All Stories

  1. Response to reader comment on: “Comprehensive genotoxicity and carcinogenicity assessment of molnupiravir”

    Article • Toxicological Sciences, December 2024, Oxford University Press (OUP)

    Sean Troth

  2. Do longer duration nonclinical toxicology studies provide predictive clinical safety value? The IQ consortium longer duration nonclinical to clinical translational database

    Article • Toxicology and Applied Pharmacology, November 2024, Elsevier

    Sean Troth

  3. Comprehensive genotoxicity and carcinogenicity assessment of molnupiravir

    Article • Toxicological Sciences, September 2024, Oxford University Press (OUP)

    Sean Troth

  4. Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats

    Article • Toxicologic Pathology, February 2024, SAGE Publications

    Sean Troth

  5. Scientific and Regulatory Policy Committee Points to Consider: Review of the United States Food and Drug Administration (FDA) Guidance on Pathology Peer Review in Nonclinical Toxicology Studies

    Article • Toxicologic Pathology, February 2024, SAGE Publications

    Sean Troth

  6. Projecting the impact of an ebola virus outbreak on endangered mountain gorillas

    Article • Scientific Reports, April 2023, Springer Science + Business Media

    Sean Troth

  7. Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy

    Article • Journal for ImmunoTherapy of Cancer, September 2022, BMJ

    Sean Troth

  8. VSV-EBOV vaccine virus lacks horizontal transmission in swine

    Article • Emerging Microbes & Infections, March 2021, Taylor & Francis

    Sean Troth

  9. Development of Pandemic Vaccines: ERVEBO Case Study

    Article • Vaccines, February 2021, MDPI AG

    Sean Troth

  10. Evaluation of 10 Urinary Biomarkers for Renal Safety With 5 Nephrotoxicants in Nonhuman Primates

    Article • Toxicologic Pathology, July 2020, SAGE Publications

    Sean Troth

  11. Vaccine toxicology study overview

    Article • Toxicologic Pathology, October 2019, SAGE Publications

    Sean Troth

  12. 3Rs Concepts for Pathologists

    Article • Toxicologic Pathology, October 2019, SAGE Publications

    Sean Troth

  13. Adversity designation for veterinary pathologists

    Article • Toxicologic Pathology, July 2019, SAGE Publications

    Sean Troth

  14. rVSVΔG-ZEBOV-GP (also designated V920) recombinant vesicular stomatitis virus pseudotyped with Ebola Zaire Glycoprotein: Standardized template with key considerations for a risk/benefit assessment

    Article • April 2019, Elsevier

    Sean Troth

  15. An overview of current strategies to assess kidney safety in drug development

    Article • Seminars in Nephrology, March 2019, Elsevier

    Sean Troth

  16. Kidney Biomarkers - a historical perspective and future opportunities

    Article • Seminars in Nephrology, March 2019, Elsevier

    Sean Troth

  17. Data Visualization in Toxicology Studies

    Article • Toxicologic Pathology, May 2018, SAGE Publications

    Sean Troth

  18. Performance Assessment of New Urinary Translational Safety Biomarkers of Drug-induced Renal Tubular Injury in Tenofovir-treated Cynomolgus Monkeys and Beagle Dogs

    Article • Toxicologic Pathology, May 2018, SAGE Publications

    Sean Troth

  19. Clinical development of a recombinant Ebola vaccine in the midst of an unprecedented epidemic

    Article • Vaccine, August 2017, Elsevier

    Sean Troth

  20. Regulatory Forum Opinion Piece*: Imaging Applications in Toxicologic Pathology—Recommendations for Use in Regulated Nonclinical Toxicity Studies

    Article • Toxicologic Pathology, June 2017, SAGE Publications

    Sean Troth

  21. Graphical display of histopathology data from toxicology studies for drug discovery and development: An industry perspective

    Article • Regulatory Toxicology and Pharmacology, December 2016, Elsevier

    Sean Troth

  22. Rat Urinary Osteopontin and Neutrophil Gelatinase-Associated Lipocalin Improve Certainty of Detecting Drug-Induced Kidney Injury

    Article • Toxicological Sciences, March 2016, Oxford University Press (OUP)

    Sean Troth

  23. Evaluation of the Relative Performance of 12 Urinary Biomarkers for Renal Safety Across 22 Rat Sensitivity and Specificity Studies

    Article • Toxicological Sciences, December 2013, Oxford University Press (OUP)

    Sean Troth

  24. Recommendations for the Evaluation of Pathology Data in Nonclinical Safety Biomarker Qualification Studies

    Article • Toxicologic Pathology, November 2011, SAGE Publications

    Sean Troth

  25. Topic of Histopathology Blinding in Nonclinical Safety Biomarker Qualification Studies

    Article • Toxicologic Pathology, June 2010, SAGE Publications

    Sean Troth

  26. A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function

    Article • Nature Biotechnology, May 2010, Springer Science + Business Media

    Sean Troth

  27. Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies

    Article • Nature Biotechnology, May 2010, Springer Science + Business Media

    Sean Troth

  28. Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium

    Article • Nature Biotechnology, May 2010, Springer Science + Business Media

    Sean Troth

  29. Towards consensus practices to qualify safety biomarkers for use in early drug development

    Article • Nature Biotechnology, May 2010, Springer Science + Business Media

    Sean Troth

  30. Urinary biomarkers trefoil factor 3 and albumin enable early detection of kidney tubular injury

    Article • Nature Biotechnology, May 2010, Springer Science + Business Media

    Sean Troth

  31. A rapid urine test for early detection of kidney injury

    Article • Kidney International, July 2009, Elsevier

    Sean Troth

  32. Integrated Pathway Analysis of Rat Urine Metabolic Profiles and Kidney Transcriptomic Profiles To Elucidate the Systems Toxicology of Model Nephrotoxicants

    Article • Chemical Research in Toxicology, August 2008, American Chemical Society (ACS)

    Sean Troth

  33. In vivo CXCR4 expression, lymphoid cell phenotype, and feline immunodeficiency virus infection

    Article • Veterinary Immunology and Immunopathology, May 2008, Elsevier

    Sean Troth