All Stories

  1. Synergistic miRNA Combinations Mitigate Doxorubicin-Induced Cardiotoxicity

    Article • JACC CardioOncology, June 2025, Elsevier

    Dr Pilar Sepulveda

  2. Extracellular vesicles from dental pulp mesenchymal stem cells modulate macrophage phenotype during acute and chronic cardiac inflammation in athymic nude rats with myocardial infarction

    Article • March 2024, Research Square

    Dr Pilar Sepulveda

  3. Identification of omega-3 oxylipins in human milk-derived extracellular vesicles with pro-resolutive actions in gastrointestinal inflammation

    Article • August 2023, Cold Spring Harbor Laboratory Press

    Dr Pilar Sepulveda

  4. Modeling Cardiotoxicity in Pediatric Oncology Patients Using Patient-Specific iPSC-Derived Cardiomyocytes Reveals Downregulation of Cardioprotective microRNAs

    Article • Antioxidants, July 2023, MDPI AG

    Dr Pilar Sepulveda, Dr Imelda Ontoria-Oviedo

  5. Reliable assessment of carbon black nanomaterial of a variety of cell culture media for in vitro toxicity assays by asymmetrical flow field-flow fractionation

    Article • Analytical and Bioanalytical Chemistry, February 2023, Springer Science + Business Media

    Dr Pilar Sepulveda

  6. Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds

    Article • Scientific Data, November 2022, Springer Science + Business Media

    Dr Pilar Sepulveda

  7. MicroRNA-4732-3p Is Dysregulated in Breast Cancer Patients with Cardiotoxicity, and Its Therapeutic Delivery Protects the Heart from Doxorubicin-Induced Oxidative Stress in Rats

    Article • Antioxidants, September 2022, MDPI AG

    Dr Pilar Sepulveda

  8. Isolation and Lipidomic Screening of Human Milk Extracellular Vesicles

    Article • September 2022, Springer Science + Business Media

    Dr Pilar Sepulveda

  9. Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice

    Article • Pharmacological Research, September 2022, Elsevier

    Dr Pilar Sepulveda

  10. Topical Administration of a Marine Oil Rich in Pro-Resolving Lipid Mediators Accelerates Wound Healing in Diabetic db/db Mice through Angiogenesis and Macrophage Polarization

    Article • International Journal of Molecular Sciences, August 2022, MDPI AG

    Dr Pilar Sepulveda, Dr Imelda Ontoria-Oviedo

  11. A Fibrosis Biomarker Early Predicts Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy

    Article • Cancers, June 2022, MDPI AG

    Dr Pilar Sepulveda

  12. Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome

    Article • Frontiers in Immunology, June 2022, Frontiers

    Dr Pilar Sepulveda

  13. The Vascular Niche for Adult Cardiac Progenitor Cells

    Article • Antioxidants, April 2022, MDPI AG

    Dr Pilar Sepulveda

  14. Corrigendum to “Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation”

    Article • Stem Cells International, March 2022, Hindawi Publishing Corporation

    Dr Pilar Sepulveda, Dr Imelda Ontoria-Oviedo

  15. Non-classical Notch signaling by MDA-MB-231 breast cancer cell-derived small extracellular vesicles promotes malignancy in poorly invasive MCF-7 cells

    Article • Cancer Gene Therapy, January 2022, Springer Science + Business Media

    Dr Pilar Sepulveda

  16. Conductive polycaprolactone/gelatin/polyaniline nanofibres as functional scaffolds for cardiac tissue regeneration

    Article • Reactive and Functional Polymers, January 2022, Elsevier

    Dr Pilar Sepulveda, Dr Imelda Ontoria-Oviedo, Dr JD Badia

  17. Modeling Transposition of the Great Arteries with Patient-Specific Induced Pluripotent Stem Cells

    Article • International Journal of Molecular Sciences, December 2021, MDPI AG

    Dr Pilar Sepulveda, Dr Imelda Ontoria-Oviedo

  18. Co-administration of human MSC overexpressing HIF-1α increases human CD34+ cell engraftment in vivo

    Article • Stem Cell Research & Therapy, December 2021, Springer Science + Business Media

