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  1. Comprehensive Review: Unveiling the Pro-Oncogenic Roles of IL-1ß and PD-1/PD-L1 in NSCLC Development and Targeting Their Pathways for Clinical Management

    Article • International Journal of Molecular Sciences, July 2023, MDPI AG

    Penelope Duerksen-Hughes

  2. Convalescent Plasma for COVID-19: A Single Center Prospective Experience with Serial Antibody Measurements and Review of the Literature

    Article • Pathogens, August 2022, MDPI AG

    Penelope Duerksen-Hughes

  3. The Biology of Veganism: Plasma Metabolomics Analysis Reveals Distinct Profiles of Vegans and Non-Vegetarians in the Adventist Health Study-2 Cohort

    Article • Nutrients, February 2022, MDPI AG

    Penelope Duerksen-Hughes

  4. ACE2 : S1 RBD Interaction-Targeted Peptides and Small Molecules as Potential COVID-19 Therapeutics

    Article • Advances in Pharmacological and Pharmaceutical Sciences, November 2021, Hindawi Publishing Corporation

    Penelope Duerksen-Hughes

  5. Keep out! SARS-CoV-2 entry inhibitors: their role and utility as COVID-19 therapeutics

    Article • Virology Journal, July 2021, Springer Science + Business Media

    Penelope Duerksen-Hughes

  6. PPI Modulators of E6 as Potential Targeted Therapeutics for Cervical Cancer: Progress and Challenges in Targeting E6

    Article • Molecules, May 2021, MDPI AG

    Penelope Duerksen-Hughes

  7. Methylomes in Vegans versus Pescatarians and Nonvegetarians

    Article • Epigenomes, December 2020, MDPI AG

    Penelope Duerksen-Hughes

  8. Oxidative stress markers in patient-derived non-cancerous cervical tissues and cells

    Article • Scientific Reports, November 2020, Springer Science + Business Media

    Penelope Duerksen-Hughes

  9. The Potential of Immune Checkpoint Blockade in Cervical Cancer: Can Combinatorial Regimens Maximize Response? A Review of the Literature

    Article • Current Treatment Options in Oncology, October 2020, Springer Science + Business Media

    Penelope Duerksen-Hughes

  10. Effects of Lifestyle Factors on Cognitive Resilience: Commentary on “What This Sunny, Religious Town in California Teaches Us About Living Longer”

    Article • Translational Stroke Research, February 2020, Springer Science + Business Media

    Penelope Duerksen-Hughes

  11. Cold parenting is associated with cellular aging in offspring: A retrospective study

    Article • Biological Psychology, July 2019, Elsevier

    Penelope Duerksen-Hughes

  12. Cancer stem cell self-renewal as a therapeutic target in human oral cancer

    Article • Oncogene, April 2019, Springer Science + Business Media

    Penelope Duerksen-Hughes

  13. Oxidative stress in clinical samples

    Article • Oxidative Medicine and Cellular Longevity, March 2019, Hindawi Publishing Corporation

    Penelope Duerksen-Hughes, Meghri Katerji

  14. Subpopulations of cancer stem cells found in papillary thyroid carcinoma

    Article • Experimental Cell Research, January 2018, Elsevier

    Penelope Duerksen-Hughes

  15. Association between markers of glucose metabolism and risk of colorectal cancer

    Article • BMJ Open, June 2016, BMJ

    Penelope Duerksen-Hughes

  16. Flavonol and imidazole derivatives block HPV16 E6 activities and reactivate apoptotic pathways in HPV+ cells

    Article • Cell Death and Disease, January 2016, Nature

    Penelope Duerksen-Hughes

  17. Combined ultrasound-curcumin treatment of human cervical cancer cells

    Article • European Journal of Obstetrics & Gynecology and Reproductive Biology, October 2015, Elsevier

    Penelope Duerksen-Hughes

  18. Recent Progress in Therapeutic Treatments and Screening Strategies for the Prevention and Treatment of HPV-Associated Head and Neck Cancer

    Article • Viruses, September 2015, MDPI AG

    Penelope Duerksen-Hughes

  19. Abstract 1828: Proteomic analysis of the effect of E6 star expression on cellular pathways in HPV positive SiHa and HPV negative C33A cervical carcinoma cells

