All Stories

  1. Quantitative analysis of oligonucleotide delivery into isolated mitochondria: a proof-of-concept method
  2. Muribaculum intestinale negatively impacts glioma growth in mice through the toll-like receptor 2
  3. Amphiphilic poly(aminoester) dendrimers: click reaction–enabled synthesis, structure-governed self-assembly and degradation
  4. Correction to “Novel Triazole Ribonucleoside Down-Regulates Heat Shock Protein 27 and Induces Potent Anticancer Activity on Drug-Resistant Pancreatic Cancer”
  5. Correction to “Discovery of Novel Arylethynyltriazole Ribonucleosides with Selective and Effective Antiviral and Antiproliferative Activity”
  6. Dendrimer engineering to overcome delivery challenges of nucleic acids
  7. Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy
  8. Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis
  9. Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group
  10. Bola-Amphiphilic Dendrimer Enhances Imatinib to Target Metastatic Ovarian Cancer via β-Catenin-HRP2 Signaling Axis
  11. P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis
  12. Impact of inner hydrophobicity of dendrimer nanomicelles on biodistribution: a PET imaging study
  13. STING‐Activating Polymers Boost Lymphatic Delivery of mRNA Vaccine to Potentiate Cancer Immunotherapy
  14. Development of an efficient NUPR1 inhibitor with anticancer activity
  15. The synergistic neurovascular electro-healing of infected diabetic wounds by a multifaceted absorbable ion-conductive adhesive patch
  16. Targeting the phosphatidylglycerol lipid: An amphiphilic dendrimer as a promising antibacterial candidate
  17. Insight into the Internal Structure of High-Performance Multicore Magnetic Nanoparticles Used in Cancer Thermotherapy
  18. Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors
  19. Capture and flocculation of toxic cyanobacteria by amphiphilic peptide dendrimers for mitigating harmful blooms
  20. Amphiphilic Dendrimer as Potent Antibacterial against Drug-Resistant Bacteria in Mouse Models of Human Infectious Diseases
  21. Modular Self‐Assembling Dendrimer Nanosystems for Magnetic Resonance and Multimodality Imaging of Tumors
  22. Progress and harmonization of gene editing to treat human diseases: Proceeding of COST Action CA21113 GenE-HumDi
  23. A PD‐L1 Antibody‐Conjugated PAMAM Dendrimer Nanosystem for Simultaneously Inhibiting Glycolysis and Promoting Immune Response in Fighting Breast Cancer
  24. Cargo-selective and adaptive delivery of nucleic acid therapeutics by bola-amphiphilic dendrimers
  25. Dendrimer nanosystems for adaptive tumor-assisted drug delivery via extracellular vesicle hijacking
  26. Amphiphilic Dendrimer Doping Enhanced pH‐Sensitivity of Liposomal Vesicle for Effective Co‐delivery toward Synergistic Ferroptosis–Apoptosis Therapy of Hepatocellular Carcinoma
