All Stories

  1. Structural basis for neutralizing antibody binding to pertussis toxin

    Article • Proceedings of the National Academy of Sciences, April 2025, Proceedings of the National Academy of Sciences

    Prof Jennifer A Maynard

  2. A conserved tryptophan in the acylated segment of RTX toxins controls their β2 integrin–independent cell penetration

    Article • Journal of Biological Chemistry, August 2023, Elsevier

    Prof Jennifer A Maynard

  3. Outsmarting Pathogens with Antibody Engineering

    Article • Annual Review of Chemical and Biomolecular Engineering, June 2023, Annual Reviews

    Prof Jennifer A Maynard

  4. Discovering a Highly Conserved S2 Epitope in SARS-CoV-2 Spike Proteins

    Article • eLife, March 2023, eLife

    Prof Jennifer A Maynard

  5. SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines

    Article • Science Immunology, December 2022, American Association for the Advancement of Science

    Prof Jennifer A Maynard

  6. Engineering antibodies for conditional activity in the solid tumor microenvironment

    Article • Current Opinion in Biotechnology, December 2022, Elsevier

    Prof Jennifer A Maynard

  7. Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis

    Article • mBio, August 2022, ASM Journals

    Prof Jennifer A Maynard

  8. Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin

    Article • Cell Reports, August 2022, Elsevier

    Prof Jennifer A Maynard

  9. An antibody Fc engineered for conditional antibody-dependent cellular cytotoxicity at the low tumor microenvironment pH

    Article • Journal of Biological Chemistry, April 2022, Elsevier

    Prof Jennifer A Maynard

  10. The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes

    Article • Nature Structural & Molecular Biology, March 2022, Springer Science + Business Media

    Prof Jennifer A Maynard

  11. Antibodies binding diverse pertactin epitopes protect mice from Bordetella pertussis infection

    Article • Journal of Biological Chemistry, March 2022, Elsevier

    Prof Jennifer A Maynard

  12. The SARS-CoV-2 spike protein reversibly samples an open-trimer conformation exposing novel epitopes

    Article • Biophysical Journal, February 2022, Elsevier

    Prof Jennifer A Maynard

  13. Expression and characterization of SARS-CoV-2 spike proteins

    Article • Nature Protocols, October 2021, Springer Science + Business Media

    Prof Jennifer A Maynard

  14. Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes

    Article • PLoS Pathogens, September 2021, PLOS

    Prof Jennifer A Maynard

  15. Recombinant antibodies recognize conformation-dependent epitopes of the leucine zipper of misfolding-prone myocilin

    Article • Journal of Biological Chemistry, September 2021, Elsevier

    Prof Jennifer A Maynard

  16. Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

    Article • Science, September 2020, American Association for the Advancement of Science

    Prof Jennifer A Maynard

  17. One step ultra-high-throughput sequencing of the paired antibody VH:VL and TCRβ:α repertoires using cell lysate resistant xenopolymerase in emulsion

    Article • The Journal of Immunology, May 2020, The American Association of Immunologists

    Prof Jennifer A Maynard

  18. A facile technology for the high-throughput sequencing of the paired VH:VL and TCRβ:TCRα repertoires

    Article • Science Advances, April 2020, American Association for the Advancement of Science

    Prof Jennifer A Maynard

  19. Neutralization of pertussis toxin by a single antibody prevents clinical pertussis in neonatal baboons

    Article • Science Advances, February 2020, American Association for the Advancement of Science

    Prof Jennifer A Maynard

  20. Human cytomegalovirus-specific T-cell receptor engineered for high affinity and soluble expression using mammalian cell display

    Article • Journal of Biological Chemistry, April 2019, Elsevier

    Prof Jennifer A Maynard

  21. Basics of pertussis pathogenesis

    Article • December 2018, Oxford University Press (OUP)

    Prof Jennifer A Maynard

  22. Humanised monoclonal antibodies neutralise pertussis toxin by receptor blockade and reduced retrograde trafficking

    Article • Cellular Microbiology, September 2018, Wiley

    Prof Jennifer A Maynard

  23. Evaluation of Adenylate Cyclase Toxoid Antigen in Acellular Pertussis Vaccines by Using a Bordetella pertussis Challenge Model in Mice

    Article • Infection and Immunity, July 2018, ASM Journals

    Prof Jennifer A Maynard

  24. Enhancing the immunotherapeutic Trastuzumab for selective activity in the low pH tumor microenvironment

    Article • The Journal of Immunology, May 2018, The American Association of Immunologists

