All Stories

  1. Transcriptomic signatures associated with mania-to-depression and depression-to-mania transitions in bipolar disorder: a case report using induced microglia-like (iMG) cells
  2. Examining the Causal Relationship Between Hikikomori and Psychological Features of New-Type Depression: A Longitudinal Study on Male Individuals With Hikikomori Condition
  3. Mind the gap: quantifying population–individual gap in depressive symptom dynamics through energy landscapes
  4. CAT‐Hokkaido: A tablet‐based assessment of cognitive impairment in schizophrenia
  5. Beyond Diagnosis: Transdiagnostic Cognitive Subgroups in Mood Disorders Linked to Work‐Related Disability
  6. Parental bonding and attachment in the hikikomori trajectory
  7. Association between higher cerebrospinal fluid levels of phosphorylated tau and reduced depressive symptoms in patients with cognitive decline
  8. Psychosis induced by invocation presenting as possession state: A case of Kitousei‐Seishinbyo still emerging in modern Japan
  9. Improvement of Game Users’ Depressive Symptoms via Behavioral Activation in a Massive Multiplayer Online Game: Randomized Controlled Trial
  10. Clozapine‐induced slowing in quantitative EEG: Delta–theta amplification and alpha peak shift in TRS patients
  11. Norman Sartorius: A true legend in psychiatry, renowned for inspiring and mentoring early‐career psychiatrists across the globe
  12. Leveraging machine learning to uncover the hidden links between trusting behavior and biological markers
  13. Hikikomori Diagnostic Evaluation‐Screening Form (HiDE‐S): A validation study
  14. Depression, Gaming Disorder, and Internet Addiction in Adolescents with Autism Spectrum Disorder
  15. Predicting social anxiety disorder based on communication logs and social network data from a massively multiplayer online game: Using a graph neural network
  16. Improving social anxiety in lesbian, gay, bisexual, transgender, questioning, intersex and asexual individuals through avatar customization and communication
  17. Human monocyte‐derived microglia‐like (iMG) cells: A tool to explore microglial dynamics
  18. Unexpected risk factors of pathological hikikomori during the COVID‐19 pandemic among working adults initially without social isolation: A longitudinal online survey
  19. Could the Construct of Modern-Type Depression Predict Internet Gaming Disorder in Italian Video Gamers? A Case–Control Study
  20. Youth hikikomori-like social withdrawal in Italy: Two clinical cases
  21. Development of depression assessment tools using humanoid robots -Can tele-operated robots talk with depressive persons like humans?
  22. Heterogeneity of gaming disorder: A clinically-based typology for developing personalized interventions
  23. Hikikomori and gaming disorder tendency: A case‐control online survey for non‐working adults
  24. TRPV4‐mediated Ca2+ deregulation causes mitochondrial dysfunction via the AKT/α‐synuclein pathway in dopaminergic neurons
  25. Analyzing changes in help-seeking from mental and physical health professionals during COVID-19 in Japan
  26. Holiday Internet Usage Time and the Risk of Internet Addiction Tendency among Working Adults in their 30s in Japan
  27. Hikikomori‐Like Social Withdrawal: An Italian Case Report
  28. High‐sensitivity C‐reactive protein and bilirubin as possible biomarkers for hikikomori in depression: a case–control study
  29. Clinical Usefulness of a Short Version of the Internet Addiction Test to Screen for Probable Internet Addiction in Adolescents with Autism Spectrum Disorder
  30. Preliminary analysis of hippocampus synaptic apoptosis and microglial phagocytosis induced by severe restraint stress
  31. A case of bipolar disorder with AIF1 (coding gene of Iba‐1) deletion: a pilot in vitro analysis using blood‐derived microglia‐like (iMG) cells
  32. One month version of Hikikomori Questionnaire‐25 ( HQ‐25M ): Development and initial validation
  33. Personality traits of female vocational school students in Japan with smartphone addiction with comorbid modern type depression traits
