All Stories

  1. Staged mechanical circulatory support in paediatric HIT: Bivalirudin anticoagulation across ECMO, VAD, and cardiac transplantation

    Article • Perfusion, December 2025, SAGE Publications

    Dr Richard W Issitt

  2. Towards goal-directed perfusion - Part II: Temperature dependence of Q 10 , oxygen-demand dependence on age and weight, further clinical insights

    Article • Perfusion, October 2025, SAGE Publications

    Prof Alex Bottle, Dr Richard W Issitt

  3. Towards goal-directed perfusion – Part I: Developing physiology-inspired mathematical framework using high-resolution paediatric CPB data

    Article • Perfusion, September 2025, SAGE Publications

    Dr Richard W Issitt, Prof Alex Bottle

  4. ABO-incompatible heart transplants in children aged 2-9 years: A new paradigm in transplant?

    Article • The Journal of Heart and Lung Transplantation, August 2025, Elsevier

    Dr Richard W Issitt

  5. GenAI exceeds clinical experts in predicting acute kidney injury following paediatric cardiopulmonary bypass

    Article • Scientific Reports, July 2025, Springer Science + Business Media

    Dr Richard W Issitt, Prof Alex Bottle

  6. Technology adoption in healthcare: Delphi consensus for the early exploration and agile adoption of emerging healthcare technology conceptual framework

    Article • BMJ Health & Care Informatics, July 2025, BMJ

    Dr Richard W Issitt

  7. Impact of COVID-19 non-pharmaceutical interventions on bacterial infections in children: an international electronic health record-based study

    Article • BMJ Public Health, July 2025, BMJ

    Dr Richard W Issitt

  8. GenAI Exceeds Clinical Experts in Predicting Acute Kidney Injury following Paediatric Cardiopulmonary Bypass

    Article • April 2025, Springer Science + Business Media

    Dr Richard W Issitt

  9. Mathematical Modelling of Oxygenation Dynamics using High-Resolution Perfusion Data – Part 2: Physiological Insights

    Article • November 2024, Cold Spring Harbor Laboratory Press

    Dr Richard W Issitt

  10. An investigation into the contributing factors to survival of ARDS patients supported by veno-venous ECMO

    Article • Perfusion, November 2024, SAGE Publications

    Dr Richard W Issitt

  11. Implications of mappings between International Classification of Diseases clinical diagnosis codes and Human Phenotype Ontology terms

    Article • JAMIA Open, October 2024, Oxford University Press (OUP)

    Dr Richard W Issitt

  12. Dual immunoadsorption for ABO-incompatible heart transplantation in a 35 kg child

    Article • Perfusion, August 2024, SAGE Publications

    Dr Richard W Issitt

  13. One- and Two-year Multidisciplinary Follow-Up of MIS-C at a Tertiary Hospital: A Retrospective Cohort Study

    Article • The Pediatric Infectious Disease Journal, June 2024, Wolters Kluwer Health

    Dr Richard W Issitt

  14. Long-term outcome after neonatal intervention for congenital critical aortic stenosis

    Article • International Journal of Cardiology, June 2024, Elsevier

    Dr Richard W Issitt

  15. The effect of excessive gas to blood ratios in an ECMO oxygenator

    Article • Perfusion, May 2024, SAGE Publications

    Dr Richard W Issitt

  16. GenAI Exceeds Clinical Experts in Predicting Acute Kidney Injury following Paediatric Cardiopulmonary Bypass2

    Article • May 2024, Cold Spring Harbor Laboratory Press

    Prof Alex Bottle, Dr Richard W Issitt

  17. Neurological diagnoses in hospitalized COVID-19 patients associated with adverse outcomes: A multinational cohort study

    Article • PLOS Digital Health, April 2024, PLOS

    Dr Richard W Issitt

  18. Mathematical Modelling of Oxygenation Dynamics using High-Resolution Perfusion Data – Part 1: Statistical Framework

    Article • March 2024, Cold Spring Harbor Laboratory Press

    Dr Richard W Issitt

  19. Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium

    Article • EClinicalMedicine, October 2023, Elsevier

    Dr Richard W Issitt

  20. Characterization of long COVID temporal sub-phenotypes by distributed representation learning from electronic health record data: a cohort study

