All Stories

  1. Chronic Occupational Exposure to Ionizing Radiation Induces Alterations in the Structure and Metabolism of the Heart: A Proteomic Analysis of Human Formalin-Fixed Paraffin-Embedded (FFPE) Cardiac Tissue

    Article • International Journal of Molecular Sciences, September 2020, MDPI AG

    Dr Soile Tapio

  2. Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles

    Article • International Journal of Molecular Sciences, March 2020, MDPI AG

    Dr Soile Tapio

  3. Combined Treatment with Low-Dose Ionizing Radiation and Ketamine Induces Adverse Changes in CA1 Neuronal Structure in Male Murine Hippocampi

    Article • International Journal of Molecular Sciences, December 2019, MDPI AG

    Dr Soile Tapio

  4. DNA damage accumulation during fractionated low-dose radiation compromises hippocampal neurogenesis

    Article • Radiotherapy and Oncology, August 2019, Elsevier

    Dr Soile Tapio

  5. Big data in radiation biology and epidemiology; an overview of the historical and contemporary landscape of data and biomaterial archives

    Article • International Journal of Radiation Biology, March 2019, Taylor & Francis

    Dr Soile Tapio, Paul Schofield

  6. Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells

    Article • Scientific Reports, September 2017, Nature

    Dr Soile Tapio

  7. PARTICLE triplexes cluster in the tumor suppressor WWOX and may extend throughout the human genome

    Article • Scientific Reports, August 2017, Nature

    Dr Soile Tapio

  8. Proteome analysis of irradiated endothelial cells reveals persistent alteration in protein degradation and the RhoGDI and NO signalling pathways

    Article • International Journal of Radiation Biology, July 2017, Taylor & Francis

    Dr Soile Tapio

  9. Long non-coding RNA PARTICLE bridges histone and DNA methylation

    Article • Scientific Reports, May 2017, Nature

    Dr Soile Tapio

  10. Quantitative changes in the protein and miRNA cargo of plasma exosome-like vesicles after exposure to ionizing radiation

    Article • International Journal of Radiation Biology, March 2017, Taylor & Francis

    Dr Soile Tapio

  11. Using proteomics to explore the effects of radiation on the heart - impacts for medicine

    Article • Expert Review of Proteomics, February 2017, Taylor & Francis

    Dr Soile Tapio

  12. Role of TGF Beta and PPAR Alpha Signaling Pathways in Radiation Response of Locally Exposed Heart: Integrated Global Transcriptomics and Proteomics Analysis

    Article • Journal of Proteome Research, January 2017, American Chemical Society (ACS)

    Dr Soile Tapio

  13. Ionizing radiation biomarkers in epidemiological studies – An update

    Article • Mutation Research/Reviews in Mutation Research, January 2017, Elsevier

    Dr Soile Tapio

  14. Low-dose radiation differentially regulates protein acetylation and histone deacetylase expression in human coronary artery endothelial cells

    Article • International Journal of Radiation Biology, October 2016, Taylor & Francis

    Dr Soile Tapio

  15. Effects of ionizing radiation on the mammalian brain

    Article • Mutation Research/Reviews in Mutation Research, October 2016, Elsevier

    Dr Soile Tapio

  16. Chronic low-dose-rate ionising radiation affects the hippocampal phosphoproteome in the ApoE−/− Alzheimer´s mouse model

    Article • Oncotarget, September 2016, Impact Journals, LLC

    Dr Soile Tapio

  17. Pathology and biology of radiation-induced cardiac disease

    Article • Journal of Radiation Research, July 2016, Oxford University Press (OUP)

    Dr Soile Tapio

  18. In-Utero Low-Dose Irradiation Leads to Persistent Alterations in the Mouse Heart Proteome

    Article • PLoS ONE, June 2016, PLOS

    Dr Soile Tapio

  19. Transcriptomic and proteomic analysis of mouse radiation-induced acute myeloid leukaemia (AML)

    Article • Oncotarget, May 2016, Impact Journals, LLC

    Dr Soile Tapio

  20. Brain Radiation Information Data Exchange (BRIDE): integration of experimental data from low-dose ionising radiation research for pathway discovery

