All Stories

  1. Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration
  2. System level network data and models attack cancer drug resistance
  3. Cancer drug resistance as learning of signaling networks
  4. Cellular forgetting, desensitisation, stress and ageing in signalling networks. When do cells refuse to learn more?
  5. Lysosome-related organelles promote stress and immune responses in C. elegans
  6. Protein Kinase D3 (PKD3) Requires Hsp90 for Stability and Promotion of Prostate Cancer Cell Migration
  7. Probabilistic edge weights fine-tune Boolean network dynamics
  8. Probabilistic Edge Weights fine-tune Boolean network dynamics
  9. Modular Reorganization of Signaling Networks during the Development of Colon Adenoma and Carcinoma
  10. Synaptic polarity and sign-balance prediction using gene expression data in the Caenorhabditis elegans chemical synapse neuronal connectome network
  11. Synaptic polarity and sign-balance prediction using gene expression data in theCaenorhabditis eleganschemical synapse neuronal connectome network
  12. Learning of Signaling Networks: Molecular Mechanisms
  13. The EntOptLayout Cytoscape plug-in for the efficient visualization of major protein complexes in protein–protein interaction and signalling networks
  14. Translocatome: a novel resource for the analysis of protein translocation between cellular organelles
  15. Author Correction: MicroRNA interactome analysis predicts post-transcriptional regulation of ADRB2 and PPP3R1 in the hypercholesterolemic myocardium
  16. MicroRNA interactome analysis predicts post-transcriptional regulation of ADRB2 and PPP3R1 in the hypercholesterolemic myocardium
  17. How can social networks of talented young people increase their creativity and deep thinking?
  18. Are rapidly growing cancers more lethal?
  19. Identification of critical paralog groups with indispensable roles in the regulation of signaling flow
  20. Intracellular and intercellular signaling networks in cancer initiation, development and precision anti-cancer therapy
  21. Oncogenic KRAS signaling and YAP1/β-catenin: Similar cell cycle control in tumor initiation
  22. Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory
  23. A unified data representation theory for network visualization, ordering and coarse-graining
  24. Confrontation of fibroblasts with cancer cells in vitro: gene network analysis of transcriptome changes and differential capacity to inhibit tumor growth
  25. Targets of drugs are generally and targets of drugs having side effects are specifically good spreaders of human interactome perturbations
  26. Cancer stem cells display extremely large evolvability: alternating plastic and rigid networks as a potential Mechanism
  27. Autophagy Regulatory Network — A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy
  28. ComPPI: a cellular compartment-specific database for protein–protein interaction network analysis
  29. Starvation-response may not involve Atg1-dependent autophagy induction in non-unikont parasites
  30. Attractor Structures of Signaling Networks: Consequences of Different Conformational Barcode Dynamics and Their Relations to Network‐Based Drug Design
  31. Perturbation Centrality and Turbine: A Novel Centrality Measure Obtained Using a Versatile Network Dynamics Tool
  32. Hsp90 chaperones PPARγ and regulates differentiation and survival of 3T3-L1 adipocytes
  33. Allosteric Conformational Barcodes Direct Signaling in the Cell
  34. Adaptation and learning of molecular networks as a description of cancer development at the systems-level: Potential use in anti-cancer therapies
  35. Cancer-related networks: A help to understand, predict and change malignant transformation
  36. Complex regulation of autophagy in cancer – Integrated approaches to discover the networks that hold a double-edged sword
  37. Nodes Having a Major Influence to Break Cooperation Define a Novel Centrality Measure: Game Centrality
  38. Structure and dynamics of molecular networks: A novel paradigm of drug discovery
