All Stories

  1. Cholecystokinin (CCK): a neuromodulator with therapeutic potential in Alzheimer’s and Parkinson’s disease

    Article • Frontiers in Neuroendocrinology, April 2024, Elsevier

    christian Holscher

  2. O-GlcNAcylation and Its Roles in Neurodegenerative Diseases

    Article • Journal of Alzheimer s Disease, January 2024, IOS Press

    christian Holscher

  3. Liraglutide Reduces Alcohol Consumption, Anxiety, Memory Impairment, and Synapse Loss in Alcohol Dependent Mice

    Article • Neurochemical Research, January 2024, Springer Science + Business Media

    christian Holscher

  4. A Cholecystokinin Analogue Ameliorates Cognitive Deficits and Regulates Mitochondrial Dynamics via the AMPK/Drp1 Pathway in APP/PS1 Mice

    Article • The Journal of Prevention of Alzheimer s Disease, January 2024, SERDI

    christian Holscher

  5. Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway

    Article • Neuropharmacology, December 2023, Elsevier

    christian Holscher

  6. Incretin Mimetics Restore the ER-Mitochondrial Axis and Switch Cell Fate Towards Survival in LUHMES Dopaminergic-Like Neurons: Implications for Novel Therapeutic Strategies in Parkinson’s Disease

    Article • Journal of Parkinson s Disease, November 2023, IOS Press

    christian Holscher

  7. A Dual GLP-1/GIP Receptor Agonist Is More Effective than Liraglutide in the A53T Mouse Model of Parkinson’s Disease

    Article • Parkinson s Disease, September 2023, Hindawi Publishing Corporation

    christian Holscher

  8. Liraglutide reduces alcohol consumption, anxiety, memory impairment, and synapse loss in alcohol dependent mice

    Article • August 2023, Research Square

    christian Holscher

  9. Integrated analysis of the lncRNA-associated ceRNA network in Alzheimer's disease

    Article • Gene, August 2023, Elsevier

    christian Holscher

  10. Inhibitory effect of Garlic Powder on MPTP-induced dopaminergic neurodegeneration by activation of Nrf2-HO1 and mitochondrial dynamics

    Article • July 2023, Research Square

    christian Holscher

  11. Cholecystokinin Signaling can Rescue Cognition and Synaptic Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease

    Article • Molecular Neurobiology, May 2023, Springer Science + Business Media

    christian Holscher

  12. Beyond appetite: Acylated ghrelin as a learning, memory and fear behavior-modulating hormone

    Article • Neuroscience & Biobehavioral Reviews, December 2022, Elsevier

    christian Holscher

  13. DA5-CH and Semaglutide Protect against Neurodegeneration and Reduce α-Synuclein Levels in the 6-OHDA Parkinson’s Disease Rat Model

    Article • Parkinson s Disease, November 2022, Hindawi Publishing Corporation

    christian Holscher

  14. <italic>MCU</italic> knockdown in hippocampal neurons improves memory performance of an Alzheimer’s disease mouse model

    Article • Acta Biochimica et Biophysica Sinica, September 2022, China Science Publishing & Media Ltd.

    christian Holscher

  15. The neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review

    Article • Frontiers in Neuroscience, September 2022, Frontiers

    christian Holscher

  16. Glucagon-like peptide 1 and glucose-dependent insulinotropic peptide hormones and novel receptor agonists protect synapses in Alzheimer’s and Parkinson’s diseases

    Article • Frontiers in Synaptic Neuroscience, July 2022, Frontiers

    christian Holscher

  17. Cholecystokinin and glucagon-like peptide-1 analogues regulate intestinal tight junction, inflammation, dopaminergic neurons and α-synuclein accumulation in the colon of two Parkinson's disease mouse models

    Article • European Journal of Pharmacology, July 2022, Elsevier

    christian Holscher

  18. Therapeutic application of GLP-1 and GIP receptor agonists in Parkinson’s disease

    Article • Expert Opinion on Therapeutic Targets, May 2022, Taylor & Francis

    christian Holscher

  19. Neuroprotective Effects of a Cholecystokinin Analogue in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Parkinson’s Disease Mouse Model

    Article • Frontiers in Neuroscience, March 2022, Frontiers

    christian Holscher

  20. Neuroprotective Mechanisms of Glucagon-Like Peptide-1-Based Therapies in Ischemic Stroke: An Update Based on Preclinical Research

    Article • Frontiers in Neurology, March 2022, Frontiers

    christian Holscher

  21. (D-Ser2) oxyntomodulin recovers hippocampal synaptic structure and theta rhythm in Alzheimer’s disease transgenic mice

    Article • Neural Regeneration Research, January 2022, Medknow

    christian Holscher

  22. A GLP-1/GIP Dual Receptor Agonist DA4-JC Effectively Attenuates Cognitive Impairment and Pathology in the APP/PS1/Tau Model of Alzheimer’s Disease

