All Stories

  1. Correction to “Novel Triazole Ribonucleoside Down-Regulates Heat Shock Protein 27 and Induces Potent Anticancer Activity on Drug-Resistant Pancreatic Cancer”
  2. Correction to “Discovery of Novel Arylethynyltriazole Ribonucleosides with Selective and Effective Antiviral and Antiproliferative Activity”
  3. Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy
  4. Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis
  5. Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group
  6. Bola-Amphiphilic Dendrimer Enhances Imatinib to Target Metastatic Ovarian Cancer via β-Catenin-HRP2 Signaling Axis
  7. P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis
  8. Impact of inner hydrophobicity of dendrimer nanomicelles on biodistribution: a PET imaging study
  9. STING‐Activating Polymers Boost Lymphatic Delivery of mRNA Vaccine to Potentiate Cancer Immunotherapy
  10. Development of an efficient NUPR1 inhibitor with anticancer activity
  11. The synergistic neurovascular electro-healing of infected diabetic wounds by a multifaceted absorbable ion-conductive adhesive patch
  12. Targeting the phosphatidylglycerol lipid: An amphiphilic dendrimer as a promising antibacterial candidate
  13. Insight into the Internal Structure of High-Performance Multicore Magnetic Nanoparticles Used in Cancer Thermotherapy
  14. Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors
  15. Capture and flocculation of toxic cyanobacteria by amphiphilic peptide dendrimers for mitigating harmful blooms
  16. Amphiphilic Dendrimer as Potent Antibacterial against Drug-Resistant Bacteria in Mouse Models of Human Infectious Diseases
  17. Modular Self‐Assembling Dendrimer Nanosystems for Magnetic Resonance and Multimodality Imaging of Tumors
  18. Progress and harmonization of gene editing to treat human diseases: Proceeding of COST Action CA21113 GenE-HumDi
  19. A PD‐L1 Antibody‐Conjugated PAMAM Dendrimer Nanosystem for Simultaneously Inhibiting Glycolysis and Promoting Immune Response in Fighting Breast Cancer
  20. Cargo-selective and adaptive delivery of nucleic acid therapeutics by bola-amphiphilic dendrimers
  21. Dendrimer nanosystems for adaptive tumor-assisted drug delivery via extracellular vesicle hijacking
  22. Amphiphilic Dendrimer Doping Enhanced pH‐Sensitivity of Liposomal Vesicle for Effective Co‐delivery toward Synergistic Ferroptosis–Apoptosis Therapy of Hepatocellular Carcinoma
  23. Solid-phase dendrimer synthesis: a promising approach to transform dendrimer construction
  24. Amphiphilic dendrimers against antibiotic resistance: light at the end of the tunnel?
  25. Bola‐Amphiphilic Glycodendrimers: New Carbohydrate‐Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins
  26. NUPR1 protects against hyperPARylation-dependent cell death
  27. Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment
  28. Amphiphilic Dendrimer Vectors for RNA Delivery: State-of-the-Art and Future Perspective
  29. A self-assembling prodrug nanosystem to enhance metabolic stability and anticancer activity of gemcitabine
  30. Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia
  31. A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery
  32. Dynamic self-assembling supramolecular dendrimer nanosystems as potent antibacterial candidates against drug-resistant bacteria and biofilms
  33. Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function
  34. NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner
  35. Dendrimeric nanosystem consistently circumvents heterogeneous drug response and resistance in pancreatic cancer
  36. Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells
  37. Self-Assembling Supramolecular Dendrimers for Biomedical Applications: Lessons Learned from Poly(amidoamine) Dendrimers
  38. ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents
  39. Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study
  40. Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma
  41. Therapeutic siRNA: state of the art
  42. Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis
  43. Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile
  44. A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging
  45. Novel aryltriazole acyclic C-azanucleosides as anticancer candidates
  46. Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy
  47. Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma
  48. Targeting intrinsically disordered proteins involved in cancer
