All Stories

  1. Discovery, characterization, and comparative analysis of new UGT72 and UGT84 family glycosyltransferases
  2. Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms
  3. Biocatalytic access to quaternary stereogenic centers using ene reductases
  4. Design, synthesis and catalytic application of water-soluble 1,1′-bis(diphenylphosphino)ferrocene ligands
  5. Loop 6 and the β‐hairpin flap are structural hotspots that determine cofactor specificity in the FMN‐dependent family of ene‐reductases
  6. Recent Advances in Pd‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reactions with Triflates or Nonaflates
  7. Constraining and Modifying Peptides Using Pd‐Mediated Cysteine Allylation
  8. Constraining and Modifying Peptides Using Pd‐Mediated Cysteine Allylation
  9. Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity
  10. Microbiota-derived genotoxin tilimycin generates colonic stem cell mutations
  11. Reaction intensification for biocatalytic production of polyphenolic natural product di‐ C ‐β‐glucosides
  12. Activity‐Based Protein Profiling of Oxidases and Reductases
  13. Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice
  14. Design and synthesis of efficient fluororethylene-peptidomimetic inhibitors of dipeptidyl peptidase III (DPP3)
  15. Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes
  16. A Modular Synthesis of Teraryl‐Based α‐Helix Mimetics, Part 3: Iodophenyltriflate Core Fragments Featuring Side Chains of Proteinogenic Amino Acids
  17. A Modular Synthesis of Teraryl‐Based α‐Helix Mimetics, Part 4: Core Fragments with Two Halide Leaving Groups Featuring Side Chains of Proteinogenic Amino Acids
  18. A Modular Synthesis of Teraryl‐Based α‐Helix Mimetics, Part 5: A Complete Set of Pyridine Boronic Acid Pinacol Esters Featuring Side Chains of Proteinogenic Amino Acids
  19. Total synthesis of the isoquinolinium metabolite ETM-204 of Trabectidin
  20. Structural Changes in the Cap of Rv0183/mtbMGL Modulate the Shape of the Binding Pocket
  21. Efficient Entropy‐Driven Inhibition of Dipeptidyl Peptidase III by Hydroxyethylene Transition‐State Peptidomimetics
  22. Pharmacological inhibition of adipose tissue adipose triglyceride lipase by Atglistatin prevents catecholamine-induced myocardial damage
  23. Organische Chemie
  24. Simultaneous quantification of enterotoxins tilimycin and tilivalline in biological matrices using HPLC high resolution ESMS2 based on isotopically 15N-labeled internal standards
  25. Inhibition of ATGL in adipose tissue ameliorates isoproterenol-induced cardiac remodeling by reducing adipose tissue inflammation
  26. Synthesis of Hydrophilic Phosphorus Ligands and Their Application in Aqueous‐Phase Metal‐Catalyzed Reactions
  27. Adipose Triglyceride Lipase is needed for homeostatic control of Sterol Element-Binding Protein-1c driven hepatic lipogenesis
  28. Activity‐Based Protein Profiling (ABPP) of Oxidoreductases
  29. Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL)
  30. Stereoselective synthesis of chiral thiol-containing 1,2-aminoalcohols via SmI2-mediated coupling
  31. Synthesis of a Bcl9 Alpha-Helix Mimetic for Inhibition of PPIs by a Combination of Electrooxidative Phenol Coupling and Pd-Catalyzed Cross Coupling
  32. Organische Chemie
  33. Pd/BIPHEPHOS is an Efficient Catalyst for the Pd‐Catalyzed S ‐Allylation of Thiols with High n ‐Selectivity
  34. Labeling and Natural Post-Translational Modification of Peptides and Proteins via Chemoselective Pd-Catalyzed Prenylation of Cysteine
  35. Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans
  36. Trendbericht Organische Chemie
  37. Synthesis of 2-Pyrrolidinones by Palladium-Catalyzed [3+2] Cycloaddition of Isocyanates
  38. Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities
  39. Selective Formation of 4,4′-Biphenols by Anodic Dehydrogenative Cross- and Homo-Coupling Reaction
  40. Aliphatic hydroxylation and epoxidation of capsaicin by cytochrome P450 CYP505X
  41. Atglistatin ameliorates functional decline in heart failure via adipocyte-specific inhibition of adipose triglyceride lipase
  42. Application of Threonine Aldolases for the Asymmetric Synthesis of α-Quaternary α-Amino Acids
  43. The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition
  44. Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases
  45. Asymmetrische reduktive Carbocyclisierung durch modifizierte En-Reduktasen
  46. The highlights in organic chemistry of 2017
  47. C H and C C bond insertion reactions of diazo compounds into aldehydes
  48. Synthesis of novel ligands targeting phenazine biosynthesis proteins as a strategy for antibiotic intervention
  49. Recent developments in the isolation, biological function, biosynthesis, and synthesis of phenazine natural products