    Article • Cancer Research, August 2015, American Association for Cancer Research (AACR)

    Penelope Duerksen-Hughes

  20. Selenium Attenuates HPV-18 Associated Apoptosis in Embryo-Derived Trophoblastic Cells but Not Inner Cell Mass In Vitro

    Article • International Journal of Reproductive Medicine, January 2015, Hindawi Publishing Corporation

    Penelope Duerksen-Hughes

  21. Long-term, Aerobic Training Increases Adiponectin Levels in Trained, Middle-aged Females more than in Comparable Males

    Article • Medical Research Archives, December 2014, Knowledge Enterprise Journals

    Penelope Duerksen-Hughes

  22. Viral Carcinogenesis: Factors Inducing DNA Damage and Virus Integration

    Article • Cancers, October 2014, MDPI AG

    Penelope Duerksen-Hughes

  23. Abstract 3175: The splice variant of the human papillomavirus 16 E6 protein, E6*, displays anti-tumor propertiesin vivo

    Article • Cancer Research, September 2014, American Association for Cancer Research (AACR)

    Penelope Duerksen-Hughes

  24. Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells

    Article • Oral Oncology, July 2014, Elsevier

    Penelope Duerksen-Hughes

  25. Paraspeckle Protein 1 (PSPC1) Is Involved in the Cisplatin Induced DNA Damage Response—Role in G1/S Checkpoint

    Article • PLoS ONE, May 2014, PLOS

    Penelope Duerksen-Hughes

  26. Human Papillomavirus Type 16 E6* Induces Oxidative Stress and DNA Damage

    Article • Journal of Virology, April 2014, ASM Journals

    Penelope Duerksen-Hughes

  27. A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

    Article • Nature Communications, February 2014, Springer Science + Business Media

    Penelope Duerksen-Hughes

  28. The small splice variant of HPV16 E6, E6⁎, reduces tumor formation in cervical carcinoma xenografts

    Article • Virology, February 2014, Elsevier

    Penelope Duerksen-Hughes

  29. Proteomic Analysis of Cellular Response Induced by Multi-Walled Carbon Nanotubes Exposure in A549 Cells

    Article • PLoS ONE, January 2014, PLOS

    Penelope Duerksen-Hughes

  30. Cellular Levels of Oxidative Stress Affect the Response of Cervical Cancer Cells to Chemotherapeutic Agents

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Penelope Duerksen-Hughes

  31. Modern Molecular and Clinical Approaches to Eradicate HPVMediated Cervical Cancer

    Article • April 2013, IntechOpen

    Penelope Duerksen-Hughes

  32. Quantum dot-related genotoxicity perturbation can be attenuated by PEG encapsulation

    Article • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, April 2013, Elsevier

    Penelope Duerksen-Hughes

  33. Modulation of Apoptotic Pathways by Human Papillomaviruses (HPV): Mechanisms and Implications for Therapy

    Article • Viruses, December 2012, MDPI AG

    Penelope Duerksen-Hughes

  34. Interleukin 24: Mechanisms and therapeutic potential of an anti-cancer gene

    Article • Cytokine & Growth Factor Reviews, December 2012, Elsevier

    Penelope Duerksen-Hughes

  35. Methyl methanesulfonate induces apoptosis in p53-deficient H1299 and Hep3B cells through a caspase 2- and mitochondria-associated pathway

    Article • Environmental Toxicology and Pharmacology, November 2012, Elsevier

    Penelope Duerksen-Hughes

  36. Cisplatin treatment leads to changes in nuclear protein and microRNA expression

    Article • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, July 2012, Elsevier

