All Stories

  1. A unified analysis of evolutionary and population constraint in protein domains highlights structural features and pathogenic sites

    Article • Communications Biology, April 2024, Springer Science + Business Media

    Dr Stuart MacGowan

  2. Classification of likely functional class for ligand binding sites identified from fragment screening

    Article • Communications Biology, March 2024, Springer Science + Business Media

    Dr Stuart MacGowan

  3. Classification of likely functional state for ligand binding sites identified from fragment screening

    Article • July 2023, Research Square

    Dr Stuart MacGowan

  4. A unified approach to evolutionary conservation and population constraint in protein domains highlights structural features and pathogenic sites

    Article • July 2023, Research Square

    Dr Stuart MacGowan

  5. Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues

    Article • Journal of Medicinal Chemistry, June 2023, American Chemical Society (ACS)

    Dr Stuart MacGowan

  6. How Genetic Variations in ACE2 Could Affect COVID-19 Risk and Spread

    Article • PLoS Computational Biology, March 2022, PLOS

    Professor Geoff Barton, Dr Stuart MacGowan

  7. Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

    Article • eLife, August 2021, eLife

    Dr Stuart MacGowan

  8. Ankyrin repeats in context with human population variation

    Article • PLoS Computational Biology, August 2021, PLOS

    Professor Geoff Barton, Dr Stuart MacGowan

  9. Ankyrin repeats in context with human population variation

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Dr Stuart MacGowan

  10. Missense variants in human ACE2 modify binding to SARS-CoV-2 Spike

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Dr Stuart MacGowan

  11. Effects of common mutations in the SARS-CoV-2 Spike RBD domain and its ligand the human ACE2 receptor on binding affinity and kinetics

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Dr Stuart MacGowan

  12. Missense variants in ACE2 are predicted to encourage and inhibit interaction with SARS-CoV-2 Spike and contribute to genetic risk in COVID-19

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr Stuart MacGowan

  13. Disease related single point mutations alter the global dynamics of a tetratricopeptide (TPR) α-solenoid domain

    Article • Journal of Structural Biology, January 2020, Elsevier

    Dr Stuart MacGowan

  14. The Dundee Resource for Sequence Analysis and Structure Prediction

    Article • Protein Science, November 2019, Wiley

    Dr Stuart MacGowan

  15. PDBe-KB: a community-driven resource for structural and functional annotations

    Article • Nucleic Acids Research, October 2019, Oxford University Press (OUP)

    Dr Stuart MacGowan

  16. Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies

    Article • Human Molecular Genetics, January 2018, Oxford University Press (OUP)

    Mr Kristian Almstrup, Dr Stuart MacGowan

  17. Human Missense Variation is Constrained by Domain Structure and Highlights Functional and Pathogenic Residues

    Article • April 2017, Cold Spring Harbor Laboratory Press

    Professor Geoff Barton, Dr Stuart MacGowan

  18. Bacteriochlorophylls in the FMO Protein

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, April 2016, Elsevier

    Professor Mathias O. Senge, Dr Stuart MacGowan

  19. ChemInform Abstract: Conformational Control of Cofactors in Nature - The Influence of Protein-Induced Macrocycle Distortion on the Biological Function of Tetrapyrroles

    Article • ChemInform, January 2016, Wiley

    Professor Mathias O. Senge, Dr Stuart MacGowan

  20. Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin

    Article • Journal of Allergy and Clinical Immunology, November 2015, Elsevier

    Dr Stuart MacGowan

  21. Expanding the clinical spectrum of hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis due to FAM111B mutations

    Article • Orphanet Journal of Rare Diseases, October 2015, Springer Science + Business Media

    Dr Stuart MacGowan

  22. Molecular fine-tuning of protein cofactors

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Professor Mathias O. Senge, Dr Stuart MacGowan

  23. chlorophyll

    Article • Symmetry, September 2014, MDPI AG

    Professor Mathias O. Senge, Dr Stuart MacGowan

  24. Computational Quantification of the Physicochemical Effects of Heme Distortion: Redox Control in the Reaction Center Cytochrome Subunit of Blastochloris viridis

    Article • Inorganic Chemistry, January 2013, American Chemical Society (ACS)

    Professor Mathias O. Senge, Dr Stuart MacGowan

  25. 61 The Structural Chemistry of Isolated Chlorophylls

    Article • February 2011, World Scientific Pub Co Pte Lt

    Professor Mathias O. Senge, Dr Stuart MacGowan

  26. Fine-tuning of chlorophylls in photosynthesis

    Article • Chemical Communications, January 2011, Royal Society of Chemistry

    Professor Mathias O. Senge, Dr Stuart MacGowan