  34. Risk factors of hikikomori among office workers during the COVID-19 pandemic: A prospective online survey
  35. Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insufficiency
  36. Machine Learning Algorithm-Based Prediction Model for the Augmented Use of Clozapine with Electroconvulsive Therapy in Patients with Schizophrenia
  37. Low-Density Lipoprotein Cholesterol Is a Possible Blood Biomarker of Schizoid Personality Traits among Females
  38. Network Analysis-Based Disentanglement of the Symptom Heterogeneity in Asian Patients with Schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics
  39. Effects of COVID-19 on Mental Health in Business: Increasing the Hikikomori-Like Workers in Japan
  40. Psychodynamic group psychotherapy for hikikomori: The case of a socially withdrawn male with schizoaffective disorder
  41. Hyperbaric Oxygen Therapy for Carbon Monoxide-Induced Delayed Neuropsychiatric Sequelae: Case Report of Two Cases and Relevant Literature Review
  42. Blood metabolic signatures of hikikomori, pathological social withdrawal
  43. Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder
  44. Autism Spectrum Conditions in Hikikomori: A Pilot Case–Control Study
  45. Forced social isolation due to COVID ‐19 and consequent mental health problems: lessons from hikikomori
  46. Network Analysis of the Depressive Symptom Profiles in Asian Patients with Depressive Disorders: Findings from the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP‐AD)
  47. Improvement Of Frontal Lobe Dysfunction And White Matter Integrity By rTMS In Treatment-Resistant Depression
  48. Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress
  49. Cuprizone-treated mice, a possible model of schizophrenia, highlighting the simultaneous abnormalities of GABA, serine and glycine in hippocampus
  50. Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia
  51. Establishing the cut-off score for aggression on the Brief Psychiatric Rating Scale-Excited Component (BPRS-EC) in schizophrenia patients
  52. Hikikomori: Multidimensional understanding, assessment and future international perspectives
  53. Development and validation of the 22‐item Tarumi's modern‐type depression trait scale; Avoidance of social roles, Complaint and low Self‐esteem (TACS‐22)
  54. Development and validation of the 25-item Hikikomori Questionnaire (HQ-25)
  55. Prevalence rate of Internet addiction among Japanese college students: Two cross-sectional studies and reconsideration of cut-off points of Young's Internet Addiction Test in Japan
  56. Does LINE addiction exist? Potential concerns about Japan's most popular form of social media on smartphones
  57. Harnessing Social Media to Explore Youth Social Withdrawal in Three Major Cities in China: Cross-Sectional Web Survey
  58. Is a Socio-Cultural Analysis of Depressive Disorders a Matter of Concern? Response to Kaiya
  59. Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study
  60. p66Shc Signaling Mediates Diabetes-Related Cognitive Decline
  61. Blood biomarkers of Hikikomori, a severe social withdrawal syndrome
  62. Hikikomori: experience in Japan and international relevance
  63. Development of a 2-h suicide prevention program for medical staff including nurses and medical residents: A two-center pilot trial
  64. Does hikikomori (severe social withdrawal) exist among young people in urban areas of China?
  65. Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia
  66. Early-onset epileptic encephalopathy and severe developmental delay in an association with de novo double mutations in NF1 and MAGEL2
  67. Modern-Type Depression as an “Adjustment” Disorder in Japan
  68. Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study
  69. Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells
  70. Suicidal ideation and burnout among psychiatric trainees in Japan
  71. Harnessing Social Media to Explore Youth Social Withdrawal in Three Major Cities in China: Cross-Sectional Web Survey (Preprint)