    Dr Pilar Sepulveda

  19. HIF-Overexpression and Pro-Inflammatory Priming in Human Mesenchymal Stromal Cells Improves the Healing Properties of Extracellular Vesicles in Experimental Crohn’s Disease

    Article • International Journal of Molecular Sciences, October 2021, MDPI AG

    Dr Pilar Sepulveda

  20. ATR-FTIR spectroscopy for the routine quality control of exosome isolations

    Article • Chemometrics and Intelligent Laboratory Systems, October 2021, Elsevier

    Dr Pilar Sepulveda

  21. miR-4732-3p in Extracellular Vesicles From Mesenchymal Stromal Cells Is Cardioprotective During Myocardial Ischemia

    Article • Frontiers in Cell and Developmental Biology, August 2021, Frontiers

    Dr Pilar Sepulveda, Dr Imelda Ontoria-Oviedo

  22. HIF-1α and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles

    Article • International Journal of Molecular Sciences, March 2021, MDPI AG

    Dr Pilar Sepulveda

  23. Polymer Conjugation of Docosahexaenoic Acid Potentiates Cardioprotective Therapy in Preclinical Models of Myocardial Ischemia/Reperfusion Injury

    Article • Advanced Healthcare Materials, March 2021, Wiley

    Dr Pilar Sepulveda, Dr Imelda Ontoria-Oviedo

  24. Prognostic value and clinical predictors of intramyocardial hemorrhage measured by CMR T2* sequences in STEMI

    Article • The International Journal of Cardiovascular Imaging, January 2021, Springer Science + Business Media

    Dr Pilar Sepulveda

  25. Two-Component Peptidic Molecular Gels for Topical Drug Delivery of Naproxen

    Article • ACS Applied Bio Materials, January 2021, American Chemical Society (ACS)

    Dr Imelda Ontoria-Oviedo, Dr Pilar Sepulveda

  26. Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation

    Article • Scientific Reports, December 2020, Springer Science + Business Media

    Dr Pilar Sepulveda

  27. Genotype FBN1 /phenotype relationship in a cohort of patients with Marfan syndrome

    Article • Clinical Genetics, November 2020, Wiley

    Dr Imelda Ontoria-Oviedo, Dr Pilar Sepulveda

  28. Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation

    Article • Stem Cells International, October 2020, Hindawi Publishing Corporation

    Dr Imelda Ontoria-Oviedo, Dr Pilar Sepulveda

  29. Cardiopulmonary Rehabilitation Improves Respiratory Muscle Function and Functional Capacity in Children with Congenital Heart Disease. A Prospective Cohort Study

    Article • International Journal of Environmental Research and Public Health, June 2020, MDPI AG

