All Stories

  1. Safety and immunogenicity of intranasal parainfluenza virus type 5 (PIV5)–vectored COVID-19 vaccine in adults and teens in an open-label phase 1 trial

    Article • Science Advances, July 2025, American Association for the Advancement of Science

    Paul Spearman

  2. The CLIC/GEEC pathway regulates particle uptake and formation of the virus-containing compartment (VCC) in HIV-1-infected macrophages

    Article • PLoS Pathogens, March 2025, PLOS

    Paul Spearman

  3. HIV-1 infection of human microglia activates inflammatory pathways associated with HIV-associated neurocognitive disorders (HAND)

    Article • February 2025, openRxiv

    Paul Spearman

  4. The CLIC/GEEC pathway regulates particle endocytosis and formation of the virus-containing compartment (VCC) in HIV-1-infected macrophages

    Article • September 2024, openRxiv

    Paul Spearman

  5. Incorporation of the HIV-1 envelope glycoprotein into viral particles is regulated by the tubular recycling endosome in a cell type-specific manner

    Article • December 2023, openRxiv

    Paul Spearman

  6. Tryptophan-based motifs in the LLP3 region of the HIV-1 envelope glycoprotein cytoplasmic tail direct trafficking to the endosomal recycling compartment and mediate particle incorporation

    Article • Journal of Virology, October 2023, ASM Journals

    Paul Spearman

  7. Intranasal parainfluenza virus type 5 (PIV5)–vectored RSV vaccine is safe and immunogenic in healthy adults in a phase 1 clinical study

    Article • Science Advances, October 2023, American Association for the Advancement of Science

    Paul Spearman

  8. KIF16B Mediates Anterograde Transport and Modulates Lysosomal Degradation of the HIV-1 Envelope Glycoprotein

    Article • Journal of Virology, July 2023, ASM Journals

    Paul Spearman

  9. Tryptophan-based motifs in the LLP3 Region of the HIV-1 envelope glycoprotein cytoplasmic tail direct trafficking to the endosomal recycling compartment and mediate particle incorporation

    Article • April 2023, openRxiv

    Paul Spearman

  10. KIF16B mediates anterograde transport and modulates lysosomal degradation of the HIV-1 envelope glycoprotein

    Article • March 2023, openRxiv

    Paul Spearman

  11. Inactivation of SARS-CoV-2 on Surfaces by Cold-Plasma-Generated Reactive Species

    Article • Bioengineering, February 2023, MDPI AG

    Paul Spearman

  12. Ebola virus protein VP40 stimulates IL-12– and IL-18–dependent activation of human natural killer cells

    Article • JCI Insight, August 2022, American Society for Clinical Investigation

    Paul Spearman

  13. Viral and Host Factors Regulating HIV-1 Envelope Protein Trafficking and Particle Incorporation

    Article • Viruses, August 2022, MDPI AG

    Paul Spearman

  14. Advances in HIV-1 Assembly

    Article • Viruses, February 2022, MDPI AG

    Paul Spearman

  15. Pediatric Infectious Disease Specialists: An Answer to Social Media Misinformation on Coronavirus Disease 2019

    Article • Journal of the Pediatric Infectious Diseases Society, December 2020, Oxford University Press (OUP)

    Paul Spearman

  16. Comparative analysis of human microglial models for studies of HIV replication and pathogenesis

    Article • Retrovirology, November 2020, Springer Science + Business Media

    Paul Spearman

  17. Comparative Analysis of Human Microglial Models for Studies of HIV Replication and Pathogenesis

    Article • October 2020, Springer Science + Business Media

    Paul Spearman

  18. Warp Speed for Coronavirus Disease 2019 (COVID-19) Vaccines: Why Are Children Stuck in Neutral?

    Article • Clinical Infectious Diseases, September 2020, Oxford University Press (OUP)