    Article • Journal of Alzheimer s Disease, September 2021, IOS Press

    christian Holscher

  23. The GLP-1 receptor agonist, liraglutide, fails to slow disease progression in SOD1G93A and TDP-43Q331K transgenic mouse models of ALS

    Article • Scientific Reports, August 2021, Springer Science + Business Media

    christian Holscher

  24. The GLP‐1/GIP dual‐receptor agonist DA5‐CH inhibits the NF‐κB inflammatory pathway in the MPTP mouse model of Parkinson's disease more effectively than the GLP‐1 single‐receptor agonist NLY01

    Article • Brain and Behavior, June 2021, Wiley

    christian Holscher

  25. Protective properties of GLP‐1 and associated peptide hormones in neurodegenerative disorders

    Article • British Journal of Pharmacology, May 2021, Wiley

    christian Holscher

  26. Neuroprotective Effects of a GLP-2 Analogue in the MPTP Parkinson’s Disease Mouse Model

    Article • Journal of Parkinson s Disease, April 2021, IOS Press

    christian Holscher

  27. Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects?

    Article • Alzheimer s Research & Therapy, February 2021, Springer Science + Business Media

    christian Holscher

  28. Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis

    Article • Journal of Natural Medicines, February 2021, Springer Science + Business Media

    christian Holscher

  29. Incretin mimetics restore the ER-mitochondrial axis and switch neuronal fate towards survival.

    Article • January 2021, Authorea, Inc.

    christian Holscher

  30. Glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual receptor agonist DA-CH5 is superior to exendin-4 in protecting neurons in the 6-hydroxydopamine rat Parkinson model

    Article • Neural Regeneration Research, January 2021, Medknow

    christian Holscher

  31. Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease

    Article • Frontiers in Neuroscience, December 2020, Frontiers

    christian Holscher

  32. A GLP-2 Analogue Protects SH-SY5Y and Neuro-2a Cells Against Mitochondrial Damage, Autophagy Impairments and Apoptosis in a Parkinson Model

    Article • Drug Research, October 2020, Thieme Publishing Group

    christian Holscher

  33. Glucagon-like peptide-1 receptor agonists as neuroprotective agents for ischemic stroke: a systematic scoping review

    Article • Journal of Cerebral Blood Flow & Metabolism, September 2020, SAGE Publications

    christian Holscher

  34. Correction to: Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer’s disease: study protocol for a randomised controlled trial (ELAD study)

    Article • Trials, July 2020, Springer Science + Business Media

    christian Holscher

  35. Dehydroabietic acid alleviates high fat diet-induced insulin resistance and hepatic steatosis through dual activation of PPAR-γ and PPAR-α

    Article • Biomedicine & Pharmacotherapy, July 2020, Elsevier

    christian Holscher

  36. A GLP-1/GIP/Gcg receptor triagonist improves memory behavior, as well as synaptic transmission, neuronal excitability and Ca2+ homeostasis in 3xTg-AD mice

    Article • Neuropharmacology, June 2020, Elsevier

    christian Holscher

  37. Driving GABAergic neurons optogenetically improves learning, reduces amyloid load and enhances autophagy in a mouse model of Alzheimer’s disease

    Article • Biochemical and Biophysical Research Communications, May 2020, Elsevier

    christian Holscher

  38. Protective Effects of DAla2-GIP-GLU-PAL against Cognitive Deficits and Amyloid Deposition in APP/PS1 AD Mice Associated with Reduction of Neuroinflammation

    Article • April 2020, Research Square

    christian Holscher

  39. The Novel Dual GLP-1/GIP Receptor Agonist DA-CH5 Is Superior to Single GLP-1 Receptor Agonists in the MPTP Model of Parkinson’s Disease

    Article • Journal of Parkinson s Disease, April 2020, IOS Press

    christian Holscher

  40. Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ

    Article • Biomedicine & Pharmacotherapy, April 2020, Elsevier

    christian Holscher

  41. Brain insulin resistance: role in neurodegenerative disease and potential for targeting

    Article • Expert Opinion on Investigational Drugs, March 2020, Taylor & Francis

    christian Holscher

  42. GIP has neuroprotective effects in Alzheimer and Parkinson’s disease models

    Article • Peptides, March 2020, Elsevier

    christian Holscher

  43. A dual GLP-1 and Gcg receptor agonist rescues spatial memory and synaptic plasticity in APP/PS1 transgenic mice

    Article • Hormones and Behavior, February 2020, Elsevier

    christian Holscher

  44. The novel GLP‐1/GIP analogue DA5‐CH reduces tau phosphorylation and normalizes theta rhythm in the icv. STZ rat model of AD

