All Stories

  1. Association of oral frailty and gut microbiota with hypertension: cross-sectional results in the Shika study

    Article • Frontiers of Medicine, December 2025, Springer Science + Business Media

    Dr Shigefumi Okamoto

  2. Gut microbiota–derived polyamine pathways associated with mean blood pressure

    Article • Hypertension Research, December 2025, Springer Science + Business Media

    Dr Shigefumi Okamoto

  3. Relationship between severe radiodermatitis and skin barrier functions in patients with head and neck cancer: A prospective observational study

    Article • Asia-Pacific Journal of Oncology Nursing, December 2025, Elsevier

    Dr Shigefumi Okamoto

  4. Oral administration of Enterococcus faecalis to mice induces acute and chronic inflammation in the pancreas: possible involvement in the pathophysiology of pancreatic diseases

    Article • Biochemical and Biophysical Research Communications, November 2025, Elsevier

    Dr Shigefumi Okamoto

  5. Changes in the Skin Microbiome of a Patient with Head and Neck Cancer with Severe Radiodermatitis: A Case Report

    Article • Case Reports in Oncology, June 2025, Karger Publishers

    Dr Shigefumi Okamoto

  6. Invasion of pancreatic ductal epithelial cells by Enterococcus faecalis is mediated by fibronectin and enterococcal fibronectin-binding protein A

    Article • Scientific Reports, January 2025, Springer Science + Business Media

    Dr Shigefumi Okamoto

  7. New multilocus sequence typing scheme for Enterococcus faecium reveals sequential outbreaks of vancomycin-resistant E. faecium ST1162 and ST610 in a Japanese tertiary medical center

    Article • Microbiology Spectrum, January 2025, ASM Journals

    Dr Shigefumi Okamoto

  8. Correction: Furugaito et al. Antimicrobial Susceptibility to 27 Drugs and the Molecular Mechanisms of Macrolide, Tetracycline, and Quinolone Resistance in Gemella sp. Antibiotics 2023, 12, 1538

    Article • Antibiotics, May 2024, MDPI AG

    Dr Shigefumi Okamoto

  9. Prediction and causal inference of hyperuricemia using gut microbiota

    Article • Scientific Reports, April 2024, Springer Science + Business Media

    Dr Shigefumi Okamoto

  10. Association between animal protein intake, oral frailty and calf circumference in middle-aged and older adults: a cross-sectional analysis from the Shika study

    Article • BMJ Open, February 2024, BMJ

    Dr Shigefumi Okamoto

  11. Skin microbiome profile in people living with HIV/AIDS in Cameroon

    Article • Frontiers in Cellular and Infection Microbiology, October 2023, Frontiers

    Dr Shigefumi Okamoto

  12. Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results

    Article • Frontiers in Cellular and Infection Microbiology, October 2023, Frontiers

    Dr Shigefumi Okamoto

  13. Antimicrobial Susceptibility to 27 Drugs and the Molecular Mechanisms of Macrolide, Tetracycline, and Quinolone Resistance in Gemella sp.

    Article • Antibiotics, October 2023, MDPI AG

    Dr Shigefumi Okamoto

  14. Soluble biomarkers of HIV-1-related systemic immune activation are associated with high plasma levels of growth factors implicated in the pathogenesis of Kaposi sarcoma in adults

    Article • Frontiers in Immunology, September 2023, Frontiers

    Dr Shigefumi Okamoto

  15. A multilocus sequence typing method of Staphylococcus aureus DNAs in a sample from human skin

    Article • Microbiology and Immunology, August 2023, Wiley

    Dr Shigefumi Okamoto

  16. Impact of gut microbiome on the renin-aldosterone system: Shika-machi Super Preventive Health Examination results

    Article • Hypertension Research, June 2023, Springer Science + Business Media

    Dr Shigefumi Okamoto

  17. Oral microbiome changes associated with the menstrual cycle in healthy young adult females

    Article • Frontiers in Cellular and Infection Microbiology, March 2023, Frontiers

    Dr Shigefumi Okamoto

  18. Potential biomarker proteins for aspiration pneumonia detected by shotgun proteomics using buccal mucosa samples: a cross-sectional case–control study