    Penelope Duerksen-Hughes

  37. DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, July 2012, Elsevier

    Penelope Duerksen-Hughes

  38. Increased Ceramide in Brains with Alzheimer's and Other Neurodegenerative Diseases

    Article • Journal of Alzheimer s Disease, March 2012, IOS Press

    Penelope Duerksen-Hughes

  39. Small molecule inhibitors of the HPV16-E6 interaction with caspase 8

    Article • Bioorganic & Medicinal Chemistry Letters, March 2012, Elsevier

    Penelope Duerksen-Hughes

  40. Nuclear proteome analysis of benzo(a)pyrene-treated HeLa cells

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, March 2012, Elsevier

    Penelope Duerksen-Hughes

  41. Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells

    Article • Cytokine, November 2011, Elsevier

    Penelope Duerksen-Hughes

  42. Mass Spectrometric Studies on Epigenetic Interaction Networks in Cell Differentiation

    Article • Journal of Biological Chemistry, April 2011, Elsevier

    Penelope Duerksen-Hughes

  43. Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK

    Article • Toxicology in Vitro, February 2011, Elsevier

    Penelope Duerksen-Hughes

  44. Long-term, progressive, aerobic training increases adiponectin in middle-aged, overweight, untrained males and females

    Article • Scandinavian Journal of Clinical and Laboratory Investigation, January 2011, Informa Healthcare

    Penelope Duerksen-Hughes

  45. Quantification of ceramide levels in mammalian cells by high performance liquid chromatography coupled to tandem mass spectrometry with multiple-reaction-monitoring mode (HPLC-MS/MS-MRM)

    Article • Analytical Methods, January 2011, Royal Society of Chemistry

    Penelope Duerksen-Hughes

  46. HPV-DNA integration and carcinogenesis: putative roles for inflammation and oxidative stress

    Article • Future Virology, January 2011, Future Medicine

    Penelope Duerksen-Hughes

  47. Nuclear proteome analysis of cisplatin-treated HeLa cells

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, September 2010, Elsevier

    Penelope Duerksen-Hughes

  48. Benzo[a]pyrene treatment leads to changes in nuclear protein expression and alternative splicing

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, April 2010, Elsevier

    Penelope Duerksen-Hughes

  49. The Full-Length Isoform of Human Papillomavirus 16 E6 and Its Splice Variant E6* Bind to Different Sites on the Procaspase 8 Death Effector Domain

    Article • Journal of Virology, November 2009, ASM Journals

    Penelope Duerksen-Hughes

  50. Complexes of Human Papillomavirus Type 16 E6 Proteins Form Pseudo-Death-Inducing Signaling Complex Structures during Tumor Necrosis Factor-Mediated Apoptosis

    Article • Journal of Virology, October 2008, ASM Journals

    Penelope Duerksen-Hughes

  51. Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes

    Article • Gene, August 2008, Elsevier

    Penelope Duerksen-Hughes

  52. The Interaction between Human Papillomavirus Type 16 and FADD Is Mediated by a Novel E6 Binding Domain

    Article • Journal of Virology, July 2008, ASM Journals

    Penelope Duerksen-Hughes

  53. C18 ceramide analysis in mammalian cells employing reversed-phase high-performance liquid chromatography tandem mass spectrometry

    Article • Analytical Biochemistry, July 2008, Elsevier

    Penelope Duerksen-Hughes

  54. Cellular binding partners of the human papillomavirus E6 protein

    Article • Archives of Virology, January 2008, Springer Science + Business Media

    Penelope Duerksen-Hughes

  55. The Early Response to DNA Damage Can Lead to Activation of Alternative Splicing Activity Resulting in CD44 Splice Pattern Changes

    Article • Cancer Research, August 2007, American Association for Cancer Research (AACR)

    Penelope Duerksen-Hughes

  56. Bid is cleaved upstream of caspase-8 activation during TRAIL-mediated apoptosis in human osteosarcoma cells

    Article • APOPTOSIS, March 2007, Springer Science + Business Media

    Penelope Duerksen-Hughes

  57. The Large and Small Isoforms of Human Papillomavirus Type 16 E6 Bind to and Differentially Affect Procaspase 8 Stability and Activity

    Article • Journal of Virology, January 2007, ASM Journals

    Penelope Duerksen-Hughes

  58. Modulation of apoptosis by human papillomavirus (HPV) oncoproteins

    Article • Archives of Virology, July 2006, Springer Science + Business Media

    Penelope Duerksen-Hughes

  59. Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis

    Article • Cell Death and Differentiation, March 2006, Springer Science + Business Media