    Paul Spearman

  19. Comparative Analysis of Human Microglial Models for Studies of HIV Replication and Pathogenesis

    Article • July 2020, Springer Science + Business Media

    Paul Spearman

  20. Rapid Boosting of HIV-1 Neutralizing Antibody Responses in Humans Following a Prolonged Immunologic Rest Period

    Article • The Journal of Infectious Diseases, January 2019, Oxford University Press (OUP)

    Paul Spearman

  21. HIV-1 Envelope Glycoprotein Trafficking through the Endosomal Recycling Compartment Is Required for Particle Incorporation

    Article • Journal of Virology, December 2017, ASM Journals

    Paul Spearman

  22. Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques

    Article • Journal of Virology, February 2017, ASM Journals

    Paul Spearman

  23. Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1

    Article • PLoS Pathogens, January 2017, PLOS

    Paul Spearman

  24. Correlated fluorescence microscopy and cryo-electron tomography of virus-infected or transfected mammalian cells

    Article • Nature Protocols, December 2016, Springer Science + Business Media

    Paul Spearman

  25. A phase 1, randomized, controlled dose-escalation study of EP-1300 polyepitope DNA vaccine against Plasmodium falciparum malaria administered via electroporation

    Article • Vaccine, November 2016, Elsevier

    Paul Spearman

  26. A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques

    Article • Nature Communications, September 2016, Springer Science + Business Media

    Paul Spearman

  27. Virus-Like Particles Displaying Trimeric Simian Immunodeficiency Virus (SIV) Envelope gp160 Enhance the Breadth of DNA/Modified Vaccinia Virus Ankara SIV Vaccine-Induced Antibody Responses in Rhesus Macaques

    Article • Journal of Virology, July 2016, ASM Journals

    Rama Amara, Paul Spearman

  28. Human Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein

    Article • PLOS One, July 2016, PLOS

    Dr James E Crowe, Paul Spearman

  29. EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression

    Article • PLoS Pathogens, May 2016, PLOS

    Prof. Ultan F Power, Michael Shields, Paul Spearman

  30. Three-Dimensional Structural Characterization of HIV-1 Tethered to Human Cells

    Article • Journal of Virology, February 2016, ASM Journals

    Paul Spearman

  31. Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations

    Article • Molecular Immunology, February 2016, Elsevier

    Dr James E Crowe, Paul Spearman

  32. HIV-specific CD4-induced Antibodies Mediate Broad and Potent Antibody-dependent Cellular Cytotoxicity Activity and are Commonly Detected in Plasma from HIV-infected Humans

    Article • EBioMedicine, October 2015, Elsevier

    Paul Spearman

  33. Association of VH4-59 Antibody Variable Gene Usage with Recognition of an Immunodominant Epitope on the HIV-1 Gag Protein

    Article • PLOS One, July 2015, PLOS

    Dr James E Crowe, Paul Spearman

  34. Platelet geometry sensing spatially regulates α-granule secretion to enable matrix self-deposition

    Article • Blood, July 2015, American Society of Hematology

    Paul Spearman

  35. P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions

    Article • Journal of Virology, July 2015, ASM Journals

    Paul Spearman

  36. Native Immunogold Labeling of Cell Surface Proteins and Viral Glycoproteins for Cryo-Electron Microscopy and Cryo-Electron Tomography Applications

    Article • Journal of Histochemistry & Cytochemistry, June 2015, SAGE Publications

    Paul Spearman

  37. A tyrosine-based motif in the HIV-1 envelope glycoprotein tail mediates cell-type– and Rab11-FIP1C–dependent incorporation into virions

    Article • Proceedings of the National Academy of Sciences, June 2015, Proceedings of the National Academy of Sciences

    Paul Spearman

  38. Placental Hofbauer cells assemble and sequester HIV-1 in tetraspanin-positive compartments that are accessible to broadly neutralizing antibodies