    Article • Clinical Proteomics, March 2023, Springer Science + Business Media

    Dr Shigefumi Okamoto

  19. Evaluation of L-Alanine Metabolism in Bacteria and Whole-Body Distribution with Bacterial Infection Model Mice

    Article • International Journal of Molecular Sciences, March 2023, MDPI AG

    Dr Shigefumi Okamoto

  20. Association between Bone Mineral Density and Oral Frailty on Renal Function: Findings from the Shika Study

    Article • Healthcare, January 2023, MDPI AG

    Dr Shigefumi Okamoto

  21. Gut bacterial aromatic amine production: aromatic amino acid decarboxylase and its effects on peripheral serotonin production

    Article • Gut Microbes, October 2022, Taylor & Francis

    Dr Shigefumi Okamoto

  22. Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference

    Article • Frontiers in Cellular and Infection Microbiology, September 2022, Frontiers

    Dr Shigefumi Okamoto

  23. Potential biomarker proteins for aspiration pneumonia detected by shotgun proteomics using buccal mucosa samples: A cross-sectional study

    Article • June 2022, Research Square

    Dr Shigefumi Okamoto

  24. 123I-BMIPP, a Radiopharmaceutical for Myocardial Fatty Acid Metabolism Scintigraphy, Could Be Utilized in Bacterial Infection Imaging

    Article • Pharmaceutics, May 2022, MDPI AG

    Dr Shigefumi Okamoto

  25. Interspecies Regulation Between Staphylococcus caprae and Staphylococcus aureus Colonized on Healed Skin After Injury

    Article • Frontiers in Microbiology, March 2022, Frontiers

    Dr Shigefumi Okamoto

  26. Comparison of L- and D-Amino Acids for Bacterial Imaging in Lung Infection Mouse Model

    Article • International Journal of Molecular Sciences, February 2022, MDPI AG

    Dr Shigefumi Okamoto

  27. Skin microbiome profile of healthy Cameroonians and Japanese

    Article • Scientific Reports, January 2022, Springer Science + Business Media

    Dr Shigefumi Okamoto

  28. Corrigendum: Comparative genome analysis of three Group A Streptococcus dysgalactiae subsp. equisimilis strains isolated in Japan

    Article • Journal of Medical Microbiology, August 2021, Society for General Microbiology

    Dr Shigefumi Okamoto

  29. Association of Skin Microbiome with the Onset and Recurrence of Pressure Injury in Bedridden Elderly People

    Article • Microorganisms, July 2021, MDPI AG

    Dr Shigefumi Okamoto

  30. GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection

    Article • mBio, June 2021, ASM Journals

    Dr Shigefumi Okamoto

  31. Relationship between Decreased Mineral Intake Due to Oral Frailty and Bone Mineral Density: Findings from Shika Study

    Article • Nutrients, April 2021, MDPI AG

    Dr Shigefumi Okamoto

  32. Comparative genome analysis of three Group A Streptococcus dysgalactiae subsp. equisimilis strains isolated in Japan

    Article • Journal of Medical Microbiology, March 2021, Society for General Microbiology

    Dr Shigefumi Okamoto

  33. Amplicon-based skin microbiome profiles collected by tape stripping with different adhesive film dressings: a comparative study

    Article • BMC Microbiology, February 2021, Springer Science + Business Media

    Dr Shigefumi Okamoto

  34. Novel Hyaluronate Lyase Involved in Pathogenicity of Streptococcus dysgalactiae subsp. equisimilis

    Article • Frontiers in Microbiology, September 2020, Frontiers

    Dr Shigefumi Okamoto

  35. GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Dr Shigefumi Okamoto

  36. Impact of Gut Microbiome on Hypertensive Patients With Low-Salt Intake: Shika Study Results

    Article • Frontiers in Medicine, September 2020, Frontiers

    Dr Shigefumi Okamoto

  37. Stability of Skin Microbiome at Sacral Regions of Healthy Young Adults, Ambulatory Older Adults, and Bedridden Older Patients After 2 Years

    Article • Biological Research For Nursing, July 2020, SAGE Publications

    Dr Shigefumi Okamoto

  38. Skin Physiology and its Microbiome as Factors Associated with the Recurrence of Pressure Injuries

    Article • Biological Research For Nursing, July 2020, SAGE Publications

    Dr Shigefumi Okamoto

  39. Distinct Skin Microbiome and Skin Physiological Functions Between Bedridden Older Patients and Healthy People: A Single-Center Study in Japan

