All Stories

  1. Protective antigen–mediated delivery of an anti-CRISPR protein for precision genome editing
  2. Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon
  3. An outcome-defining role for the triple-helical domain in regulating collagen-I assembly
  4. Sitetack: a deep learning model that improves PTM prediction by using known PTMs
  5. Mammalian Esterase Activity: Implications for Peptide Prodrugs
  6. Pauli Exclusion by n→π* Interactions: Implications for Paleobiology
  7. Peptidic “Molecular Beacon” for Collagen
  8. Chemoselective Reagents for the Traceless Bioreversible Modification of Native Proteins
  9. Pentaphosphorylation via the Anhydride of Dihydrogen Pentametaphosphate: Access to Nucleoside Hexa- and Heptaphosphates and Study of Their Interaction with Ribonuclease A
  10. Endosomolytic Peptides Enable the Cellular Delivery of Peptide Nucleic Acids
  11. Facile Access to Branched Multispecific Proteins
  12. Taming the 1,5‐sigmatropic shift across protonated spirocyclic 4H‐pyrazoles
  13. Sitetack: A Deep Learning Model that Improves PTM Prediction by Using Known PTMs
  14. Evaluation of the Cytosolic Uptake of HaloTag Using a pH-Sensitive Dye
  15. Sensitive detection of SARS‐CoV‐2 main protease 3CLpro with an engineered ribonuclease zymogen
  16. Click Organocatalysis: Acceleration of Azide–Alkyne Cycloadditions with Mutually Orthogonal Click Reactions
  17. Endosomolytic peptides enable the cellular delivery of peptide nucleic acids
  18. Synthetic Collagen Hydrogels through Symmetric Self‐Assembly of Small Peptides
  19. Detection of Pulmonary Fibrosis with a Collagen-Mimetic Peptide
  20. Computational study of an oxetane 4H-pyrazole as a Diels–Alder diene
  21. Bayesian Inference Elucidates the Catalytic Competency of the SARS-CoV-2 Main Protease 3CLpro
  22. Fluorescent Guanidinium-Azacarbazole for Oxoanion Binding in Water
  23. Differential membrane binding of α/β-peptide foldamers: implications for cellular delivery and mitochondrial targeting
  24. Chemoselective Caging of Carboxyl Groups for On‐Demand Protein Activation with Small Molecules
  25. Chemoselective Caging of Carboxyl Groups for On‐Demand Protein Activation with Small Molecules
  26. Modular Diazo Compound for the Bioreversible Late-Stage Modification of Proteins
  27. Inhibition of HIV-1 Protease by a Boronic Acid with High Oxidative Stability
  28. Spirocyclization enhances the Diels–Alder reactivities of geminally substituted cyclopentadienes and 4H‐pyrazoles
  29. Nα‐Methylation of arginine: Implications for cell‐penetrating peptides
  30. Bioorthogonal 4H-pyrazole “click” reagents
  31. Emergent Organoboron Acid Catalysts
  32. Host–Guest Complexation by β-Cyclodextrin Enhances the Solubility of an Esterified Protein
  33. Context‐Dependence of the Reactivity of Cysteine and Lysine Residues
  34. Bifunctional Peptide that Anneals to Damaged Collagen and Clusters TGF-β Receptors Enhances Wound Healing
  35. Emerging biological functions of ribonuclease 1 and angiogenin
  36. Ribonuclease zymogen induces cytotoxicity upon HIV-1 infection
  37. Bifunctional Peptide that Anneals to Damaged Collagen and Clusters TGF-β Receptors Enhances Wound Healing
  38. Geminal repulsion disrupts Diels–Alder reactions of geminally substituted cyclopentadienes and 4H-pyrazoles
  39. Acceleration of 1,3-Dipolar Cycloadditions by Integration of Strain and Electronic Tuning
  40. Endogenous Enzymes Enable Antimicrobial Activity
  41. Two-Step Synthesis of α-Aryl-α-diazoamides as Modular Bioreversible Labels
  42. Boronic acid with high oxidative stability and utility in biological contexts
  43. Click Chemistry with Cyclopentadiene
  44. Palladium–Protein Oxidative Addition Complexes by Amine-Selective Acylation
  45. Semisynthesis of Human Ribonuclease–S
  46. Boronic Acid with High Oxidative Stability and Utility in Biological Contexts
  47. Triple, Mutually Orthogonal Bioorthogonal Pairs through the Design of Electronically Activated Sulfamate-Containing Cycloalkynes
  48. Daniel S. Kemp (1936–2020): A Pioneer of Bioorganic Chemistry
  49. Antimicrobial Synergy of a Ribonuclease and a Peptide Secreted by Human Cells
  50. Optical imaging of collagen fiber damage to assess thermally injured human skin
  51. n→π* Interactions Modulate the Disulfide Reduction Potential of Epidithiodiketopiperazines
