All Stories

  1. Optimization of a DNA encoded library derived autotaxin inhibitor hit to a potent in vivo LPA lowering quinazolinone compound with a non‑zinc binding mode
  2. Simple User‐Friendly Reaction Format
  3. Accelerating compound synthesis in drug discovery: the role of digitalisation and automation
  4. Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche’s Endocannabinoid System Projects
  5. RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models
  6. Simple User-Friendly Reaction Format
  7. sp3‐Rich Heterocycle Synthesis on DNA: Application to DNA‐Encoded Library Production
  8. sp3‐Rich Heterocycle Synthesis on DNA: Application to DNA‐Encoded Library Production
  9. Geometric deep learning-guided Suzuki reaction conditions assessment for applications in medicinal chemistry
  10. Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning
  11. Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening
  12. Investigations into mRNA Lipid Nanoparticles Shelf-Life Stability under Nonfrozen Conditions
  13. Development and Demonstration of a High-Volume Manufacturing Process for a Key Intermediate of Dalcetrapib: Investigations on the Alkylation of Carboxylic Acids, Esters, and Nitriles
  14. Simple User-Friendly Reaction Format
  15. Diligent Design Enables Antibody-ASO Conjugates with Optimal Pharmacokinetic Properties
  16. Graph transformer neural network for chemical reactivity prediction
  17. Rapid 18F‐ and 19F‐Difluoromethylation via Desulfurative Fluorination of Transient N‐, O‐, and C‐Linked Dithioles
  18. Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning
  19. Late-stage Functionalization and its Impact on Modern Drug Discovery
  20. Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner
  21. Quaternary Ammonium Trifluoromethoxide Salts as Stable Sources of Nucleophilic OCF3
  22. Paracrine crosstalk between intestinal L- and D-cells controls secretion of glucagon-like peptide-1 in mice
  23. Modulation of Pharmacologically Relevant Properties of Piperidine Derivatives by Functional Groups in an Equatorial or Axial β‐Position to the Amino Group
  24. A Convenient Synthesis of Difluoroalkyl Ethers from Thionoesters using Silver(I) Fluoride
  25. Electrostatic Effects Accelerate Decatungstate-Catalyzed C–H Fluorination Using [18F]- and [19F]NFSI in Small Molecules and Peptide Mimics
  26. 18F-Branched-Chain Amino Acids: Structure–Activity Relationships and PET Imaging Potential
  27. Site-Selective, Late-Stage C−H 18 F-Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging
  28. Site-Selective, Late-Stage C−H 18 F-Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging
  29. A carbohydrate-derived trifunctional scaffold for medicinal chemistry library synthesis
  30. 2H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design
  31. Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives
  32. Synthesis of acyl fluorides via photocatalytic fluorination of aldehydic C–H bonds
  33. A carbohydrate-derived trifunctional scaffold for DNA-encoded libraries
  34. Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors
  35. 18F-Fluorination of Unactivated C–H Bonds in Branched Aliphatic Amino Acids: Direct Synthesis of Oncological Positron Emission Tomography Imaging Agents
  36. Intramolecular Inverse Electron-Demand [4 + 2] Cycloadditions of Ynamides with Pyrimidines: Scope and Density Functional Theory Insights
  37. A Convenient Late-Stage Fluorination of Pyridylic C−H Bonds with N -Fluorobenzenesulfonimide
  38. Going with the flow
  39. Inverse Electron-Demand [4 + 2]-Cycloadditions of Ynamides: Access to Novel Pyridine Scaffolds
  40. Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)
  41. Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys
  42. Direct photocatalytic fluorination of benzylic C–H bonds with N-fluorobenzenesulfonimide
  43. A Convenient Photocatalytic Fluorination of Unactivated CH Bonds
  44. Inside Cover: Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors (Angew. Chem. Int. Ed. 6/2014)
  45. Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors
  46. Converting oxazoles into imidazoles: new opportunities for diversity-oriented synthesis
  47. Flow synthesis of annulated 5-aryl-substituted pyridines by tandem intramolecular inverse-electron-demand hetero-/retro-Diels–Alder reaction
  48. Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists
  49. The Kondrat’eva Reaction in Flow: Direct Access to Annulated Pyridines
  50. Cover Picture: 2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5) (ChemMedChem 4/2013)
  51. Photocatalytic Synthesis of Allylic Trifluoromethyl Substituted Styrene Derivatives in Batch and Flow
  52. 2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5)
  53. Evaluation of a flow-photochemistry platform for the synthesis of compact modules
  54. Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands
  55. Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions
  56. Neighborhood-Preserving Visualization of Adaptive Structure-Activity Landscapes: Application to Drug Discovery
  57. G Protein-Coupled Receptor Transmembrane Binding Pockets and their Applications in GPCR Research and Drug Discovery: A Survey
  58. Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods
  59. Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
  60. Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes
  61. Piperidinyl-nicotinamides as potent and selective somatostatin receptor subtype 5 antagonists
  62. Novel, non-peptidic somatostatin receptor subtype 5 antagonists improve glucose tolerance in rodents
  63. Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists
  64. Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist
  65. Synthesis of Light-Emitting Conjugated Polymers for Applications in Electroluminescent Devices
  66. Discovery of the First Nonpeptidic, Small-Molecule, Highly Selective Somatostatin Receptor Subtype 5 Antagonists: A Chemogenomics Approach
  67. From Astemizole to a Novel Hit Series of Small-Molecule Somatostatin 5 Receptor Antagonists via GPCR Affinity Profiling
  68. Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities
  69. Remote Modulation of Amine Basicity by a Phenylsulfone and a Phenylthio Group
  70. Cyclopropanation of 3,4-dihydro-1 H-benzo[e][1,4]diazepine-2,5-diones
  71. Joint Meeting on Medicinal Chemistry in Vienna
  72. Ligand identification for G-protein-coupled receptors: a lead generation perspective
  73. Preparation of 5-amino-6-oxo-1,6-dihydro[1,2,4]triazine-3-carboxylic acid derivatives and synthesis of compound libraries thereof