    Article • Frontiers in Medicine, April 2020, Frontiers

    Dr Shigefumi Okamoto

  40. Development of recurrent pressure ulcers, risk factors in older patients: a prospective observational study

    Article • Journal of Wound Care, April 2020, Mark Allen Group

    Dr Shigefumi Okamoto

  41. Pathogenicity Characterization of Prevalent-Type Streptococcus dysgalactiae subsp. equisimilis Strains

    Article • Frontiers in Microbiology, February 2020, Frontiers

    Dr Shigefumi Okamoto

  42. Feasibility of microbial sample collection on the skin from people in Yaoundé, Cameroon

    Article • Drug Discoveries & Therapeutics, December 2019, International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)

    Dr Shigefumi Okamoto

  43. Prevalence and genomic characterization of Group A Streptococcus dysgalactiae subsp. equisimilis isolated from patients with invasive infections in Toyama prefecture, Japan

    Article • Microbiology and Immunology, December 2019, Wiley

    Dr Shigefumi Okamoto

  44. Measuring the Antimicrobial Activity of Lauric Acid against Various Bacteria in Human Gut Microbiota Using a New Method

    Article • Cell Transplantation, October 2019, SAGE Publications

    Dr Shigefumi Okamoto

  45. Food bolus‐forming ability predicts incidence of aspiration pneumonia in nursing home older adults: A prospective observational study

    Article • Journal of Oral Rehabilitation, August 2019, Wiley

    Dr Shigefumi Okamoto

  46. Corrigendum: A Comparison of Techniques for Collecting Skin Microbiome Samples: Swabbing Versus Tape-Stripping

    Article • Frontiers in Microbiology, November 2018, Frontiers

    Dr Shigefumi Okamoto

  47. A Comparison of Techniques for Collecting Skin Microbiome Samples: Swabbing Versus Tape-Stripping

    Article • Frontiers in Microbiology, October 2018, Frontiers

    Dr Shigefumi Okamoto

  48. Pathogenic mechanisms of invasive group A Streptococcus infections by influenza virus-group A Streptococcus superinfection

    Article • Microbiology and Immunology, March 2018, Wiley

    Dr Shigefumi Okamoto

  49. Toll-like receptor 9 ligand D-type oligodeoxynucleotide D35 as a broad inhibitor for influenza A virus replication that is associated with suppression of neuraminidase activity

    Article • Antiviral Research, May 2016, Elsevier

    Dr Shigefumi Okamoto

  50. Dextran sulfate-resistant A/Puerto Rico/8/34 influenza virus is associated with the emergence of specific mutations in the neuraminidase glycoprotein

    Article • Antiviral Research, November 2014, Elsevier

    Dr Shigefumi Okamoto, Kenji Mizuguchi

  51. Neuraminidase gene homology contributes to the protective activity of influenza vaccines prepared from the influenza virus library

    Article • Journal of General Virology, July 2014, Society for General Microbiology

    Dr Shigefumi Okamoto

  52. An MDCK Cell Culture-Derived Formalin-Inactivated Influenza Virus Whole-Virion Vaccine from an Influenza Virus Library Confers Cross-Protective Immunity by Intranasal Administration in Mice

    Article • Clinical and Vaccine Immunology, May 2013, ASM Journals

    Dr Shigefumi Okamoto

  53. Study of Next Generation Influenza Vaccine Focused on ^|^ldquo;Cross-Protection by Mucosal Immunization^|^rdquo; and ^|^ldquo;Seed Virus Strains^|^rdquo;

    Article • YAKUGAKU ZASSHI, January 2013, Pharmaceutical Society of Japan

    Dr Shigefumi Okamoto

  54. Influenza virus neuraminidase contributes to the dextran sulfate-dependent suppressive replication of some influenza A virus strains

    Article • Antiviral Research, December 2012, Elsevier

    Dr Shigefumi Okamoto

  55. Comparison of the Cross-Reactive Anti-Influenza Neutralizing Activity of Polymeric and Monomeric IgA Monoclonal Antibodies