    Article • Brain and Behavior, January 2020, Wiley

    christian Holscher

  45. Evidence for pathophysiological commonalities between metabolic and neurodegenerative diseases

    Article • January 2020, Elsevier

    christian Holscher

  46. Neuroprotective and restorative properties of the GLP-1/GIP dual agonist DA-JC1 compared with a GLP-1 single agonist in Alzheimer's disease

    Article • Neuropharmacology, January 2020, Elsevier

    christian Holscher

  47. The diabetes drug semaglutide reduces infarct size, inflammation, and apoptosis, and normalizes neurogenesis in a rat model of stroke

    Article • Neuropharmacology, November 2019, Elsevier

    christian Holscher

  48. D‐Ser2‐oxyntomodulin ameliorated Aβ31‐35‐induced circadian rhythm disorder in mice

    Article • CNS Neuroscience & Therapeutics, August 2019, Wiley

    christian Holscher

  49. The novel GLP-1/GIP dual receptor agonist DA3-CH is neuroprotective in the pilocarpine-induced epileptogenesis rat model

    Article • Epilepsy Research, August 2019, Elsevier

    christian Holscher

  50. Insulin Signaling Impairment in the Brain as a Risk Factor in Alzheimer’s Disease

    Article • Frontiers in Aging Neuroscience, April 2019, Frontiers

    christian Holscher

  51. DA-JC1 improves learning and memory by antagonizing Aβ31–35-induced circadian rhythm disorder

    Article • Molecular Brain, February 2019, Springer Science + Business Media

    christian Holscher

  52. Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of β-amyloid pathology

    Article • Neuropharmacology, January 2019, Elsevier

    christian Holscher

  53. Moving towards a more realistic concept of what constitutes Alzheimer's disease

    Article • EBioMedicine, January 2019, Elsevier

    christian Holscher

  54. Evidence That Parietal Lobe Fatty Acids May Be More Profoundly Affected in Moderate Alzheimer’s Disease (AD) Pathology Than in Severe AD Pathology

    Article • Metabolites, October 2018, MDPI AG

    christian Holscher

  55. The Novel DA–CH3 Dual Incretin Restores Endoplasmic Reticulum Stress and Autophagy Impairments to Attenuate Alzheimer-Like Pathology and Cognitive Decrements in the APPSWE/PS1ΔE9 Mouse Model

    Article • Journal of Alzheimer s Disease, October 2018, IOS Press

    christian Holscher

  56. Prolonged Drug-Releasing Fibers Attenuate Alzheimer’s Disease-like Pathogenesis

    Article • ACS Applied Materials & Interfaces, October 2018, American Chemical Society (ACS)

    Dr Cristina Pacheco-Soares, christian Holscher

  57. Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model

    Article • Neuropeptides, October 2018, Elsevier

    christian Holscher

  58. Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity

    Article • Brain Research, September 2018, Elsevier

    christian Holscher

  59. Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones?

    Article • Neuropharmacology, July 2018, Elsevier

    christian Holscher

  60. Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models

    Article • Neuropharmacology, July 2018, Elsevier

    christian Holscher

  61. DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease

    Article • European Journal of Pharmacology, May 2018, Elsevier

    christian Holscher

  62. Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease

    Article • Neuropharmacology, May 2018, Elsevier

    christian Holscher

  63. Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus

    Article • Epilepsy Research, May 2018, Elsevier

    christian Holscher

  64. The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease

    Article • The Journal of Pathology, April 2018, Wiley

    André Felipe Batista, christian Holscher

  65. A novel GLP-1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimer's disease

    Article • Hippocampus, March 2018, Wiley

    christian Holscher

  66. GLP-1 receptor agonists show neuroprotective effects in animal models of diabetes

    Article • Peptides, February 2018, Elsevier

    christian Holscher

  67. Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease

    Article • Brain Research, January 2018, Elsevier

    christian Holscher

  68. Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells

    Article • Scientific Reports, November 2017, Springer Science + Business Media

    christian Holscher

  69. A novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson's disease

    Article • European Journal of Pharmacology, October 2017, Elsevier

    christian Holscher

  70. Integrating microRNA and messenger RNA expression profiles in a rat model of deep vein thrombosis

    Article • International Journal of Molecular Medicine, August 2017, Spandidos Publications

    christian Holscher

  71. Therapeutic Potential of Baicalein in Alzheimer’s Disease and Parkinson’s Disease

    Article • CNS Drugs, June 2017, Springer Science + Business Media

    christian Holscher

  72. Metabolomic Profiling of Bile Acids in Clinical and Experimental Samples of Alzheimer’s Disease

    Article • Metabolites, June 2017, MDPI AG

    christian Holscher

  73. A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model

    Article • Behavioural Brain Research, June 2017, Elsevier

    christian Holscher

  74. A novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson's disease

    Article • Neuropharmacology, May 2017, Elsevier

    christian Holscher

  75. D-Ala2-GIP-glu-PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation

    Article • European Journal of Pharmacology, February 2017, Elsevier

    christian Holscher

  76. Lixisenatide attenuates the detrimental effects of amyloid β protein on spatial working memory and hippocampal neurons in rats

