All Stories

  1. Blood phosphorylated tau elevation as a biomarker in immunoglobulin light chain and transthyretin amyloidosis

    Article • Nature Medicine, March 2026, Springer Science + Business Media

    Stephan Kaeser

  2. Neurofilament light chain may serve as a cross-species blood biomarker to assess aging and predict mortality

    Article • PLoS Biology, February 2026, PLOS

    Stephan Kaeser

  3. Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease

    Article • Nature Communications, November 2024, Springer Science + Business Media

    Stephan Kaeser

  4. Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae

    Article • Nature Communications, November 2022, Springer Science + Business Media

    Stephan Kaeser

  5. High Soluble Amyloid-β42 Predicts Normal Cognition in Amyloid-Positive Individuals with Alzheimer’s Disease-Causing Mutations

    Article • Journal of Alzheimer’s Disease, October 2022, IOS Press

    Gregg Day, Stephan Kaeser, Professor Ralph Nigel Martins

  6. Signatures of glial activity can be detected in the CSF proteome

    Article • Proceedings of the National Academy of Sciences, June 2022, Proceedings of the National Academy of Sciences

    Stephan Kaeser

  7. CSF p-tau increase in response to Aβ-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles

    Article • Acta Neuropathologica, December 2021, Springer Science + Business Media

    Stephan Kaeser

  8. Cerebrospinal fluid cytokine levels are associated with macrophage infiltration into tumor tissues of glioma patients

    Article • BMC Cancer, October 2021, Springer Science + Business Media

    Stephan Kaeser

  9. A neuronal blood marker is associated with mortality in old age

    Article • Nature Aging, February 2021, Springer Science + Business Media

    Stephan Kaeser

  10. Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

    Article • Nature Neuroscience, November 2020, Springer Science + Business Media

    Stephan Kaeser

  11. Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids

    Article • Molecular Psychiatry, July 2020, Springer Science + Business Media

    Stephan Kaeser

  12. Neurofilaments in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice

    Article • EMBO Molecular Medicine, June 2020, Springer Science + Business Media

    Stephan Kaeser

  13. Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids

    Article • January 2020, openRxiv

    Stephan Kaeser

  14. Neurofilaments as blood biomarkers at the preataxic and ataxic stage of spinocerebellar ataxia type 3: a cross-species analysis in humans and mice

    Article • November 2019, openRxiv

    Stephan Kaeser

  15. Early Aβ reduction prevents progression of cerebral amyloid angiopathy

    Article • Annals of Neurology, August 2019, Wiley

    Stephan Kaeser

  16. Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

    Article • Nature Medicine, January 2019, Springer Science + Business Media

    Stephan Kaeser

  17. Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease

    Article • Proceedings of the National Academy of Sciences, November 2017, Proceedings of the National Academy of Sciences

    Stephan Kaeser

  18. Aβ seeding potency peaks in the early stages of cerebral β‐amyloidosis

    Article • EMBO Reports, July 2017, Springer Science + Business Media

    Stephan Kaeser

  19. Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition

    Article • Alzheimer s & Dementia, October 2016, Wiley

    Stephan Kaeser

  20. Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

    Article • Neuron, July 2016, Elsevier

    Stephan Kaeser

  21. Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

    Article • Neuron, July 2016, Elsevier

    Stephan Kaeser

  22. Conversion of Synthetic Aβ toIn VivoActive Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model

    Article • Journal of Neuroscience, May 2016, Society for Neuroscience

    Stephan Kaeser

  23. Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease

    Article • Current Alzheimer Research, April 2016, Bentham Science Publishers

    Stephan Kaeser

  24. Parenchymal cystatin C focal deposits and glial scar formation around brain arteries in Hereditary Cystatin C Amyloid Angiopathy

    Article • Brain Research, October 2015, Elsevier

    Stephan Kaeser

  25. Persistence of Aβ seeds in APP null mouse brain

    Article • Nature Neuroscience, September 2015, Springer Science + Business Media

    Stephan Kaeser

  26. Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models

    Article • EMBO Molecular Medicine, May 2015, Springer Science + Business Media

    Stephan Kaeser

  27. Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid

    Article • Brain, September 2014, Oxford University Press (OUP)

    Stephan Kaeser

  28. Deposition of collagen IV and aggrecan in leptomeningeal arteries of hereditary brain haemorrhage with amyloidosis

    Article • Brain Research, October 2013, Elsevier

    Stephan Kaeser

  29. Seeded strain‐like transmission of β‐amyloid morphotypes in APP transgenic mice

    Article • EMBO Reports, September 2013, Springer Science + Business Media

    Stephan Kaeser

  30. Changes in Amyloid-β and Tau in the Cerebrospinal Fluid of Transgenic Mice Overexpressing Amyloid Precursor Protein

    Article • Science Translational Medicine, July 2013, American Association for the Advancement of Science

    Stephan Kaeser

  31. CSF biomarker variability in the Alzheimer's Association quality control program

    Article • Alzheimer s & Dementia, May 2013, Elsevier

    Professor Piero Parchi, Stephan Kaeser

  32. BRI2 Protein Regulates β-Amyloid Degradation by Increasing Levels of Secreted Insulin-degrading Enzyme (IDE)

    Article • Journal of Biological Chemistry, October 2011, Elsevier

    Stephan Kaeser

  33. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

    Article • Alzheimer s & Dementia, July 2011, Wiley

    Stephan Kaeser

  34. Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

    Article • Science, November 2010, American Association for the Advancement of Science

    Stephan Kaeser

  35. Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

    Article • Proceedings of the National Academy of Sciences, April 2010, Proceedings of the National Academy of Sciences

    Stephan Kaeser

  36. Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

    Article • Nature Neuroscience, October 2009, Springer Science + Business Media

    Stephan Kaeser

  37. Cystatin C modulates cerebral β-amyloidosis

    Article • Nature Genetics, November 2007, Springer Science + Business Media

    Stephan Kaeser

  38. Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

    Article • Science, September 2006, American Association for the Advancement of Science

    Stephan Kaeser

  39. Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

    Article • EMBO Reports, August 2006, EMBO

    christian Holscher, Stephan Kaeser

  40. Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice

    Article • Neurobiology of Aging, May 2005, Elsevier

    Stephan Kaeser

  41. Extracellular amyloid formation and associated pathology in neural grafts

    Article • Nature Neuroscience, February 2003, Springer Science + Business Media

    Stephan Kaeser