Questionnaire‐25 ( HQ‐25M ): Development and initial validation
  29. Personality traits of female vocational school students in Japan with smartphone addiction with comorbid modern type depression traits
  30. Risk factors of hikikomori among office workers during the COVID-19 pandemic: A prospective online survey
  31. Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insufficiency
  32. Machine Learning Algorithm-Based Prediction Model for the Augmented Use of Clozapine with Electroconvulsive Therapy in Patients with Schizophrenia
  33. Low-Density Lipoprotein Cholesterol Is a Possible Blood Biomarker of Schizoid Personality Traits among Females
  34. Network Analysis-Based Disentanglement of the Symptom Heterogeneity in Asian Patients with Schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics
  35. Effects of COVID-19 on Mental Health in Business: Increasing the Hikikomori-Like Workers in Japan
  36. Psychodynamic group psychotherapy for hikikomori: The case of a socially withdrawn male with schizoaffective disorder
  37. Hyperbaric Oxygen Therapy for Carbon Monoxide-Induced Delayed Neuropsychiatric Sequelae: Case Report of Two Cases and Relevant Literature Review
  38. Blood metabolic signatures of hikikomori, pathological social withdrawal
  39. Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder
  40. Autism Spectrum Conditions in Hikikomori: A Pilot Case–Control Study
  41. Forced social isolation due to COVID ‐19 and consequent mental health problems: lessons from hikikomori
  42. Network Analysis of the Depressive Symptom Profiles in Asian Patients with Depressive Disorders: Findings from the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP‐AD)
  43. Improvement Of Frontal Lobe Dysfunction And White Matter Integrity By rTMS In Treatment-Resistant Depression
  44. Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress
  45. Cuprizone-treated mice, a possible model of schizophrenia, highlighting the simultaneous abnormalities of GABA, serine and glycine in hippocampus
  46. Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia
  47. Establishing the cut-off score for aggression on the Brief Psychiatric Rating Scale-Excited Component (BPRS-EC) in schizophrenia patients
  48. Hikikomori: Multidimensional understanding, assessment and future international perspectives
  49. Development and validation of the 22‐item Tarumi's modern‐type depression trait scale; Avoidance of social roles, Complaint and low Self‐esteem (TACS‐22)
  50. Development and validation of the 25-item Hikikomori Questionnaire (HQ-25)
  51. Prevalence rate of Internet addiction among Japanese college students: Two cross-sectional studies and reconsideration of cut-off points of Young's Internet Addiction Test in Japan
  52. Does LINE addiction exist? Potential concerns about Japan's most popular form of social media on smartphones
  53. Harnessing Social Media to Explore Youth Social Withdrawal in Three Major Cities in China: Cross-Sectional Web Survey
  54. Is a Socio-Cultural Analysis of Depressive Disorders a Matter of Concern? Response to Kaiya
  55. Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study
  56. p66Shc Signaling Mediates Diabetes-Related Cognitive Decline
  57. Blood biomarkers of Hikikomori, a severe social withdrawal syndrome
  58. Hikikomori: experience in Japan and international relevance
  59. Development of a 2-h suicide prevention program for medical staff including nurses and medical residents: A two-center pilot trial
  60. Does hikikomori (severe social withdrawal) exist among young people in urban areas of China?
  61. Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia
  62. Early-onset epileptic encephalopathy and severe developmental delay in an association with de novo double mutations in NF1 and MAGEL2
  63. Modern-Type Depression as an “Adjustment” Disorder in Japan
  64. Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study
  65. Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells
  66. Suicidal ideation and burnout among psychiatric trainees in Japan
  67. Harnessing Social Media to Explore Youth Social Withdrawal in Three Major Cities in China: Cross-Sectional Web Survey (Preprint)