    Article • Behavioural Brain Research, February 2017, Elsevier

    christian Holscher

  77. Therapeutic potential of flavonoids in spinal cord injury

    Article • Reviews in the Neurosciences, January 2017, De Gruyter

    christian Holscher

  78. Levo-tetrahydropalmatine inhibits the acquisition of ketamine-induced conditioned place preference by regulating the expression of ERK and CREB phosphorylation in rats

    Article • Behavioural Brain Research, January 2017, Elsevier

    christian Holscher

  79. A Novel Bioresorbable Device as a Controlled Release System for Protecting Cells from Oxidative Stress from Alzheimer’s Disease

    Article • Molecular Neurobiology, October 2016, Springer Science + Business Media

    Dr Cristina Pacheco-Soares, christian Holscher

  80. Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases

    Article • Reviews in the Neurosciences, October 2016, De Gruyter

    christian Holscher

  81. Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide analogues as novel treatments for Alzheimer’s and Parkinson’s disease

    Article • Cardiovascular Endocrinology, September 2016, Wolters Kluwer Health

    christian Holscher

  82. Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells

    Article • Journal of Neurochemistry, August 2016, Wiley

    christian Holscher

  83. Therapeutic Potential of Genipin in Central Neurodegenerative Diseases

    Article • CNS Drugs, July 2016, Springer Science + Business Media

    christian Holscher

  84. A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson’s disease by reducing chronic inflammation in the brain

    Article • Neuroreport, April 2016, Wolters Kluwer Health

    christian Holscher

  85. A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson′s disease by increasing expression of BNDF

    Article • Brain Research, March 2016, Elsevier

    christian Holscher

  86. Alzheimer's disease–like pathology has transient effects on the brain and blood metabolome

    Article • Neurobiology of Aging, February 2016, Elsevier

    christian Holscher

  87. Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model

    Article • Neuropharmacology, February 2016, Elsevier

    christian Holscher

  88. Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

    Article • Brain, January 2016, Oxford University Press (OUP)

    christian Holscher

  89. A novel dual-glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist is neuroprotective in transient focal cerebral ischemia in the rat

    Article • Neuroreport, January 2016, Wolters Kluwer Health

    christian Holscher

  90. Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer’s disease

    Article • Reviews in the Neurosciences, January 2016, De Gruyter

    christian Holscher

  91. Neuroprotective role of (Val8) GLP-1-Glu-PAL in an in vitro model of Parkinson′s disease

    Article • Neural Regeneration Research, January 2016, Medknow

    christian Holscher

  92. Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease

    Article • European Journal of Pharmacology, December 2015, Elsevier

    christian Holscher

  93. Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson’s disease mouse model

    Article • Behavioural Brain Research, October 2015, Elsevier

    christian Holscher

  94. Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice

    Article • Behavioural Brain Research, October 2015, Elsevier

    christian Holscher

  95. Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease

    Article • European Journal of Pharmacology, October 2015, Elsevier

    christian Holscher

  96. Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease

    Article • Neuroscience, September 2015, Elsevier

    christian Holscher

  97. GLIA Bilbao 2015: Abstracts Oral Presentations, Posters, Indexes

    Article • Glia, June 2015, Wiley

    christian Holscher

  98. Untargeted Metabolomic Analysis of Human Plasma Indicates Differentially Affected Polyamine and L-Arginine Metabolism in Mild Cognitive Impairment Subjects Converting to Alzheimer’s Disease

    Article • PLoS ONE, March 2015, PLOS

    christian Holscher

  99. Quantitative Measurement of [Na+] and [K+] in Postmortem Human Brain Tissue Indicates Disturbances in Subjects with Alzheimer's Disease and Dementia with Lewy Bodies

    Article • Journal of Alzheimer s Disease, February 2015, IOS Press

    christian Holscher

  100. Restoration of Cerebral and Systemic Microvascular Architecture in APP/PS1 Transgenic Mice Following Treatment with Liraglutide™

    Article • Microcirculation, February 2015, Wiley

    christian Holscher

  101. Neuroprotective effects of geniposide on Alzheimer’s disease pathology

    Article • Reviews in the Neurosciences, January 2015, De Gruyter

    christian Holscher

  102. Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice

    Article • Neuropharmacology, November 2014, Elsevier

    christian Holscher

  103. Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

    Article • Neuropharmacology, November 2014, Elsevier

    christian Holscher

  104. Age-Associated Changes of Brain Copper, Iron, and Zinc in Alzheimer's Disease and Dementia with Lewy Bodies

    Article • Journal of Alzheimer s Disease, October 2014, IOS Press

    christian Holscher

  105. Increased number of orexin/hypocretin neurons with high and prolonged external stress-induced depression

    Article • Behavioural Brain Research, October 2014, Elsevier

    christian Holscher

  106. Lixisenatide rescues spatial memory and synaptic plasticity from amyloid β protein-induced impairments in rats

    Article • Neuroscience, September 2014, Elsevier

    christian Holscher

  107. Peptide drugs that have been developed to treat type 2 diabetes show neuroprotective effects

    Article • Regulatory Peptides, June 2014, Elsevier

    christian Holscher

  108. Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

    Article • Biochemical Society Transactions, March 2014, Portland Press Ltd.