  50. Biosynthesis of the Enterotoxic Pyrrolobenzodiazepine Natural Product Tilivalline
  51. Mechanisms and Specificity of Phenazine Biosynthesis Protein PhzF
  52. Erratum: Corrigendum: Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice
  53. Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice
  54. Highlights in organic chemistry 2016
  55. Synthesis of α,β-unsaturated aldehydes as potential substrates for bacterial luciferases
  56. Additive-Free Pd-Catalyzed α-Allylation of Imine-Containing Heterocycles
  57. Sequential and iterative Pd-catalyzed cross-coupling reactions in organic synthesis
  58. Characterization of the monolignol oxidoreductase AtBBE-like protein 15 L182V for biocatalytic applications
  59. Comparative Activity-Based Flavin-Dependent Oxidase Profiling
  60. Enzymatic hydrolysis of poly(ethylene furanoate)
  61. ChemInform Abstract: A General and Direct Reductive Amination of Aldehydes and Ketones with Electron-Deficient Anilines.
  62. Target identification of small molecule drugs and chemical probes
  63. Target identification of covalently binding drugs by activity-based protein profiling (ABPP)
  64. Tracking Protein S-Fatty Acylation with Proteomics
  65. Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p
  66. Future Directions of Modern Organic Synthesis
  67. Organic Chemistry 2015
  68. A General and Direct Reductive Amination of Aldehydes and Ketones with Electron-Deficient Anilines
  69. Aus zwei mach eins: die Biosynthese der Phenazine
  70. ChemInform Abstract: Chemical Genetic Approaches for the Investigation of Neutral Lipid Metabolism
  71. Chemical Genetic Approaches for the Investigation of Neutral Lipid Metabolism
  72. ChemInform Abstract: A Rapid and Efficient One-Pot Method for the Reduction of N-Protected α-Amino Acids to Chiral α-Amino Aldehydes Using CDI/DIBAL-H.
  73. ChemInform Abstract: A Robust and Simple Protocol for the Synthesis of Arylfluorophosphonates.
  74. Improved and scalable synthesis of building blocks for the modular synthesis of teraryl-based alpha-helix mimetics
  75. Diversity-Oriented Synthesis of a Library of Star-Shaped 2H-Imidazolines
  76. α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate
  77. A robust and simple protocol for the synthesis of arylfluorophosphonates
  78. Reductions of Carboxylic Acids and Derivatives
  79. Expanding the threonine aldolase toolbox for the asymmetric synthesis of tertiary α-amino acids
  80. Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells
  81. Biocatalyzed approach for the surface functionalization of poly(L-lactic acid) films using hydrolytic enzymes
  82. Structure–activity studies in the development of a hydrazone based inhibitor of adipose-triglyceride lipase (ATGL)
  83. Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling
  84. Weighing the Proteasome for Covalent Modifications
  85. ChemInform Abstract: Recent Advances and Applications of Reductive Desulfurization in Organic Synthesis
  86. A rapid and efficient one-pot method for the reduction of N-protected α-amino acids to chiral α-amino aldehydes using CDI/DIBAL-H
  87. Recent advances and applications of reductive desulfurization in organic synthesis
  88. Biosynthese der Phenazine
  89. Enterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis
  90. ChemInform Abstract: The Development of a Modular Synthesis of Teraryl-Based α-Helix Mimetics as Potential Inhibitors of Protein-Protein Interactions
  91. Exploring the new threonine aldolases with broad donor specificity
  92. Stereochemistry and Mechanism of Enzymatic and Non-Enzymatic Hydrolysis of Benzylicsec-Sulfate Esters
  93. Enzymes in Organic Synthesis
  94. The Development of a Modular Synthesis of Teraryl-Based α-Helix Mimetics as Potential Inhibitors of Protein–Protein Interactions
  95. Organische Chemie 2013
  96. More than just a Halogenase: Modification of Fatty Acyl Moieties by a Trifunctional Metal Enzyme
  97. Towards the synthesis of glycosylated dihydrochalcone natural products using glycosyltransferase-catalysed cascade reactions
  98. Investigation of one-enzyme systems in the ω-transaminase-catalyzed synthesis of chiral amines
  99. Development of small-molecule inhibitors targeting adipose triglyceride lipase
  100. Conformational Plasticity and Ligand Binding of Bacterial Monoacylglycerol Lipase
  101. Chemical Synthesis of Hormones, Pheromones and Other Bioregulators
  102. Racemization-Free Chemoenzymatic Peptide Synthesis Enabled by the Ruthenium-Catalyzed Synthesis of Peptide Enol EstersviaAlkyne-Addition and Subsequent Conversion Using Alcalase-Cross-Linked Enzyme Aggregates
  103. ChemInform Abstract: An Efficient Labeling Strategy of Drug Like Molecules with Functionalized Alkyl Linkers Using CH-Activation.