  68. Progressive brain atrophy and cognitive decline along with multiple episodes of delirium
  69. Microglia-derived neuregulin expression in psychiatric disorders
  70. Editorial: Minding Glial Cells in the Novel Understandings of Mental Illness
  71. Comparison of treatment patterns in schizophrenia between China and Japan (2001-2009)
  72. Microglial CD206 Gene Has Potential as a State Marker of Bipolar Disorder
  73. Effect of Excessive Coffee Consumption on the Clinical Course of a Patient With Bipolar Disorder
  74. Can Pokémon GO rescue shut-ins (hikikomori) from their isolated world?
  75. Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis
  76. Aripiprazole inhibits polyI:C-induced microglial activation possibly via TRPM7
  77. New game software (Pokémon Go) may help youth with severe social withdrawal, hikikomori
  78. Directly Induced Glial/Neuronal Cells from Human Peripheral Tissues: A Novel Translational Research Tool for Neuropsychiatric Disorders
  79. Internet addiction and self-evaluated attention-deficit hyperactivity disorder traits among Japanese college students
  80. TNF-α from hippocampal microglia induces working memory deficits by acute stress in mice
  81. A 39-Year-Old “Adultolescent”: Understanding Social Withdrawal in Japan
  82. Boundless syndromes in modern society: An interconnected world producing novel psychopathology in the 21st century
  83. Neurocognitive Disorders in Chronic Kidney Disease: A Case Report and Literature Review
  84. Multidimensional anatomy of ‘modern type depression’ in Japan: A proposal for a different diagnostic approach to depression beyond the DSM-5
  85. Effectiveness of suicide prevention gatekeeper-training for university administrative staff in Japan
  86. Abnormal behaviours during pramipexole treatment for Cotard's syndrome: a case report
  87. A patient with Alzheimer's disease complicated by elderly-onset Cushing's syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia
  88. Psychopathology associated with social withdrawal: Idiopathic and comorbid presentations
  89. Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: a novel translational research tool for psychiatric disorders
  90. MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia
  91. Relationship between Trusting Behaviors and Psychometrics Associated with Social Network and Depression among Young Generation: A Pilot Study
  92. Mania occurring during systemic lupus erythematosus relapse and its amelioration on clinical and neuroimaging follow-up
  93. Microglial intracellular Ca2+ signaling as a target of antipsychotic actions for the treatment of schizophrenia
  94. The prevalence and correlates of severe social withdrawal in Hong Kong
  95. Anti-allergic mechanisms of Japanese herbal medicine,yokukansanon mast cells
  96. Identification of the hikikomori syndrome of social withdrawal: Psychosocial features and treatment preferences in four countries
  97. Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease
  98. Brain-derived Neurotrophic Factor (BDNF) Induces Sustained Intracellular Ca2+Elevation through the Up-regulation of Surface Transient Receptor Potential 3 (TRPC3) Channels in Rodent Microglia
  99. Minocycline, a Microglial Inhibitor, Diminishes Terminal Patients' Delirium?
  100. Why medical students choose psychiatry - a 20 country cross-sectional survey
  101. Neurodevelopmental and Neuropsychiatric Disorders
  102. Pretreatment of aripiprazole and minocycline, but not haloperidol, suppresses oligodendrocyte damage from interferon-γ-stimulated microglia in co-culture model
  103. Suicide Intervention Skills Among Japanese Medical Residents
  104. Undergraduate medical students’ attitudes towards psychiatry: An international cross-sectional survey between India and Japan
  105. Emerging devices for epilepsy
  106. Effectiveness of brief suicide management training programme for medical residents in Japan: a cluster randomized controlled trial
  107. Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange
  108. Neuroinflammation in schizophrenia especially focused on the role of microglia
  109. Nationwide Survey of Work Environment, Work-Life Balance and Burnout among Psychiatrists in Japan
  110. Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia
  111. Neuron-Glia Interaction as a Possible Glue to Translate the Mind-Brain Gap: A Novel Multi-Dimensional Approach Toward Psychology and Psychiatry (R1)
  112. Hikikomori as a possible clinical term in psychiatry: a questionnaire survey
  113. Minocycline Modulates Human Social Decision-Making: Possible Impact of Microglia on Personality-Oriented Social Behaviors
  114. Introducing the concept of modern depression in Japan; an international case vignette survey
  115. Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction?
  116. Are Japan's hikikomori and depression in young people spreading abroad?
  117. Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: Implication for antioxidative psychotropic actions via microglia
  118. Does the ‘hikikomori’ syndrome of social withdrawal exist outside Japan? A preliminary international investigation
  119. Anti-Inflammatory Properties of Antipsychotics Via Microglia Modulations: Are Antipsychotics a ‘Fire Extinguisher’ in the Brain of Schizophrenia?
  120. Possible Role of BDNF-Induced Microglial Intracellular Ca2+ Elevation in the Pathophysiology of Neuropsychiatric Disorders
  121. Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium
  122. Successful treatment of chronic urticaria with a Japanese herbal medicine, yokukansan
  123. Impact of biopsychosocial factors on psychiatric training in Japan and overseas: Are psychiatrists oriented to mind, brain, or sociocultural issues?
  124. Development of 2-hour suicide intervention program among medical residents: First pilot trial
  125. Differences in the preferred antipsychotics for acute schizophrenia among young psychiatrists in two regions of Japan
  126. Attitudes of early-career psychiatrists in Japan toward child and adolescent psychiatry and their career decision
  127. Brain-Derived Neurotrophic Factor Induces Sustained Elevation of Intracellular Ca2+ in Rodent Microglia
  128. Cytokines and schizophrenia: Microglia hypothesis of schizophrenia
  129. Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease
  130. Attitude of young psychiatrists toward coercive measures in psychiatry: a case vignette study in Japan
  131. Inhibitory effects of aripiprazole on interferon--induced microglial activation via intracellular Ca2+regulationin vitro
  132. The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-γ
  133. Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide
  134. Risperidone significantly inhibits interferon-γ-induced microglial activation in vitro
  135. Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid β and interferon-γ-induced microglial activation
  136. Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia
  137. Interictal Psychosis After Stroke With Forced Normalization
  138. Different SPECT findings before and after Capgras’ syndrome in interictal psychosis
  139. Laminin and its Related Peptides for the Treatment of Alzheimers Disease