    christian Holscher

  109. Neural Circuit Interactions between the Dorsal Raphe Nucleus and the Lateral Hypothalamus: An Experimental and Computational Study

    Article • PLoS ONE, February 2014, PLOS

    christian Holscher

  110. Editorial

    Article • Alzheimer s & Dementia, February 2014, Wiley

    christian Holscher

  111. First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease

    Article • Alzheimer s & Dementia, February 2014, Wiley

    christian Holscher

  112. The incretin hormones glucagonlike peptide 1 and glucose‐dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease

    Article • Alzheimer s & Dementia, February 2014, Wiley

    christian Holscher

  113. New drug treatments show neuroprotective effects in Alzheimer′s and Parkinson′s diseases

    Article • Neural Regeneration Research, January 2014, Medknow

    christian Holscher

  114. Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

    Article • Neuropharmacology, January 2014, Elsevier

    christian Holscher

  115. Metabolic signatures of human Alzheimer’s disease (AD): 1H NMR analysis of the polar metabolome of post-mortem brain tissue

    Article • Metabolomics, December 2013, Springer Science + Business Media

    christian Holscher

  116. TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

    Article • Cell Metabolism, December 2013, Elsevier

    christian Holscher

  117. Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress

    Article • Journal of Neurochemistry, October 2013, Wiley

    christian Holscher

  118. Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

    Article • September 2013, Bioscientifica

    christian Holscher

  119. Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

    Article • CNS Drugs, May 2013, Springer Science + Business Media

    christian Holscher

  120. D-Ala2GIP Facilitated Synaptic Plasticity and Reduces Plaque Load in Aged Wild Type Mice and in an Alzheimer's Disease Mouse Model

    Article • Journal of Alzheimer s Disease, April 2013, IOS Press

    christian Holscher

  121. 1H NMR metabolomics investigation of an Alzheimer’s disease (AD) mouse model pinpoints important biochemical disturbances in brain and plasma

    Article • Metabolomics, March 2013, Springer Science + Business Media

    christian Holscher

  122. Chronic Treatment with the GLP1 Analogue Liraglutide Increases Cell Proliferation and Differentiation into Neurons in an AD Mouse Model

    Article • PLoS ONE, March 2013, PLOS

    christian Holscher

  123. Cell signalling and diabetes

    Article • Diabetic Medicine, March 2013, Wiley

    christian Holscher

  124. Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats

    Article • Neurobiology of Aging, February 2013, Elsevier

    christian Holscher

  125. A Novel Retro-Inverso Peptide Inhibitor Reduces Amyloid Deposition, Oxidation and Inflammation and Stimulates Neurogenesis in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease

    Article • PLoS ONE, January 2013, PLOS

    christian Holscher

  126. Val8-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β peptide in rats

    Article • Journal of Neuroscience Research, January 2013, Wiley

    christian Holscher

  127. Investigation of the Human Brain Metabolome to Identify Potential Markers for Early Diagnosis and Therapeutic Targets of Alzheimer’s Disease

    Article • Analytical Chemistry, January 2013, American Chemical Society (ACS)

    christian Holscher

  128. New animal models of Alzheimer’s disease that display insulin desensitization in the brain

    Article • Reviews in the Neurosciences, January 2013, De Gruyter

    christian Holscher

  129. Neuroprotective effects of D-Ala2GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model

    Article • Alzheimer s Research & Therapy, January 2013, Springer Science + Business Media

    christian Holscher

  130. The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain

    Article • European Journal of Pharmacology, January 2013, Elsevier

    christian Holscher

  131. The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer’s disease

    Article • Neuroscience, January 2013, Elsevier

    christian Holscher

  132. Potential Role of Glucagon-Like Peptide-1 (GLP-1) in Neuroprotection

    Article • CNS Drugs, October 2012, Springer Science + Business Media

    christian Holscher

  133. The Diabetes Drug Liraglutide Ameliorates Aberrant Insulin Receptor Localisation and Signalling in Parallel with Decreasing Both Amyloid-β Plaque and Glial Pathology in a Mouse Model of Alzheimer’s Disease