  74. μSR in polymers
  75. Muon-spin relaxation study of anisotropic charge carrier motion in polyphenylene vinylene-based polymers
  76. Third-order nonlinear optical properties of in-backbone substituted conjugated polymers
  77. Anodic and Cathodic Electrochemically Generated Chemiluminescence in Conjugated Polymers
  78. New family of polyfluorene copolymers for light-emitting devices
  79. Multi-layer Polymer Light-emitting Diodes with 2,3-Dialkoxy-p-phenylene Vinylene and its Blends.
  80. White-light-continuum spectroscopy to determine third-order nonlinear optical properties
  81. Versatile synthesis of various conjugated aromatic homo- and copolymers
  82. Efficient electroluminescent poly(p-phenylene vinylene) copolymers for application in LEDs
  83. Polymer and small molecule multi-layer light-emitting diodes
  84. Electrochemiluminescence of conjugated polymer
  85. Muon-spin relaxation study of charge carrier dynamics in the conducting polymer PPV
  86. Ortho-Metallation as a key step for the synthesis of silyl substituted Poly(p-phenylenevinylene)s
  87. Insulated Molecular Wires: Dendritic Encapsulation of Poly(triacetylene) Oligomers, Attempted Dendritic Stabilization of Novel Poly(pentaacetylene) Oligomers, and an Organometallic Approach to Dendritic Rods
  88. New routes to monomers and polymers for LEDs
  89. Conjugated Oligomers and Polymers, Synthesis of
  90. Design of Luminescent Polymers for Leds
  91. Synthesis and Physical Investigation of Donor–Donor and Acceptor–Acceptor End-Functionalized Monodisperse Poly(triacetylene) Oligomers
  92. Monodisperse Poly(triacetylene) Oligomers Extending from Monomer to Hexadecamer: Joint Experimental and Theoretical Investigation of Physical Properties
  93. μSR of conducting and non-conducting polymers
  94. Synthesis of conjugated polymers for application in light-emitting diodes (PLEDs)
  95. The copolymer route to new luminescent materials for LEDs
  96. Efficient blue–green light emitting poly(1,4-phenylene vinylene) copolymers
  97. Synthesis of New Building Blocks for Light Emitting Polymers
  98. Synthesis of New Building Blocks for Light Emitting Polymers
  99. Scaling laws of second-order hyperpolarizabilities in molecular wires
  100. Design and synthesis of conjugated materials for efficient optoelectronic devices
  101. Scaling law for second-order hyperpolarizability in poly(triacetylene) molecular wires
  102. Modulation ofπ-Electron Conjugation in Oligo(triacetylene) Chromophores by Incorporation of a Central Spacer
  103. Linear Monodisperse π-Conjugated Oligomers: Model Compounds for Polymers and More
  104. Monodisperse Poly(triacetylene) Rods: Synthesis of a 11.9 nm Long Molecular Wire and Direct Determination of the Effective Conjugation Length by UV/Vis and Raman Spectroscopies
  105. PM3 geometry optimization and CNDO/S-CI computation of UV/Vis spectra of large organic structures: Program description and application to poly(triacetylene) hexamer and taxotere
  106. PM3 geometry optimization and CNDO/S-CI computation of UV/Vis spectra of large organic structures: Program description and application to poly(triacetylene) hexamer and taxotere
  107. Versatile Syntheses of Various Homo- and Copolymers of Poly(1,4-Arylene Vinylene)S
  108. Determination of End-to-End Distances in a Series of TEMPO Diradicals of up to 2.8 nm Length with a New Four-Pulse Double Electron Electron Resonance Experiment
  109. Determination of End-to-End Distances in a Series of TEMPO Diradicals of up to 2.8 nm Length with a New Four-Pulse Double Electron Electron Resonance Experiment
  110. Structure−Property Relationships in Third-Order Nonlinear Optical Chromophores
  111. Dendritic rods with a poly(triacetylene) backbone: insulated molecular wires
  112. Photochemical trans–cis isomerisation of donor/acceptor-substituted (E )-hex-3-ene-1,5-diynes (1,2-diethynylethenes, DEEs) and 3,4-diethynylhex-3-ene-1,5-diynes (tetraethynylethenes, TEEs)
  113. Poly(triacetylene) Oligomers: Synthesis, Characterization, and Estimation of the Effective Conjugation Length by Electrochemical, UV/Vis, and Nonlinear Optical Methods
  114. Electronic Characteristics of Arylated Tetraethynylethenes:  A Cooperative Computational and Electrochemical Investigation
  115. Functionalized One and Two-Dimensionally Conjugated Molecules for Thrid Order Nonlinear Optics