  52. Structure and Dynamics of N-Glycosylated Human Ribonuclease 1
  53. Differential Effects of Nitrogen Substitution in 5‐ and 6‐Membered Aromatic Motifs
  54. Front Cover: Differential Effects of Nitrogen Substitution in 5‐ and 6‐Membered Aromatic Motifs (Chem. Eur. J. 41/2020)
  55. Synthesis and Diels–Alder Reactivity of 4-Fluoro-4-Methyl-4H-Pyrazoles
  56. Role for Cell-Surface Collagen of Streptococcus pyogenes in Infections
  57. Disulfide Chromophores Arise from Stereoelectronic Effects
  58. Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme
  59. Hox genes maintain critical roles in the adult skeleton
  60. Cyclic Peptide Mimetic of Damaged Collagen
  61. Stereoelectronic Effects Impact Glycan Recognition
  62. Templated Collagen “Double Helices” Maintain Their Structure
  63. Nucleoside Tetra- and Pentaphosphates Prepared Using a Tetraphosphorylation Reagent Are Potent Inhibitors of Ribonuclease A
  64. Hyperconjugative Antiaromaticity Activates 4H-Pyrazoles as Inverse-Electron-Demand Diels–Alder Dienes
  65. Angiogenin activates the astrocytic Nrf2/antioxidant-response element pathway and thereby protects murine neurons from oxidative stress
  66. Circular zymogens of human ribonuclease 1
  67. Secondary Forces in Protein Folding
  68. Terbium(III) Luminescence-Based Assay for Esterase Activity
  69. Phenotype of ribonuclease 1 deficiency in mice
  70. Collagen Prolyl Hydroxylases Are Bifunctional Growth Regulators in Melanoma
  71. Hyperconjugative π → σ*CF Interactions Stabilize the Enol Form of Perfluorinated Cyclic Keto–Enol Systems
  72. Esterification Delivers a Functional Enzyme into a Human Cell
  73. Delivery of Proteins and Nucleic Acids: Achievements and Challenges
  74. Consequences of the Endogenous N-Glycosylation of Human Ribonuclease 1
  75. Catalysis of Hydrogen–Deuterium Exchange Reactions by 4-Substituted Proline Derivatives
  76. Optimization of interstrand interactions enables burn detection with a collagen-mimetic peptide
  77. Efficient metal-free conversion of glucose to 5-hydroxymethylfurfural using a boronic acid
  78. A Human Ribonuclease Variant and ERK-Pathway Inhibitors Exhibit Highly Synergistic Toxicity for Cancer Cells
  79. An n→π* Interaction in the Bound Substrate of Aspartic Proteases Replicates the Oxyanion Hole
  80. n→π* Interactions Modulate the Properties of Cysteine Residues and Disulfide Bonds in Proteins
  81. Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid
  82. Collagen Prolyl 4-Hydroxylase as a Therapeutic Target
  83. A substrate selected by phage display exhibits enhanced side-chain hydrogen bonding to HIV-1 protease
  84. Enzyme-Activated Fluorogenic Probes for Live-Cell and in Vivo Imaging
  85. Human angiogenin is a potent cytotoxin in the absence of ribonuclease inhibitor
  86. Site-Specific Antibody Functionalization Using Tetrazine–Styrene Cycloaddition
  87. Cytosolic Uptake of Large Monofunctionalized Dextrans
  88. A pendant peptide endows a sunscreen with water-resistance
  89. Peptides on the Rise
  90. Cytosolic Delivery of Proteins by Bioreversible Esterification
  91. Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation
  92. The n→π* Interaction
  93. Comparative functional analysis of ribonuclease 1 homologs: molecular insights into evolving vertebrate physiology
  94. Fine-Tuning Strain and Electronic Activation of Strain-Promoted 1,3-Dipolar Cycloadditions with Endocyclic Sulfamates in SNO-OCTs
  95. Electronic and Steric Optimization of Fluorogenic Probes for Biomolecular Imaging
  96. A Boronic Acid Conjugate of Angiogenin that Shows ROS-Responsive Neuroprotective Activity
  97. A Boronic Acid Conjugate of Angiogenin that Shows ROS-Responsive Neuroprotective Activity
  98. Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond
  99. Molecular basis for the autonomous promotion of cell proliferation by angiogenin
  100. PTENpred: A Designer Protein Impact Predictor for PTEN-related Disorders
  101. Knockout of the Ribonuclease Inhibitor Gene Leaves Human Cells Vulnerable to Secretory Ribonucleases
  102. Diazo Compounds: Versatile Tools for Chemical Biology
  103. A prevalent intraresidue hydrogen bond stabilizes proteins
  104. 1,3-Dipolar Cycloaddition with Diazo Groups: Noncovalent Interactions Overwhelm Strain
  105. n→π* Interactions Are Competitive with Hydrogen Bonds
  106. Peptide tessellation yields micrometre-scale collagen triple helices