    Article • NeuroMolecular Medicine, September 2012, Springer Science + Business Media

    christian Holscher

  134. Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain

    Article • Brain Research, September 2012, Elsevier

    christian Holscher

  135. Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice

    Article • International Journal of Obesity, June 2012, Springer Science + Business Media

    christian Holscher

  136. Roles of Glucagon-Like Peptide and Glucose-Dependent Insolinotropic Polypeptide Hormones in Brain Function and Neurodegeneration

    Article • May 2012, Wiley

    christian Holscher

  137. Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice

    Article • Peptides, May 2012, Elsevier

    christian Holscher

  138. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

    Article • Journal of Clinical Investigation, April 2012, American Society for Clinical Investigation

    christian Holscher

  139. The effect of ageing on neurogenesis and oxidative stress in the APPswe/PS1deltaE9 mouse model of Alzheimer's disease

    Article • Brain Research, April 2012, Elsevier

    christian Holscher

  140. Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis

    Article • BMC Neuroscience, March 2012, Springer Science + Business Media

    christian Holscher

  141. Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

    Article • Neurobiology of Aging, February 2012, Elsevier

    christian Holscher

  142. (Val8) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains

    Article • European Journal of Pharmacology, January 2012, Elsevier

    christian Holscher

  143. Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice

    Article • European Journal of Pharmacology, January 2012, Elsevier

    christian Holscher

  144. GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

    Article • Reviews in the Neurosciences, December 2011, De Gruyter

    christian Holscher

  145. Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease

    Article • Biochemical Society Transactions, July 2011, Portland Press Ltd.

    christian Holscher

  146. The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

    Article • Journal of Neuroscience, April 2011, Society for Neuroscience

    christian Holscher

  147. Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis

    Article • Journal of Neurophysiology, April 2011, American Physiological Society

    christian Holscher

  148. Hepcidin Treatment Modulates the Expression of Divalent Metal Transporter-1, Ceruloplasmin, and Ferroportin-1 in the Rat Cerebral Cortex and Hippocampus

    Article • Biological Trace Element Research, January 2011, Springer Science + Business Media

    christian Holscher

  149. Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

    Article • Journal of Neuroscience Research, January 2011, Wiley

    christian Holscher

  150. Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice

    Article • European Journal of Pharmacology, January 2011, Elsevier

    christian Holscher

  151. Val8-glucagon-like peptide-1 protects against Aβ1–40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats

    Article • Neuroscience, November 2010, Elsevier

    christian Holscher

  152. New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimer’s disease?

    Article • Neurobiology of Aging, September 2010, Elsevier

    christian Holscher

  153. Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

    Article • Diabetes Obesity and Metabolism, August 2010, Wiley

    christian Holscher

  154. Incretin Analogues that have been Developed to Treat Type 2 Diabetes Hold Promise as a Novel Treatment Strategy for Alzheimers Disease

    Article • Recent Patents on CNS Drug Discovery, June 2010, Bentham Science Publishers

    christian Holscher

  155. Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

    Article • International Journal of Obesity, March 2010, Springer Science + Business Media

    christian Holscher

  156. Synaptic Plasticity in the Hippocampus of a APP/PS1 Mouse Model of Alzheimer's Disease Is Impaired in Old but Not Young Mice

    Article • PLoS ONE, March 2010, PLOS

    christian Holscher

  157. Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease

    Article • European Journal of Pharmacology, March 2010, Elsevier

    christian Holscher

  158. The effect of mGlu8deficiency in animal models of psychiatric diseases

    Article • Genes Brain & Behavior, February 2010, Wiley

    christian Holscher

  159. The Role of GLP-1 in Neuronal Activity and Neurodegeneration

    Article • January 2010, Elsevier

    christian Holscher

  160. Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease

    Article • Behavioural Brain Research, December 2009, Elsevier

    christian Holscher

  161. Quantitative analysis of iron concentration and expression of ferroportin 1 in the cortex and hippocampus of rats induced by cerebral ischemia

    Article • Journal of Clinical Neuroscience, November 2009, Elsevier

    christian Holscher

  162. Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system

    Article • Neuroreport, August 2009, Wolters Kluwer Health

    christian Holscher

  163. Seems familiar

    Article • The New Scientist, May 2009, Elsevier

    christian Holscher

  164. Coexistences of insulin signaling-related proteins and choline acetyltransferase in neurons

    Article • Brain Research, January 2009, Elsevier

    christian Holscher

  165. Information Processing by Neuronal Populations

    Article • October 2008, Cambridge University Press

    christian Holscher

  166. Distributed population codes in sensory and memory representations of the neocortex

    Article • October 2008, Cambridge University Press

    christian Holscher

  167. Functional roles of theta and gamma oscillations in the association and dissociation of neuronal networks in primates and rodents