    Article • EClinicalMedicine, October 2023, Elsevier

    Dr Richard W Issitt

  21. Potential pitfalls in the use of real-world data for studying long COVID

    Article • Nature Reports Stem Cells, April 2023, Springer Science + Business Media

    Dr Richard W Issitt

  22. Oxygen delivery in pediatric cardiac surgery and its association with acute kidney injury using machine learning

    Article • Journal of Thoracic and Cardiovascular Surgery, April 2023, Elsevier

    Dr Richard W Issitt

  23. Rapid desensitization through immunoadsorption during cardiopulmonary bypass. A novel method to facilitate human leukocyte antigen incompatible heart transplantation

    Article • Perfusion, January 2023, SAGE Publications

    Dr Richard W Issitt

  24. Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium

    Article • PLOS One, January 2023, PLOS

    Dr Richard W Issitt

  25. Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: an international multi-centre observational cohort study

    Article • EClinicalMedicine, January 2023, Elsevier

    Dr Antonio Bellasi, Dr Richard W Issitt

  26. Clinical Phenotypes and Outcomes in Children with Multisystem Inflammatory Syndrome Across Sars-CoV-2 Variant Eras: A Multinational Study from the 4CE Consortium

    Article • January 2023, Elsevier

    Dr Richard W Issitt

  27. Hospitalizations Associated With Mental Health Conditions Among Adolescents in the US and France During the COVID-19 Pandemic

    Article • JAMA Network Open, December 2022, American Medical Association (AMA)

    Dr Richard W Issitt

  28. Lung transplantation in an 18-month-old with donor specific antibodies – The use of intraoperative, targeted plasma exchange

    Article • Perfusion, July 2022, SAGE Publications

    Dr Richard W Issitt

  29. Efficacy of outcome prediction of the respiratory ECMO survival prediction score and the predicting death for severe ARDS on VV-ECMO score for patients with acute respiratory distress syndrome on extracorporeal membrane oxygenation

    Article • Perfusion, July 2022, SAGE Publications

    Dr Richard W Issitt

  30. International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality

    Article • npj Digital Medicine, June 2022, Springer Science + Business Media

    Dr Richard W Issitt

  31. Distinguishing Admissions Specifically for COVID-19 From Incidental SARS-CoV-2 Admissions: National Retrospective Electronic Health Record Study

    Article • Journal of Medical Internet Research, May 2022, JMIR Publications Inc.

    Dr Richard W Issitt

  32. Classification Performance of Neural Networks Versus Logistic Regression Models: Evidence From Healthcare Practice

    Article • Cureus, February 2022, Springer Science + Business Media

    Dr Richard W Issitt

  33. 72 Normoxic perfusion strategy in cyanotic heart disease results in a significant increase in oxygen extraction ratio

    Article • December 2021, BMJ

    Dr Richard W Issitt

  34. 87 Automated data processes in clinical operations – a pilot study for the cardiac M&M meetings

    Article • December 2021, BMJ

    Dr Richard W Issitt

  35. 8 Reducing blood product usage through technology in transplantation

    Article • December 2021, BMJ

    Dr Richard W Issitt

  36. 95 GOSH legacy and epic inpatient data show changing patient case mix and patient requirements since 2000

    Article • December 2021, BMJ

    Dr Richard W Issitt

  37. Early thromboembolic complications after total cavopulmonary connection/Fontan operation in children: A five year single centre review

    Article • Progress in Pediatric Cardiology, December 2021, Elsevier

    Dr Richard W Issitt

  38. Intraoperative anti-A/B immunoadsorption is associated with significantly reduced blood product utilization with similar outcomes in pediatric ABO-incompatible heart transplantation

    Article • The Journal of Heart and Lung Transplantation, November 2021, Elsevier

    Dr Richard W Issitt

  39. Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19

    Article • Scientific Reports, October 2021, Springer Science + Business Media

    Dr Richard W Issitt

  40. International Changes in COVID-19 Clinical Trajectories Across 315 Hospitals and 6 Countries: Retrospective Cohort Study

    Article • Journal of Medical Internet Research, October 2021, JMIR Publications Inc.