  107. Decreasing Distortion Energies without Strain: Diazo-Selective 1,3-Dipolar Cycloadditions
  108. Rapid cycloaddition of a diazo group with an unstrained dipolarophile
  109. Human Collagen Prolyl 4-Hydroxylase Is Activated by Ligands for Its Iron Center
  110. 1,3-Dipolar Cycloadditions of Diazo Compounds in the Presence of Azides
  111. Crystal structure ofN-(3-oxobutanoyl)-L-homoserine lactone
  112. Replacing a single atom accelerates the folding of a protein and increases its thermostability
  113. Boronic Acid for the Traceless Delivery of Proteins into Cells
  114. Target selection by natural and redesigned PUF proteins
  115. Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human Cells
  116. Convenient synthesis of collagen-related tripeptides for segment condensation
  117. Biomass to Furanics: Renewable Routes to Chemicals and Fuels
  118. Coevolution of RtcB and Archease created a multiple-turnover RNA ligase
  119. α/β-Peptide Foldamers Targeting Intracellular Protein–Protein Interactions with Activity in Living Cells
  120. Fluorogenic Assay for Inhibitors of HIV-1 Protease with Sub-picomolar Affinity
  121. Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1
  122. Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates
  123. Optimized Diazo Scaffold for Protein Esterification
  124. Separation of Lignin from Corn Stover Hydrolysate with Quantitative Recovery of Ionic Liquid
  125. 4-ketoproline: An electrophilic proline analog for bioconjugation
  126. Diazo Groups Endure Metabolism and Enable Chemoselectivity in Cellulo
  127. Conformational Stability and Catalytic Activity of PTEN Variants Linked to Cancers and Autism Spectrum Disorders
  128. Catalysis by the Tumor-Suppressor Enzymes PTEN and PTEN-L
  129. Intrinsic site-selectivity of ubiquitin dimer formation
  130. Diazo compounds for the bioreversible esterification of proteins
  131. Thioamides in the collagen triple helix
  132. Fluorescence Polarization Assay to Quantify Protein-Protein Interactions: An Update
  133. Creating Site-Specific Isopeptide Linkages Between Proteins with the Traceless Staudinger Ligation
  134. An Evolved Mxe GyrA Intein for Enhanced Production of Fusion Proteins
  135. Affinity of monoclonal antibodies for Globo-series glycans
  136. Optimal Interstrand Bridges for Collagen-like Biomaterials
  137. Bovine Brain Ribonuclease Is the Functional Homolog of Human Ribonuclease 1
  138. Structure of RNA 3′-phosphate cyclase bound to substrate RNA
  139. Functional Evolution of Ribonuclease Inhibitor: Insights from Birds and Reptiles
  140. Pyrazine-derived disulfide-reducing agent for chemical biology
  141. n→π* Interactions Engender Chirality in Carbonyl Groups
  142. Collagen‐based biomaterials for wound healing
  143. Effects of a second-generation human anti-ErbB2 ImmunoRNase on trastuzumab-resistant tumors and cardiac cells
  144. Anchoring a cytoactive factor in a wound bed promotes healing
  145. Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles
  146. Bright Building Blocks for Chemical Biology
  147. Assignments of RNase A by ADAPT-NMR and enhancer
  148. A Keyn→π* Interaction inN-Acyl Homoserine Lactones
  149. Signatures of n→π* interactions in proteins
  150. A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation
  151. Effects of a second-generation human anti-ErbB2 ImmunoRNase on trastuzumab-resistant tumors and cardiac cells
  152. Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase
  153. Interplay of Hydrogen Bonds and n→π* Interactions in Proteins
  154. Thiols and Selenols as Electron-Relay Catalysts for Disulfide-Bond Reduction
  155. Detection of Boronic Acids through Excited-State Intramolecular Proton-Transfer Fluorescence
  156. Conversion of Azides into Diazo Compounds in Water
  157. Contribution of Electrostatics to the Binding of Pancreatic-Type Ribonucleases to Membranes
  158. Facile Chemical Functionalization of Proteins through Intein-Linked Yeast Display
  159. Simulated Moving Bed Chromatography: Separation and Recovery of Sugars and Ionic Liquid from Biomass Hydrolysates
  160. Human Ribonuclease with a Pendant Poly(Ethylene Glycol) Inhibits Tumor Growth in Mice
  161. Bioavailable affinity label for collagen prolyl 4-hydroxylase
  162. n→π* Interactions of Amides and Thioamides: Implications for Protein Stability