    Article • BMC Bioinformatics, May 2016, Springer Science + Business Media

    Dr Soile Tapio

  21. Age-related effects of X-ray irradiation on mouse hippocampus

    Article • Oncotarget, April 2016, Impact Journals, LLC

    Dr Soile Tapio

  22. Long-term consequences of in utero irradiated mice indicate proteomic changes in synaptic plasticity related signalling

    Article • Proteome Science, November 2015, Springer Science + Business Media

    Dr Soile Tapio

  23. Neonatal Irradiation Leads to Persistent Proteome Alterations Involved in Synaptic Plasticity in the Mouse Hippocampus and Cortex

    Article • Journal of Proteome Research, November 2015, American Chemical Society (ACS)

    Dr Soile Tapio

  24. Late proliferating and inflammatory effects on murine microvascular heart and lung endothelial cells after irradiation

    Article • Radiotherapy and Oncology, November 2015, Elsevier

    Dr Soile Tapio

  25. Acceleration of atherogenesis in ApoE−/− mice exposed to acute or low-dose-rate ionizing radiation

    Article • Oncotarget, August 2015, Impact Journals, LLC

    Dr Soile Tapio

  26. Quantitative and integrated proteome and microRNA analysis of endothelial replicative senescence

    Article • Journal of Proteomics, August 2015, Elsevier

    Dr Soile Tapio

  27. Unique proteomic signature for radiation sensitive patients; a comparative study between normo-sensitive and radiation sensitive breast cancer patients

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, June 2015, Elsevier

    Dr Soile Tapio

  28. Low-Dose Ionizing Radiation Rapidly Affects Mitochondrial and Synaptic Signaling Pathways in Murine Hippocampus and Cortex

    Article • Journal of Proteome Research, May 2015, American Chemical Society (ACS)

    Dr Soile Tapio

  29. Ionizing radiation induces immediate protein acetylation changes in human cardiac microvascular endothelial cells

    Article • Journal of Radiation Research, April 2015, Oxford University Press (OUP)

    Dr Soile Tapio

  30. Low-dose ionising radiation and cardiovascular diseases – Strategies for molecular epidemiological studies in Europe

    Article • Mutation Research/Reviews in Mutation Research, April 2015, Elsevier

    Dr Soile Tapio

  31. Integrative Proteomics and Targeted Transcriptomics Analyses in Cardiac Endothelial Cells Unravel Mechanisms of Long-Term Radiation-Induced Vascular Dysfunction

    Article • Journal of Proteome Research, February 2015, American Chemical Society (ACS)

    Dr Soile Tapio

  32. Total Body Exposure to Low-Dose Ionizing Radiation Induces Long-Term Alterations to the Liver Proteome of Neonatally Exposed Mice

    Article • Journal of Proteome Research, January 2015, American Chemical Society (ACS)

    Dr Soile Tapio

  33. Qualitative and Quantitative Proteomic Analysis of Formalin-Fixed Paraffin-Embedded (FFPE) Tissue

    Article • January 2015, Springer Science + Business Media

    Dr Soile Tapio

  34. A dose-dependent perturbation in cardiac energy metabolism is linked to radiation-induced ischemic heart disease in Mayak nuclear workers

    Article • Oncotarget, November 2014, Impact Journals, LLC

    Dr Soile Tapio

  35. Ionising Radiation Immediately Impairs Synaptic Plasticity-Associated Cytoskeletal Signalling Pathways in HT22 Cells and in Mouse Brain: An In Vitro/In Vivo Comparison Study

    Article • PLoS ONE, October 2014, PLOS

    Dr Soile Tapio

  36. Adhesion Molecule Expression and Function of Primary Endothelial Cells in Benign and Malignant Tissues Correlates with Proliferation

    Article • PLoS ONE, March 2014, PLOS

    Dr Soile Tapio

  37. The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation

    Article • Molecular Neurodegeneration, January 2014, Springer Science + Business Media