  27. Solid-phase dendrimer synthesis: a promising approach to transform dendrimer construction
  28. Amphiphilic dendrimers against antibiotic resistance: light at the end of the tunnel?
  29. Bola‐Amphiphilic Glycodendrimers: New Carbohydrate‐Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins
  30. NUPR1 protects against hyperPARylation-dependent cell death
  31. Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment
  32. Amphiphilic Dendrimer Vectors for RNA Delivery: State-of-the-Art and Future Perspective
  33. A self-assembling prodrug nanosystem to enhance metabolic stability and anticancer activity of gemcitabine
  34. Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia
  35. A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery
  36. Dynamic self-assembling supramolecular dendrimer nanosystems as potent antibacterial candidates against drug-resistant bacteria and biofilms
  37. Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function
  38. NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner
  39. Dendrimeric nanosystem consistently circumvents heterogeneous drug response and resistance in pancreatic cancer
  40. Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells
  41. Self-Assembling Supramolecular Dendrimers for Biomedical Applications: Lessons Learned from Poly(amidoamine) Dendrimers
  42. ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents
  43. Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study
  44. Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma
  45. Therapeutic siRNA: state of the art
  46. Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis
  47. Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile
  48. A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging
  49. Novel aryltriazole acyclic C-azanucleosides as anticancer candidates
  50. Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy
  51. Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma
  52. Targeting intrinsically disordered proteins involved in cancer
  53. Poly(amidoamine) dendrimers: covalent and supramolecular synthesis
  54. Efficient and Innocuous Delivery of Small Interfering RNA to Microglia Using an Amphiphilic Dendrimer Nanovector
  55. Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm
  56. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis
  57. Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation
  58. Carbon/Nitrogen Metabolic Balance: Lessons from Cyanobacteria
  59. Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors
  60. A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy
  61. Dendrimer-based magnetic resonance imaging agents for brain cancer
  62. E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments
  63. Blocking Stemness and Metastatic Properties of Ovarian Cancer Cells by Targeting p70S6K with Dendrimer Nanovector-Based siRNA Delivery
  64. Negative dendritic effect on enzymatic hydrolysis of dendrimer conjugates
  65. Potent drugless dendrimers
  66. Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing
  67. Acyclonucleosides bearing coplanar arylethynyltriazole nucleobases: synthesis, structural analysis, and biological evaluation
  68. Mix and Match: Coassembly of Amphiphilic Dendrimers and Phospholipids Creates Robust, Modular, and Controllable Interfaces
  69. Mastering Dendrimer Self‐Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing
  70. Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis
  71. A Novel Triazole Nucleoside Suppresses Prostate Cancer Cell Growth by Inhibiting Heat Shock Factor 1 and Androgen Receptor
  72. Synthesis of poly(aminoester) dendrimers via ‘click’ chemistry in combination with the divergent and convergent strategies
  73. Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance
  74. Promoting siRNA delivery via enhanced cellular uptake using an arginine-decorated amphiphilic dendrimer
  75. Pd-catalyzed oxidative C–H alkenylation for synthesizing arylvinyltriazole nucleosides
  76. Microwave promoted C–O coupling for synthesizing O-aryloxytriazole nucleoside analogues
  77. Shape separation of gold nanoparticles using a pH-responsive amphiphilic dendrimer according to their shape anisotropy distinction
  78. Structural characterization of new defective molecules in poly(amidoamide) dendrimers by combining mass spectrometry and nuclear magnetic resonance
  79. Targeted delivery of Dicer-substrate siRNAs using a dual targeting peptide decorated dendrimer delivery system
  80. Adaptive Amphiphilic Dendrimer-Based Nanoassemblies as Robust and Versatile siRNA Delivery Systems
  81. Pd(dba)2 vs Pd2(dba)3: An in-Depth Comparison of Catalytic Reactivity and Mechanism via Mixed-Ligand Promoted C–N and C–S Coupling Reactions
  82. Structurally flexible triethanolamine-core poly(amidoamine) dendrimers as effective nanovectors to deliver RNAi-based therapeutics
  83. Combination of Dendrimer-Nanovector-Mediated Small Interfering RNA Delivery to Target Akt with the Clinical Anticancer Drug Paclitaxel for Effective and Potent Anticancer Activity in Treating Ovarian Cancer
  84. Mixed‐Ligand Catalysts: A Powerful Tool in Transition‐Metal‐Catalyzed Cross‐Coupling Reactions
  85. Arginine-Terminated Generation 4 PAMAM Dendrimer as an Effective Nanovector for Functional siRNA Delivery in Vitro and in Vivo
  86. Copper(ii) binding to flexible triethanolamine-core PAMAM dendrimers: a combined experimental/in silico approach
  87. Mimicking the 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations
