All Stories

  1. TauP301L disengages from the proteosome core complex and neurogranin coincident with enhanced neuronal network excitability

    Article • Cell Death and Disease, June 2024, Springer Science + Business Media

    Robert Williams

  2. Epigallocatechin Gallate Modulates Microglia Phenotype to Suppress Pro-inflammatory Signalling Cues and Inhibit Phagocytosis

    Article • Molecular Neurobiology, December 2023, Springer Science + Business Media

    Robert Williams

  3. Epigallocatechin Gallate Modulates Microglia Phenotype to Suppress Pro-Inflammatory Signalling Cues and Inhibit Phagocytosis

    Article • May 2023, Cold Spring Harbor Laboratory Press

    Robert Williams

  4. Anionic lipid vesicles have differential effects on the aggregation of early onset-associated α-synuclein missense mutants

    Article • Journal of Biological Chemistry, December 2022, Elsevier

    Robert Williams

  5. Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells

    Article • PLoS Genetics, June 2022, PLOS

    Robert Williams

  6. Library-Derived Peptide Aggregation Modulators of Parkinson’s Disease Early-Onset α-Synuclein Variants

    Article • ACS Chemical Neuroscience, May 2022, American Chemical Society (ACS)

    Robert Williams

  7. A Downsized and Optimised Intracellular Library-Derived Peptide Prevents Alpha-Synuclein Primary Nucleation and Toxicity Without Impacting Upon Lipid Binding

    Article • Journal of Molecular Biology, December 2021, Elsevier

    Robert Williams

  8. Neuro-nutraceuticals: Natural products nourish the brain but be aware of contrary effects

    Article • Neurochemistry International, November 2021, Elsevier

    Robert Williams

  9. Oral (−)-Epicatechin Inhibits Progressive Tau Pathology in rTg4510 Mice Independent of Direct Actions at GSK3β

    Article • Frontiers in Neuroscience, June 2021, Frontiers

    Robert Williams

  10. Chromatin interaction maps identify Wnt responsivecis-regulatory elements coordinatingPaupar-Pax6expression in neuronal cells

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Robert Williams

  11. Flavonoids as an Intervention for Alzheimer’s Disease: Progress and Hurdles Towards Defining a Mechanism of Action

    Article • Brain Plasticity, February 2021, IOS Press

    Robert Williams

  12. The Library Derived 4554W Peptide Inhibits Primary Nucleation of α-Synuclein

    Article • Journal of Molecular Biology, December 2020, Elsevier

    Robert Williams

  13. The Bidirectional Relationship Between Sleep and Inflammation Links Traumatic Brain Injury and Alzheimer’s Disease

    Article • Frontiers in Neuroscience, August 2020, Frontiers

    Robert Williams

  14. A series of helical α-synuclein fibril polymorphs are populated in the presence of lipid vesicles

    Article • npj Parkinson s Disease, August 2020, Springer Science + Business Media

    Robert Williams

  15. Analysis of Protein Glycation Using Phenylboronate Acrylamide Gel Electrophoresis

    Article • November 2018, Springer Science + Business Media

    Tony D James, Robert Williams

  16. Excitation-Energy-Dependent Molecular Beacon Detects Early Stage Neurotoxic Aβ Aggregates in the Presence of Cortical Neurons

    Article • ACS Chemical Neuroscience, October 2018, American Chemical Society (ACS)

    Robert Williams

  17. Advanced Glycation End Products Modulate Amyloidogenic APP Processing and Tau Phosphorylation: A Mechanistic Link between Glycation and the Development of Alzheimer’s Disease

    Article • ACS Chemical Neuroscience, January 2018, American Chemical Society (ACS)

    Robert Williams

  18. Increased Foxo3a Nuclear Translocation and Activity is an Early Neuronal Response to βγ-Secretase-Mediated Processing of the Amyloid-β Protein Precursor: Utility of an AβPP-GAL4 Reporter Assay