  104. A Modular Synthesis of Teraryl-Based α-Helix Mimetics, Part 1: Synthesis of Core Fragments with Two Electronically Differentiated Leaving Groups
  105. Investigation of the origin and synthetic application of the pseudodilution effect for Pd-catalyzed macrocyclisations in concentrated solutions with immobilized catalysts
  106. A Modular Synthesis of Teraryl-Based α-Helix Mimetics, Part 2: Synthesis of 5-Pyridine Boronic Acid Pinacol Ester Building Blocks with Amino Acid Side Chains in 3-Position
  107. Activity-Based Probes for Studying the Activity of Flavin-Dependent Oxidases and for the Protein Target Profiling of Monoamine Oxidase Inhibitors
  108. Aktivitätsbasierte Sondenmoleküle zur Untersuchung der Aktivität Flavin-abhängiger Oxidasen und zum Zielprotein-Profiling von Monoaminooxidase-Inhibitoren
  109. An efficient labeling strategy of drug like molecules with functionalized alkyl linkers using CH-activation
  110. ChemInform Abstract: The Witkop-Winterfeldt Oxidation Converts Tetrahydropyridoindoles into Pyrroloquinolones and Cinnolines by an Unprecedented Scaffold Rearrangement.
  111. ChemInform Abstract: A Simple Synthesis of Functionalized 3-Methyl-1-pyridinyl-1H-imidazolium Salts as Bidentate N-Heterocyclic-carbene Precursors and Their Application in Ir-Catalyzed Arene Borylation.
  112. The Witkop–Winterfeldt oxidation converts tetrahydropyridoindoles into pyrroloquinolones and cinnolines by an unprecedented scaffold rearrangement
  113. Activity-Based Protein Profiling for Natural Product Target Discovery
  114. ChemInform Abstract: Combinatorial Chemistry and the Synthesis of Compound Libraries
  115. A simple synthesis of functionalized 3-methyl-1-pyridinyl-1H-imidazolium salts as bidentate N-heterocyclic-carbene precursors and their application in Ir-catalyzed arene borylation
  116. ChemInform Abstract: Suzuki and Heck Reactions Catalyzed by Preformed Palladium Clusters and Palladium/Nickel Bimetallic Clusters.
  117. ChemInform Abstract: From Protein Domains to Drug Candidates - Natural Products as Guiding Principles in the Design and Synthesis of Compound Libraries.
  118. ChemInform Abstract: Solid-Phase Synthesis of Biomolecules
  119. Organische Chemie 2009
  120. Preparation of Biomolecule Microstructures and Microarrays by Thiol-ene Photoimmobilization
  121. ChemInform Abstract: Of Two Make One: The Biosynthesis of Phenazines
  122. The Active Site of an Enzyme Can Host Both Enantiomers of a Racemic Ligand Simultaneously
  123. Gleichzeitige Bindung beider Enantiomere eines racemischen Wirkstoffs durch das aktive Zentrum eines Enzyms
  124. Combinatorial Chemistry and the Synthesis of Compound Libraries
  125. Crystal Structure of PhzA/B from Burkholderia cepacia R18194 in complex with (S)-5-bromo-2-(piperidin-3-ylamino)benzoic acid
  126. Crystal Structure of PhzA/B from Burkholderia cepacia R18194 in complex with 5-bromo-2-((1S,3R)-3-carboxycyclohexylamino)benzoic acid
  127. Crystal Structure of PhzA/B from Burkholderia cepacia R18194 cocrystallized with 2 mM racemic 5-bromo-2-(piperidin-3-ylamino)benzoic acid
  128. Crystal Structure of PhzA/B from Burkholderia cepacia R18194 in complex with (R)-5-bromo-2-(piperidin-3-ylamino)benzoic acid
  129. Crystal Structure of PhzA/B from Burkholderia cepacia R18194 in simultaneous complex with racemic 5-bromo-2-(piperidin-3-ylamino)benzoic acid
  130. ChemInform Abstract: An Environmentally Benign Electrochemical Process for the Reduction of Carboxylic Acid Hydrazides to Amides.