  163. Pyramidalization of a carbonyl C atom in (2S)-N-(selenoacetyl)proline methyl ester
  164. Structures of the Noncanonical RNA Ligase RtcB Reveal the Mechanism of Histidine Guanylylation
  165. Fluorogenic Probe for Constitutive Cellular Endocytosis
  166. Protein prosthesis: β‐peptides as reverse‐turn surrogates
  167. Organocatalytic conversion of cellulose into a platform chemical
  168. An n→π* interaction reduces the electrophilicity of the acceptor carbonyl group
  169. A divalent protecting group for benzoxaboroles
  170. n→π* interactions in poly(lactic acid) suggest a role in protein folding
  171. Fluorogenic label to quantify the cytosolic delivery of macromolecules
  172. A novel fully human antitumor ImmunoRNase resistant to the RNase inhibitor
  173. Intimate Interactions with Carbonyl Groups: Dipole–Dipole or n→π*?
  174. Ribonucleoside 3′-Phosphates as Pro-Moieties for an Orally Administered Drug
  175. Synthesis of 5-Fluoro- and 5-Hydroxymethanoprolines via Lithiation of N-BOC-methanopyrrolidines. Constrained Cγ-Exo and Cγ-Endo Flp and Hyp Conformer Mimics
  176. Interaction of Nucleic Acids with the Glycocalyx
  177. Ribonuclease-Activated Cancer Prodrug
  178. A Potent, Versatile Disulfide-Reducing Agent from Aspartic Acid
  179. Boronate-Mediated Biologic Delivery
  180. tRNA Ligase Catalyzes the GTP-Dependent Ligation of RNA with3′-Phosphate and 5′-Hydroxyl Termini
  181. Peptides that anneal to natural collagen in vitro and ex vivo
  182. Trimethyl lock: a trigger for molecular release in chemistry, biology, and pharmacology
  183. Diazo compounds as highly tunable reactants in 1,3-dipolar cycloaddition reactions with cycloalkynes
  184. Rational Design and Evaluation of Mammalian Ribonuclease Cytotoxins
  185. A conserved interaction with the chromophore of fluorescent proteins
  186. Arginine Residues Are More Effective than Lysine Residues in Eliciting the Cellular Uptake of Onconase
  187. Sensitive fluorogenic substrate for alkaline phosphatase
  188. Ann→π* Interaction in Aspirin: Implications for Structure and Reactivity
  189. ChemInform Abstract: An Evaluation of Peptide-Bond Isosteres
  190. Mechanism of Ribonuclease A Endocytosis: Analogies to Cell-Penetrating Peptides
  191. Bovine Pancreatic Ribonuclease: Fifty Years of the First Enzymatic Reaction Mechanism
  192. Chemoselectivity in Chemical Biology: Acyl Transfer Reactions with Sulfur and Selenium
  193. Site-specific folate conjugation to a cytotoxic protein
  194. Site-specific PEGylation endows a mammalian ribonuclease with antitumor activity
  195. An Evaluation of Peptide-Bond Isosteres
  196. Interstrand Dipole-Dipole Interactions Can Stabilize the Collagen Triple Helix
  197. Synthesis of Conformationally Constrained 5-Fluoro- and 5-Hydroxymethanopyrrolidines. Ring-Puckered Mimics ofGauche- andAnti-3-Fluoro- and 3-Hydroxypyrrolidines
  198. Potentiation of ribonuclease cytotoxicity by a poly(amidoamine) dendrimer
  199. Signature of n→π* interactions in α-helices
  200. Conversion of Fructose into 5-(Hydroxymethyl)furfural in Sulfolane
  201. ChemInform Abstract: Carpe Diubiquitin
  202. Disruption and Formation of Surface Salt Bridges Are Coupled to DNA Binding by the Integration Host Factor: A Computational Analysis
  203. Tunable, Post-translational Hydroxylation of Collagen Domains inEscherichia coli
  204. Functional and structural analyses of N-acylsulfonamide-linked dinucleoside inhibitors of RNase A
  205. Ribonuclease S redux
  206. Synthesis and utility of fluorogenic acetoxymethyl ethers
  207. Oligomers of a 5-Carboxy-methanopyrrolidine β-Amino Acid. A Search for Order
  208. Cellular Uptake of Ribonuclease A Relies on Anionic Glycans
  209. Carpe Diubiquitin
  210. Carpe Diubiquitin
  211. Antitumor Activity of Ribonuclease Multimers Created by Site-Specific Covalent Tethering
  212. Synthesis of Furfural from Xylose and Xylan
  213. The Aberrance of the 4SDiastereomer of 4-Hydroxyproline
  214. n→π* interactions in proteins
  215. A Stereoelectronic Effect in Prebiotic Nucleotide Synthesis
  216. n→ π* Interaction andn)(π Pauli Repulsion Are Antagonistic for Protein Stability
  217. Quantum mechanical origin of the conformational preferences of 4-thiaproline and its S-oxides
  218. Prolyl 4-hydroxylase
  219. Fermentable sugars by chemical hydrolysis of biomass