    Article • Journal of Alzheimer’s Disease, December 2017, IOS Press

    Robert Williams

  19. Structural evidence of quercetin multi-target bioactivity: A reverse virtual screening strategy

    Article • European Journal of Pharmaceutical Sciences, August 2017, Elsevier

    Robert Williams

  20. Nutrition for the ageing brain: Towards evidence for an optimal diet

    Article • Ageing Research Reviews, May 2017, Elsevier

    Dr David Vauzour, Robert Williams

  21. Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer’s Disease

    Article • Scientific Reports, February 2017, Springer Science + Business Media

    Tony D James, Robert Williams

  22. Neuro-nutraceuticals: Further insights into their promise for brain health

    Article • Neurochemistry International, May 2016, Elsevier

    Robert Williams

  23. Neuro-nutraceuticals: The path to brain health via nourishment is not so distant

    Article • Neurochemistry International, October 2015, Elsevier

    Robert Williams

  24. Dietary (−)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing

    Article • Neurobiology of Aging, January 2015, Elsevier

    Robert Williams

  25. Decreased rabphilin 3A immunoreactivity in Alzheimer’s disease is associated with Aβ burden

    Article • Neurochemistry International, January 2014, Elsevier

    Robert Williams

  26. AMPA Receptor Activation Promotes Non-Amyloidogenic Amyloid Precursor Protein Processing and Suppresses Neuronal Amyloid-β Production

    Article • PLOS One, October 2013, PLOS

    Robert Williams

  27. Analysis of protein glycation using fluorescent phenylboronate gel electrophoresis

    Article • Scientific Reports, March 2013, Nature

    Tony D James, Robert Williams

  28. Potential Neuroprotective Actions of Dietary Flavonoids

    Article • January 2013, Springer Science + Business Media

    Dr David Vauzour, Robert Williams

  29. Tau phosphorylation in human brain: relationship to behavioral disturbance in dementia

    Article • Neurobiology of Aging, December 2012, Elsevier

    Robert Williams

  30. Prion protein expression alters APP cleavage without interaction with BACE-1

    Article • Neurochemistry International, October 2012, Elsevier

    Robert Williams

  31. Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity

    Article • Journal of Neurochemistry, August 2012, Wiley

    Robert Williams

  32. Pro-oxidant diet enhances β/γ secretase-mediated APP processing in APP/PS1 transgenic mice

    Article • Neurobiology of Aging, May 2012, Elsevier

    Robert Williams

  33. Neuroinflammation: Modulation by flavonoids and mechanisms of action

    Article • Molecular Aspects of Medicine, February 2012, Elsevier

    Dr David Vauzour, Robert Williams

  34. Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

    Article • Free Radical Biology and Medicine, January 2012, Elsevier

    Robert Williams

  35. Synthesis, physical–chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer’s disease

    Article • Bioorganic & Medicinal Chemistry, February 2011, Elsevier

    Robert Williams

  36. Association of Plasma Clusterin Concentration With Severity, Pathology, and Progression in Alzheimer Disease

    Article • Archives of General Psychiatry, July 2010, American Medical Association (AMA)

    Robert Williams

  37. Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration

    Article • Journal of Neurochemistry, May 2010, Wiley

    Robert Williams

  38. Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production

    Article • Journal of Neuroscience, April 2009, Society for Neuroscience

    Robert Williams

  39. The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury

    Article • Archives of Biochemistry and Biophysics, April 2009, Elsevier

    Dr David Vauzour, Robert Williams

  40. Glial metabolism of quercetin reduces its neurotoxic potential

    Article • Archives of Biochemistry and Biophysics, October 2008, Elsevier

    Dr David Vauzour, Robert Williams

  41. Dietary flavonoid (−)epicatechin stimulates phosphatidylinositol 3‐kinase‐dependent anti‐oxidant response element activity and up‐regulates glutathione in cortical astrocytes

