All Stories

  1. Nav1.8: Intrinsic limits on the functional effect of abrogation in DRG neurons

    Article • Proceedings of the National Academy of Sciences, September 2025, Proceedings of the National Academy of Sciences

    Roberta Gualdani

  2. Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids

    Article • Proceedings of the National Academy of Sciences, January 2025, Proceedings of the National Academy of Sciences

    Roberta Gualdani

  3. TRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin sensitization, and capsaicin desensitization

    Article • Proceedings of the National Academy of Sciences, September 2024, Proceedings of the National Academy of Sciences

    Roberta Gualdani

  4. Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol

    Article • Communications Biology, January 2024, Springer Science + Business Media

    Roberta Gualdani

  5. Inflammation differentially controls transport of depolarizing Nav versus hyperpolarizing Kv channels to drive rat nociceptor activity

    Article • Proceedings of the National Academy of Sciences, March 2023, Proceedings of the National Academy of Sciences

    Roberta Gualdani

  6. A mutation of the TRPM7 channel provides new insights into familial Trigeminal Neuralgia

    Article • Proceedings of the National Academy of Sciences, September 2022, Proceedings of the National Academy of Sciences

    Roberta Gualdani

  7. Superparamagnetic iron oxide nanoparticles (SPIONs) modulate hERG ion channel activity

    Article • Nanotoxicology, August 2019, Taylor & Francis

    Dr Francesco Tadini-Buoninsegni, Roberta Gualdani

  8. A gain-of-function sodium channelβ2-subunit mutation in painful diabetic neuropathy

    Article • Molecular Pain, January 2019, SAGE Publications

    Roberta Gualdani, Massimo Mantegazza

  9. A novel gain-of-function Nav1.7 mutation in a carbamazepine-responsive patient with adult-onset painful peripheral neuropathy

    Article • Molecular Pain, January 2018, SAGE Publications

    Roberta Gualdani

  10. Reverse pharmacogenomics: carbamazepine normalizes activation and attenuates thermal hyperexcitability of sensory neurons due to Nav 1.7 mutation I234T

    Article • British Journal of Pharmacology, July 2017, Wiley

    Sulayman Dib-Hajj, Roberta Gualdani

  11. A SCN10A SNP biases human pain sensitivity

    Article • Molecular Pain, January 2016, SAGE Publications

    Roberta Gualdani

  12. A painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca2+ dysregulation and decrease in ATP levels

    Article • Molecular Pain, January 2016, SAGE Publications

    Roberta Gualdani