All Stories

  1. Combining Viral Vectored and Protein-in-adjuvant Vaccines Against the Blood-stage Malaria Antigen AMA1: Report on a Phase 1a Clinical Trial

    Article • Molecular Therapy, December 2014, Elsevier

    Dr Simon J Draper

  2. Assessment of Humoral Immune Responses to Blood-Stage Malaria Antigens following ChAd63-MVA Immunization, Controlled Human Malaria Infection and Natural Exposure

    Article • PLoS ONE, September 2014, PLOS

    Dr Simon J Draper

  3. Microneedle-mediated immunization of an adenovirus-based malaria vaccine enhances antigen-specific antibody immunity and reduces anti-vector responses compared to the intradermal route

    Article • Scientific Reports, August 2014, Springer Science + Business Media

    Dr Simon J Draper

  4. Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies

    Article • Nature, August 2014, Springer Science + Business Media

    Dr Simon J Draper

  5. Analysis of human B‐cell responses following ChAd63‐MVA MSP1 and AMA1 immunization and controlled malaria infection

    Article • Immunology, March 2014, Wiley

    Dr Simon J Draper

  6. Neutralization of Plasmodium falciparum Merozoites by Antibodies against PfRH5

    Article • The Journal of Immunology, November 2013, The American Association of Immunologists

    Dr Simon J Draper

  7. Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation

    Article • Nature Communications, November 2013, Springer Science + Business Media

    Dr Simon J Draper, Prof Arturo Reyes-Sandoval

  8. Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome

    Article • Journal of Leukocyte Biology, October 2013, Society for Leukocyte Biology

    Dr Simon J Draper

  9. Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes

    Article • International Journal for Parasitology, October 2013, Elsevier

    Dr Simon J Draper

  10. Challenges of assessing the clinical efficacy of asexual blood-stagePlasmodium falciparummalaria vaccines

    Article • Human Vaccines & Immunotherapeutics, September 2013, Taylor & Francis

    Dr Simon J Draper

  11. Utilizing poxviral vectored vaccines for antibody induction—Progress and prospects

    Article • Vaccine, September 2013, Elsevier

    Dr Simon J Draper

  12. The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment

    Article • Scientific Reports, April 2013, Springer Science + Business Media

    Dr Simon J Draper

  13. Comparison of Modeling Methods to Determine Liver-to-blood Inocula and Parasite Multiplication Rates During Controlled Human Malaria Infection

    Article • The Journal of Infectious Diseases, April 2013, Oxford University Press (OUP)

    Dr Simon J Draper

  14. Recent advances in antibody-inducing poxviral and adenoviral vectored vaccine delivery platforms for difficult disease targets

    Article • Expert Review of Vaccines, April 2013, Taylor & Francis

    Dr Simon J Draper

  15. Assessment of Immune Interference, Antagonism, and Diversion following Human Immunization with Biallelic Blood-Stage Malaria Viral-Vectored Vaccines and Controlled Malaria Infection

    Article • The Journal of Immunology, January 2013, The American Association of Immunologists

    Dr Simon J Draper

  16. ChAd63-MVA–vectored Blood-stage Malaria Vaccines Targeting MSP1 and AMA1: Assessment of Efficacy Against Mosquito Bite Challenge in Humans

    Article • Molecular Therapy, December 2012, Elsevier

    Dr Simon J Draper

  17. Enhancing Blockade of Plasmodium falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies against PfRH5 and Other Merozoite Antigens

    Article • PLoS Pathogens, November 2012, PLOS

    Dr Simon J Draper

  18. T Cell Responses Induced by Adenoviral Vectored Vaccines Can Be Adjuvanted by Fusion of Antigen to the Oligomerization Domain of C4b-Binding Protein

    Article • PLoS ONE, September 2012, PLOS

    Dr Simon J Draper

  19. Recombinant Viral-Vectored Vaccines Expressing Plasmodium chabaudi AS Apical Membrane Antigen 1: Mechanisms of Vaccine-Induced Blood-Stage Protection

    Article • The Journal of Immunology, April 2012, The American Association of Immunologists

    Dr Simon J Draper

  20. Coated microneedle arrays for transcutaneous delivery of live virus vaccines

    Article • Journal of Controlled Release, April 2012, Elsevier

    Dr Simon J Draper

  21. Controlled Human Blood Stage Malaria Infection: Current Status and Potential Applications

    Article • American Journal of Tropical Medicine and Hygiene, April 2012, American Society of Tropical Medicine and Hygiene

    Dr Simon J Draper

  22. Fusion of the Mycobacterium tuberculosis Antigen 85A to an Oligomerization Domain Enhances Its Immunogenicity in Both Mice and Non-Human Primates

    Article • PLoS ONE, March 2012, PLOS

    Dr Simon J Draper

  23. Phase Ia Clinical Evaluation of the Safety and Immunogenicity of the Plasmodium falciparum Blood-Stage Antigen AMA1 in ChAd63 and MVA Vaccine Vectors

    Article • PLoS ONE, February 2012, PLOS

    Dr Simon J Draper

  24. A Viral Vectored Prime-Boost Immunization Regime Targeting the Malaria Pfs25 Antigen Induces Transmission-Blocking Activity