    Article • Journal of Neurochemistry, August 2008, Wiley

    Robert Williams

  42. Aβ1–42 modulation of Akt phosphorylation via α7 nAChR and NMDA receptors

    Article • Neurobiology of Aging, July 2008, Elsevier

    Robert Williams

  43. Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation

    Article • Neuroscience Letters, June 2008, Elsevier

    Robert Williams

  44. Phosphatidylinositol 3-Kinase Is a Key Mediator of Central Sensitization in Painful Inflammatory Conditions

    Article • Journal of Neuroscience, April 2008, Society for Neuroscience

    Robert Williams

  45. Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY‐5Y cells

    Article • Journal of Neurochemistry, March 2008, Wiley

    Robert Williams

  46. Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons

    Article • Journal of Neurochemistry, November 2007, Wiley

    Dr David Vauzour, Robert Williams

  47. CB2 cannabinoid receptors promote mouse neural stem cell proliferation

    Article • European Journal of Neuroscience, February 2007, Wiley

    Daniel Garcia-Ovejero, Robert Williams

  48. Metals ions and neurodegeneration

    Article • BioMetals, February 2007, Springer Science + Business Media

    Robert Williams

  49. (‐)Epicatechin stimulates ERK‐dependent cyclic AMP response element activity and up‐regulates GluR2 in cortical neurons

    Article • Journal of Neurochemistry, January 2007, Wiley

    Robert Williams

  50. Serotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro

    Article • Journal of Psychopharmacology, March 2006, SAGE Publications

    Robert Williams

  51. Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11α protein up-regulation in Alzheimer’s disease

    Article • Neuroscience, January 2006, Elsevier

    Robert Williams

  52. Activity‐dependent phosphorylation of Akt/PKB in adult DRG neurons

    Article • European Journal of Neuroscience, April 2005, Wiley

    Robert Williams

  53. Zinc–histidine complex protects cultured cortical neurons against oxidative stress-induced damage

    Article • Neuroscience Letters, November 2004, Elsevier

    Robert Williams

  54. Flavonoids: antioxidants or signalling molecules?

    Article • Free Radical Biology and Medicine, April 2004, Elsevier

    Robert Williams

  55. Inhibiting Src family tyrosine kinase activity blocks glutamate signalling to ERK1/2 and Akt/PKB but not JNK in cultured striatal neurones

    Article • Journal of Neurochemistry, February 2004, Wiley

    Robert Williams

  56. Expression of SOD1 G93A or wild‐type SOD1 in primary cultures of astrocytes down‐regulates the glutamate transporter GLT‐1: lack of involvement of oxidative stress

    Article • Journal of Neurochemistry, December 2003, Wiley

    Robert Williams

  57. Modulation of Pro-survival Akt/Protein Kinase B and ERK1/2 Signaling Cascades by Quercetin and Its in Vivo Metabolites Underlie Their Action on Neuronal Viability

    Article • Journal of Biological Chemistry, September 2003, Elsevier

    Robert Williams

  58. Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites

    Article • Biochemical Journal, May 2003, Portland Press Ltd.

    Robert Williams

  59. The ‘glial’ glutamate transporter, EAAT2 (Glt‐1) accounts for high affinity glutamate uptake into adult rodent nerve endings

    Article • Journal of Neurochemistry, January 2003, Wiley

    Robert Williams

  60. Noxious Stimulation Induces Trk Receptor and Downstream ERK Phosphorylation in Spinal Dorsal Horn

    Article • Molecular and Cellular Neuroscience, December 2002, Elsevier

    Robert Williams

  61. Cyclothiazide Unmasks an AMPA-Evoked Release of Arachidonic Acid from Cultured Striatal Neurones

    Article • Journal of Neurochemistry, November 2002, Wiley

    Robert Williams

  62. Glucose Regulates Glutamate-Evoked Arachidonic Acid Release from Cultured Striatal Neurons

    Article • Journal of Neurochemistry, November 2002, Wiley

    Robert Williams

  63. Hydrogen Peroxide Enhances Signal-Responsive Arachidonic Acid Release from Neurons: Role of Mitogen-Activated Protein Kinase