  88. A “click” chemistry constructed affinity system for 2-oxoglutaric acid receptors and binding proteins
  89. Conformational sensitivity of conjugated poly(ethylene oxide)-poly(amidoamine) molecules to cations adducted upon electrospray ionization – A mass spectrometry, ion mobility and molecular modeling study
  90. Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo
  91. CS Coupling Using a Mixed‐Ligand Pd Catalyst: A Highly Effective Strategy for Synthesizing Arylthio‐Substituted Heterocycles
  92. Conformational changes of small PAMAM dendrimers as a function of their charge state: A combined electrospray mass spectrometry, traveling-wave ion mobility and molecular modeling study
  93. Nucleoside analog inhibits microRNA-214 through targeting heat-shock factor 1 in human epithelial ovarian cancer
  94. Structural Requirements of 2-Oxoglutaric Acid Analogues To Mimic Its Signaling Function
  95. Photoactivatable Lipid Probes for Studying Biomembranes by Photoaffinity Labeling
  96. Impact of siRNA Overhangs for Dendrimer-Mediated siRNA Delivery and Gene Silencing
  97. A bola-phospholipid bearing tetrafluorophenylazido chromophore as a promising lipid probe for biomembrane photolabeling studies
  98. 19F NMR: a valuable tool for studying biological events
  99. The Seemingly Trivial Yet Challenging Synthesis of Poly(aminoester) Dendrimers
  100. An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing In Vitro and In Vivo
  101. A Novel Bitriazolyl Acyclonucleoside Endowed with Dual Antiproliferative and Immunomodulatory Activity
  102. Targeting heat shock factor 1 with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer
  103. Genome-Wide Profiling Identified a Set of miRNAs that Are Differentially Expressed in Glioblastoma Stem Cells and Normal Neural Stem Cells
  104. Efficient Delivery of Sticky siRNA and Potent Gene Silencing in a Prostate Cancer Model Using a Generation 5 Triethanolamine-Core PAMAM Dendrimer
  105. High resolution magic angle spinning NMR to investigate ligand–receptor binding events for mass-limited samples in liquids
  106. An Efficient Mixed‐Ligand Pd Catalytic System to Promote CN Coupling for the Synthesis of N‐Arylaminotriazole Nucleosides
  107. Rationalizing the F⋯S interaction discovered within a tetrafluorophenylazido-containing bola-phospholipid
  108. Dendrimers as non-viral vectors for siRNA delivery
  109. Targeting heat shock response pathways to treat pancreatic cancer
  110. Structurally Flexible Triethanolamine Core PAMAM Dendrimers Are Effective Nanovectors for DNA Transfection in Vitro and in Vivo to the Mouse Thymus
  111. Systemic Administration of Combinatorial dsiRNAs via Nanoparticles Efficiently Suppresses HIV-1 Infection in Humanized Mice
  112. Electrospray tandem mass spectrometry of poly(amino)ester dendrimers: Dissociation rules and structural characterization of defective molecules
  113. Photoactivatable Phospholipids Bearing Tetrafluorophenylazido Chromophores Exhibit Unprecedented Protonation-State-Dependent 19F NMR Signals
  114. 2-Difluoromethylene-4-methylenepentanoic Acid, A Paradoxical Probe Able To Mimic the Signaling Role of 2-Oxoglutaric Acid in Cyanobacteria
  115. Bitriazolyl acyclonucleosides synthesized via Huisgen reaction using internal alkynes show antiviral activity against tobacco mosaic virus
  116. Ligand-Mediated Highly Effective and Selective C−N Coupling for Synthesizing Bioactive N-Aryltriazole Acyclonucleosides
  117. Synthesis of Poly(amino)ester Dendrimers via Active Cyanomethyl Ester Intermediates
  118. A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells
  119. Triazole Nucleoside Derivatives Bearing Aryl Functionalities on the Nucleobases Show Antiviral and Anticancer Activity
  120. Structural characterization of poly(amino)ester dendrimers and related impurities by electrospray tandem mass spectrometry
  121. S-Aryltriazole acyclonucleosides: Synthesis and biological evaluation against hepatitis C virus
  122. N-Aryltriazole ribonucleosides with potent antiproliferative activity against drug-resistant pancreatic cancer
  123. Novel Triazole Ribonucleoside Down-Regulates Heat Shock Protein 27 and Induces Potent Anticancer Activity on Drug-Resistant Pancreatic Cancer
  124. Cu-Mediated SelectiveN-Arylation of Aminotriazole Acyclonucleosides
  125. PAMAM Dendrimers Mediate siRNA Delivery to Target Hsp27 and Produce Potent Antiproliferative Effects on Prostate Cancer Cells
  126. Efficient synthesis of esters containing tertiary amine functionalities via active cyanomethyl ester intermediates
  127. Discovery of Novel Arylethynyltriazole Ribonucleosides with Selective and Effective Antiviral and Antiproliferative Activity
  128. Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication
  129. Bitriazolyl acyclonucleosides with antiviral activity against tobacco mosaic virus
  130. Propagation of structural deviations of poly(amidoamine) fan-shape dendrimers (generations 0–3) characterized by MALDI and electrospray mass spectrometry
  131. Direct synthesis of 5-aryltriazole acyclonucleosides via Suzuki coupling in aqueous solution
  132. Importance of size-to-charge ratio in construction of stable and uniform nanoscale RNA/dendrimer complexes
  133. Synthesis of bitriazolyl nucleosides and unexpectedly different reactivity of azidotriazole nucleoside isomers in the Huisgen reaction
  134. Palmitoylation is required for efficient Fas cell death signaling
  135. Studying the Signaling Role of 2-Oxoglutaric Acid Using Analogs that Mimic the Ketone and Ketal Forms of 2-Oxoglutaric Acid