  220. Advances in Bioconjugation
  221. Stereoelectronic and steric effects in side chains preorganize a protein main chain
  222. 1,9-Bis(2-pyridyl)-1,2,8,9-tetrathia-5-oxanonane
  223. 5(6)-anti-Substituted-2-azabicyclo[2.1.1]hexanes: A Nucleophilic Displacement Route
  224. Stringency of the 2-His–1-Asp Active-Site Motif in Prolyl 4-Hydroxylase
  225. Structure and Function ofBacillus subtilisYphP, a Prokaryotic Disulfide Isomerase with a CXC Catalytic Motif,
  226. Origin of the stability conferred upon collagen by fluorination
  227. ROMP from ROMP: A New Approach to Graft Copolymer Synthesis
  228. Onconase cytotoxicity relies on the distribution of its positive charge
  229. Silencing an Inhibitor Unleashes a Cytotoxic Enzyme
  230. Nature of Amide Carbonyl−Carbonyl Interactions in Proteins
  231. Collagen Structure and Stability
  232. Ribonuclease Inhibitor Regulates Neovascularization by Human Angiogenin
  233. Direct and continuous assay for prolyl 4-hydroxylase
  234. Simple Chemical Transformation of Lignocellulosic Biomass into Furans for Fuels and Chemicals
  235. Coulombic effects on the traceless Staudinger ligation in water
  236. Fluorogenic affinity label for the facile, rapid imaging of proteins in live cells
  237. Polyarginine as a multifunctional fusion tag
  238. Modulating Collagen Triple-Helix Stability with 4-Chloro, 4-Fluoro, and 4-Methylprolines
  239. Chapter 2 Protein Engineering with the Traceless Staudinger Ligation
  240. Variants of ribonuclease inhibitor that resist oxidation
  241. Green fluorescent protein as a signal for protein-protein interactions
  242. Ribonuclease S-peptide as a carrier in fusion proteins
  243. Interaction of onconase with the human ribonuclease inhibitor protein
  244. Olefin metathesis for chemical biology
  245. Peptides and peptidomimetics as prototypes
  246. A Phosphine-Mediated Conversion of Azides into Diazo Compounds
  247. A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells
  248. Design and Characterization of an HIV-Specific Ribonuclease Zymogen
  249. Hydrolytic Stability of Hydrazones and Oximes
  250. Conformational Preferences of Substrates for Human Prolyl 4-Hydroxylase†
  251. Hydrolytic Stability of Hydrazones and Oximes
  252. Catalysis of Protein Folding by an Immobilized Small-Molecule Dithiol
  253. Practical syntheses of 4-fluoroprolines
  254. Evasion of Ribonuclease Inhibitor as a Determinant of Ribonuclease Cytotoxicity
  255. Jeremy R. Knowles (1935−2008)
  256. 4-Chloroprolines: Synthesis, conformational analysis, and effect on the collagen triple helix
  257. Bright Ideas for Chemical Biology
  258. Stabilization of the Collagen Triple Helix byO-Methylation of Hydroxyproline Residues
  259. Genetic selection for peptide inhibitors of angiogenin
  260. Trimethyl Lock: A Stable Chromogenic Substrate for Esterases
  261. Electronic and steric effects on the rate of the traceless Staudinger ligation
  262. Structural Basis for Catalysis by Onconase
  263. Self-assembled collagen-like peptide fibers as templates for metallic nanowires
  264. Ribonucleases as Novel Chemotherapeutics
  265. Catalysis of imido group hydrolysis in a maleimide conjugate
  266. Olefin Metathesis in Homogeneous Aqueous Media Catalyzed by Conventional Ruthenium Catalysts
  267. Intraspecies Regulation of Ribonucleolytic Activity
  268. Increasing the potency of a cytotoxin with an arginine graft
  269. Protein Prosthesis:  1,5-Disubstituted[1,2,3]triazoles ascis-Peptide Bond Surrogates
  270. Using Measurements of Anchoring Energies of Liquid Crystals on Surfaces To Quantify Proteins Captured by Immobilized Ligands
  271. Water-Soluble Phosphinothiols for Traceless Staudinger Ligation and Integration with Expressed Protein Ligation
  272. Cytotoxic Ribonucleases:  The Dichotomy of Coulombic Forces
  273. Tuning the p K a of Fluorescein to Optimize Binding Assays
  274. Genetic selection reveals the role of a buried, conserved polar residue
  275. General Method for Site-Specific Protein Immobilization by Staudinger Ligation
  276. Inhibition of Human Pancreatic Ribonuclease by the Human Ribonuclease Inhibitor Protein
  277. Arginine Grafting to Endow Cell Permeability
  278. Multilayered Films Fabricated from an Oligoarginine-Conjugated Protein Promote Efficient Surface-Mediated Protein Transduction