    Prof Jennifer A Maynard

  25. Characterization of Individual Human Antibodies That Bind Pertussis Toxin Stimulated by Acellular Immunization

    Article • Infection and Immunity, March 2018, ASM Journals

    Prof Jennifer A Maynard

  26. Identification of high affinity HER2 binding antibodies using CHO Fab surface display

    Article • Protein Engineering Design and Selection, March 2018, Oxford University Press (OUP)

    Prof Jennifer A Maynard

  27. Engineering therapeutic antibodies to combat infectious diseases

    Article • Current Opinion in Chemical Engineering, March 2018, Elsevier

    Prof Jennifer A Maynard

  28. When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions

    Article • mAbs, February 2018, Taylor & Francis

    Prof Jennifer A Maynard

  29. Charge Shielding Prevents Aggregation of Supercharged GFP Variants at High Protein Concentration

    Article • Molecular Pharmaceutics, September 2017, American Chemical Society (ACS)

    Prof Jennifer A Maynard

  30. De novo design of antibody complementarity determining regions binding a FLAG tetra-peptide

    Article • Scientific Reports, August 2017, Springer Science + Business Media

    Prof Jennifer A Maynard

  31. Fine Epitope Mapping of Two Antibodies Neutralizing the Bordetella Adenylate Cyclase Toxin

    Article • Biochemistry, February 2017, American Chemical Society (ACS)

    Prof Jennifer A Maynard

  32. Passive Immunization with Anti-Pertussis Toxin Humanized Monoclonal Antibody Mitigates Clinical Signs of Pertussis Infection in Newborn Baboons

    Article • Open Forum Infectious Diseases, January 2017, Oxford University Press (OUP)

    Prof Jennifer A Maynard

  33. Prior exposure to <i>Bordetella</i> species as an exclusion criterion in the baboon model of pertussis

    Article • Journal of Veterinary Medical Science, January 2017, Japanese Society of Veterinary Science

    Prof Jennifer A Maynard

  34. Viscosity Reduction of a Concentrated Monoclonal Antibody with Arginine·HCl and Arginine·Glutamate

    Article • Industrial & Engineering Chemistry Research, October 2016, American Chemical Society (ACS)

    Thomas Truskett, Prof Jennifer A Maynard

  35. Synergistic Neutralization of Pertussis Toxin by a Bispecific AntibodyIn VitroandIn Vivo

    Article • Clinical and Vaccine Immunology, August 2016, ASM Journals

    Prof Jennifer A Maynard

  36. Inclusion of an RGD Motif Alters Invasin Integrin-Binding Affinity and Specificity

    Article • Biochemistry, March 2016, American Chemical Society (ACS)

    Prof Jennifer A Maynard

  37. A cocktail of humanized anti–pertussis toxin antibodies limits disease in murine and baboon models of whooping cough

    Article • Science Translational Medicine, December 2015, American Association for the Advancement of Science

    Prof Jennifer A Maynard

  38. Rapid Fine Conformational Epitope Mapping Using Comprehensive Mutagenesis and Deep Sequencing

    Article • Journal of Biological Chemistry, October 2015, Elsevier

    Prof Jennifer A Maynard

  39. The Bordetella adenylate cyclase repeat-in-toxin (RTX) domain is immunodominant and elicits neutralizing antibodies.

    Article • Journal of Biological Chemistry, September 2015, Elsevier

    Prof Jennifer A Maynard

  40. Increased Fab thermoresistance via VH-targeted directed evolution

    Article • Protein Engineering Design and Selection, August 2015, Oxford University Press (OUP)

    Prof Jennifer A Maynard

  41. Immunotherapeutic Approaches To Prevent Cytomegalovirus-Mediated Disease

    Article • May 2015, ASM Journals

    Prof Jennifer A Maynard

  42. Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization

    Article • Acta Crystallographica Section D Biological Crystallography, March 2015, International Union of Crystallography

    Prof Jennifer A Maynard

  43. The Use of Engineered Antibody Fragments to Promote Crystallization of Membrane Proteins

    Article • Biophysical Journal, January 2014, Elsevier

    Prof Jennifer A Maynard

  44. Back to the future: recombinant polyclonal antibody therapeutics

    Article • Current Opinion in Chemical Engineering, November 2013, Elsevier

    Prof Jennifer A Maynard

  45. In Vivo Whole Animal Fluorescence Imaging of a Microparticle-Based Oral Vaccine Containing (CuInSexS2–x)/ZnS Core/Shell Quantum Dots

    Article • Nano Letters, August 2013, American Chemical Society (ACS)