  136. Discovery of Bitriazolyl Compounds as Novel Antiviral Candidates for Combating the Tobacco Mosaic Virus.
  137. Discovery of bitriazolyl compounds as novel antiviral candidates for combating the tobacco mosaic virus
  138. Cooperative binding and self-assembling behavior of cationic low molecular-weight dendrons with RNA molecules
  139. PAMAM dendrimers for efficient siRNA delivery and potent gene silencing
  140. Heterocyst differentiation and pattern formation in cyanobacteria: a chorus of signals
  141. para‐Sulfonated Calixarenes Used as Synthetic Receptors for Complexing Photolabile Cholinergic Ligand
  142. Synthesis of a photoactivatable phospholipidic probe containing tetrafluorophenylazide
  143. Nonmetabolizable analogue of 2-oxoglutarate elicits heterocyst differentiation under repressive conditions in Anabaena sp. PCC 7120
  144. Synthesis and characterization of photolabeling probes of miltefosine
  145. PHOTOLABELING PROBES OF RIBAVIRIN AND EICAR
  146. Polycationic dendrimers interact with RNA molecules: polyamine dendrimers inhibit the catalytic activity of Candida ribozymes
  147. Synthesis of Bitriazolyl Compounds via Huisgen Reaction
  148. Design, Synthesis, and Characterization of Photolabeling Probes for the Study of the Mechanisms of the Antiviral Effects of Ribavirin
  149. Synthesis and Characterization of Potential Photolabeling Probes for Studying the Antiviral Mechanisms of EICAR
  150. Mutually Induced Formation of Host–Guest Complexes between p‐Sulfonated Calix[8]arene and Photolabile Cholinergic Ligands
  151. p-Hydroxyphenacyl bromide as photoremoveable thiol label: a potential phototrigger for thiol-containing biomolecules
  152. Cryophotolysis of ortho-Nitrobenzyl Derivatives of Enzyme Ligands for the Potential Kinetic Crystallography of Macromolecules
  153. Dynamic Deconvolution of a Pre-Equilibrated Dynamic Combinatorial Library of Acetylcholinesterase Inhibitors
  154. Developmental Regulation of the Cell Division Protein FtsZ in Anabaena sp. Strain PCC 7120, a Cyanobacterium Capable of Terminal Differentiation
  155. Characterization of Caged Cholinergic Ligands; Sulfonated Calix[4]arene Inclusion Complexes
  156. 2-Nitrobenzylarsonium Compounds That Photorelease Heavy-Atom Cholinergic Ligands for Time-Resolved Crystallographic Studies on Cholinesterases
  157. Warum Pentose‐ und nicht Hexose‐Nucleinsäuren??. Teil V. (Purin‐Purin)‐Basenpaarung in der homo‐DNS‐Reihe: Guanin, Isoguanin, 2,6‐Diaminopurin und Xanthin
  158. 2-Nitrobenzyl Quaternary Ammonium Derivatives Photoreleasing Nor-butyrylcholine in the Microsecond Time Range
  159. Synthesis and Characterization of Photolabile Compounds Releasing Noracetylcholine in the Microsecond Time Range
  160. Photoregulation of cholinesterase activity
  161. Biochemical Evaluation of Photolabile Precursors of Choline and of Carbamylcholine for Potential Time-Resolved Crystallographic Studies on Cholinesterases
  162. Synthesis and Characterization of Photolabile Choline Precursors as Reversible Inhibitors of Cholinesterases:  Release of Choline in the Microsecond Time Range
  163. Synthesis and Properties of Photoactivatable Phospholipid Derivatives Designed To Probe the Membrane-Associate Domains of Proteins
  164. Photochemical labeling of membrane‐associated and channel‐forming domains of proteins directed by energy transfer