  49. Poly(amidoamine) dendrimers: covalent and supramolecular synthesis
  50. Efficient and Innocuous Delivery of Small Interfering RNA to Microglia Using an Amphiphilic Dendrimer Nanovector
  51. Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm
  52. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis
  53. Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation
  54. Carbon/Nitrogen Metabolic Balance: Lessons from Cyanobacteria
  55. Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors
  56. A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy
  57. Dendrimer-based magnetic resonance imaging agents for brain cancer
  58. E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments
  59. Blocking Stemness and Metastatic Properties of Ovarian Cancer Cells by Targeting p70S6K with Dendrimer Nanovector-Based siRNA Delivery
  60. Potent drugless dendrimers
  61. Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing
  62. Acyclonucleosides bearing coplanar arylethynyltriazole nucleobases: synthesis, structural analysis, and biological evaluation
  63. Mix and Match: Coassembly of Amphiphilic Dendrimers and Phospholipids Creates Robust, Modular, and Controllable Interfaces
  64. Mastering Dendrimer Self‐Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing
  65. Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis
  66. A Novel Triazole Nucleoside Suppresses Prostate Cancer Cell Growth by Inhibiting Heat Shock Factor 1 and Androgen Receptor
  67. Synthesis of poly(aminoester) dendrimers via ‘click’ chemistry in combination with the divergent and convergent strategies
  68. Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance
  69. Promoting siRNA delivery via enhanced cellular uptake using an arginine-decorated amphiphilic dendrimer
  70. Pd-catalyzed oxidative C–H alkenylation for synthesizing arylvinyltriazole nucleosides
  71. Microwave promoted C–O coupling for synthesizing O-aryloxytriazole nucleoside analogues
  72. Shape separation of gold nanoparticles using a pH-responsive amphiphilic dendrimer according to their shape anisotropy distinction
  73. Structural characterization of new defective molecules in poly(amidoamide) dendrimers by combining mass spectrometry and nuclear magnetic resonance
  74. Targeted delivery of Dicer-substrate siRNAs using a dual targeting peptide decorated dendrimer delivery system
  75. Adaptive Amphiphilic Dendrimer-Based Nanoassemblies as Robust and Versatile siRNA Delivery Systems
  76. Pd(dba)2 vs Pd2(dba)3: An in-Depth Comparison of Catalytic Reactivity and Mechanism via Mixed-Ligand Promoted C–N and C–S Coupling Reactions
  77. Structurally flexible triethanolamine-core poly(amidoamine) dendrimers as effective nanovectors to deliver RNAi-based therapeutics
  78. Combination of Dendrimer-Nanovector-Mediated Small Interfering RNA Delivery to Target Akt with the Clinical Anticancer Drug Paclitaxel for Effective and Potent Anticancer Activity in Treating Ovarian Cancer
  79. Mixed‐Ligand Catalysts: A Powerful Tool in Transition‐Metal‐Catalyzed Cross‐Coupling Reactions
  80. Arginine-Terminated Generation 4 PAMAM Dendrimer as an Effective Nanovector for Functional siRNA Delivery in Vitro and in Vivo
  81. Copper(ii) binding to flexible triethanolamine-core PAMAM dendrimers: a combined experimental/in silico approach
  82. Mimicking the 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations
  83. A “click” chemistry constructed affinity system for 2-oxoglutaric acid receptors and binding proteins
  84. Conformational sensitivity of conjugated poly(ethylene oxide)-poly(amidoamine) molecules to cations adducted upon electrospray ionization – A mass spectrometry, ion mobility and molecular modeling study
  85. Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo
  86. CS Coupling Using a Mixed‐Ligand Pd Catalyst: A Highly Effective Strategy for Synthesizing Arylthio‐Substituted Heterocycles
  87. Conformational changes of small PAMAM dendrimers as a function of their charge state: A combined electrospray mass spectrometry, traveling-wave ion mobility and molecular modeling study
  88. Nucleoside analog inhibits microRNA-214 through targeting heat-shock factor 1 in human epithelial ovarian cancer
  89. Structural Requirements of 2-Oxoglutaric Acid Analogues To Mimic Its Signaling Function
  90. Photoactivatable Lipid Probes for Studying Biomembranes by Photoaffinity Labeling