    Dr Pilar Sepulveda

  30. Polycaprolactone/gelatin-based scaffolds with tailored performance: in vitro and in vivo validation

    Article • Materials Science and Engineering C, February 2020, Elsevier

    Dr Imelda Ontoria-Oviedo, Dr Pilar Sepulveda, Dr JD Badia

  31. Balance of Active, Passive, and Anatomical Cardiac Properties in Doxorubicin-Induced Heart Failure

    Article • Biophysical Journal, December 2019, Elsevier

    Dr Pilar Sepulveda

  32. Circulating exosomes deliver free fatty acids from the bloodstream to cardiac cells: Possible role of CD36

    Article • PLOS One, May 2019, PLOS

    Dr Pilar Sepulveda

  33. Extracellular Vesicles Secreted by Hypoxic AC10 Cardiomyocytes Modulate Fibroblast Cell Motility

    Article • Frontiers in Cardiovascular Medicine, October 2018, Frontiers

    Dr Imelda Ontoria-Oviedo, Dr Pilar Sepulveda

  34. In vitro validation of biomedical polyester-based scaffolds: Poly(lactide- co -glycolide) as model-case

    Article • Polymer Testing, April 2018, Elsevier

    Dr JD Badia, Dr Imelda Ontoria-Oviedo, Dr Pilar Sepulveda

  35. Analysis of Exosome Transfer in Mammalian Cells by Fluorescence Recovery after Photobleaching

    Article • BIO-PROTOCOL, January 2018, Bio-Protocol, LLC

    Dr Pilar Sepulveda

  36. Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells

    Article • Stem Cell Research & Therapy, September 2017, Springer Science + Business Media

    Dr Imelda Ontoria-Oviedo, Dr Pilar Sepulveda

  37. Mesenchymal Stem Cell Migration and Proliferation Are Mediated by Hypoxia-Inducible Factor-1α Upstream of Notch and SUMO Pathways

    Article • Stem Cells and Development, July 2017, Mary Ann Liebert Inc

    Dr Imelda Ontoria-Oviedo, Dr Pilar Sepulveda

  38. Electrospun poly(hydroxybutyrate) scaffolds promote engraftment of human skin equivalents via macrophage M2 polarization and angiogenesis

    Article • Journal of Tissue Engineering and Regenerative Medicine, June 2017, Wiley

    Dr Pilar Sepulveda, ana sanchis, Dr Imelda Ontoria-Oviedo

  39. Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells

    Article • May 2017, Cold Spring Harbor Laboratory Press

    Dr Pilar Sepulveda

  40. Hydrogen Sulfide Improves Cardiomyocyte Function in a Cardiac Arrest Model

    Article • Annals of Transplantation, May 2017, International Scientific Literature

    Dr Pilar Sepulveda, Jose Millet

  41. Hypoxia Inducible Factor-1α Potentiates Jagged 1-Mediated Angiogenesis by Mesenchymal Stem Cell-Derived Exosomes

    Article • Stem Cells, April 2017, Wiley

    Dr Pilar Sepulveda, Dr Imelda Ontoria-Oviedo

  42. Potency of Human Cardiosphere-Derived Cells from Patients with Ischemic Heart Disease Is Associated with Robust Vascular Supportive Ability

    Article • Stem Cells Translational Medicine, February 2017, Wiley

    Enca Martin-Rendon, Dr Pilar Sepulveda

  43. IFNγ Regulates Activated Vδ2+ T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells

    Article • PLOS One, January 2017, PLOS

    Dr Pilar Sepulveda

  44. Anthracycline mediated cardiotoxicity: Detection of miRNA based early biomarkers for the prediction of myocardial injury. Hecatos study

    Article • Annals of Oncology, October 2016, Elsevier

    Dr Pilar Sepulveda

  45. Estudio comparativo de los cambios funcionales y estructurales producidos en un modelo porcino de infarto de miocardio agudo y crónico

    Article • Archivos de Cardiología de México, January 2016, Elsevier

    Dr Pilar Sepulveda

  46. Protein complementation for metabolic regulation from cardiomyocyte to endothelium

    Article • Cardiovascular Research, November 2015, European Society of Cardiology

    Dr Antonio Diez-Juan, Dr Pilar Sepulveda

  47. Cardioplejía Del Nido: una estrategia de protección miocárdica segura, eficaz y económica

    Article • Cirugía Cardiovascular, November 2015, Elsevier

    Dr Pilar Sepulveda

  48. Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells

    Article • PLOS One, September 2015, PLOS

    Dr Antonio Diez-Juan, Dr Pilar Sepulveda, Dr Imelda Ontoria-Oviedo

  49. Polymer Therapeutics as Nano-Sized Medicines for Tissue Regeneration and Repair

    Article • January 2015, Wiley

    Dr Pilar Sepulveda

  50. Is really epicardial fat a new marker of cardiovascular risk? A case-control cardiac magnetic resonance study

    Article • Journal of Cardiovascular Magnetic Resonance, January 2015, Springer Science + Business Media