  39. Teaching the bioinformatics of signaling networks: an integrated approach to facilitate multi-disciplinary learning
  40. Potential Application of Network Descriptions for Understanding Conformational Changes and Protonation States of ABC Transporters
  41. Editorial (Hot Topic: From Allosteric Drugs to Allo-Network Drugs: State of the Art and Trends of Design, Synthesis and Computational Methods)
  42. Allo-Network Drugs: Extension of the Allosteric Drug Concept to Protein- Protein Interaction and Signaling Networks
  43. Novel signatures of cancer‐associated fibroblasts
  44. SignaLink 2 – a signaling pathway resource with multi-layered regulatory networks
  45. NRF2-ome: An Integrated Web Resource to Discover Protein Interaction and Regulatory Networks of NRF2
  46. Large-Scale Functional Organization of Long-Range Chromatin Interaction Networks
  47. Rigidity and flexibility of biological networks
  48. RNA Interference Links Oxidative Stress to the Inhibition of Heat Stress Adaptation
  49. How creative elements help the recovery of networks after crisis: lessons from biology
  50. ModuLand plug-in for Cytoscape: determination of hierarchical layers of overlapping network modules and community centrality
  51. The NRF2‐related interactome and regulome contain multifunctional proteins and fine‐tuned autoregulatory loops
  52. A Role for SKN-1/Nrf in Pathogen Resistance and Immunosenescence in Caenorhabditis elegans
  53. Disordered Proteins and Network Disorder in Network Descriptions of Protein Structure, Dynamics and Function: Hypotheses and a Comprehensive Review
  54. Allo-network drugs: harnessing allostery in cellular networks
  55. Misfolded proteins inhibit proliferation and promote stress‐induced death in SV40‐transformed mammalian cells
  56. Heat Shock Partially Dissociates the Overlapping Modules of the Yeast Protein-Protein Interaction Network: A Systems Level Model of Adaptation
  57. Network-Based Tools for the Identification of Novel Drug TargetsAdapted from the opening presentation at the International Conference on Systems Biology of Human Disease (SBHD) in Boston, Massachusetts, 16 to 18 June 2010.
  58. Signalogs: Orthology-Based Identification of Novel Signaling Pathway Components in Three Metazoans
  59. Induced fit, conformational selection and independent dynamic segments: an extended view of binding events
  60. Community Landscapes: An Integrative Approach to Determine Overlapping Network Module Hierarchy, Identify Key Nodes and Predict Network Dynamics
  61. Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery
  62. The Heat Shock Connection of Metabolic Stress and Dietary Restriction
  63. Network modules help the identification of key transport routes, signaling pathways in cellular and other networks
  64. Spondyloarthropathies and bone resorption: A possible role of heat shock protein (Hsp70)
  65. Ageing as a price of cooperation and complexity
  66. Perturbation Waves in Proteins and Protein Networks: Applications of Percolation and Game Theories in Signaling and Drug Design
  67. Network strategies to understand the aging process and help age-related drug design
  68. Creative elements: network-based predictions of active centres in proteins and cellular and social networks
  69. Nuclear translocation of the phosphoprotein Hop (Hsp70/Hsp90 organizing protein) occurs under heat shock, and its proposed nuclear localization signal is involved in Hsp90 binding
  70. Erratum for Ann. N.Y. Acad. Sci. 1113: 304–310. Stress Responses in Biology and Medicine: Stress of Life in Molecules, Cells, Organisms, and Psychosocial Communities Péter Csermely, Tamás Korcsmáros, and Katalin Sulyok, Eds.
  71. Zinc supplementation boosts the stress response in the elderly: Hsp70 status is linked to zinc availability in peripheral lymphocytes
  72. Learning and Innovative Elements of Strategy Adoption Rules Expand Cooperative Network Topologies
  73. Salivary Genomics, Transcriptomics and Proteomics: The Emerging Concept of the Oral Ecosystem and their Use in the Early Diagnosis of Cancer and other Diseases