  72. Progressive brain atrophy and cognitive decline along with multiple episodes of delirium
  73. Microglia-derived neuregulin expression in psychiatric disorders
  74. Editorial: Minding Glial Cells in the Novel Understandings of Mental Illness
  75. Comparison of treatment patterns in schizophrenia between China and Japan (2001-2009)
  76. Microglial CD206 Gene Has Potential as a State Marker of Bipolar Disorder
  77. Effect of Excessive Coffee Consumption on the Clinical Course of a Patient With Bipolar Disorder
  78. Can Pokémon GO rescue shut-ins (hikikomori) from their isolated world?
  79. Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis
  80. Aripiprazole inhibits polyI:C-induced microglial activation possibly via TRPM7
  81. New game software (Pokémon Go) may help youth with severe social withdrawal, hikikomori
  82. Directly Induced Glial/Neuronal Cells from Human Peripheral Tissues: A Novel Translational Research Tool for Neuropsychiatric Disorders
  83. Internet addiction and self-evaluated attention-deficit hyperactivity disorder traits among Japanese college students
  84. TNF-α from hippocampal microglia induces working memory deficits by acute stress in mice
  85. A 39-Year-Old “Adultolescent”: Understanding Social Withdrawal in Japan
  86. Boundless syndromes in modern society: An interconnected world producing novel psychopathology in the 21st century
  87. Neurocognitive Disorders in Chronic Kidney Disease: A Case Report and Literature Review
  88. Multidimensional anatomy of ‘modern type depression’ in Japan: A proposal for a different diagnostic approach to depression beyond the DSM-5
  89. Effectiveness of suicide prevention gatekeeper-training for university administrative staff in Japan
  90. Abnormal behaviours during pramipexole treatment for Cotard's syndrome: a case report
  91. A patient with Alzheimer's disease complicated by elderly-onset Cushing's syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia
  92. Psychopathology associated with social withdrawal: Idiopathic and comorbid presentations
  93. Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: a novel translational research tool for psychiatric disorders
  94. MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia
  95. Relationship between Trusting Behaviors and Psychometrics Associated with Social Network and Depression among Young Generation: A Pilot Study
  96. Mania occurring during systemic lupus erythematosus relapse and its amelioration on clinical and neuroimaging follow-up
  97. Microglial intracellular Ca2+ signaling as a target of antipsychotic actions for the treatment of schizophrenia
  98. The prevalence and correlates of severe social withdrawal in Hong Kong
  99. Anti-allergic mechanisms of Japanese herbal medicine,yokukansanon mast cells
  100. Identification of the hikikomori syndrome of social withdrawal: Psychosocial features and treatment preferences in four countries
  101. Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease
  102. Brain-derived Neurotrophic Factor (BDNF) Induces Sustained Intracellular Ca2+Elevation through the Up-regulation of Surface Transient Receptor Potential 3 (TRPC3) Channels in Rodent Microglia
  103. Minocycline, a Microglial Inhibitor, Diminishes Terminal Patients' Delirium?
  104. Why medical students choose psychiatry - a 20 country cross-sectional survey
  105. Neurodevelopmental and Neuropsychiatric Disorders
  106. Pretreatment of aripiprazole and minocycline, but not haloperidol, suppresses oligodendrocyte damage from interferon-γ-stimulated microglia in co-culture model
  107. Suicide Intervention Skills Among Japanese Medical Residents
  108. Undergraduate medical students’ attitudes towards psychiatry: An international cross-sectional survey between India and Japan
  109. Emerging devices for epilepsy
  110. Effectiveness of brief suicide management training programme for medical residents in Japan: a cluster randomized controlled trial
  111. Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange
  112. Neuroinflammation in schizophrenia especially focused on the role of microglia
  113. Nationwide Survey of Work Environment, Work-Life Balance and Burnout among Psychiatrists in Japan
  114. Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia
  115. Neuron-Glia Interaction as a Possible Glue to Translate the Mind-Brain Gap: A Novel Multi-Dimensional Approach Toward Psychology and Psychiatry (R1)
  116. Hikikomori as a possible clinical term in psychiatry: a questionnaire survey
  117. Minocycline Modulates Human Social Decision-Making: Possible Impact of Microglia on Personality-Oriented Social Behaviors
  118. Introducing the concept of modern depression in Japan; an international case vignette survey
  119. Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction?
  120. Are Japan's hikikomori and depression in young people spreading abroad?
  121. Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: Implication for antioxidative psychotropic actions via microglia
  122. Does the ‘hikikomori’ syndrome of social withdrawal exist outside Japan? A preliminary international investigation
  123. Anti-Inflammatory Properties of Antipsychotics Via Microglia Modulations: Are Antipsychotics a ‘Fire Extinguisher’ in the Brain of Schizophrenia?
  124. Possible Role of BDNF-Induced Microglial Intracellular Ca2+ Elevation in the Pathophysiology of Neuropsychiatric Disorders
  125. Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium
  126. Successful treatment of chronic urticaria with a Japanese herbal medicine, yokukansan
  127. Impact of biopsychosocial factors on psychiatric training in Japan and overseas: Are psychiatrists oriented to mind, brain, or sociocultural issues?
  128. Development of 2-hour suicide intervention program among medical residents: First pilot trial
  129. Differences in the preferred antipsychotics for acute schizophrenia among young psychiatrists in two regions of Japan
  130. Attitudes of early-career psychiatrists in Japan toward child and adolescent psychiatry and their career decision
  131. Brain-Derived Neurotrophic Factor Induces Sustained Elevation of Intracellular Ca2+ in Rodent Microglia
  132. Cytokines and schizophrenia: Microglia hypothesis of schizophrenia
  133. Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease
  134. Attitude of young psychiatrists toward coercive measures in psychiatry: a case vignette study in Japan
  135. Inhibitory effects of aripiprazole on interferon--induced microglial activation via intracellular Ca2+regulationin vitro
  136. The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-γ
  137. Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide
  138. Risperidone significantly inhibits interferon-γ-induced microglial activation in vitro
  139. Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid β and interferon-γ-induced microglial activation
  140. Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia
  141. Interictal Psychosis After Stroke With Forced Normalization
  142. Different SPECT findings before and after Capgras’ syndrome in interictal psychosis
  143. Laminin and its Related Peptides for the Treatment of Alzheimers Disease