All Stories

  1. Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitis

    Article • Mucosal Immunology, April 2023, Elsevier

    Susanna Zierler

  2. TRPM7 kinase is required for insulin production and compensatory islet responses during obesity

    Article • JCI Insight, February 2023, American Society for Clinical Investigation

    Susanna Zierler

  3. Inactivation of TRPM7 kinase targets AKT signaling and cyclooxygenase-2 expression in human CML cells

    Article • January 2023, Springer Science + Business Media

    Susanna Zierler

  4. Inactivation of TRPM7 Kinase Targets AKT Signaling and Cyclooxygenase-2 Expression in Human CML Cells

    Article • Function, January 2023, Oxford University Press (OUP)

    Susanna Zierler

  5. TPC Functions in the Immune System

    Article • January 2023, Springer Science + Business Media

    Susanna Zierler

  6. Ion Channels and Transporters in Immunity—Where do We Stand?

    Article • Function, December 2022, Oxford University Press (OUP)

    Susanna Zierler

  7. Engulf and digest – TRPM7 as key regulator of macrophage phagosome maturation

    Article • Cell Calcium, September 2022, Elsevier

    Susanna Zierler

  8. Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7

    Article • Cell Calcium, September 2022, Elsevier

    Susanna Zierler

  9. TRPM7 restrains plasmin activity and promotes transforming growth factor-β1 signaling in primary human lung fibroblasts

    Article • Archives of Toxicology, July 2022, Springer Science + Business Media

    Susanna Zierler

  10. Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection

    Article • Journal of Clinical Investigation, July 2022, American Society for Clinical Investigation

    Susanna Zierler

  11. Two-Pore Channels Regulate Inter-Organellar Ca2+ Homeostasis in Immune Cells

    Article • Cells, April 2022, MDPI AG

    Susanna Zierler

  12. Structural mechanism of TRPM7 channel regulation by intracellular magnesium

    Article • Cellular and Molecular Life Sciences, April 2022, Springer Science + Business Media

    Susanna Zierler

  13. Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system – no evidence for a role of neuronal P2X7 receptors in colitis

    Article • February 2022, Cold Spring Harbor Laboratory Press

    Susanna Zierler

  14. Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice

    Article • Nature Communications, January 2022, Springer Science + Business Media

    Susanna Zierler

  15. The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics

    Article • eLife, November 2021, eLife

    Susanna Zierler

  16. The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation

    Article • Cardiovascular Research, April 2021, Oxford University Press (OUP)

    Susanna Zierler

  17. Editorial: TRP Channels in Inflammation and Immunity

    Article • Frontiers in Immunology, April 2021, Frontiers

    Susanna Zierler

  18. TRPM7 Kinase Is Essential for Neutrophil Recruitment and Function via Regulation of Akt/mTOR Signaling

    Article • Frontiers in Immunology, February 2021, Frontiers

    Susanna Zierler

  19. TRP Channels in Inflammation and Immunity

    Article • January 2021, Frontiers

    Susanna Zierler

  20. TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity

    Article • Proceedings of the National Academy of Sciences, July 2020, Proceedings of the National Academy of Sciences

    Susanna Zierler

  21. Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

    Article • eLife, March 2020, eLife

    Susanna Zierler

  22. Inhibition of TRPM7 blocks MRTF/SRF-dependent transcriptional and tumorigenic activity

    Article • Oncogene, December 2019, Springer Science + Business Media

    Susanna Zierler

  23. The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis

    Article • Cells, August 2018, MDPI AG

    Susanna Zierler

  24. The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis

    Article • July 2018, MDPI AG

    Susanna Zierler

  25. TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice

    Article • Arteriosclerosis Thrombosis and Vascular Biology, February 2018, Wolters Kluwer Health

    Susanna Zierler , Dr Peter J Noy

  26. TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut

    Article • Nature Communications, December 2017, Springer Science + Business Media

    Susanna Zierler

  27. TRPM channels as potential therapeutic targets against pro-inflammatory diseases

    Article • Cell Calcium, November 2017, Elsevier

    Susanna Zierler

  28. TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP

    Article • Scientific Reports, August 2017, Springer Science + Business Media

    Susanna Zierler

  29. Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

    Article • eLife, December 2016, eLife

    Susanna Zierler

  30. Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture

    Article • Nature Communications, March 2016, Springer Science + Business Media

    Susanna Zierler

  31. TRPM7 kinase activity regulates murine mast cell degranulation

    Article • The Journal of Physiology, January 2016, Wiley

    Susanna Zierler

  32. Mibefradil represents a new class of benzimidazole TRPM7 channel agonists

    Article • Pflügers Archiv - European Journal of Physiology, December 2015, Springer Science + Business Media

    Susanna Zierler

  33. The IP3R Binding Protein Released With Inositol 1,4,5-Trisphosphate Is Expressed in Rodent Reproductive Tissue and Spermatozoa

    Article • Journal of Cellular Physiology, November 2015, Wiley

    Susanna Zierler

  34. NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa

    Article • Molecular Biology of the Cell, March 2014, American Society for Cell Biology (ASCB)

    Susanna Zierler

  35. Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade

    Article • Leukemia, January 2014, Springer Science + Business Media

    Susanna Zierler

  36. Human Sensory Neuron-specific Mas-related G Protein-coupled Receptors-X1 Sensitize and Directly Activate Transient Receptor Potential Cation Channel V1 via Distinct Signaling Pathways

    Article • Journal of Biological Chemistry, October 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Susanna Zierler

  37. Waixenicin A Inhibits Cell Proliferation through Magnesium-dependent Block of Transient Receptor Potential Melastatin 7 (TRPM7) Channels

    Article • Journal of Biological Chemistry, September 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Susanna Zierler

  38. A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating

    Article • Journal of General Physiology, November 2010, Rockefeller University Press

    Susanna Zierler

  39. TRPM7 is essential for Mg2+ homeostasis in mammals

    Article • Nature Communications, November 2010, Springer Science + Business Media

    Susanna Zierler

  40. Heterogeneous effects of distinct tocopherol analogues on NO release, cell volume, and cell death in microglial cells

    Article • Journal of Neuroscience Research, December 2008, Wiley

    Susanna Zierler

  41. Chloride Influx Provokes Lamellipodium Formation in Microglial Cells

    Article • Cellular Physiology and Biochemistry, January 2008, Karger Publishers

    Susanna Zierler

  42. Blockade of chloride channels suppresses engulfment of microspheres in the microglial cell line, BV-2

    Article • Brain Research, December 2007, Elsevier

    Susanna Zierler

  43. cAMP mediates ammonia-induced programmed cell death in the microglial cell line BV-2

    Article • European Journal of Neuroscience, April 2007, Wiley

    Susanna Zierler

  44. An artificial three-dimensional matrix promotes ramification in the microglial cell-line, BV-2

    Article • Neuroscience Letters, December 2006, Elsevier

    Susanna Zierler

  45. Ultraviolet irradiation-induced apoptosis does not trigger nuclear fragmentation but translocation of chromatin from nucleus into cytoplasm in the microglial cell-line, BV-2

    Article • Brain Research, November 2006, Elsevier

    Susanna Zierler

  46. Blockade of chloride conductance antagonizes PMA-induced ramification in the murine microglial cell line, BV-2

    Article • Brain Research, March 2005, Elsevier

    Susanna Zierler