  74. Drug-therapy networks and the prediction of novel drug targets
  75. Resveratrol Induces the Heat-Shock Response and Protects Human Cells from Severe Heat Stress
  76. Chaperones as integrators of cellular networks: Changes of cellular integrity in stress and diseases
  77. Introduction
  78. Attitude toward Death: Does It Influence Dental Fear?
  79. A kapcsolati hálózat egyes paramétereinek hatása a szorongásra
  80. How to design multi-target drugs
  81. Network analysis of protein dynamics
  82. Stress‐induced rearrangements of cellular networks: Consequences for protection and drug design
  83. Molecular chaperones: The modular evolution of cellular networks
  84. Protein stress and stress proteins: implications in aging and disease
  85. Potential immunological functions of salivary Hsp70 in mucosal and periodontal defense mechanisms
  86. Nuclear Translocation of the Tumor Marker Pyruvate Kinase M2 Induces Programmed Cell Death
  87. Crowding Stress
  88. Aging cellular networks: Chaperones as major participants
  89. Changes of endoplasmic reticulum chaperone complexes, redox state, and impaired protein disulfide reductase activity in misfolding αi‐antitrypsin transgenic mice
  90. Chance and necessity in the evolution of minimal metabolic networks
  91. Chaperone-related immune dysfunction: an emergent property of distorted chaperone networks
  92. Uncoupled Redox Systems in the Lumen of the Endoplasmic Reticulum
  93. COST Action B17: A successful network of 27 countries on insulin resistance, obesity and diabetes mellitus in the elderly
  94. Cellular networks and the aging process
  95. FAD oxidizes the ERO1-PDI electron transfer chain: The role of membrane integrity
  96. Heat shock proteins as emerging therapeutic targets
  97. Diabetic changes in the redox status of the microsomal protein folding machinery
  98. Multiple weak hits confuse complex systems: A transcriptional regulatory network as an example
  99. Water and molecular chaperones act as weak links of protein folding networks: Energy landscape and punctuated equilibrium changes point towards a game theory of proteins
  100. Molecular chaperones as regulatory elements of cellular networks
  101. The efficiency of multi-target drugs: the network approach might help drug design
  102. Pharmacological attenuation of apoptosis in reoxygenated endothelial cells
  103. DUK114, the Drosophila orthologue of bovine brain calpain activator protein, is a molecular chaperone
  104. The role of structural disorder in the function of RNA and protein chaperones
  105. Strong links are important, but weak links stabilize them
  106. Photo-acoustic stimulation increases the amount of 70 kDa heat shock protein (Hsp70) in human whole saliva. A pilot study
  107. Hsp90 isoforms: functions, expression and clinical importance
  108. Enhancement of complement-induced cell lysis: a novel mechanism for the anticancer effects of Hsp90 inhibitors
  109. Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy
  110. Inhibition of Hsp90: a new strategy for inhibiting protein kinases
  111. FAD Transport and FAD-dependent Protein Thiol Oxidation in Rat Liver Microsomes
  112. Molecular chaperones, evolution and medicine
  113. The effect of treatment with BRX-220, a co-inducer of heat shock proteins, on sensory fibers of the rat following peripheral nerve injury
  114. Interaction of Neuropeptide Y and Hsp90 through a Novel Peptide Binding Region
  115. Aging and molecular chaperones
  116. Hsp90 Inhibition Accelerates Cell Lysis
  117. Recruiting the younger generation to science
  118. Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1
  119. Comparative analysis of the ATP‐binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C‐terminal ATP‐binding site
  120. Heat shock protein coinducers with no effect on protein denaturation specifically modulate the membrane lipid phase
  121. Chaperones and aging: role in neurodegeneration and in other civilizational diseases
  122. Inhibition of arachidonic acid release from human peripheral mononuclear cells by heat shock treatment and geldanamycin
  123. Upregulation of Heat Shock Proteins Rescues Motoneurones from Axotomy-Induced Cell Death in Neonatal Rats
  124. Pharmacologically activated migration of aortic endothelial cells is mediated through p38 SAPK
  125. A Nucleotide-dependent Molecular Switch Controls ATP Binding at the C-terminal Domain of Hsp90