  131. Of Two Make One: The Biosynthesis of Phenazines
  132. Polystyrene Sulfonyl Chloride: A Highly Orthogonal Linker Resin for the Synthesis of Nitrogen-Containing Heterocycles
  133. Polystyrolsulfonylchlorid - ein hochorthogonales Linkerharz für die Synthese von Stickstoffheterocyclen
  134. The Power of Functional Resins in Organic Synthesis.Herausgegeben von Judit Tulla-Puche und Fernando Albericio.
  135. The Power of Functional Resins in Organic Synthesis.Edited by Judit Tulla-Puche and Fernando Albericio.
  136. Classics in Stereoselective Synthesis
  137. An Environmentally Benign Electrochemical Process for the Reduction of Carboxylic Acid Hydrazides to Amides
  138. Organische Chemie 2008
  139. Crystal structure of phenazine biosynthesis protein PhzA/B from Burkholderia cepacia R18194, apo form
  140. Crystal structure of phenazine biosynthesis protein PhzA/B from Burkholderia cepacia R18194, complex with 2-(cyclohexylamino)benzoic acid
  141. Crystal structure of PhzA/B from Burkholderia cepacia R18194 crystallized in C2221
  142. ChemInform Abstract: Combinatorial Solid-Phase Natural Product Chemistry
  143. PhzA/B Catalyzes the Formation of the Tricycle in Phenazine Biosynthesis
  144. Photochemical Surface Patterning by the Thiol-Ene Reaction
  145. Photochemical Surface Patterning by the Thiol-Ene Reaction
  146. Solid-Phase Synthesis of Biomolecules
  147. The Synthetic Organic Chemist’s Companion
  148. ChemInform Abstract: The Witkop-Winterfeldt Oxidation of Indoles
  149. The Way of Synthesis: Evolution of Design and Methods for Natural Products
  150. Electrons as a Reagent in Solid-Phase Organic Synthesis
  151. A Microarray Strategy for Mapping the Substrate Specificity of Protein Tyrosine Phosphatase
  152. Eine Mikroarray-Strategie zur Untersuchung der Substratspezifitäten von Protein-Tyrosin-Phosphatasen
  153. Organic Reactions in Water: Principles, Strategies and Applications
  154. Electrons as a Reagent in Solid-Phase Organic Synthesis (Eur. J. Org. Chem. 26/2007)
  155. Electrons as a Reagent in Solid‐Phase Organic Synthesis
  156. The Investigation of Organic Reactions and their Mechanisms
  157. Organische Chemie 2006
  158. Domino Reactions in Organic Synthesis
  159. The Witkop-Winterfeldt-Oxidation of Indoles
  160. Combinatorial Chemistry - From Theory to Application (Methods and Principles in Medicinal Chemistry, Vol. 26)
  161. A generic building block for C- and N-terminal protein-labeling and protein-immobilization
  162. Electroorganic Reductions Syntheses
  163. High-Throughput Screening in Chemical Catalysis - Technologies, Strategies and Applications
  164. Homogeneous Polymer-Supported Synthesis of N-Substituted Pyrroles
  165. Organische Chemie 2005
  166. Site-Selective Protein Immobilization by Staudinger Ligation
  167. Site-Selective Protein Immobilization by Staudinger Ligation
  168. Electrolysis as an Efficient Key Step in the Homogeneous Polymer-Supported Synthesis of N-Substituted Pyrroles
  169. Evaluation of Enzyme Inhibitors in Drug Discovery. Von Robert A. Copeland.
  170. Evaluation of Enzyme Inhibitors in Drug Discovery. By Robert A. Copeland.
  171. Solid-Supported Reagents and Catalysts for the Preparation of Large Ring Compounds
  172. Nutzen und Gefahren der Biotechnologie: Liebling, Du hast die Katze geklont. Von Reinhard Renneberg, Manfred Bofinger, Jens Reich. Wiley-VCH, Weinheim 2004.260 Seiten, geb., 24,90 Euro. ISBN 3-527-31075-4
  173. Electroorganic Synthesis of 2,5-Dialkoxydihydrofurans and Pyridazines on Solid Phase Using Polymer Beads as Supports
  174. Solid-supported reagents and catalysts for the preparation of large ring compounds
  175. Preface
  176. The Staudinger Ligation — A Gift to Chemical Biology
  177. Polymer-Supported Synthesis of Non-Oligomeric Natural Products
  178. Molecular Biology in Medicinal Chemistry. Band 21 der Reihe Methods and Principles in Medicinal Chemistry. Herausgegeben von Theodor Dingermann, Dieter Steinhilber und Gerd Folkers.
