All Stories

  1. Structure and activity of a thermally stable mutant of Acanthamoeba actophorin
  2. Improved resolution crystal structure ofAcanthamoebaactophorin reveals structural plasticity not induced by microgravity
  3. Calcium-ligand variants of the myocilin olfactomedin propeller selected from invertebrate phyla reveal cross-talk with N-terminal blade and surface helices
  4. How does a protein’s structure spell the difference between health and disease? Our journey to understand glaucoma-associated myocilin
  5. Progress toward development of a proteostasis drug for myocilin-associated glaucoma
  6. Effects of protein engineering and rational mutagenesis on crystal lattice of single chain antibody fragments
  7. myocilin amyloid fibrils
  8. Non-Native Structural Properties of the Glaucoma-Associated Olfactomedin Domain of Myocilin Lead to Amyloid Fibrils
  9. New direction for glaucoma therapeutics: focus on the olfactomedin domain of myocilin
  10. Determination of Soluble and Membrane Protein Structures by X-Ray Crystallography
  11. Crystallization chaperone strategies for membrane proteins
  12. A Guided Tour of the Structural Biology of Gaucher Disease: Acid-β-Glucosidase and Saposin C
  13. Binding of 3,4,5,6-Tetrahydroxyazepanes to the Acid-β-glucosidase Active Site: Implications for Pharmacological Chaperone Design for Gaucher Disease
  14. The Stability of Myocilin Olfactomedin Domain Variants Provides New Insight into Glaucoma as a Protein Misfolding Disorder
  15. Biophysical Characterization of the Olfactomedin Domain of Myocilin, an Extracellular Matrix Protein Implicated in Inherited Forms of Glaucoma
  16. Rescue of Glaucoma-Causing Mutant Myocilin Thermal Stability by Chemical Chaperones
  17. Effects of pH and Iminosugar Pharmacological Chaperones on Lysosomal Glycosidase Structure and Stability
  18. Structure of acid β-glucosidase with pharmacological chaperone provides insight into Gaucher disease
  19. Characterization of the Particulate Methane Monooxygenase Metal Centers in Multiple Redox States by X-ray Absorption Spectroscopy
  20. X-ray Crystallography and Biological Metal Centers:  Is Seeing Believing?
  21. Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane
  22. The quest for the particulate methane monooxygenase active site
  23. Biological Methane Oxidation: Regulation, Biochemistry, and Active Site Structure of Particulate Methane Monooxygenase
  24. Crystal Structure of a Novel Red Copper Protein from Nitrosomonas europaea,
  25. Synthesis, structure and magnetic properties of a chromium(III)nicotinamide complex [Cr3O(O2CCH3)6(na)3]+ (na=nicotinamide)