    Dr Richard W Issitt

  41. Evolving phenotypes of non-hospitalized patients that indicate long COVID

    Article • BMC Medicine, September 2021, Springer Science + Business Media

    Dr Richard W Issitt

  42. International Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 Countries

    Article • JAMA Network Open, June 2021, American Medical Association (AMA)

    Dr Richard W Issitt

  43. Machine Learning Approaches to Determine Feature Importance for Predicting Infant Autopsy Outcome

    Article • Pediatric and Developmental Pathology, March 2021, SAGE Publications

    Dr Richard W Issitt

  44. What Every Reader Should Know About Studies Using Electronic Health Record Data but May Be Afraid to Ask

    Article • Journal of Medical Internet Research, March 2021, JMIR Publications Inc.

    Dr Richard W Issitt

  45. Cone reconstruction for Ebstein anomaly: Late biventricular function and possible remodeling

    Article • Journal of Thoracic and Cardiovascular Surgery, March 2021, Elsevier

    Dr Richard W Issitt

  46. Fourth ventricle tumors in children: complications and influence of surgical approach

    Article • Journal of Neurosurgery Pediatrics, January 2021, Journal of Neurosurgery Publishing Group (JNSPG)

    Kristian Aquilina, Dr Richard W Issitt

  47. Intraoperative Anti-A/B Immunoadsorption Is Associated With Significantly Reduced Blood Product Utilisation With Similar Outcomes in Paediatric ABO-Incompatible Heart Transplantation

    Article • SSRN Electronic Journal, January 2021, Elsevier

    Dr Richard W Issitt

  48. International Comparisons of Harmonized Laboratory Value Trajectories to Predict Severe COVID-19: Leveraging the 4CE Collaborative Across 342 Hospitals and 6 Countries: A Retrospective Cohort Study

    Article • December 2020, Cold Spring Harbor Laboratory Press

    Dr Richard W Issitt

  49. 109 COCATOO: a cohort comparison tool for GOSH clinical researchers

    Article • November 2020, BMJ

    Dr Richard W Issitt

  50. 10 Researching SARS-CoV-2 from home: maximising the benefit of the GOSH digital research environment during national lockdown

    Article • November 2020, BMJ

    Dr Richard W Issitt

  51. 110 Clinical and operational insights: working to embed data-driven processes at GOSH

    Article • November 2020, BMJ

    Dr Richard W Issitt

  52. 11 Towards international federated health data analysis: experience with the 4CE consortium for characterisation of Covid-19

    Article • November 2020, BMJ

    Dr Richard W Issitt

  53. Children with COVID-19 at a specialist centre: initial experience and outcome

    Article • The Lancet Child & Adolescent Health, August 2020, Elsevier

    Dr Richard W Issitt

  54. The Great Ormond Street Hospital immunoadsorption method for ABO-incompatible heart transplantation: a practical technique

    Article • Perfusion, June 2020, SAGE Publications

    Dr Richard W Issitt

  55. The utility of aortic valve leaflet reconstruction techniques in children and young adults

    Article • Journal of Thoracic and Cardiovascular Surgery, June 2020, Elsevier

    Dr Richard W Issitt

  56. Coronavirus (COVID-19) infection in children at a specialist centre: outcome and implications of underlying ‘high-risk’ comorbidities in a paediatric population