  179. Molecular Biology in Medicinal Chemistry. (Series: Methods and Principles in Medicinal Chemistry, Vol. 21.) Edited by Theodor Dingermann, Dieter Steinhilber and Gerd Folkers.
  180. The Staudinger Ligation—A Gift to Chemical Biology
  181. Die Staudinger-Ligation– ein Geschenk für die Chemische Biologie
  182. Der Gipfel der Stereochemie: Bürgenstock 2004
  183. The Peak of Stereochemistry: Bürgenstock 2004
  184. Electroorganic Synthesis on the Solid Phase using Polymer Beads as Supports
  185. Elektroorganische Synthese an der festen Phase mit Polymerkügelchen als Trägermaterial
  186. An efficient and inexpensive scavenger resin for Grubbs’ catalyst
  187. Small Molecule Arrays
  188. Staudinger Ligation: A New Immobilization Strategy for the Preparation of Small-Molecule Arrays
  189. Staudinger-Ligation: eine Immobilisierungsstrategie zur Herstellung von Wirkstoff-Arrays
  190. Azide-Alkyne Coupling: A Powerful Reaction for Bioconjugate Chemistry
  191. An Easily Accessible Resin-Supported Palladium Catalyst for Sonogashira Coupling.
  192. Die chemische Genetik entdeckt das (Zebra-)Fischen
  193. Chemical Genetics Goes (Zebra) Fishing
  194. Protein Structure Similarity as Guiding Principle for Combinatorial Library Design
  195. Polymer‐Supported Synthesis of Non‐Oligomeric Natural Products
  196. An Easily Accessible Resin-SupportedPalladium Catalyst for Sonogashira Coupling
  197. Natural Product Guided Compound Library Development
  198. Book Review: Handbook of Combinatorial Chemistry. Vols. 1+2. By Kyriacos C. Nicolaou, R. Hanko and W. Hartwig
  199. Buchbesprechung: Handbook of Combinatorial Chemistry. Band 1+2. Herausgegeben von Kyriacos C. Nicolaou, R. Hanko und W. Hartwig
  200. From Protein Domains to Drug Candidates—Natural Products as Guiding Principles in the Design and Synthesis of Compound Libraries
  201. Von Proteindomänen zu Wirkstoffkandidaten – Naturstoffe als Leitstrukturen für das Design und die Synthese von Substanzbibliotheken
  202. Nachwuchswissenschaftler-Symposium Bioorganische Chemie
  203. Web Site: Lehrbücher mit Websites
  204. Web Site: Lehrbücher mit Websites
  205. Web Site: Companion Sites for Textbooks
  206. Web Site: Companion Sites for Textbooks
  207. Essentials of Biological Chemistry. Von Lorraine Buckberry und Paul Teesdale
  208. Essentials of Biological Chemistry. By Lorraine Buckberry and Paul Teesdale
  209. Size-Selective Electrochemical Preparation of Surfactant-Stabilized Pd-, Ni- and Pt/Pd Colloids
  210. Organische Chemie der Carbonylverbindungen: Modern Carbonyl Chemistry. Hrsg. von Junzo Otera. Wiley-VCH, Weinheim, 2000. 613 5., geb., 298,- DM. ISBN 3-527-29871-1
  211. Cooperative Asymmetric Catalysis with Dendrimeric [Co(salen)] Complexes
  212. Cooperative Asymmetric Catalysis with Dendrimeric [Co(salen)] Complexes
  213. POLYMER CHEMISTRY:Nickel Comes Full Cycle
  214. Nanostructured nickel-clusters as catalysts in [3+2]cycloaddition reactions
  215. Suzuki and Heck reactions catalyzed by preformed palladium clusters and bimetallic clusters
  216. A New Strategy in Heterogeneous Catalysis: The Design of Cortex Catalysts
  217. Eine neue Strategie in der heterogenen Katalyse: das Design von Cortex-Katalysatoren
  218. Polymer-Supported Synthesis of Non-Oligomeric Natural Products
  219. Reverse Chemical Genetics– An Important Strategy for the Study of Protein Function in Chemical Biology and Drug Discovery
  220. Combinatorial Solid-Phase Natural Product Chemistry