    Article • PLoS ONE, December 2011, PLOS

    Dr Simon J Draper

  25. The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

    Article • Nature Communications, December 2011, Springer Science + Business Media

    Dr Simon J Draper

  26. Phase Ia Clinical Evaluation of the Plasmodium falciparum Blood-stage Antigen MSP1 in ChAd63 and MVA Vaccine Vectors

    Article • Molecular Therapy, December 2011, Elsevier

    Dr Simon J Draper

  27. Accelerating vaccine development and deployment: report of a Royal Society satellite meeting

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, September 2011, Royal Society Publishing

    Dr Simon J Draper

  28. Combining Liver- and Blood-Stage Malaria Viral-Vectored Vaccines: Investigating Mechanisms of CD8+ T Cell Interference

    Article • The Journal of Immunology, August 2011, The American Association of Immunologists

    Dr Simon J Draper

  29. The Requirement for Potent Adjuvants To Enhance the Immunogenicity and Protective Efficacy of Protein Vaccines Can Be Overcome by Prior Immunization with a Recombinant Adenovirus

    Article • The Journal of Immunology, August 2011, The American Association of Immunologists

    Dr Simon J Draper

  30. The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP119)

    Article • BMC Biotechnology, July 2011, Springer Science + Business Media

    Dr Anthony A Holder, Dr Simon J Draper

  31. Impact on Malaria Parasite Multiplication Rates in Infected Volunteers of the Protein-in-Adjuvant Vaccine AMA1-C1/Alhydrogel+CPG 7909

    Article • PLoS ONE, July 2011, PLOS

    Dr Simon J Draper

  32. Transgene Optimization, Immunogenicity and In Vitro Efficacy of Viral Vectored Vaccines Expressing Two Alleles of Plasmodium falciparum AMA1

    Article • PLoS ONE, June 2011, PLOS

    Dr Anthony A Holder, Dr Simon J Draper

  33. Substantially Reduced Pre-patent Parasite Multiplication Rates Are Associated With Naturally Acquired Immunity to Plasmodium falciparum

    Article • The Journal of Infectious Diseases, March 2011, Oxford University Press (OUP)

    Dr Simon J Draper

  34. Enhancing Blood-Stage Malaria Subunit Vaccine Immunogenicity in Rhesus Macaques by Combining Adenovirus, Poxvirus, and Protein-in-Adjuvant Vaccines

    Article • The Journal of Immunology, November 2010, The American Association of Immunologists

    Dr Simon J Draper

  35. Tailoring subunit vaccine immunogenicity: Maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1

    Article • Vaccine, October 2010, Elsevier

    Dr Simon J Draper

  36. New Candidate Vaccines against Blood-Stage Plasmodium falciparum Malaria: Prime-Boost Immunization Regimens Incorporating Human and Simian Adenoviral Vectors and Poxviral Vectors Expressing an Optimized Antigen Based on Merozoite Surface Protein 1

    Article • Infection and Immunity, August 2010, ASM Journals

    Dr Simon J Draper

  37. Blood-stage malaria vaccines — recent progress and future challenges

    Article • Annals of Tropical Medicine and Parasitology, April 2010, Taylor & Francis

    Dr Simon J Draper

  38. Prime-boost vectored malaria vaccines: Progress and prospects

    Article • Human Vaccines, January 2010, Taylor & Francis

    Dr Simon J Draper, Prof Arturo Reyes-Sandoval

  39. Viruses as vaccine vectors for infectious diseases and cancer

    Article • Nature Reviews Microbiology, December 2009, Springer Science + Business Media

    Dr Simon J Draper, Professor Jonathan Luke Heeney

  40. Toward the Discovery of Vaccine Adjuvants: Coupling In Silico Screening and In Vitro Analysis of Antagonist Binding to Human and Mouse CCR4 Receptors

    Article • PLoS ONE, November 2009, PLOS

    Dr Simon J Draper

  41. Recombinant Viral Vaccines Expressing Merozoite Surface Protein-1 Induce Antibody- and T Cell-Mediated Multistage Protection against Malaria

    Article • Cell Host & Microbe, January 2009, Elsevier

    Dr Simon J Draper

  42. Effective induction of high-titer antibodies by viral vector vaccines

    Article • Nature Reports Stem Cells, July 2008, Springer Science + Business Media

    Dr Anthony A Holder, Dr Simon J Draper

  43. In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination

    Article • Proceedings of the National Academy of Sciences, July 2008, Proceedings of the National Academy of Sciences

    Dr Simon J Draper

  44. Single-Dose Protection against Plasmodium berghei by a Simian Adenovirus Vector Using a Human Cytomegalovirus Promoter Containing Intron A

    Article • Journal of Virology, February 2008, ASM Journals

    Dr Simon J Draper, Prof Arturo Reyes-Sandoval

  45. Requirement of Fission Yeast Cid14 in Polyadenylation of rRNAs

    Article • Molecular and Cellular Biology, March 2006, ASM Journals

    Dr Simon J Draper

  46. Anti-CD25 Antibody Enhancement of Vaccine-Induced Immunogenicity: Increased Durable Cellular Immunity with Reduced Immunodominance

    Article • The Journal of Immunology, November 2005, The American Association of Immunologists

    Dr Simon J Draper