All Stories

  1. A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products

    Article • Proceedings of the National Academy of Sciences, February 2023, Proceedings of the National Academy of Sciences

    Professor Steven G Van Lanen

  2. Enzymatic strategies and biocatalysts for amide bond formation: tricks of the trade outside of the ribosome

    Article • Molecular BioSystems, January 2015, Royal Society of Chemistry

    Professor Steven G Van Lanen

  3. Facile Chemoenzymatic Strategies for the Synthesis and Utilization ofS-Adenosyl-L-Methionine Analogues

    Article • Angewandte Chemie, March 2014, Wiley

    Professor Steven G Van Lanen

  4. Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

    Article • Journal of Industrial Microbiology & Biotechnology, December 2013, Springer Science + Business Media

    Professor Steven G Van Lanen

  5. Structure-Based Gene Targeting Discovery of Sphaerimicin, a Bacterial Translocase I Inhibitor

    Article • Angewandte Chemie, September 2013, Wiley

    Professor Steven G Van Lanen

  6. Structure-Based Gene Targeting Discovery of Sphaerimicin, a Bacterial Translocase I Inhibitor

    Article • Angewandte Chemie International Edition, September 2013, Wiley

    Professor Steven G Van Lanen

  7. A sulfonate relay revealed

    Article • Nature Chemical Biology, August 2013, Springer Science + Business Media

    Professor Steven G Van Lanen

  8. The muraminomicin biosynthetic gene cluster and enzymatic formation of the 2-deoxyaminoribosyl appendage

    Article • MedChemComm, January 2013, Royal Society of Chemistry

    Professor Steven G Van Lanen

  9. Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis: Discovery of an l -Threonine:Uridine-5′-Aldehyde Transaldolase

    Article • Journal of the American Chemical Society, November 2012, American Chemical Society (ACS)

    Professor Steven G Van Lanen

  10. Biosynthesis of Albomycin δ 2 Provides a Template for Assembling Siderophore and Aminoacyl-tRNA Synthetase Inhibitor Conjugates

    Article • ACS Chemical Biology, September 2012, American Chemical Society (ACS)

    Professor Steven G Van Lanen, Shawn Chen

  11. Zusammenwirken zweier difunktionaler Enzyme bei Aufbau und Verknüpfung von Desoxyzuckern des Antitumor-Antibiotikums Mithramycin

    Article • Angewandte Chemie, September 2012, Wiley

    Professor Steven G Van Lanen

  12. Cooperation of Two Bifunctional Enzymes in the Biosynthesis and Attachment of Deoxysugars of the Antitumor Antibiotic Mithramycin

    Article • Angewandte Chemie International Edition, September 2012, Wiley

    Professor Steven G Van Lanen

  13. Roles of the Synergistic Reductive O -Methyltransferase GilM and of O -Methyltransferase GilMT in the Gilvocarcin Biosynthetic Pathway

    Article • Journal of the American Chemical Society, August 2012, American Chemical Society (ACS)

    Professor Steven G Van Lanen

  14. Fe(II)-Dependent, Uridine-5′-Monophosphate α-Ketoglutarate Dioxygenases in the Synthesis of 5′-Modified Nucleosides

    Article • January 2012, Elsevier

    Professor Steven G Van Lanen

  15. Enzymatic Total Synthesis of Defucogilvocarcin M and Its Implications for Gilvocarcin Biosynthesis

    Article • Angewandte Chemie International Edition, December 2011, Wiley

    Professor Steven G Van Lanen

  16. Enzymatic Total Synthesis of Defucogilvocarcin M and Its Implications for Gilvocarcin Biosynthesis

    Article • Angewandte Chemie, December 2011, Wiley

    Professor Steven G Van Lanen

  17. Combinatorial Biosynthesis of Anticancer Natural Products

    Article • October 2011, Taylor & Francis

    Professor Steven G Van Lanen

  18. Biosynthetic Origin and Mechanism of Formation of the Aminoribosyl Moiety of Peptidyl Nucleoside Antibiotics

    Article • Journal of the American Chemical Society, September 2011, American Chemical Society (ACS)

    Professor Steven G Van Lanen

  19. Characterization of a dual specificity aryl acid adenylation enzyme with dual function in nikkomycin biosynthesis

    Article • Biopolymers, June 2010, Wiley

    Professor Steven G Van Lanen

  20. An ATP-independent strategy for amide bond formation in antibiotic biosynthesis

    Article • Nature Chemical Biology, June 2010, Springer Science + Business Media

    Professor Steven G Van Lanen

  21. Delineating the earliest steps of gilvocarcin biosynthesis: role of GilP and GilQ in starter unit specificity

    Article • Organic & Biomolecular Chemistry, January 2010, Royal Society of Chemistry