    Dr Soile Tapio

  38. Proteomic Strategies: SILAC and 2D-DIGE—Powerful Tool to Investigate Cellular Alterations

    Article • October 2013, Springer Science + Business Media

    Dr Soile Tapio

  39. Cell Survival Following Radiation Exposure Requires miR-525-3p Mediated Suppression of ARRB1 and TXN1

    Article • PLoS ONE, October 2013, PLOS

    Dr Soile Tapio

  40. Proteomics in radiation research: present status and future perspectives

    Article • Radiation and Environmental Biophysics, October 2013, Springer Science + Business Media

    Dr Soile Tapio

  41. The PI3K/Akt/mTOR Pathway Is Implicated in the Premature Senescence of Primary Human Endothelial Cells Exposed to Chronic Radiation

    Article • PLoS ONE, August 2013, PLOS

    Dr Soile Tapio

  42. Long-term effects of acute low-dose ionizing radiation on the neonatal mouse heart: a proteomic study

    Article • Radiation and Environmental Biophysics, July 2013, Springer Science + Business Media

    Dr Soile Tapio

  43. PPAR Alpha: A Novel Radiation Target in Locally Exposed Mus musculus Heart Revealed by Quantitative Proteomics

    Article • Journal of Proteome Research, June 2013, American Chemical Society (ACS)

    Dr Soile Tapio

  44. Quantitative proteomic analysis reveals induction of premature senescence in human umbilical vein endothelial cells exposed to chronic low-dose rate gamma radiation

    Article • PROTEOMICS, March 2013, Wiley

    Dr Soile Tapio

  45. Ionising radiation induces persistent alterations in the cardiac mitochondrial function of C57BL/6 mice 40weeks after local heart exposure

    Article • Radiotherapy and Oncology, March 2013, Elsevier

    Dr Soile Tapio

  46. Comment on “Dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors” (Radiat. Environ. Biophys (2012) 51:165–178) by Schöllnberger et al.

    Article • Radiation and Environmental Biophysics, January 2013, Springer Science + Business Media

    Dr Soile Tapio

  47. Ionizing Radiation Effects on Cells, Organelles and Tissues on Proteome Level

    Article • January 2013, Springer Science + Business Media

    Dr Soile Tapio

  48. Estimating Risk of Circulatory Disease: Little et al. Respond

    Article • Environmental Health Perspectives, December 2012, Environmental Health Perspectives

    Dr Soile Tapio

  49. Integrative proteomic and microRNA analysis of primary human coronary artery endothelial cells exposed to low-dose gamma radiation

    Article • Radiation and Environmental Biophysics, November 2012, Springer Science + Business Media

    Dr Soile Tapio

  50. Long-term effects of ionising radiation on the brain: cause for concern?

    Article • Radiation and Environmental Biophysics, October 2012, Springer Science + Business Media

    Dr Soile Tapio

  51. Ionizing radiation biomarkers for potential use in epidemiological studies

    Article • Mutation Research/Reviews in Mutation Research, October 2012, Elsevier

    Dr Soile Tapio, Dr Radhia M'kacher

  52. Systematic Review and Meta-analysis of Circulatory Disease from Exposure to Low-Level Ionizing Radiation and Estimates of Potential Population Mortality Risks

    Article • Environmental Health Perspectives, June 2012, Environmental Health Perspectives

    Dr Soile Tapio

  53. Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation

    Article • Journal of Proteomics, April 2012, Elsevier

    Dr Soile Tapio

  54. Proteomic analysis by SILAC and 2D-DIGE reveals radiation-induced endothelial response: Four key pathways

    Article • Journal of Proteomics, April 2012, Elsevier

    Dr Soile Tapio

  55. Nucleic acids from long-term preserved FFPE tissues are suitable for downstream analyses

    Article • Virchows Archiv, January 2012, Springer Science + Business Media

    Dr Soile Tapio

  56. Radiation–Induced Signaling Results in Mitochondrial Impairment in Mouse Heart at 4 Weeks after Exposure to X-Rays

    Article • PLoS ONE, December 2011, PLOS

    Dr Soile Tapio

  57. Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation

    Article • PROTEOMICS, July 2011, Wiley

    Dr Soile Tapio

  58. The European Radiobiological Archives: Online Access to Data from Radiobiological Experiments

    Article • Radiation Research, April 2011, Radiation Research Society

    Dr Soile Tapio

  59. Archiving lessons from radiobiology

    Article • Nature, December 2010, Nature

    Dr Soile Tapio

  60. Low-dose irradiation causes rapid alterations to the proteome of the human endothelial cell line EA.hy926

    Article • Radiation and Environmental Biophysics, November 2010, Springer Science + Business Media