  279. Salicylaldimine Ruthenium Alkylidene Complexes: Metathesis Catalysts Tuned for Protic Solvents
  280. Is glycine a surrogate for a D-amino acid in the collagen triple helix?
  281. A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus
  282. Staudinger Ligation of Peptides at Non-Glycyl Residues
  283. Synthesis and characterization of a novel class of reducing agents that are highly neuroprotective for retinal ganglion cells
  284. Energetics of ann→π* Interaction that Impacts Protein Structure
  285. Macrocyclic Scaffold for the Collagen Triple Helix
  286. Genetic Selection for Critical Residues in Ribonucleases
  287. Reactivity of Intein Thioesters: Appending a Functional Group to a Protein
  288. Characterization of Protein Immobilization at Silver Surfaces by Near Edge X-ray Absorption Fine Structure Spectroscopy
  289. Latent Blue and Red Fluorophores Based on the Trimethyl Lock
  290. Internalization of cationic peptides: the road less (or more?) traveled
  291. Reaction Mechanism and Kinetics of the Traceless Staudinger Ligation
  292. Reciprocity of Steric and Stereoelectronic Effects in the Collagen Triple Helix
  293. Fluorogenic Label for Biomolecular Imaging
  294. 2005 Emil Thomas Kaiser Award
  295. Contrast Agents for Magnetic Resonance Imaging Synthesized with Ring-Opening Metathesis Polymerization
  296. Semisynthesis and Characterization of Mammalian Thioredoxin Reductase†
  297. Self-assembly of synthetic collagen triple helices
  298. Stereoelectronic effects on polyproline conformation
  299. Cytotoxicity of Bovine Seminal Ribonuclease:  Monomer versus Dimer†
  300. Disruption of Shape-Complementarity Markers to Create Cytotoxic Variants of Ribonuclease A
  301. Stereoelectronic and Steric Effects in the Collagen Triple Helix:  Toward a Code for Strand Association
  302. Catalysis of Protein Disulfide Bond Isomerization in a Homogeneous Substrate†
  303. Reconstitution of a Defunct Glycolytic Pathway via Recruitment of Ambiguous Sugar Kinases†
  304. Peptide Bond Isosteres:  Ester or (E)-Alkene in the Backbone of the Collagen Triple Helix
  305. Chemical Synthesis of Proteins
  306. Latent Fluorophore Based on the Trimethyl Lock
  307. Binding of non-natural 3′-nucleotides to ribonuclease A
  308. Synthetic Surfaces for Ribonuclease Adsorption
  309. O-acylation of hydroxyproline residues: Effect on peptide-bond isomerization and collagen stability
  310. Ribonuclease Inhibitor: Structure and Function
  311. Production of human prolyl 4-hydroxylase in Escherichia coli
  312. Substituted 2-Azabicyclo[2.1.1]hexanes as Constrained Proline Analogues:  Implications for Collagen Stability
  313. Imaging the Binding Ability of Proteins Immobilized on Surfaces with Different Orientations by Using Liquid Crystals
  314. Identifying Latent Enzyme Activities:  Substrate Ambiguity within Modern Bacterial Sugar Kinases†
  315. Zinc(II)-mediated inhibition of ribonuclease Sa by an N-hydroxyurea nucleotide and its basis
  316. Pathway for Polyarginine Entry into Mammalian Cells †
  317. Glycosylation of onconase increases its conformational stability and toxicity for cancer cells
  318. Comprehensive comparison of the cytotoxic activities of onconase and bovine seminal ribonuclease
  319. Contribution of Active-Site Residues to the Function of Onconase, a Ribonuclease with Antitumoral Activity†
  320. Site-Specific Protein Immobilization by Staudinger Ligation
  321. Catalysis of Protein Folding by Protein Disulfide Isomerase and Small-Molecule Mimics
  322. Stereoelectronic Effects on Collagen Stability:  The Dichotomy of 4-Fluoroproline Diastereomers
  323. Compensating effects on the cytotoxicity of ribonuclease A variants
  324. An electronic effect on protein structure
  325. Potent Inhibition of Ribonuclease A by Oligo(vinylsulfonic Acid)
  326. Protein Prosthesis:  A Nonnatural Residue Accelerates Folding and Increases Stability
  327. Activation of the Prolyl Hydroxylase Oxygen-sensor Results in Induction of GLUT1, Heme Oxygenase-1, and Nitric-oxide Synthase Proteins and Confers Protection from Metabolic Inhibition to Cardiomyocytes
  328. Effect of 3-Hydroxyproline Residues on Collagen Stability
  329. Protein Assembly by Orthogonal Chemical Ligation Methods
  330. The CXC Motif:  A Functional Mimic of Protein Disulfide Isomerase†
  331. Catalysis by Ribonuclease A Is Limited by the Rate of Substrate Association†
  332. Ribonuclease inhibitor as an intracellular sentry
  333. Zinc(II)-mediated inhibition of a ribonuclease by an N-hydroxyurea nucleotide