  91. Impact of siRNA Overhangs for Dendrimer-Mediated siRNA Delivery and Gene Silencing
  92. A bola-phospholipid bearing tetrafluorophenylazido chromophore as a promising lipid probe for biomembrane photolabeling studies
  93. 19F NMR: a valuable tool for studying biological events
  94. The Seemingly Trivial Yet Challenging Synthesis of Poly(aminoester) Dendrimers
  95. An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing In Vitro and In Vivo
  96. A Novel Bitriazolyl Acyclonucleoside Endowed with Dual Antiproliferative and Immunomodulatory Activity
  97. Targeting heat shock factor 1 with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer
  98. Genome-Wide Profiling Identified a Set of miRNAs that Are Differentially Expressed in Glioblastoma Stem Cells and Normal Neural Stem Cells
  99. Efficient Delivery of Sticky siRNA and Potent Gene Silencing in a Prostate Cancer Model Using a Generation 5 Triethanolamine-Core PAMAM Dendrimer
  100. High resolution magic angle spinning NMR to investigate ligand–receptor binding events for mass-limited samples in liquids
  101. An Efficient Mixed‐Ligand Pd Catalytic System to Promote CN Coupling for the Synthesis of N‐Arylaminotriazole Nucleosides
  102. Rationalizing the F⋯S interaction discovered within a tetrafluorophenylazido-containing bola-phospholipid
  103. Dendrimers as non-viral vectors for siRNA delivery
  104. Targeting heat shock response pathways to treat pancreatic cancer
  105. Structurally Flexible Triethanolamine Core PAMAM Dendrimers Are Effective Nanovectors for DNA Transfection in Vitro and in Vivo to the Mouse Thymus
  106. Systemic Administration of Combinatorial dsiRNAs via Nanoparticles Efficiently Suppresses HIV-1 Infection in Humanized Mice
  107. Electrospray tandem mass spectrometry of poly(amino)ester dendrimers: Dissociation rules and structural characterization of defective molecules
  108. Photoactivatable Phospholipids Bearing Tetrafluorophenylazido Chromophores Exhibit Unprecedented Protonation-State-Dependent 19F NMR Signals
  109. 2-Difluoromethylene-4-methylenepentanoic Acid, A Paradoxical Probe Able To Mimic the Signaling Role of 2-Oxoglutaric Acid in Cyanobacteria
  110. Bitriazolyl acyclonucleosides synthesized via Huisgen reaction using internal alkynes show antiviral activity against tobacco mosaic virus
  111. Ligand-Mediated Highly Effective and Selective C−N Coupling for Synthesizing Bioactive N-Aryltriazole Acyclonucleosides
  112. Synthesis of Poly(amino)ester Dendrimers via Active Cyanomethyl Ester Intermediates
  113. A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells
  114. Triazole Nucleoside Derivatives Bearing Aryl Functionalities on the Nucleobases Show Antiviral and Anticancer Activity
  115. Structural characterization of poly(amino)ester dendrimers and related impurities by electrospray tandem mass spectrometry
  116. S-Aryltriazole acyclonucleosides: Synthesis and biological evaluation against hepatitis C virus
  117. N-Aryltriazole ribonucleosides with potent antiproliferative activity against drug-resistant pancreatic cancer
  118. Novel Triazole Ribonucleoside Down-Regulates Heat Shock Protein 27 and Induces Potent Anticancer Activity on Drug-Resistant Pancreatic Cancer
  119. Cu-Mediated SelectiveN-Arylation of Aminotriazole Acyclonucleosides
  120. PAMAM Dendrimers Mediate siRNA Delivery to Target Hsp27 and Produce Potent Antiproliferative Effects on Prostate Cancer Cells
  121. Discovery of Novel Arylethynyltriazole Ribonucleosides with Selective and Effective Antiviral and Antiproliferative Activity
  122. Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication
  123. Bitriazolyl acyclonucleosides with antiviral activity against tobacco mosaic virus
  124. Propagation of structural deviations of poly(amidoamine) fan-shape dendrimers (generations 0–3) characterized by MALDI and electrospray mass spectrometry
  125. Direct synthesis of 5-aryltriazole acyclonucleosides via Suzuki coupling in aqueous solution
  126. Importance of size-to-charge ratio in construction of stable and uniform nanoscale RNA/dendrimer complexes
  127. Synthesis of bitriazolyl nucleosides and unexpectedly different reactivity of azidotriazole nucleoside isomers in the Huisgen reaction
  128. Palmitoylation is required for efficient Fas cell death signaling
  129. Studying the Signaling Role of 2-Oxoglutaric Acid Using Analogs that Mimic the Ketone and Ketal Forms of 2-Oxoglutaric Acid