    Dr Pilar Sepulveda

  51. miR-133a Enhances the Protective Capacity of Cardiac Progenitors Cells after Myocardial Infarction

    Article • Stem Cell Reports, December 2014, Elsevier

    Dr Antonio Diez-Juan, Dr Pilar Sepulveda

  52. Targeted Disruption of theSUCNR1Metabolic Receptor Leads to Dichotomous Effects on Obesity

    Article • Diabetes, October 2014, American Diabetes Association

    Dr Pilar Sepulveda

  53. A Comparison of Electrospun Polymers Reveals Poly(3-Hydroxybutyrate) Fiber as a Superior Scaffold for Cardiac Repair

    Article • Stem Cells and Development, July 2014, Mary Ann Liebert Inc

    Dr Pilar Sepulveda

  54. Human mesenchymal stromal cells modulate T‐cell responses through TNF‐α‐mediated activation of NF‐κB

    Article • European Journal of Immunology, December 2013, Wiley

    Dr Pilar Sepulveda

  55. Podocalyxin-like protein 1 is a relevant marker for human c-kitposcardiac stem cells

    Article • Journal of Tissue Engineering and Regenerative Medicine, July 2013, Wiley

    Dr Antonio Diez-Juan, Dr Pilar Sepulveda

  56. Hypoxia-Inducible Factor 1 Alpha Contributes to Cardiac Healing in Mesenchymal Stem Cells-Mediated Cardiac Repair

    Article • Stem Cells and Development, February 2013, Mary Ann Liebert Inc

    Dr Antonio Diez-Juan, Dr Pilar Sepulveda

  57. Allogenicity of Human Cardiac Stem/Progenitor Cells Orchestrated by Programmed Death Ligand 1Novelty and Significance

    Article • Circulation Research, December 2012, Wolters Kluwer Health

    Dr Pilar Sepulveda

  58. IL1β Induces Mesenchymal Stem Cells Migration and Leucocyte Chemotaxis Through NF-κB

    Article • Stem Cell Reviews and Reports, March 2012, Springer Science + Business Media

    Dr Pilar Sepulveda

  59. Cardiac Cell Therapy: Boosting Mesenchymal Stem Cells Effects

    Article • Stem Cell Reviews and Reports, February 2012, Springer Science + Business Media

    Dr Antonio Diez-Juan, Dr Pilar Sepulveda

  60. The Biology of HIFα Proteins in Cell Differentiation and Disease

    Article • January 2011, Elsevier

    Dr Pilar Sepulveda

  61. Human progenitor cells derived from cardiac adipose tissue ameliorate myocardial infarction in rodents

    Article • Journal of Molecular and Cellular Cardiology, November 2010, Elsevier

    Dr Pilar Sepulveda

  62. Mesenchymal Stem Cells Provide Better Results Than Hematopoietic Precursors for the Treatment of Myocardial Infarction

    Article • Journal of the American College of Cardiology, May 2010, Elsevier

    Dr Pilar Sepulveda

  63. Hypoxia Promotes Efficient Differentiation of Human Embryonic Stem Cells to Functional Endothelium

    Article • Stem Cells, January 2010, Oxford University Press (OUP)

    Dr Pilar Sepulveda

  64. Cardiac Transcription Factors Driven Lineage-Specification of Adult Stem Cells

    Article • Journal of Cardiovascular Translational Research, October 2009, Springer Science + Business Media

    Dr Pilar Sepulveda

  65. Cardiac Differentiation Is Driven by NKX2.5 and GATA4 Nuclear Translocation in Tissue-Specific Mesenchymal Stem Cells

    Article • Stem Cells and Development, July 2009, Mary Ann Liebert Inc

    Dr Pilar Sepulveda

  66. Human Dental Pulp Stem Cells Improve Left Ventricular Function, Induce Angiogenesis, and Reduce Infarct Size in Rats with Acute Myocardial Infarction