  334. Creation of a zymogen
  335. X-ray Structure of Two Crystalline Forms of aStreptomycete Ribonuclease with Cytotoxic Activity
  336. Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway
  337. Genetic screen to dissect protein–protein interactions: ribonuclease inhibitor–ribonuclease A as a model system
  338. Fluorescence Assay for the Binding of Ribonuclease A to the Ribonuclease Inhibitor Protein
  339. Protein Prosthesis:  A Semisynthetic Enzyme with a β-Peptide Reverse Turn
  340. Staudinger Ligation of α-Azido Acids Retains Stereochemistry
  341. Evolution of Ribonuclease Inhibitor by Exon Duplication
  342. Collagen Stability:  Insights from NMR Spectroscopic and Hybrid Density Functional Computational Investigations of the Effect of Electronegative Substituents on Prolyl Ring Conformations
  343. KFERQ Sequence in Ribonuclease A-mediated Cytotoxicity
  344. The Ribonucleolytic Activity of Angiogenin†
  345. Translocation of a β-Peptide Across Cell Membranes
  346. Semisynthesis of Proteins Containing Selenocysteine
  347. Insights on the conformational stability of collagen
  348. Adjacent cysteine residues as a redox switch
  349. Endowing Human Pancreatic Ribonuclease with Toxicity for Cancer Cells
  350. Quantitative Analysis of the Effect of Salt Concentration on Enzymatic Catalysis
  351. Cleavage of 3‘,5‘-Pyrophosphate-Linked Dinucleotides by Ribonuclease A and Angiogenin†,‡
  352. High-Level Soluble Production and Characterization of Porcine Ribonuclease Inhibitor
  353. Contribution of tertiary amides to the conformational stability of collagen triple helices
  354. Cancer chemotherapy – ribonucleases to the rescue
  355. Selenocysteine in Native Chemical Ligation and Expressed Protein Ligation
  356. Contribution of the Active Site Histidine Residues of Ribonuclease A to Nucleic Acid Binding†
  357. Conformational Stability of Collagen Relies on a Stereoelectronic Effect
  358. High-Yielding Staudinger Ligation of a Phosphinothioester and Azide To Form a Peptide
  359. Fast, Facile, Hypersensitive Assays for Ribonucleolytic Activity
  360. A Highly Active Immobilized Ribonuclease
  361. Excavating an Active Site:  The Nucleobase Specificity of Ribonuclease A†
  362. Contribution of Individual Disulfide Bonds to the Oxidative Folding of Ribonuclease A†
  363. Native disulfide bond formation in proteins
  364. Pentavalent Organo-Vanadates as Transition State Analogues for Phosphoryl Transfer Reactions
  365. Effect of bovine seminal ribonuclease and bovine pancreatic ribonuclease A on bovine oocyte maturation
  366. Decavanadate Inhibits Catalysis by Ribonuclease A
  367. Genetic selection for dissociative inhibitors of designated protein–protein interactions
  368. A synapomorphic disulfide bond is critical for the conformational stability and cytotoxicity of an amphibian ribonuclease
  369. Conformational Stability Is a Determinant of Ribonuclease A Cytotoxicity
  370. Staudinger Ligation:  A Peptide from a Thioester and Azide
  371. Sulfur Shuffle:  Modulating Enzymatic Activity by Thiol-Disulfide Interchange
  372. Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans
  373. A Ribonuclease A Variant with Low Catalytic Activity but High Cytotoxicity
  374. Origin of the ‘inactivation’ of ribonuclease A at low salt concentration
  375. Dimer formation by a “monomeric” protein
  376. Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A
  377. [16] Green fluorescent protein chimeras to probe protein-protein interactions
  378. [23] The S·tag fusion system for protein purification
  379. A small-molecule catalyst of protein folding in vitro and in vivo
  380. Chemical Mechanism of DNA Cleavage by the Homing Endonuclease I-PpoI†
  381. Hypersensitive substrate for ribonucleases
  382. The CXXC motif: crystal structure of an active-site variant of Escherichia coli thioredoxin
  383. Extending the Limits to Enzymatic Catalysis:  Diffusion of Ribonuclease A in One Dimension†
  384. His ... Asp Catalytic Dyad of Ribonuclease A: Histidine pKa Values in the Wild-Type, D121N, and D121A Enzymes
  385. A hyperstable collagen mimic
  386. A New Remote Subsite in Ribonuclease A
  387. Coulombic Effects of Remote Subsites on the Active Site of Ribonuclease A†
  388. His···Asp Catalytic Dyad of Ribonuclease A:  Conformational Stability of the Wild-Type, D121N, D121A, and H119A Enzymes†
  389. No Role for Pepstatin-A-Sensitive Acidic Proteinases in Reovirus Infections of L or MDCK Cells