    Article • October 2008, Cambridge University Press

    christian Holscher

  168. Summary of chapters, conclusion, and future targets

    Article • October 2008, Cambridge University Press

    christian Holscher

  169. Theta rhythm and bidirectional plasticity in the hippocampus

    Article • October 2008, Cambridge University Press

    christian Holscher

  170. Anaesthesia generates neuronal insulin resistance by inducing hypothermia

    Article • BMC Neuroscience, October 2008, Springer Science + Business Media

    christian Holscher

  171. GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid

    Article • European Journal of Pharmacology, June 2008, Elsevier

    christian Holscher

  172. Protease-Resistant Glucose-Dependent Insulinotropic Polypeptide Agonists Facilitate Hippocampal LTP and Reverse the Impairment of LTP Induced by Beta-Amyloid

    Article • Journal of Neurophysiology, April 2008, American Physiological Society

    christian Holscher

  173. Common pathological processes in Alzheimer disease and type 2 diabetes: A review

    Article • Brain Research Reviews, December 2007, Elsevier

    christian Holscher

  174. Soluble beta-amyloid[25–35] reversibly impairs hippocampal synaptic plasticity and spatial learning

    Article • European Journal of Pharmacology, April 2007, Elsevier

    christian Holscher

  175. Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid (25–35) are dependent on stimulation-protocol and genetic background

    Article • Experimental Brain Research, December 2006, Springer Science + Business Media

    christian Holscher

  176. Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

    Article • EMBO Reports, August 2006, EMBO

    christian Holscher

  177. Inactivation of the rat dorsal striatum impairs performance in spatial tasks and alters hippocampal theta in the freely moving rat

    Article • Behavioural Brain Research, October 2005, Elsevier

    christian Holscher

  178. Lack of the metabotropic glutamate receptor subtype 7 selectively modulates Theta rhythm and working memory

    Article • Learning & Memory, September 2005, Cold Spring Harbor Laboratory Press

    christian Holscher

  179. Rats are able to navigate in virtual environments

    Article • Journal of Experimental Biology, February 2005, The Company of Biologists

    christian Holscher

  180. Development of Beta-Amyloid-induced Neurodegeneration in Alzheimer's Disease and Novel Neuroprotective Strategies

    Article • Reviews in the Neurosciences, January 2005, De Gruyter

    christian Holscher

  181. Lack of the metabotropic glutamate receptor subtype 7 selectively impairs short-term working memory but not long-term memory

    Article • Behavioural Brain Research, October 2004, Elsevier

    christian Holscher

  182. Learned association of allocentric and egocentric information in the hippocampus

    Article • Experimental Brain Research, April 2004, Springer Science + Business Media

    christian Holscher

  183. Perirhinal cortex neuronal activity related to long-term familiarity memory in the macaque

    Article • European Journal of Neuroscience, October 2003, Wiley

    christian Holscher

  184. Reward modulates neuronal activity in the hippocampus of the rat

    Article • Behavioural Brain Research, June 2003, Elsevier

    christian Holscher

  185. Time, Space and Hippocampal Functions

    Article • Reviews in the Neurosciences, January 2003, De Gruyter

    christian Holscher

  186. Different strains of rats show different sensitivity to block of long-term potentiation by nitric oxide synthase inhibitors

    Article • European Journal of Pharmacology, December 2002, Elsevier

    christian Holscher

  187. Metabotropic glutamate receptors control gating of spike transmission in the hippocampus area CA1

    Article • Pharmacology Biochemistry and Behavior, September 2002, Elsevier

    christian Holscher

  188. Perirhinal Cortex Neuronal Activity is Actively Related to Working Memory in the Macaque

    Article • Neural Plasticity, January 2002, Hindawi Publishing Corporation

    christian Holscher

  189. Neuronal Mechanisms of Memory Formation

    Article • November 2000, Cambridge University Press

    christian Holscher

  190. Conclusions and Future Targets

    Article • November 2000, Cambridge University Press

    christian Holscher

  191. Introduction: Long-Term Potentiation as a Model for Memory Mechanisms: The Story So Far

    Article • November 2000, Cambridge University Press

    christian Holscher

  192. Theta-Facilitated Induction of Long-Term Potentiation: A Better Model for Memory Formation?

    Article • November 2000, Cambridge University Press

    christian Holscher

  193. Consciousness in mind: a correlate for ACh?

    Article • Trends in Neurosciences, December 1999, Elsevier

    christian Holscher

  194. Synaptic plasticity and learning and memory: LTP and beyond

    Article • Journal of Neuroscience Research, October 1999, Wiley

    christian Holscher

  195. Synaptic plasticity and learning and memory: LTP and beyond

    Article • Journal of Neuroscience Research, September 1999, Wiley

    christian Holscher

  196. Retraction

    Article • European Journal of Neuroscience, July 1999, Wiley

    christian Holscher

  197. Stress impairs performance in spatial water maze learning tasks

    Article • Behavioural Brain Research, April 1999, Elsevier

    christian Holscher

  198. Metabotropic glutamate receptor activation and blockade: their role in long-term potentiation, learning and neurotoxicity