    Prof Jennifer A Maynard

  46. Tunable equilibrium nanocluster dispersions at high protein concentrations

    Article • Soft Matter, January 2013, Royal Society of Chemistry

    Thomas Truskett, Prof Jennifer A Maynard

  47. Flanking Residues Are Central to DO11.10 T Cell Hybridoma Stimulation by Ovalbumin 323–339

    Article • PLOS One, October 2012, PLOS

    Prof Jennifer A Maynard

  48. Antibody nanoparticle dispersions formed with mixtures of crowding molecules retain activity and In Vivo bioavailability

    Article • Journal of Pharmaceutical Sciences, October 2012, Elsevier

    Thomas Truskett, Prof Jennifer A Maynard

  49. The Skp Chaperone Helps Fold Soluble Proteins in Vitro by Inhibiting Aggregation

    Article • Biochemistry, June 2012, American Chemical Society (ACS)

    Prof Jennifer A Maynard

  50. Restriction enzyme-free construction of random gene mutagenesis libraries in Escherichia coli

    Article • Analytical Biochemistry, February 2012, Elsevier

    Prof Jennifer A Maynard

  51. Crystallization chaperone strategies for membrane proteins

    Article • Methods, December 2011, Elsevier

    Raquel Lieberman, Prof Jennifer A Maynard

  52. Antibodies Recognizing Protective Pertussis Toxin Epitopes Are Preferentially Elicited by Natural Infection versus Acellular Immunization

    Article • Clinical and Vaccine Immunology, April 2011, ASM Journals

    Prof Jennifer A Maynard

  53. Conversion of scFv peptide-binding specificity for crystal chaperone development

    Article • Protein Engineering Design and Selection, January 2011, Oxford University Press (OUP)

    Prof Jennifer A Maynard

  54. Characterization of a Key Neutralizing Epitope on Pertussis Toxin Recognized by Monoclonal Antibody 1B7

    Article • Biochemistry, November 2009, American Chemical Society (ACS)

    Prof Jennifer A Maynard

  55. Surface plasmon resonance for high‐throughput ligand screening of membrane‐bound proteins

    Article • Biotechnology Journal, November 2009, Wiley

    Prof Jennifer A Maynard

  56. Crystal Structure of the Engineered Neutralizing Antibody M18 Complexed to Domain 4 of the Anthrax Protective Antigen

    Article • Journal of Molecular Biology, April 2009, Elsevier

    Prof Jennifer A Maynard

  57. Progress Towards Recombinant Anti-Infective Antibodies

    Article • Recent Patents on Anti-Infective Drug Discovery, January 2009, Bentham Science Publishers

    Prof Jennifer A Maynard

  58. Structural evidence for a germline-encoded T cell receptor–major histocompatibility complex interaction 'codon'

    Article • Nature Immunology, August 2007, Springer Science + Business Media

    Prof Jennifer A Maynard

  59. Modeling the structure of mAb 14B7 bound to the anthrax protective antigen

    Article • Proteins Structure Function and Bioinformatics, August 2007, Wiley

    Prof Jennifer A Maynard

  60. High-level bacterial secretion of single-chain αβ T-cell receptors

    Article • Journal of Immunological Methods, November 2005, Elsevier

    Prof Jennifer A Maynard

  61. Structure of an Autoimmune T Cell Receptor Complexed with Class II Peptide-MHC

    Article • Immunity, January 2005, Elsevier

    Prof Jennifer A Maynard

  62. Structure of an Autoimmune T Cell Receptor Complexed with Class II Peptide-MHCInsights into MHC Bias and Antigen Specificity

    Article • Immunity, January 2005, Elsevier

    Prof Jennifer A Maynard

  63. Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity

    Article • Nature Biotechnology, June 2002, Springer Science + Business Media

    Prof Jennifer A Maynard

  64. In Vitro Scanning-Saturation Mutagenesis

    Article • January 2002, Springer Science + Business Media

    Prof Jennifer A Maynard

  65. A Novel All Helix Fold of the AP180 Amino-Terminal Domain for Phosphoinositide Binding and Clathrin Assembly in Synaptic Vesicle Endocytosis

    Article • Cell, February 2001, Elsevier

    Prof Jennifer A Maynard

  66. Antibody Engineering

    Article • Annual Review of Biomedical Engineering, August 2000, Annual Reviews

    Prof Jennifer A Maynard

  67. Rhizoremediation of Trichloroethylene by a Recombinant, Root-Colonizing Pseudomonas fluorescens Strain Expressing Toluene ortho -Monooxygenase Constitutively

    Article • Applied and Environmental Microbiology, January 1998, ASM Journals

    Prof Jennifer A Maynard