All Stories

  1. Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism

    Article • Hypoxia, August 2014, Taylor & Francis

    Dr Patrick J Pollard

  2. Concise Review: Genetic Dissection of Hypoxia Signaling Pathways in Normal and Leukemic Stem Cells

    Article • Stem Cells, May 2014, Oxford University Press (OUP)

    Dr Patrick J Pollard

  3. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

    Article • Proceedings of the National Academy of Sciences, February 2014, Proceedings of the National Academy of Sciences

    Dr Patrick J Pollard

  4. Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas

    Article • Human Molecular Genetics, December 2013, Oxford University Press (OUP)

    Dr Patrick J Pollard

  5. Renal cell carcinoma: translational aspects of metabolism and therapeutic consequences

    Article • Kidney International, October 2013, Elsevier

    Dr Patrick J Pollard

  6. Oncometabolites: linking altered metabolism with cancer

    Article • Journal of Clinical Investigation, September 2013, American Society for Clinical Investigation

    Dr Patrick J Pollard

  7. Hif-2  is not essential for cell-autonomous hematopoietic stem cell maintenance

    Article • Blood, July 2013, American Society of Hematology

    Dr Patrick J Pollard

  8. Rare insights into cancer biology

    Article • Oncogene, July 2013, Springer Science + Business Media

    Dr Patrick J Pollard

  9. Succinate: A New Epigenetic Hacker

    Article • Cancer Cell, June 2013, Elsevier

    Dr Patrick J Pollard

  10. A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

    Article • Cell Reports, May 2013, Elsevier

    Dr Patrick J Pollard, Dr Daniel A Tennant

  11. Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency

    Article • Cell Reports, March 2013, Elsevier

    Dr Patrick J Pollard

  12. Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice

    Article • The Journal of Physiology, August 2012, Wiley

    Dr Patrick J Pollard

  13. Cells Lacking the Fumarase Tumor Suppressor Are Protected from Apoptosis through a Hypoxia-Inducible Factor-Independent, AMPK-Dependent Mechanism

    Article • Molecular and Cellular Biology, May 2012, ASM Journals

    Dr Patrick J Pollard

  14. Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway

    Article • Cell Metabolism, March 2012, Elsevier

    Dr Mogens Johannsen, Dr Patrick J Pollard, Dr Daniel A Tennant

  15. The emerging role of fumarate as an oncometabolite

    Article • Frontiers in Oncology, January 2012, Frontiers

    Dr Patrick J Pollard

  16. SDH mutations in cancer

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, November 2011, Elsevier

    Dr Patrick J Pollard

  17. The C-terminus of Apc does not influence intestinal adenoma development or progression

    Article • The Journal of Pathology, October 2011, Wiley

    Dr Patrick J Pollard

  18. Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

    Article • Cancer Cell, October 2011, Elsevier

    Dr Patrick J Pollard

  19. Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

    Article • Nature, August 2011, Springer Science + Business Media

    Dr Patrick J Pollard

  20. Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

    Article • The Journal of Pathology, June 2011, Wiley

    Dr Patrick J Pollard

  21. Inborn and acquired metabolic defects in cancer

    Article • Journal of Molecular Medicine, February 2011, Springer Science + Business Media

    Dr Patrick J Pollard

  22. Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)

    Article • PLoS ONE, January 2011, PLOS

    Dr Patrick J Pollard

  23. Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

    Article • Cancer Research, October 2010, American Association for Cancer Research (AACR)

    Dr Patrick J Pollard

  24. In the ring with polycystic kidney disease-avoiding the knockout punch

    Article • The Journal of Pathology, October 2010, Wiley

    Dr Patrick J Pollard

  25. Severe polyposis in Apc1322Tmice is associated with submaximal Wnt signalling and increased expression of the stem cell markerLgr5

    Article • Gut, October 2010, BMJ

    Dr Patrick J Pollard

  26. Hypoxia Signaling in Hematopoietic Stem Cells: A Double-Edged Sword

    Article • Cell Stem Cell, September 2010, Elsevier

    Dr Patrick J Pollard

  27. Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism

    Article • Human Molecular Genetics, July 2010, Oxford University Press (OUP)

    Dr Patrick J Pollard

  28. The Apc1322T Mouse Develops Severe Polyposis Associated With Submaximal Nuclear β-Catenin Expression

    Article • Gastroenterology, June 2009, Elsevier

    Dr Patrick J Pollard

  29. Genome-wide Association of Hypoxia-inducible Factor (HIF)-1  and HIF-2  DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

    Article • Journal of Biological Chemistry, April 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Patrick J Pollard, Professor Jonathan M Gleadle

  30. CANCER: Puzzling Patterns of Predisposition

    Article • Science, April 2009, American Association for the Advancement of Science

    Dr Patrick J Pollard

  31. Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

    Article • Cell, March 2009, Elsevier

    Dr Patrick J Pollard

  32. Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

    Article • Biochemical Journal, December 2008, Portland Press Ltd.

    Dr Patrick J Pollard, Professor Jonathan M Gleadle

  33. Clinical manifestations of familial paraganglioma and phaeochromocytomas insuccinate dehydrogenase B(SDH-B) gene mutation carriers

    Article • Clinical Endocrinology, October 2008, Wiley

    Dr Patrick J Pollard

  34. Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer

    Article • Cancer Genetics and Cytogenetics, June 2008, Elsevier

    Dr Patrick J Pollard

  35. Targeted Inactivation of Fh1 Causes Proliferative Renal Cyst Development and Activation of the Hypoxia Pathway

    Article • Cancer Cell, April 2007, Elsevier

    Dr Patrick J Pollard

  36. Bone Marrow‐Derived Cells Contribute to Podocyte Regeneration and Amelioration of Renal Disease in a Mouse Model of Alport Syndrome

    Article • Stem Cells, November 2006, Oxford University Press (OUP)

    Dr Patrick J Pollard

  37. Expression of HIF-1α, HIF-2α (EPAS1), and Their Target Genes in Paraganglioma and Pheochromocytoma withVHLandSDHMutations

    Article • The Journal of Clinical Endocrinology & Metabolism, November 2006, Endocrine Society

    Dr Patrick J Pollard

  38. Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma

    Article • Fertility and Sterility, October 2006, Elsevier

    Dr Patrick J Pollard

  39. Adult Leydig Cell Tumors of the Testis Caused by Germline Fumarate Hydratase Mutations

    Article • The Journal of Clinical Endocrinology & Metabolism, August 2006, Endocrine Society

    Dr Patrick J Pollard

  40. Distinct expression profile in fumarate-hydratase-deficient uterine fibroids

    Article • Human Molecular Genetics, November 2005, Oxford University Press (OUP)

    Dr Patrick J Pollard

  41. Accumulation of Krebs cycle intermediates and over-expression of HIF1  in tumours which result from germline FH and SDH mutations

    Article • Human Molecular Genetics, June 2005, Oxford University Press (OUP)

    Dr Patrick J Pollard

  42. Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia

    Article • Oncogene, March 2005, Springer Science + Business Media

    Dr Patrick J Pollard

  43. Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome

    Article • The Journal of Pathology, January 2005, Wiley

    Dr Patrick J Pollard

  44. Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency

    Article • Human Molecular Genetics, June 2003, Oxford University Press (OUP)

    Dr Patrick J Pollard

  45. The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase

    Article • Annals of Medicine, January 2003, Taylor & Francis

    Dr Patrick J Pollard

  46. Myosin V-mediated vacuole distribution and fusion in fission yeast

    Article • Current Biology, July 2001, Elsevier

    Dr Patrick J Pollard, Dr Daniel Mulvihill