All Stories

  1. Epidemiological cut-off values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing ofM. tuberculosis

    Article • European Respiratory Journal, March 2022, European Respiratory Society (ERS)

    Philip Fowler

  2. Robust Prediction of Resistance to Trimethoprim in Staphylococcus aureus

    Article • Cell Chemical Biology, March 2018, Elsevier

    Philip Fowler

  3. Automated detection of Mycobacterial growth on 96-well plates for rapid and accurate Tuberculosis drug susceptibility testing

    Article • December 2017, Cold Spring Harbor Laboratory Press

    Philip Fowler

  4. Protein crowding and lipid complexity influence the nanoscale dynamic organization of ion channels in cell membranes

    Article • Scientific Reports, November 2017, Springer Science + Business Media

    Philip Fowler

  5. Effect of the Southeast Asian Ovalocytosis Deletion on the Conformational Dynamics of Signal-Anchor Transmembrane Segment 1 of Red Cell Anion Exchanger 1 (AE1, Band 3, or SLC4A1)

    Article • Biochemistry, January 2017, American Chemical Society (ACS)

    Philip Fowler

  6. Accurate Prediction of Ligand Affinities for a Proton-Dependent Oligopeptide Transporter

    Article • Cell Chemical Biology, February 2016, Elsevier

    Philip Fowler

  7. Membrane stiffness is modified by integral membrane proteins

    Article • Soft Matter, January 2016, Royal Society of Chemistry

    Philip Fowler

  8. Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport

    Article • Structure, October 2015, Elsevier

    Philip Fowler

  9. Alchembed: A Computational Method for Incorporating Multiple Proteins into Complex Lipid Geometries

    Article • Journal of Chemical Theory and Computation, May 2015, American Chemical Society (ACS)

    Philip Fowler

  10. Nothing to Sneeze At: A Dynamic and Integrative Computational Model of an Influenza A Virion

    Article • Structure, March 2015, Elsevier

    Philip Fowler

  11. Gating Topology of the Proton-Coupled Oligopeptide Symporters

    Article • Structure, February 2015, Elsevier

    Philip Fowler

  12. Insights into the structural nature of the transition state in the Kir channel gating pathway

    Article • Channels, October 2014, Taylor & Francis

    Philip Fowler

  13. State-Dependent Network Connectivity Determines Gating in a K+ Channel

    Article • Structure, July 2014, Elsevier

    Philip Fowler

  14. Flexible Gates Generate Occluded Intermediates in the Transport Cycle of LacY

    Article • Journal of Molecular Biology, February 2014, Elsevier

    Philip Fowler

  15. NRas slows the rate at which a model lipid bilayer phase separates

    Article • Faraday Discussions, January 2014, Royal Society of Chemistry

    Philip Fowler

  16. Energetics of Multi-Ion Conduction Pathways in Potassium Ion Channels

    Article • Journal of Chemical Theory and Computation, October 2013, American Chemical Society (ACS)

    Philip Fowler

  17. Detailed Examination of a Single Conduction Event in a Potassium Channel

    Article • The Journal of Physical Chemistry Letters, September 2013, American Chemical Society (ACS)

    Philip Fowler

  18. The pore of voltage-gated potassium ion channels is strained when closed

    Article • Nature Communications, May 2013, Springer Science + Business Media

    Philip Fowler

  19. Alternating access mechanism in the POT family of oligopeptide transporters

    Article • The EMBO Journal, June 2012, Wiley

    Philip Fowler

  20. Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2

    Article • The EMBO Journal, December 2010, Wiley

    Philip Fowler

  21. Functional Complementation and Genetic Deletion Studies of KirBac Channels

    Article • Journal of Biological Chemistry, September 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Philip Fowler

  22. Insights into How Nucleotide-Binding Domains Power ABC Transport

    Article • Structure, September 2009, Elsevier

    Philip Fowler

  23. A Novel Rate Theory Approach To Transport In Ion Channels

    Article • January 2009, American Institute of Physics

    Philip Fowler

  24. The Selectivity of K+ Ion Channels: Testing the Hypotheses

    Article • Biophysical Journal, December 2008, Elsevier

    Philip Fowler

  25. Helix−Helix Interactions in Membrane Proteins: Coarse-Grained Simulations of Glycophorin A Helix Dimerization†

    Article • Biochemistry, October 2008, American Chemical Society (ACS)

    Philip Fowler

  26. Chapter 12 Molecular Modeling and Simulation Studies of Ion Channel Structures, Dynamics and Mechanisms

    Article • January 2008, Elsevier

    Philip Fowler

  27. H Bonding at the Helix-Bundle Crossing Controls Gating in Kir Potassium Channels

    Article • Neuron, August 2007, Elsevier

    Philip Fowler

  28. Rapid, Accurate, and Precise Calculation of Relative Binding Affinities for the SH2 Domain Using a Computational Grid

    Article • Journal of Chemical Theory and Computation, May 2007, American Chemical Society (ACS)

    Philip Fowler

  29. Monotopic Enzymes and Lipid Bilayers:  A Comparative Study†

    Article • Biochemistry, March 2007, American Chemical Society (ACS)

    Philip Fowler

  30. A Computational Protocol for the Integration of the Monotopic Protein Prostaglandin H2 Synthase into a Phospholipid Bilayer

    Article • Biophysical Journal, July 2006, Elsevier

    Philip Fowler

  31. Grid-based steered thermodynamic integration accelerates the calculation of binding free energies

    Article • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, August 2005, Royal Society Publishing

    Philip Fowler

  32. Large scale molecular dynamics simulation of native and mutant dihydropteroate synthase–sulphanilamide complexes suggests the molecular basis for dihydropteroate synthase drug resistance

    Article • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, August 2005, Royal Society Publishing

    Philip Fowler

  33. Modelling biological complexity: a physical scientist's perspective

    Article • Journal of The Royal Society Interface, June 2005, Royal Society Publishing

    Philip Fowler