    Professor Steven G Van Lanen

  22. The Biosynthesis of Liposidomycin-like A-90289 Antibiotics Featuring a New Type of Sulfotransferase

    Article • ChemBioChem, December 2009, Wiley

    Professor Steven G Van Lanen

  23. Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027

    Article • FEMS Microbiology Letters, November 2009, Oxford University Press (OUP)

    Professor Steven G Van Lanen

  24. Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196

    Article • The Journal of Antibiotics, May 2009, Springer Science + Business Media

    Professor Steven G Van Lanen

  25. chapter 5 Iterative Type I Polyketide Synthases for Enediyne Core Biosynthesis

    Article • January 2009, Elsevier

    Professor Steven G Van Lanen

  26. Characterization of the Two-Component, FAD-Dependent Monooxygenase SgcC That Requires Carrier Protein-Tethered Substrates for the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027

    Article • Journal of the American Chemical Society, May 2008, American Chemical Society (ACS)

    Professor Steven G Van Lanen

  27. The Role of Tandem Acyl Carrier Protein Domains in Polyunsaturated Fatty Acid Biosynthesis

    Article • Journal of the American Chemical Society, May 2008, American Chemical Society (ACS)

    Professor Steven G Van Lanen

  28. Biosynthesis of Enediyne Antitumor Antibiotics

    Article • Current Topics in Medicinal Chemistry, April 2008, Bentham Science Publishers

    Professor Steven G Van Lanen

  29. Mechanistic Studies of Bacillus subtilis QueF, the Nitrile Oxidoreductase Involved in Queuosine Biosynthesis †

    Article • Biochemistry, November 2007, American Chemical Society (ACS)

    Professor Steven G Van Lanen

  30. Regiospecific Chlorination of ( S )-β-Tyrosyl- S -Carrier Protein Catalyzed by SgcC3 in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027

    Article • Journal of the American Chemical Society, October 2007, American Chemical Society (ACS)

    Professor Steven G Van Lanen

  31. Characterization of the Maduropeptin Biosynthetic Gene Cluster from Actinomadura madurae ATCC 39144 Supporting a Unifying Paradigm for Enediyne Biosynthesis

    Article • Journal of the American Chemical Society, October 2007, American Chemical Society (ACS)

    Professor Steven G Van Lanen

  32. The Structure of l -Tyrosine 2,3-Aminomutase from the C-1027 Enediyne Antitumor Antibiotic Biosynthetic Pathway † , ‡

    Article • Biochemistry, June 2007, American Chemical Society (ACS)

    Professor Steven G Van Lanen

  33. Characterization of NcsB2 as a Promiscuous Naphthoic Acid/Coenzyme A Ligase Integral to the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin

    Article • Journal of the American Chemical Society, June 2007, American Chemical Society (ACS)

    Professor Steven G Van Lanen

  34. Progress in combinatorial biosynthesis for drug discovery

    Article • Drug Discovery Today Technologies, September 2006, Elsevier

    Professor Steven G Van Lanen

  35. The Bifunctional Glyceryl Transferase/Phosphatase OzmB Belonging to the HAD Superfamily That Diverts 1,3-Bisphosphoglycerate into Polyketide Biosynthesis

    Article • Journal of the American Chemical Society, August 2006, American Chemical Society (ACS)

    Professor Steven G Van Lanen

  36. Microbial genomics for the improvement of natural product discovery

    Article • Current Opinion in Microbiology, June 2006, Elsevier

    Professor Steven G Van Lanen

  37. Biosynthesis of the β-Amino Acid Moiety of the Enediyne Antitumor Antibiotic C-1027 Featuring β-Amino Acyl- S -carrier Protein Intermediates

    Article • Journal of the American Chemical Society, August 2005, American Chemical Society (ACS)

    Professor Steven G Van Lanen

  38. Antitumor Antibiotics: Bleomycin, Enediynes, and Mitomycin

    Article • ChemInform, June 2005, Wiley

    Professor Steven G Van Lanen

  39. The Neocarzinostatin Biosynthetic Gene Cluster from Streptomyces carzinostaticus ATCC 15944 Involving Two Iterative Type I Polyketide Synthases

    Article • Chemistry & Biology, March 2005, Elsevier

    Professor Steven G Van Lanen

  40. Antitumor Antibiotics:  Bleomycin, Enediynes, and Mitomycin

    Article • Chemical Reviews, February 2005, American Chemical Society (ACS)

    Professor Steven G Van Lanen

  41. Kinetic Mechanism of the tRNA-Modifying Enzyme S -Adenosylmethionine:tRNA Ribosyltransferase-Isomerase (QueA) †

    Article • Biochemistry, May 2003, American Chemical Society (ACS)

    Professor Steven G Van Lanen