    Article • Stem Cells, March 2008, Wiley

    Dr Pilar Sepulveda

  67. Modulation of Cellular Apoptosis with Apoptotic Protease-Activating Factor 1 (Apaf-1) Inhibitors

    Article • Journal of Medicinal Chemistry, January 2008, American Chemical Society (ACS)

    Dr Pilar Sepulveda

  68. Neoangiogenesis With Endothelial Precursors for the Treatment of Ischemia

    Article • Transplantation Proceedings, September 2007, Elsevier

    Dr Pilar Sepulveda

  69. BCL-2 expression is mainly regulated by JAK/STAT3 pathway in human CD34+ hematopoietic cells

    Article • Cell Death and Differentiation, July 2006, Springer Science + Business Media

    Dr Pilar Sepulveda

  70. Cloning of a cDNA fragment encoding part of the protein moiety of the 58-kDa fibrinogen-binding mannoprotein of Candida albicans

    Article • FEMS Microbiology Letters, January 2006, Oxford University Press (OUP)

    Dr Pilar Sepulveda

  71. Identification of HLA-A*0201-restricted cytotoxic T-cell epitopes of Trypanosoma cruzi TcP2β protein in HLA-transgenic mice and patients

    Article • Microbes and Infection, April 2003, Elsevier

    Dr Pilar Sepulveda

  72. A monoclonal antibody against the immunodominant epitope of the ribosomal P2β protein ofTrypanosoma cruzi interacts with the human β 1-adrenergic receptor

    Article • European Journal of Immunology, July 2001, Wiley

    Dr Pilar Sepulveda

  73. DNA-Based Immunization with Trypanosoma cruzi Complement Regulatory Protein Elicits Complement Lytic Antibodies and Confers Protection against Trypanosoma cruzi Infection

    Article • Infection and Immunity, September 2000, ASM Journals

    Dr Pilar Sepulveda

  74. Modulation of Cardiocyte Functional Activity by Antibodies against Trypanosoma cruzi Ribosomal P2 Protein C Terminus

    Article • Infection and Immunity, September 2000, ASM Journals

    Dr Pilar Sepulveda

  75. Trypanosoma cruzi, agent de la maladie de Chagas ou trypanosomose américaine

    Article • Annales de l Institut Pasteur / Actualités, January 1999, Elsevier

    Dr Pilar Sepulveda

  76. Cloning of a cDNA fragment encoding part of the protein moiety of the 58-kDa fibrinogen-binding mannoprotein of Candida albicans

    Article • FEMS Microbiology Letters, December 1997, Oxford University Press (OUP)

    Dr Pilar Sepulveda

  77. Expression of the fibrinogen binding mannoprotein and the laminin receptor of Candida albicans in vitro and in infected tissues

    Article • FEMS Microbiology Letters, August 1996, Oxford University Press (OUP)

    Dr Pilar Sepulveda

  78. Cloning and characterization of a cDNA coding forCandida albicanspolyubiquitin

    Article • Medical Mycology, January 1996, Oxford University Press (OUP)

    Dr Pilar Sepulveda

  79. Preliminary characterization of the material released to the culture medium byCandida albicans yeast and mycelial cells

    Article • Antonie van Leeuwenhoek, October 1995, Springer Science + Business Media

    Dr Pilar Sepulveda

  80. A comparative study on cell wall antigens and cell surface hydrophobicity in clinical isolates ofCandida albicans

    Article • Mycopathologia, July 1994, Springer Science + Business Media

    Dr Pilar Sepulveda

  81. Diagnosis of systemic candidiasis by enzyme immunoassay detection of specific antibodies to mycelial phase cell wall and cytoplasmic candidal antigens

    Article • European Journal of Clinical Microbiology & Infectious Diseases, November 1993, Springer Science + Business Media

    Dr Pilar Sepulveda