All Stories

  1. Hypoxia-induced production of the cyclolipodepsipeptide BE-43547 by Micromonospora sp. RV43
  2. Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel
  3. Gut lactate increases circulating l-Lac-Phe and key metabolites linked to GLP-1 and human health
  4. Reactivity-based metabolomics reveal cysteine has glyoxalase 1-like and glyoxalase 2-like activities
  5. Metabolic profiles associate with mortality and neurological outcomes in out-of-hospital cardiac arrest patients
  6. Butyrate increases cardiac output and causes vasorelaxation in a healthy porcine model
  7. Glyoxalase 2 Coordinates de Novo Serine Metabolism
  8. Butyrate increases cardiac output and causes vasorelaxation in a healthy porcine model
  9. Preparation and Preclinical Characterization of a Simple Ester for Dual Exogenous Supply of Lactate and Beta-hydroxybutyrate
  10. Molecular Mechanisms of Temperature Tolerance Plasticity in an Arthropod
  11. Desorption Electrospray Ionization Mass Spectrometry Imaging of Powder-Treated Fingermarks on Forensic Gelatin Lifters and its Application for Separating Overlapping Fingermarks
  12. Enantiomer‐Specific Cardiovascular Effects of the Ketone Body 3‐Hydroxybutyrate
  13. Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds
  14. The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation
  15. Circulating 3‐hydroxy butyrate predicts mortality in patients with chronic heart failure with reduced ejection fraction
  16. T‐cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy
  17. Stimulation of the Hydroxycarboxylic Acid Receptor 2 With the Ketone Body 3‐Hydroxybutyrate and Niacin in Patients With Chronic Heart Failure: Hemodynamic and Metabolic Effects
  18. Exercise increases myocardial free fatty acid oxidation in subjects with metabolic dysfunction-associated fatty liver disease
  19. Large‐Scale metabolomics: Predicting biological age using 10,133 routine untargeted LC–MS measurements
  20. Ketone Body Infusion Abrogates Growth Hormone–Induced Lipolysis and Insulin Resistance
  21. Investigating effects of sodium beta‐hydroxybutyrate on metabolism in placebo‐controlled, bilaterally infused human leg with focus on skeletal muscle protein dynamics
  22. Metabolite Profiling of the Social Spider Stegodyphus dumicola Along a Climate Gradient
  23. A Retrospective Metabolomics Analysis of Gamma-Hydroxybutyrate in Humans: New Potential Markers and Changes in Metabolism Related to GHB Consumption
  24. Oral lactate slows gastric emptying and suppresses appetite in young males
  25. The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model
  26. How do we retain as much information as possible in LCMS data preprocessing by the XCMS software
  27. SGLT2 Inhibition Does Not Affect Myocardial Fatty Acid Oxidation or Uptake, but Reduces Myocardial Glucose Uptake and Blood Flow in Individuals With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Crossover Trial
  28. Oral D/L-3-Hydroxybutyrate Stimulates Cholecystokinin and Insulin Secretion and Slows Gastric Emptying in Healthy Males
  29. Dicarbonyl derived post-translational modifications: chemistry bridging biology and aging-related disease
  30. Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation
  31. Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes
  32. ReactELISA method for quantifying methylglyoxal levels in plasma and cell cultures
  33. STEFs: Activated Vinylogous Protein-Reactive Electrophiles
  34. Sensitive determination of monoamine neurotransmitters, their main metabolites and precursor amino acids in different mouse brain components by liquid chromatography-electrospray tandem mass spectrometry after selective sample clean-up
  35. Profiling of Methylglyoxal Blood Metabolism and Advanced Glycation End-Product Proteome Using a Chemical Probe
  36. Substrate metabolism, hormone and cytokine levels and adipose tissue signalling in individuals with type 1 diabetes after insulin withdrawal and subsequent insulin therapy to model the initiating steps of ketoacidosis
  37. Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during LPS-induced inflammation in humans: anticatabolic impact of ketone bodies
  38. APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells
  39. cGAS is activated by DNA in a length‐dependent manner
  40. Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Diabetic and Dietary Ketosis
  41. ReactELISA: Monitoring a Carbon Nucleophilic Metabolite by ELISA—a Study of Lipid Metabolism
  42. Untargeted metabolomics reveals a mild impact of remote ischemic conditioning on the plasma metabolome and α-hydroxybutyrate as a possible cardioprotective factor and biomarker of tissue ischemia