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr Richard W Issitt

  57. Machine Learning Approaches to Determine Feature Importance for Predicting Infant Autopsy Outcome

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr Richard W Issitt

  58. 108 Management of vein of galen on cardiopulmonary bypass

    Article • November 2019, BMJ

    Dr Richard W Issitt

  59. 117 Beyond the divide: research on FHIR in the post-epic age

    Article • November 2019, BMJ

    Dr Richard W Issitt

  60. 38 Web apps for delivering predictive analytics at the bedside

    Article • November 2019, BMJ

    Dr Richard W Issitt

  61. 87 Clinician to informatician – transitioning from blood flow to data flow

    Article • November 2019, BMJ

    Dr Richard W Issitt

  62. 061 An exploration of a clinical decision support system for perfusionists

    Article • December 2018, BMJ

    Dr Richard W Issitt

  63. 134 Research and design for cardiac perfusion – visualisation of data ‘quality markers’

    Article • December 2018, BMJ

    Dr Richard W Issitt

  64. A novel method for ABO-incompatible heart transplantation

    Article • The Journal of Heart and Lung Transplantation, April 2018, Elsevier

    Dr Richard W Issitt

  65. Cardiopulmonary Bypass for a Patient With Congenital Hyperinsulinemia

    Article • World Journal for Pediatric and Congenital Heart Surgery, January 2018, SAGE Publications

    Dr Richard W Issitt

  66. D2.3 An ex-vivo model for the incorporation of immunoadsorption into the extracorporeal circuit: a novel method for abo incompatible heart transplantation

    Article • October 2017, BMJ

    Dr Richard W Issitt

  67. Beta-thalassemia in the paediatric cardiac surgery setting - a case report and literature review

    Article • Perfusion, September 2017, SAGE Publications

    Dr Richard W Issitt

  68. Quantification of Lipid Filtration and the Effects on Cerebral Injury During Cardiopulmonary Bypass

    Article • The Annals of Thoracic Surgery, September 2017, Elsevier

    Dr Richard W Issitt

  69. Leukocyte filtration of the cardiotomy suction. Does it affect systemic leukocyte activation or pulmonary function?

    Article • Perfusion, May 2017, SAGE Publications

    Dr Richard W Issitt

  70. Do lipid microemboli induce acute kidney injury during cardiopulmonary bypass?

    Article • Perfusion, April 2017, SAGE Publications

    Dr Richard W Issitt

  71. Oncotic pressure and paediatric cardiopulmonary bypass: establishing baseline data for complex congenital cardiac surgery and its relation to risk stratification.

    Article • Perfusion, January 2017, SAGE Publications

    Dr Richard W Issitt

  72. Invited Commentary on: Effect of cardiopulmonary bypass on platelet mitochondrial respiration and correlation with aggregation and bleeding: a pilot study

    Article • Perfusion, July 2016, SAGE Publications

    Dr Richard W Issitt

  73. Conclusions from in vitro vs in vivo data

    Article • Perfusion, October 2014, SAGE Publications

    Dr Richard W Issitt

  74. Tetralogy of Fallot with pulmonary atresia and major aortopulmonary collateral vessels

    Article • Perfusion, June 2014, SAGE Publications

    Dr Richard W Issitt

  75. Clinical experience with Affinity Pixie™ oxygenation system in paediatric and infant patients

    Article • Perfusion, January 2014, SAGE Publications

    Dr Richard W Issitt

  76. Incompatible ABO-plasma exchange and its impact on patient selection in paediatric cardiac transplantation

    Article • Perfusion, July 2012, SAGE Publications

    Dr Richard W Issitt

  77. Invited Commentary

    Article • The Annals of Thoracic Surgery, May 2011, Elsevier

    Dr Richard W Issitt

  78. Dealing with pericardial suction blood and residual pump volume: a review of current practices in the UK

    Article • Perfusion, August 2010, SAGE Publications

    Dr Richard W Issitt

  79. Aortic Surgery Using Total Miniaturized Cardiopulmonary Bypass

    Article • The Annals of Thoracic Surgery, August 2008, Elsevier

    Dr Richard W Issitt

  80. Clinical evaluation of the Admiral 1.35m2 hollow-fibre membrane oxygenator

    Article • Perfusion, January 2008, SAGE Publications

    Dr Richard W Issitt

  81. Fat Filtration and Organ Injury following Cardiac Surgery

    Article • Springer Science + Business Media

    Dr Richard W Issitt