    Article • Neuroscience & Biobehavioral Reviews, January 1999, Elsevier

    Professor Shane M O'Mara, christian Holscher

  199. Nitric oxide is required for expression of LTP that is induced by stimulation phase-locked with theta rhythm

    Article • European Journal of Neuroscience, January 1999, Wiley

    christian Holscher

  200. Possible Causes of Alzheimer's Disease: Amyloid Fragments, Free Radicals, and Calcium Homeostasis

    Article • Neurobiology of Disease, September 1998, Elsevier

    christian Holscher

  201. b-amyloid induced reduction in synaptic transmission is reversed by inhibitors of nitric oxide synthase

    Article • Neuroreport, April 1998, Wolters Kluwer Health

    christian Holscher

  202. Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress

    Article • Proceedings of the National Academy of Sciences, March 1998, Proceedings of the National Academy of Sciences

    christian Holscher

  203. Block of theta-burst-induced long-term potentiation by (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid: further evidence against long-term potentiation as a model for learning

    Article • Neuroscience, August 1997, Elsevier

    christian Holscher

  204. Nitric oxide, the enigmatic neuronal messenger: its role in synaptic plasticity

    Article • Trends in Neurosciences, July 1997, Elsevier

    christian Holscher

  205. HFS-induced long-term potentiation and LFS-induced depotentiation in area CA1 of the hippocampus are not good models for learning

    Article • Psychopharmacology, March 1997, Springer Science + Business Media

    christian Holscher

  206. Activation of group-II metabotropic glutamate receptors blocks induction of long-term potentiation and depotentiation in area CA1 of the rat in vivo

    Article • European Journal of Pharmacology, March 1997, Elsevier

    christian Holscher

  207. Block of HFS-induced LTP in the dentate gyrus by 1S,3S-ACPD

    Article • Neuroreport, January 1997, Wolters Kluwer Health

    christian Holscher

  208. Long-term potentiation: A good model for learning and memory?

    Article • Progress in Neuro-Psychopharmacology and Biological Psychiatry, January 1997, Elsevier

    christian Holscher

  209. l-AP4 (l-(+)-2-amino-4-phosphonobutyric acid) induced impairment of spatial learning in the rat is antagonized by MAP4 ((S)-2-amino-2methyl-4-phosphonobutanoic acid)

    Article • Behavioural Brain Research, November 1996, Elsevier

    christian Holscher

  210. 7-Nitro indazole, a selective neuronal nitric oxide synthase inhibitor in vivo, impairs spatial learning in the rat.

    Article • Learning & Memory, January 1996, Cold Spring Harbor Laboratory Press

    christian Holscher

  211. Training in the Morris water maze occludes the synergism between ACPD and arachidonic acid on glutamate release in synaptosomes prepared from rat hippocampus.

    Article • Learning & Memory, January 1996, Cold Spring Harbor Laboratory Press

    christian Holscher

  212. Prostaglandins play a role in memory consolidation in the chick

    Article • European Journal of Pharmacology, December 1995, Elsevier

    christian Holscher

  213. Inhibitors of Cyclooxygenases produce Amnesia for a Passive Avoidance Task in the Chick

    Article • European Journal of Neuroscience, June 1995, Wiley

    christian Holscher

  214. Quinacrine Acts like an Acetylcholine Receptor Antagonist Rather Than like a Phospholipase A2 Inhibitor in a Passive Avoidance Task in the Chick

    Article • Neurobiology of Learning and Memory, March 1995, Elsevier

    christian Holscher

  215. Inhibitors of PLA2 and NO synthase cooperate in producing amnesia of a spatial task

    Article • Neuroreport, March 1995, Wolters Kluwer Health

    christian Holscher

  216. Two retrograde messengers are better than one?

    Article • Neuroreport, March 1995, Wolters Kluwer Health

    christian Holscher

  217. Quinolinic acid lesion of the rat entorhinal cortex pars medialis produces selective amnesia in allocentric working memory (WM), but not in egocentric WM

    Article • Behavioural Brain Research, August 1994, Elsevier

    christian Holscher

  218. Inhibitors of metabotropic glutamate receptors produce amnestic effects in chicks

    Article • Neuroreport, May 1994, Wolters Kluwer Health

    christian Holscher

  219. Inhibitors of phospholipase A2 produce amnesia for a passive avoidance task in the chick

    Article • Behavioral and Neural Biology, May 1994, Elsevier

    christian Holscher

  220. Inhibiting synthesis of the putative retrograde messenger nitric oxide results in amnesia in a passive avoidance task in the chick

    Article • Brain Research, August 1993, Elsevier

    christian Holscher

  221. An inhibitor of nitric oxide synthesis prevents memory formation in the chick

    Article • Neuroscience Letters, October 1992, Elsevier

    christian Holscher

  222. How could populations of neurons encode information?

    Article • Cambridge University Press

    christian Holscher