  43. IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
  44. Untargeted Metabolomics Analysis of ABCC6-Deficient Mice Discloses an Altered Metabolic Liver Profile
  45. Citric Acid Cycle Metabolites Predict the Severity of Myocardial Stunning and Mortality in Newborn Pigs
  46. Synthesis of ent-BE-43547A1 reveals a potent hypoxia-selective anticancer agent and uncovers the biosynthetic origin of the APD-CLD natural products
  47. Effects of insulin-induced hypoglycaemia on lipolysis rate, lipid oxidation and adipose tissue signalling in human volunteers: a randomised clinical study
  48. Reply: Letter to the editor – A dietary amino acid load causes a transient decrease in the function of human neutrophil granulocytes
  49. Untargeted Metabolomics Analysis Reveals a Link between ETHE1-Mediated Disruptive Redox State and Altered Metabolic Regulation
  50. Anabolic effects of leucine-rich whey protein, carbohydrate, and soy protein with and without β-hydroxy-β-methylbutyrate (HMB) during fasting-induced catabolism: A human randomized crossover trial
  51. Amino acid supplementation is anabolic during the acute phase of endotoxin-induced inflammation: A human randomized crossover trial
  52. Combined Insulin Deficiency and Endotoxin Exposure Stimulate Lipid Mobilization and Alter Adipose Tissue Signaling in an Experimental Model of Ketoacidosis in Subjects With Type 1 Diabetes: A Randomized Controlled Crossover Trial
  53. A Metabolomics Study of Retrospective Forensic Data from Whole Blood Samples of Humans Exposed to 3,4-Methylenedioxymethamphetamine: A New Approach for Identifying Drug Metabolites and Changes in Metabolism Related to Drug Consumption
  54. In vivo drug release behavior and osseointegration of a doxorubicin-loaded tissue-engineered scaffold
  55. The natural product brartemicin is a high affinity ligand for the carbohydrate-recognition domain of the macrophage receptor mincle
  56. A cleavable azide resin for direct click chemistry mediated enrichment of alkyne-labeled proteins
  57. Remote ischemic preconditioning with – but not without – metabolic support protects the neonatal porcine heart against ischemia-reperfusion injury
  58. Simultaneous determination of β-hydroxybutyrate and β-hydroxy-β-methylbutyrate in human whole blood using hydrophilic interaction liquid chromatography electrospray tandem mass spectrometry
  59. Protection against Myocardial Ischemia-Reperfusion Injury at Onset of Type 2 Diabetes in Zucker Diabetic Fatty Rats Is Associated with Altered Glucose Oxidation
  60. Development of a chemical probe for identifying protein targets of α-oxoaldehydes
  61. Screening analysis for medicinal drugs and drugs of abuse in whole blood using ultra-performance liquid chromatography time-of-flight mass spectrometry (UPLC–TOF-MS)—Toxicological findings in cases of alleged sexual assault
  62. Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway
  63. A UPLC–MS/MS application for profiling of intermediary energy metabolites in microdialysis samples—A method for high-throughput
  64. Inhibition of the malate–aspartate shuttle by pre-ischaemic aminooxyacetate loading of the heart induces cardioprotection
  65. ChemInform Abstract: Catalytic Enantioselective Aza Diels-Alder Reactions of Imino Dienophiles.
  66. ChemInform Abstract: A Highly Enantioselective Hetero-Diels-Alder Reaction Catalyzed by Chiral Polybinaphthyl-Aluminum Complexes.
  67. ChemInform Abstract: Catalytic Asymmetric Addition Reactions of Carbonyls. A Common Catalytic Approach
  68. ChemInform Abstract: Catalytic Approach for the Formation of Optically Active Allyl α-Amino Acids by Addition of Allylic Metal Compounds to α-Imino Esters.
  69. ChemInform Abstract: An Enantioselective Synthesis of Heteroaromatic N-Tosyl α-Amino Acids.
  70. ChemInform Abstract: Synthesis and First Application of a New Family of Monophosphine Ferrocene Ligands (MOPF).
  71. ChemInform Abstract: An Enantioselective Synthesis of Optically Pure Azaferrocenyl Anions - First General and Practical Approach to Chiral Azaferrocenes.
  72. ChemInform Abstract: A Novel Stereoselective Synthesis of N-Heterocycles by Intramolecular Hydrovinylation.
  73. ChemInform Abstract: Highly Enantioselective Hydrosilylation of Aromatic Alkenes.
  74. ChemInform Abstract: Organocatalysis with Endogenous Compounds: Towards Novel Nonenyzmatic Reactions.
  75. Organocatalysis with endogenous compounds: Towards novel non-enzymatic reactions
  76. A fatal poisoning involving Bromo-Dragonfly
  77. Synthesis and Application of Aryl-Ferrocenyl (Pseudo-Biarylic) Complexes. Part 5. Design and Synthesis of a New Type of Ferrocene-Based Planar Chiral DMAP Analogues. A New Catalyst System for Asymmetric Nucleophilic Catalysis.