  126. Chaperone overload is a possible contributor to ‘civilization diseases’
  127. Physical and Functional Interactions between Protein Tyrosine Phosphatase α, PI 3-Kinase, and PKCδ
  128. The somatostatin analogue TT-232 induces apoptosis in A431 cells
  129. The Antitumor Somatostatin Analogue TT-232 Induces Cell Cycle Arrest through PKCδ and c-Src
  130. Protein-disulfide Isomerase- and Protein Thiol-dependent Dehydroascorbate Reduction and Ascorbate Accumulation in the Lumen of the Endoplasmic Reticulum
  131. Streptozotocin-induced diabetes alters the oligomerization pattern of acetylcholinesterase in rat skeletal muscle
  132. Reactive Cysteines of the 90-kDa Heat Shock Protein, Hsp90
  133. Interaction of the human DnaJ homologue, HSJ1b with the 90 kDa heat shock protein, Hsp90
  134. Research training between 14 and 18 in Hungary
  135. Interactions of Hsp90 with histones and related peptides
  136. Mammalian Hsp70 and Hsp110 Proteins Bind to RNA Motifs Involved in mRNA Stability
  137. Acetylcholine-induced Phosphorylation in Isolated Outer Hair Cells
  138. Attenuation of diabetic retinopathy by the molecular chaperone-inducer amino acid analogue canavanine in streptozotocin-diabetic rats
  139. The 90-kDa Molecular Chaperone Family
  140. The Hsp90-specific inhibitor, geldanamycin, blocks CD28-mediated activation of human T lymphocytes
  141. Introduction
  142. Changes in the expression of Na+/K+-ATPase isoenzymes in the left ventricle of diabetic rat hearts: effect of insulin treatment
  143. Defensins purified from human granulocytes bind C1q and activate the classical complement pathway like the transmenbrane glycoprotein gq41 of HIV-1
  144. Binding affinity of proteins to hsp90 correlates with both hydrophobicity and positive charges. A surface plasmon resonance study
  145. Proteins, RNAs and chaperones in enzyme evolution: a folding perspective
  146. Insulin-induced phosphorylation of a 38 kDa DNA-binding protein in ventricular cardiomyocytes: possible implication of nuclear protein phosphatase activity
  147. Characterization of the 90 kDa heat shock protein (HSP90)-associated ATP/GTPase
  148. Signalling and transport through the nuclear membrane
  149. Chronic overcrowding decreases cytoplasmic free calcium levels in T lymphocytes of aged CBA/CA mice
  150. Alterations in the properties and isoform ratios of brain Na+/K+-ATPase in streptozotocin diabetic rats
  151. ATP Induces Dissociation of the 90-kDa Heat Shock Protein (hsp90) from F-Actin: Interference with the Binding of Heavy Meromyosin
  152. Autophosphorylation of grp94 (Endoplasmin)
  153. The 90-kDa Heat Shock Protein (hsp90) Induces the Condensation of the Chromatin Structure
  154. Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone
  155. Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone.
  156. The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes
  157. Lipocortin I is not accessible for protein kinase C bound to the cytoplasmic surface of the plasma membrane in streptolysin-O-permeabilized pig granulocytes
  158. Quantitative dissociation between EGF effects on c‐myc and c‐fos gene expression, DNA synthesis, and epidermal growth factor receptor tyrosine kinase activity
  159. Protein Kinase C Is Involved in the Early Signals of Interferon-α But Not of Interferon-γ in U937 Cells
  160. Zinc forms complexes with higher kinetical stability than calcium, 5-F-BAPTA as a good example
  161. Tumor promoter 12‐0‐tetradecanoyl‐phorbol‐13‐acetate (TPA) can reduce the Ca‐transporting ability of Ca‐lonophores in T lymphocytes: The involvement of intracellular heavy metal lons
  162. Zinc increases the affinity of phorbol ester receptor in T lymphocytes
  163. The tumor promoter tetradecanoyl-phorbol-acetate (TPA) elicits the redistribution of zinc in subcellular fractions of rabbit thymocytes measured by X-ray fluorescence
  164. Effect of chemical modification on the crystallization of Ca2+-ATPase in sarcoplasmic reticulum
  165. The tumor promoter tetradecanoylphorbol-13-acetate elicits the redistribution of heavy metals in subcellular fractions of rabbit thymocytes as measured by plasma emission spectroscopy
  166. Competition between decavanadate and fluorescein isothiocyanate on the Ca2+-ATPase of sarcoplasmic reticulum
  167. The binding of vanadium (V) oligoanions to sarcoplasmic reticulum
  168. Chaperones as Parts of Cellular Networks
  169. Hsp90 and Developmental Networks