    Article • Journal of the International AIDS Society, January 2015, Wiley

    Paul Spearman

  39. Acute pancreatitis associated with dolutegravir and lamivudine/abacavir administration

    Article • AIDS, January 2015, Wolters Kluwer Health

    Dr Amelia Thompson, Paul Spearman

  40. Immunogenicity of Avian Influenza A/Anhui/01/2005(H5N1) Vaccine With MF59 Adjuvant

    Article • JAMA, October 2014, American Medical Association (AMA)

    Paul Spearman

  41. Serological Responses to an Avian Influenza A/H7N9 Vaccine Mixed at the Point-of-Use With MF59 Adjuvant

    Article • JAMA, October 2014, American Medical Association (AMA)

    Paul Spearman

  42. Immunogenicity and safety of four different dosing regimens of anthrax vaccine adsorbed for post-exposure prophylaxis for anthrax in adults

    Article • Vaccine, October 2014, Elsevier

    Paul Spearman

  43. An siRNA Screen of Membrane Trafficking Genes Highlights Pathways Common to HIV-1 and M-PMV Virus Assembly and Release

    Article • PLOS One, September 2014, PLOS

    Paul Spearman

  44. Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans

    Article • Proceedings of the National Academy of Sciences, August 2014, Proceedings of the National Academy of Sciences

    Dr Florian Krammer, Paul Spearman

  45. Microscale Generation of Cardiospheres Promotes Robust Enrichment of Cardiomyocytes Derived from Human Pluripotent Stem Cells

    Article • Stem Cell Reports, August 2014, Elsevier

    Dr Todd C McDevitt, Paul Spearman

  46. Methicillin-resistant Staphylococcus aureus Empyema Necessitatis in a Breast-fed Neonate

    Article • The Pediatric Infectious Disease Journal, June 2014, Wolters Kluwer Health

    Paul Spearman

  47. ROCK1 and LIM Kinase Modulate Retrovirus Particle Release and Cell-Cell Transmission Events

    Article • Journal of Virology, April 2014, ASM Journals

    Paul Spearman

  48. Direct evidence for intracellular anterograde co-transport of M-PMV Gag and Env on microtubules

    Article • Virology, January 2014, Elsevier

    Paul Spearman

  49. A Mason-Pfizer Monkey Virus Gag-GFP Fusion Vector Allows Visualization of Capsid Transport in Live Cells and Demonstrates a Role for Microtubules

    Article • PLOS One, December 2013, PLOS

    Paul Spearman

  50. Capturing Enveloped Viruses on Affinity Grids for Downstream Cryo-Electron Microscopy Applications

    Article • Microscopy and Microanalysis, November 2013, Oxford University Press (OUP)

    Paul Spearman

  51. Tetherin does not significantly restrict dendritic cell-mediated HIV-1 transmission and its expression is upregulated by newly synthesized HIV-1 Nef

    Article • Retrovirology, April 2011, Springer Science + Business Media

    Paul Spearman

  52. HIV Interactions with Host Cell Proteins

    Article • January 2009, Springer Science + Business Media

    Paul Spearman

  53. HIV-1 assembly and cellular trafficking pathways: current understanding and potential for future therapeutics

    Article • Future HIV Therapy, May 2007, Future Medicine

    Paul Spearman

  54. Cellular cofactors involved in HIV assembly and budding

    Article • Current Opinion in HIV and AIDS, May 2006, Wolters Kluwer Health

    Paul Spearman

  55. Current Progress in the Development of HIV Vaccines

    Article • Current Pharmaceutical Design, March 2006, Bentham Science Publishers

    Paul Spearman

  56. HIV-1 Egress is Gated Through Late Endosomal Membranes

    Article • Traffic, November 2003, Wiley

    Paul Spearman

  57. HIV Vaccine Development: Lessons from the Past and Promise for the Future

    Article • Current HIV Research, January 2003, Bentham Science Publishers

    Paul Spearman