  78. Design and Synthesis of a New Type of Ferrocene-Based Planar Chiral DMAP Analogues. A New Catalyst System for Asymmetric Nucleophilic Catalysis.
  79. Design and Synthesis of a New Type of Ferrocene-Based Planar Chiral DMAP Analogues. A New Catalyst System for Asymmetric Nucleophilic Catalysis
  80. Synthesis and Application of Aryl-Ferrocenyl (Pseudo-Biarylic) Complexes. Part 4. New Air-Stable Planar Chiral Ferrocenyl Monophosphine Ligands: Suzuki Cross-Coupling of Aryl Chlorides and Bromides.
  81. New Air-Stable Planar Chiral Ferrocenyl Monophosphine Ligands:  Suzuki Cross-Coupling of Aryl Chlorides and Bromides
  82. Synthesis and Application of Arylmonophosphinoferrocene Ligands: Ultrafast Asymmetric Hydrosilylation of Styrene.
  83. Pentamethylated and Pentaphenylated Azaferro- and Azaruthenocenes:  Simple and General Methodology for the Preparation of Enantiopure Derivatives
  84. Modular Approach to Novel Chiral Aryl-Ferrocenyl Phosphines by Suzuki Cross-Coupling
  85. Synthesis and Application of Arylmonophosphinoferrocene Ligands:  Ultrafast Asymmetric Hydrosilylation of Styrene
  86. Highly Enantioselective Hydrosilylation of Aromatic Alkenes
  87. A novel stereoselective synthesis of N-heterocycles by intramolecular hydrovinylationElectronic supplementary information (ESI) available: 1H and 13C NMR spectra of compounds 1a–f, 2a–d, 3–5, 8–10. See http://www.rsc.org/suppdata/p1/b1/b108310d/
  88. An Enantioselective Synthesis of Optically Pure Azaferrocenyl AnionsFirst General and Practical Approach to Chiral Azaferrocenes
  89. Catalytic Approach for the Formation of Optically Active Allyl α-Amino Acids by Addition of Allylic Metal Compounds to α-Imino Esters
  90. Catalytic Asymmetric Addition Reactions of Carbonyls. A Common Catalytic Approach
  91. An enantioselective synthesis of heteroaromatic N-tosyl α-amino acids
  92. Synthesis and first application of a new family of monophosphine ferrocene ligands (MOPF)
  93. A Highly Enantioselective Hetero-Diels−Alder Reaction Catalyzed by Chiral Polybinaphthyl−Aluminum Complexes
  94. Catalytic Enantioselective Aza Diels-Alder Reactions of Imino Dienophiles
  95. Katalytische enantioselektive Aza-Diels-Alder-Reaktionen von Imino-Dienophilen
  96. Katalytische enantioselektive Aza-Diels-Alder-Reaktionen von Imino-Dienophilen
  97. Highly Enantioselective Catalytic Hetero-Diels-Alder Reaction with Inverse Electron Demand
  98. Hochenantioselektive katalytische Hetero-Diels-Alder-Reaktion mit inversem Elektronenbedarf
  99. Catalytic Asymmetric Hetero-Diels−Alder Reactions of Ketones:  Chemzymatic Reactions
  100. Synthesis and Application of the First Chiral and Highly Lewis Acidic Silyl Cationic Catalyst
  101. Allylic Amination
  102. Metal-catalyzed asymmetric hetero-DielsAlder reactions of unactivated dienes with glyoxylates
  103. Total Synthesis of (R)-Dihydroactinidiolide and (R)-Actinidiolide Using Asymmetric Catalytic Hetero-Diels−Alder Methodology
  104. The first highly enantioselective catalytic hetero-Diels–Alder reaction of ketones
  105. Zinc(II)-catalysed asymmetric hetero-Diels–Alder reactions of conjugated dienes with glyoxylate
  106. Solvent vs. counterion acceleration of enantioselective carbo and hetero Diels–Alder reactions
  107. Solvent effects in asymmetric hetero Diels-Alder and ene reactions
  108. A highly chemo- and enantio-selective hetero-Diels–Alder reaction catalysed by chiral aluminium complexes
  109. Mechanistic aspects of iron-catalyzed allylic amination
  110. Asymmetric hetero Diels-Alder reactions and ene reactions catalyzed by chiral copper(II) complexes
  111. Iron-catalyzed allylic amination