    Article • Journal of Neurochemistry, November 2002, Wiley

    Robert Williams

  64. MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

    Article • Neurobiology of Aging, September 2002, Elsevier

    Robert Williams

  65. Phosphatidylinositol 3‐kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones

    Article • Journal of Neurochemistry, January 2002, Wiley

    Robert Williams

  66. Hydrogen peroxide‐mediated phosphorylation of ERK1/2, 
Akt/PKB and JNK in cortical neurones: dependence 
on Ca2+ and PI3‐kinase

    Article • Journal of Neurochemistry, December 2001, Wiley

    Robert Williams

  67. Contrasting influences of glucuronidation and O -methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts

    Article • Free Radical Biology and Medicine, November 2001, Elsevier

    Robert Williams

  68. Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3

    Article • Biochemical Journal, September 2001, Portland Press Ltd.

    Robert Williams

  69. Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein

    Article • Free Radical Biology and Medicine, December 2000, Elsevier

    Robert Williams

  70. Ca2+-Permeable AMPA Receptors Induce Phosphorylation of cAMP Response Element-Binding Protein through a Phosphatidylinositol 3-Kinase-Dependent Stimulation of the Mitogen-Activated Protein Kinase Signaling Cascade in Neurons

    Article • Journal of Neuroscience, July 1999, Society for Neuroscience

    Robert Williams

  71. Genes encoding multiple forms of phospholipase A2 are expressed in rat brain

    Article • Neuroscience Letters, December 1998, Elsevier

    Robert Williams

  72. Reduction of gaba and glutamate transporter messenger rnas in the severe-seizure genetically epilepsy-prone rat

    Article • Neuroscience, August 1998, Elsevier

    Robert Williams

  73. Ethanol modulates N-methyl-d-aspartate-evoked arachidonic acid release from neurones

    Article • European Journal of Pharmacology, December 1997, Elsevier

    Robert Williams

  74. Reduced glucose metabolism enhances the glutamate-evoked release of arachidonic acid from striatal neurons

    Article • Neuroscience, July 1996, Elsevier

    Robert Williams

  75. Effects of acute and chronic ethanol on cyclic AMP accumulation in NG108-15 cells: differential dependence of changes on extracellular adenosine

    Article • British Journal of Pharmacology, April 1995, Wiley

    Robert Williams

  76. Inhibition of ADP-ribosyltransferase increases synthesis of Gsα in neuroblastoma × glioma hybrid cells and reverses iloprost-dependent heterologous loss of fluoride-sensitive adenylate cyclase

    Article • Biochemical Pharmacology, March 1995, Elsevier

    Robert Williams

  77. Gsα-dependent and -independent desensitisation of prostanoid IP receptor-activated adenylyl cyclase in NG108-15 cells

    Article • European Journal of Pharmacology Molecular Pharmacology, July 1994, Elsevier

    Robert Williams

  78. Chronic Ethanol Reduces Immunologically Detectable Gqα/11α in NG108–15 Cells

    Article • Journal of Neurochemistry, September 1993, Wiley

    Robert Williams

  79. Binding sites for LH in Candida albicans: comparison with the mammalian corpus luteum LH receptor

    Article • Journal of Endocrinology, August 1991, Bioscientifica

    Robert Williams

  80. Characterization of a factor(s) from partially purified human gonadotrophin preparations which inhibit(s) the binding of radiolabelled human LH and human chorionic gonadotrophin to Candida albicans

    Article • Journal of Endocrinology, January 1991, Bioscientifica

    Robert Williams

  81. Receptor-mediated elevation of adenylate cyclase by luteinizing hormone in Candida albicans

    Article • Journal of General Microbiology, November 1990, Society for General Microbiology

    Robert Williams

  82. Specific, high-affinity binding sites for human luteinizing hormone (hLH) and human chorionic gonadotrophin (hCG) in candida species

    Article • Biochemical and Biophysical Research Communications, March 1990, Elsevier

    Robert Williams

  83. Measurement of Adenylyl Cyclase Activity in Cell Membranes

    Article • Springer Science + Business Media

    Robert Williams