    Article • Viral Immunology, October 2012, Mary Ann Liebert Inc

    Dr Shigefumi Okamoto

  56. A community-based survey of varicella-zoster virus-specific immune responses in the elderly

    Article • Journal of Clinical Virology, September 2012, Elsevier

    Dr Shigefumi Okamoto

  57. Intranasal Immunization with a Formalin-Inactivated Human Influenza A Virus Whole-Virion Vaccine Alone and Intranasal Immunization with a Split-Virion Vaccine with Mucosal Adjuvants Show Similar Levels of Cross-Protection

    Article • Clinical and Vaccine Immunology, May 2012, ASM Journals

    Dr Shigefumi Okamoto

  58. Multiple Reversions of an IL2RG Mutation Restore T cell Function in an X-linked Severe Combined Immunodeficiency Patient

    Article • Journal of Clinical Immunology, March 2012, Springer Science + Business Media

    Dr Shigefumi Okamoto

  59. Poly-γ-Glutamic Acid Nanoparticles and Aluminum Adjuvant Used as an Adjuvant with a Single Dose of Japanese Encephalitis Virus-Like Particles Provide Effective Protection from Japanese Encephalitis Virus

    Article • Clinical and Vaccine Immunology, November 2011, ASM Journals

    Dr Shigefumi Okamoto

  60. Interleukin-1 Family Cytokines as Mucosal Vaccine Adjuvants for Induction of Protective Immunity against Influenza Virus

    Article • Journal of Virology, September 2010, ASM Journals

    Dr Shigefumi Okamoto

  61. Rapid and efficient introduction of a foreign gene into bacterial artificial chromosome-cloned varicella vaccine by Tn7-mediated site-specific transposition

    Article • Virology, June 2010, Elsevier

    Dr Shigefumi Okamoto

  62. Comparison of Varicella‐Zoster Virus–Specific Immunity of Patients with Diabetes Mellitus and Healthy Individuals

    Article • The Journal of Infectious Diseases, November 2009, Oxford University Press (OUP)

    Dr Shigefumi Okamoto

  63. Poly(γ-glutamic acid) nano-particles combined with mucosal influenza virus hemagglutinin vaccine protects against influenza virus infection in mice

    Article • Vaccine, September 2009, Elsevier

    Dr Shigefumi Okamoto

  64. A novel streptococcal leucine zipper protein (Lzp) binds to human immunoglobulins

    Article • Biochemical and Biophysical Research Communications, December 2008, Elsevier

    Dr Shigefumi Okamoto

  65. Measurement of Varicella‐Zoster Virus (VZV)–Specific Cell‐Mediated Immunity: Comparison between VZV Skin Test and Interferon‐γ Enzyme‐Linked Immunospot Assay

    Article • The Journal of Infectious Diseases, November 2008, Oxford University Press (OUP)

    Dr Shigefumi Okamoto

  66. Molecular and biological characterization of histidine triad protein in group A streptococci

    Article • Microbes and Infection, April 2008, Elsevier

    Dr Shigefumi Okamoto

  67. Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse B lymphocytes

    Article • FEMS Microbiology Letters, April 2008, Oxford University Press (OUP)

    Dr Shigefumi Okamoto

  68. Single dose of inactivated Japanese encephalitis vaccine with poly(γ-glutamic acid) nanoparticles provides effective protection from Japanese encephalitis virus

    Article • Vaccine, January 2008, Elsevier

    Dr Shigefumi Okamoto

  69. Generation of a recombinant Oka varicella vaccine expressing mumps virus hemagglutinin-neuraminidase protein as a polyvalent live vaccine

    Article • Vaccine, December 2007, Elsevier

    Dr Shigefumi Okamoto

  70. Influenza hemagglutinin vaccine with poly(γ-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity

    Article • Vaccine, November 2007, Elsevier

    Dr Shigefumi Okamoto

  71. Inflammatory Immune Responses by Water-insoluble α-glucans

    Article • Journal of Dental Research, March 2007, SAGE Publications

    Dr Shigefumi Okamoto

  72. Protective Immunity against Streptococcus pyogenes Challenge in Mice after Immunization with Fibronectin‐Binding Protein