    Penelope Duerksen-Hughes

  60. The human papillomavirus 16 E6 protein can either protect or further sensitize cells to TNF: effect of dose

    Article • Cell Death and Differentiation, June 2005, Springer Science + Business Media

    Penelope Duerksen-Hughes

  61. The Human Papillomavirus 16 E6 Protein Binds to Fas-associated Death Domain and Protects Cells from Fas-triggered Apoptosis

    Article • Journal of Biological Chemistry, June 2004, Elsevier

    Penelope Duerksen-Hughes

  62. Ceramide and Other Sphingolipids in Cellular Responses

    Article • Cell Biochemistry and Biophysics, January 2004, Springer Science + Business Media

    Penelope Duerksen-Hughes

  63. ATM and ATR: Sensing DNA damage

    Article • World Journal of Gastroenterology, January 2004, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Penelope Duerksen-Hughes

  64. ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses

    Article • Carcinogenesis, July 2003, Oxford University Press (OUP)

    Penelope Duerksen-Hughes

  65. Inorganic and Dimethylated Arsenic Species Induce Cellular p53

    Article • Chemical Research in Toxicology, March 2003, American Chemical Society (ACS)

    Penelope Duerksen-Hughes

  66. Protein kinases and their involvement in the cellular responses to genotoxic stress

    Article • Mutation Research/Reviews in Mutation Research, January 2003, Elsevier

    Penelope Duerksen-Hughes

  67. The Human Papillomavirus 16 E6 Protein Binds to Tumor Necrosis Factor (TNF) R1 and Protects Cells from TNF-induced Apoptosis

    Article • Journal of Biological Chemistry, June 2002, Elsevier

    Penelope Duerksen-Hughes

  68. Activation of a p53-independent, Sphingolipid-mediated Cytolytic Pathway in p53-negative Mouse Fibroblast Cells Treated with N-Methyl-N-nitro-N-nitrosoguanidine

    Article • Journal of Biological Chemistry, July 2001, Elsevier

    Penelope Duerksen-Hughes

  69. HPV 16 E6 Blocks TNF-Mediated Apoptosis in Mouse Fibroblast LM Cells

    Article • Virology, November 1999, Elsevier

    Penelope Duerksen-Hughes

  70. p53 Induction as a Genotoxic Test for Twenty-Five Chemicals Undergoing in Vivo Carcinogenicity Testing

    Article • Environmental Health Perspectives, October 1999, JSTOR

    Penelope Duerksen-Hughes

  71. p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing

    Article • Environmental Health Perspectives, October 1999, Environmental Health Perspectives

    Penelope Duerksen-Hughes

  72. A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage

    Article • Carcinogenesis, June 1998, Oxford University Press (OUP)

    Penelope Duerksen-Hughes

  73. Macrophage-Mediated Cytotoxicity

    Article • January 1993, Springer Science + Business Media

    Penelope Duerksen-Hughes

  74. Adenovirus E1A renders infected cells sensitive to cytolysis by tumor necrosis factor.

    Article • The Journal of Immunology, December 1989, The American Association of Immunologists

    Penelope Duerksen-Hughes

  75. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase

    Article • Science, November 1989, American Association for the Advancement of Science

    Penelope Duerksen-Hughes

  76. Affinity chromatography using protein immobilized via arginine residues: purification of ubiquitin carboxyl-terminal hydrolases

    Article • Biochemistry, October 1989, American Chemical Society (ACS)

    Penelope Duerksen-Hughes

  77. Structure and function of ubiquitin: evidence for differential interactions of arginine-74 with the activating enzyme and the proteases of ATP-dependent proteolysis

    Article • Biochemistry, November 1987, American Chemical Society (ACS)

    Penelope Duerksen-Hughes

  78. Immobilization of proteins via arginine residues

    Article • Analytical Biochemistry, February 1987, Elsevier

    Penelope Duerksen-Hughes

  79. Measurement of Macrophage-Mediated Cytolysis of Adenovirus-Infected Cells

    Article • Springer Science + Business Media

    Penelope Duerksen-Hughes