    Dr Soile Tapio

  61. Formalin-Fixed Paraffin-Embedded (FFPE) Proteome Analysis Using Gel-Free and Gel-Based Proteomics

    Article • Journal of Proteome Research, September 2010, American Chemical Society (ACS)

    Dr Soile Tapio

  62. Use of proteomics in radiobiological research: current state of the art

    Article • Radiation and Environmental Biophysics, January 2010, Springer Science + Business Media

    Dr Soile Tapio

  63. Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms

    Article • Radiation and Environmental Biophysics, October 2009, Springer Science + Business Media

    Dr Soile Tapio, PhD François E Paris

  64. Overexpression of PTK6 (breast tumor kinase) protein—a prognostic factor for long-term breast cancer survival—is not due to gene amplification

    Article • Virchows Archiv, July 2009, Springer Science + Business Media

    Dr Soile Tapio

  65. Tumorigenesis

    Article • January 2009, Springer Science + Business Media

    Dr Soile Tapio

  66. Major histopathological patterns of lung cancer related to arsenic exposure in German uranium miners

    Article • International Archives of Occupational and Environmental Health, November 2008, Springer Science + Business Media

    Dr Soile Tapio

  67. Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients

    Article • British Journal of Cancer, September 2008, Nature

    Dr Soile Tapio

  68. Comments: The non-cancer mortality experience of male workers at British Nuclear Fuels plc, 1946-2005

    Article • International Journal of Epidemiology, July 2008, Oxford University Press (OUP)

    Dr Soile Tapio

  69. A Systematic Review of Epidemiological Associations between Low and Moderate Doses of Ionizing Radiation and Late Cardiovascular Effects, and Their Possible Mechanisms

    Article • Radiation Research, January 2008, Radiation Research Society

    Dr Soile Tapio, PhD François E Paris

  70. Progress in updating the European Radiobiology Archives

    Article • International Journal of Radiation Biology, January 2008, Taylor & Francis

    Dr Soile Tapio

  71. Molecular information obtained from radiobiological tissue archives: achievements of the past and visions of the future

    Article • Radiation and Environmental Biophysics, December 2007, Springer Science + Business Media

    Dr Soile Tapio

  72. Radioadaptive response revisited

    Article • Radiation and Environmental Biophysics, November 2006, Springer Science + Business Media

    Dr Soile Tapio

  73. Arsenic in the aetiology of cancer

    Article • Mutation Research/Reviews in Mutation Research, June 2006, Elsevier

    Dr Soile Tapio

  74. Combined effects of gamma radiation and arsenite on the proteome of human TK6 lymphoblastoid cells

    Article • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, March 2005, Elsevier

    Dr Soile Tapio

  75. Starvation in vivo for aminoacyl-tRNA increases the spatial separation between the two ribosomal subunits

    Article • Cell, November 1994, Elsevier

    Dr Soile Tapio

  76. Base 2661 in Escherichia coli 23S rRNA influences the binding of elongation factor Tu during protein synthesis in vivo

    Article • European Journal of Biochemistry, December 1991, Wiley

    Dr Soile Tapio

  77. Antisuppression by mutations in elongation factor Tu

    Article • European Journal of Biochemistry, March 1990, Wiley

    Dr Soile Tapio

  78. Impaired in vitro kinetics of EF-Tu mutant Aa

    Article • European Journal of Biochemistry, March 1990, Wiley

    Dr Soile Tapio

  79. Antagonistic effects of mutant elongation factor Tu and ribosomal protein S12 on control of translational accuracy, suppression and cellular growth

    Article • Biochimie, February 1988, Elsevier

    Dr Soile Tapio

  80. Mutant EF-Tu increases missense error in vitro

    Article • Molecular Genetics and Genomics, October 1986, Springer Science + Business Media

    Dr Soile Tapio