    Article • The Journal of Infectious Diseases, December 2005, Oxford University Press (OUP)

    Dr Shigefumi Okamoto

  73. Systemic immunization with streptococcal immunoglobulin-binding protein Sib35 induces protective immunity against group A Streptococcus challenge in mice

    Article • Vaccine, September 2005, Elsevier

    Dr Shigefumi Okamoto

  74. The Streptococcus pyogenes Capsule Is Required for Adhesion of Bacteria to Virus-Infected Alveolar Epithelial Cells and Lethal Bacterial-Viral Superinfection

    Article • Infection and Immunity, October 2004, ASM Journals

    Dr Shigefumi Okamoto

  75. Proapoptotic Effect of Proteolytic Activation of Matrix Metalloproteinases by Streptococcus pyogenes Thiol Proteinase (Streptococcus Pyrogenic Exotoxin B)

    Article • Infection and Immunity, August 2004, ASM Journals

    Dr Shigefumi Okamoto

  76. Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza Streptococcus pyogenes superinfection

    Article • Vaccine, July 2004, Elsevier

    Dr Shigefumi Okamoto

  77. A model of invasive type of Streptococcus pyogenes infection after intranasal superinfection in influenza A virus-infected mice

    Article • International Congress Series, June 2004, Elsevier

    Dr Shigefumi Okamoto

  78. Influenza A Virus-Infected Hosts Boost an Invasive Type of Streptococcus pyogenes Infection in Mice

    Article • Journal of Virology, April 2003, ASM Journals

    Dr Shigefumi Okamoto

  79. Administration of Superantigens Protects Mice from Lethal Listeria monocytogenes Infection by Enhancing Cytotoxic T Cells

    Article • Infection and Immunity, November 2001, ASM Journals

    Dr Shigefumi Okamoto

  80. Extracellular Nicotinamide Adenine Dinucleotide Induces T Cell Apoptosis In Vivo and In Vitro

    Article • The Journal of Immunology, November 2001, The American Association of Immunologists

    Dr Shigefumi Okamoto

  81. Fas-Mediated Apoptosis Causes Elimination of Virus-Specific Cytotoxic T Cells in the Virus-Infected Liver

    Article • The Journal of Immunology, March 2001, The American Association of Immunologists

    Dr Shigefumi Okamoto

  82. NK Cells Cause Liver Injury and Facilitate the Induction of T Cell-Mediated Immunity to a Viral Liver Infection

    Article • The Journal of Immunology, June 2000, The American Association of Immunologists

    Dr Shigefumi Okamoto

  83. Fas- and tumor necrosis factor receptor 1-dependent but not perforin-dependent pathways cause injury in livers infected with an adenovirus construct in mice

    Article • Hepatology, March 2000, Wiley

    Dr Shigefumi Okamoto

  84. Superantigenicity of helper T‐cell mitogen (SPM‐2) isolated from culture supernatants of Streptococcus pyogenes

    Article • Immunology, July 1997, Wiley

    Dr Shigefumi Okamoto

  85. Molecular Cloning of a Functional Murine Arginine-Specific Mono-ADP-Ribosyltransferase and Its Expression in Lymphoid Cells

    Article • DNA and Cell Biology, February 1997, Mary Ann Liebert Inc

    Dr Shigefumi Okamoto

  86. Isolation of a new superantigen with potent mitogenic activity to murine T cells from Streptococcus pyogenes

    Article • FEMS Immunology & Medical Microbiology, September 1996, Oxford University Press (OUP)

    Dr Shigefumi Okamoto

  87. Isolation of a new superantigen with potent mitogenic activity to murine T cells from Streptococcus pyogenes

    Article • FEMS Immunology & Medical Microbiology, September 1996, Wiley

    Dr Shigefumi Okamoto

  88. Elevated production of interleukin 6 by hepatic MNC correlates with ICAM-1 expression on the hepatic sinusoidal endothelial cells in autoimmune MRL/lpr mice

    Article • Immunology Letters, May 1993, Elsevier

    Dr Shigefumi Okamoto

  89. Water-insoluble α-glucans from Streptococcus sobrinus induce inflammatory immune responses

    Article • Springer Science + Business Media

    Dr Shigefumi Okamoto