  130. Discovery of Bitriazolyl Compounds as Novel Antiviral Candidates for Combating the Tobacco Mosaic Virus.
  131. Discovery of bitriazolyl compounds as novel antiviral candidates for combating the tobacco mosaic virus
  132. Cooperative binding and self-assembling behavior of cationic low molecular-weight dendrons with RNA molecules
  133. PAMAM dendrimers for efficient siRNA delivery and potent gene silencing
  134. Heterocyst differentiation and pattern formation in cyanobacteria: a chorus of signals
  135. para‐Sulfonated Calixarenes Used as Synthetic Receptors for Complexing Photolabile Cholinergic Ligand
  136. Synthesis of a photoactivatable phospholipidic probe containing tetrafluorophenylazide
  137. Nonmetabolizable analogue of 2-oxoglutarate elicits heterocyst differentiation under repressive conditions in Anabaena sp. PCC 7120
  138. Synthesis and characterization of photolabeling probes of miltefosine
  139. PHOTOLABELING PROBES OF RIBAVIRIN AND EICAR
  140. Polycationic dendrimers interact with RNA molecules: polyamine dendrimers inhibit the catalytic activity of Candida ribozymes
  141. Synthesis of Bitriazolyl Compounds via Huisgen Reaction
  142. Design, Synthesis, and Characterization of Photolabeling Probes for the Study of the Mechanisms of the Antiviral Effects of Ribavirin
  143. Synthesis and Characterization of Potential Photolabeling Probes for Studying the Antiviral Mechanisms of EICAR
  144. Mutually Induced Formation of Host–Guest Complexes between p‐Sulfonated Calix[8]arene and Photolabile Cholinergic Ligands
  145. p-Hydroxyphenacyl bromide as photoremoveable thiol label: a potential phototrigger for thiol-containing biomolecules
  146. Cryophotolysis of ortho-Nitrobenzyl Derivatives of Enzyme Ligands for the Potential Kinetic Crystallography of Macromolecules
  147. Dynamic Deconvolution of a Pre-Equilibrated Dynamic Combinatorial Library of Acetylcholinesterase Inhibitors
  148. Developmental Regulation of the Cell Division Protein FtsZ in Anabaena sp. Strain PCC 7120, a Cyanobacterium Capable of Terminal Differentiation
  149. Characterization of Caged Cholinergic Ligands; Sulfonated Calix[4]arene Inclusion Complexes
  150. 2-Nitrobenzylarsonium Compounds That Photorelease Heavy-Atom Cholinergic Ligands for Time-Resolved Crystallographic Studies on Cholinesterases
  151. Warum Pentose‐ und nicht Hexose‐Nucleinsäuren??. Teil V. (Purin‐Purin)‐Basenpaarung in der homo‐DNS‐Reihe: Guanin, Isoguanin, 2,6‐Diaminopurin und Xanthin
  152. 2-Nitrobenzyl Quaternary Ammonium Derivatives Photoreleasing Nor-butyrylcholine in the Microsecond Time Range
  153. Synthesis and Characterization of Photolabile Compounds Releasing Noracetylcholine in the Microsecond Time Range
  154. Photoregulation of cholinesterase activity
  155. Biochemical Evaluation of Photolabile Precursors of Choline and of Carbamylcholine for Potential Time-Resolved Crystallographic Studies on Cholinesterases
  156. Synthesis and Characterization of Photolabile Choline Precursors as Reversible Inhibitors of Cholinesterases:  Release of Choline in the Microsecond Time Range
  157. Synthesis and Properties of Photoactivatable Phospholipid Derivatives Designed To Probe the Membrane-Associate Domains of Proteins
  158. Photochemical labeling of membrane‐associated and channel‐forming domains of proteins directed by energy transfer