  390. Evans Osteotomy in the Adult Foot: An Anatomic Study of Structures at Risk
  391. Ribonuclease A variants with potent cytotoxic activity
  392. Coulombic Forces in Protein−RNA Interactions:  Binding and Cleavage by Ribonuclease A and Variants at Lys7, Arg10, and Lys66†
  393. Increasing the secretory capacity of Saccharomyces cerevisiae for production of single-chain antibody fragments
  394. Structure and stability of the P93G variant of ribonuclease A
  395. His···Asp Catalytic Dyad of Ribonuclease A:  Structure and Function of the Wild-Type, D121N, and D121A Enzymes†
  396. Ribonuclease A
  397. Code for collagen's stability deciphered
  398. Degenerate DNA recognition by I-PpoI endonuclease
  399. Gastric Inlet Patch Containing Submucosally Infiltrating Adenocarcinoma
  400. General Acid/Base Catalysis in the Active Site ofEscherichia coliThioredoxin†
  401. Microscopic pKaValues ofEscherichia coliThioredoxin†
  402. Ribonucleases Endowed with Specific Toxicity for Spermatogenic Layers
  403. Nature's transitory covalent bond
  404. The CXXC Motif:  A Rheostat in the Active Site†
  405. Computer-aided breast cancer detection and diagnosis of masses using difference of Gaussians and derivative-based feature saliency
  406. Short Communication
  407. Contribution of a tyrosine side chain to ribonuclease A catalysis and stability-Contribution of Tyr 97 to RNase A catalysis and stability
  408. Production of Human Pancreatic Ribonuclease inSaccharomyces cerevisiaeandEscherichia coli
  409. Substrate Binding and Turnover by the Highly Specific I-PpoI Endonuclease†
  410. Inductive Effects on the Energetics of Prolyl Peptide Bond Isomerization:  Implications for Collagen Folding and Stability
  411. Limits to Catalysis by Ribonuclease A
  412. Mechanism of Ribonuclease Cytotoxicity
  413. The Essential Function of Protein-disulfide Isomerase Is to Unscramble Non-native Disulfide Bonds
  414. Production of Rat Protein Disulfide Isomerase in Saccharomyces cerevisiae
  415. A Residue to Residue Hydrogen Bond Mediates the Nucleotide Specificity of Ribonuclease A
  416. Ribonuclease A: Revealing Structure-Function Relationships with Semisynthesis
  417. Replacing a Surface Loop Endows Ribonuclease A with Angiogenic Activity
  418. Structural Basis for the Biological Activities of Bovine Seminal Ribonuclease
  419. Analysis of Receptor-Ligand Interactions
  420. Dibromobimane as a Fluorescent Crosslinking Reagent
  421. The Extent to Which Ribonucleases Cleave Ribonucleic Acid
  422. Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11
  423. A Misfolded but Active Dimer of Bovine Seminal Ribonuclease
  424. Energetics of Catalysis by Ribonucleases: Fate of the 2',3'-Cyclic Phosphodiester Intermediate
  425. Value of General Acid-Base Catalysis to Ribonuclease A
  426. Peptide Tags for a Dual Affinity Fusion System
  427. Structural Determinants of Enzymic Processivity
  428. Amide-Amide and Amide-Water Hydrogen Bonds: Implications for Protein Folding and Stability
  429. RNS2: a senescence-associated RNase of Arabidopsis that diverged from the S-RNases before speciation.
  430. Thermodynamic origin of prolyl peptide bond isomers
  431. Solvent effects on the energetics of prolyl peptide bond isomerization
  432. Binding energy and enzymatic catalysis
  433. Evolutionary optimization of the catalytic effectiveness of an enzyme
  434. Triosephosphate isomerase catalysis is diffusion controlled
  435. Kinetics and thermodynamics of the interaction of 5-fluoro-2'-deoxyuridylate with thymidylate synthase
  436. Enzyme relaxation in the reaction catalyzed by triosephosphate isomerase: detection and kinetic characterization of two unliganded forms of the enzyme
  437. Reaction energetics of a mutant triose phosphate isomerase in which the active-site glutamate has been changed to aspartate
  438. The Mechanistic Pathway of a Mutant Triosephosphate Isomerase
  439. Active site of triosephosphate isomerase: in vitro mutagenesis and characterization of an altered enzyme.
  440. Mechanistic studies on the pyridoxal phosphate enzyme 1-aminocyclopropane-1-carboxylate deaminase from Pseudomonas sp
  441. Mechanistic studies on the reactions of bacterial methionine .gamma.-lyase with olefinic amino acids
  442. Mechanism-based enzyme inactivation using an allyl sulfoxide-allyl sulfenate ester rearrangement
  443. Fluorescence Gel Retardation Assay to Detect Protein–Protein Interactions
  444. Fluorescence Polarization Assay to Quantify Protein–Protein Interactions