All Stories

  1. CFTR in GtoPdb v.2025.3

    Article • IUPHAR/BPS Guide to Pharmacology CITE, September 2025, Edinburgh University Library

    Dr Paola Vergani

  2. K978C CFTR restores essential epithelial function with greater efficiency than wildtype CFTR when expressed in CF airway cells

    Article • August 2022, Cold Spring Harbor Laboratory Press

    Dr Paola Vergani

  3. Can two wrongs make a right? F508del-CFTR ion channel rescue by second-site mutations in its transmembrane domains

    Article • Journal of Biological Chemistry, March 2022, Elsevier

    Dr Paola Vergani

  4. Can two wrongs make a right? F508del-CFTR ion channel rescue by second-site mutations in its transmembrane domains

    Article • September 2021, Cold Spring Harbor Laboratory Press

    Dr Paola Vergani

  5. Fluorescence assay for simultaneous quantification of CFTR ion-channel function and plasma membrane proximity

    Article • Journal of Biological Chemistry, December 2020, Elsevier

    Dr Paola Vergani

  6. Strategies for cystic fibrosis transmembrane conductance regulator inhibition: from molecular mechanisms to treatment for secretory diarrhoeas

    Article • FEBS Letters, November 2020, Wiley

    Dr Paola Vergani

  7. Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach

    Article • Journal of Medicinal Chemistry, December 2019, American Chemical Society (ACS)

    Johan Neyts, Dr Paola Vergani

  8. High-content assay for CFTR monitoring: simultaneous quantification of channel function and biogenesis

    Article • May 2019, Cold Spring Harbor Laboratory Press

    Dr Paola Vergani

  9. Does Disruption of the E873-R933 Salt Bridge in CFTR and Alteration of the Membrane Bilayer Around It Play a Biological Role?

    Article • Biophysical Journal, February 2019, Elsevier

    Dr Paola Vergani

  10. Structure, Gating, and Regulation of the CFTR Anion Channel

    Article • Physiological Reviews, January 2019, American Physiological Society

    Dr Paola Vergani

  11. CFTR potentiation by VX-770 involves stabilization of the pre-hydrolytic, O1 state

    Article • British Journal of Pharmacology, August 2018, Wiley

    Dr Paola Vergani

  12. Structure of Transmembrane Helix 8 and Possible Membrane Defects in CFTR

    Article • Biophysical Journal, April 2018, Elsevier

    Dr Paola Vergani

  13. Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds

    Article • British Journal of Pharmacology, February 2017, Wiley

    Dr Paola Vergani, Dr Emily Langron, David Selwood

  14. Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases

    Article • Journal of Medicinal Chemistry, February 2017, American Chemical Society (ACS)

    Dr Emily Langron, Dr Paola Vergani, Johan Neyts

  15. Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

    Article • Journal of Biological Chemistry, July 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Paola Vergani

  16. Increased apical Na+permeability in cystic fibrosis is supported by a quantitative model of epithelial ion transport

    Article • The Journal of Physiology, July 2013, Wiley

    Dr Paola Vergani

  17. Conformational changes in the catalytically inactive nucleotide-binding site of CFTR

    Article • Journal of General Physiology, June 2013, Rockefeller University Press

    Dr Paola Vergani

  18. Mutant cycles at CFTR’s non-canonical ATP-binding site support little interface separation during gating

    Article • Journal of General Physiology, May 2011, Rockefeller University Press

    Dr Paola Vergani

  19. Electrophysiological, Biochemical, and Bioinformatic Methods for Studying CFTR Channel Gating and Its Regulation

    Article • January 2011, Springer Science + Business Media

    Dr Paola Vergani

  20. Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2

    Article • Journal of General Physiology, September 2010, Rockefeller University Press

    Dr Paola Vergani

  21. Strict coupling between CFTR’s catalytic cycle and gating of its Cl − ion pore revealed by distributions of open channel burst durations

    Article • Proceedings of the National Academy of Sciences, December 2009, Proceedings of the National Academy of Sciences

    Dr Paola Vergani

  22. ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, January 2009, Royal Society Publishing

    Dr Paola Vergani

  23. In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer

    Article • The EMBO Journal, October 2006, Wiley

    Dr Paola Vergani

  24. The ABC protein turned chloride channel whose failure causes cystic fibrosis

    Article • Nature, March 2006, Springer Science + Business Media

    Dr Paola Vergani

  25. Control of the CFTR channel's gates

    Article • Biochemical Society Transactions, October 2005, Portland Press Ltd.

    Dr Paola Vergani

  26. CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains

    Article • Nature, February 2005, Springer Science + Business Media

    Dr Paola Vergani

  27. Prolonged Nonhydrolytic Interaction of Nucleotide with CFTR's NH2-terminal Nucleotide Binding Domain and its Role in Channel Gating

    Article • Journal of General Physiology, August 2003, Rockefeller University Press

    Dr Paola Vergani

  28. On the Mechanism of MgATP-dependent Gating of CFTR Cl−Channels

    Article • Journal of General Physiology, December 2002, Rockefeller University Press

    Dr Paola Vergani

  29. Mutations in the yeast two pore K+channel YKC1 identify functional differences between the pore domains

    Article • FEBS Letters, September 1999, Wiley

    Dr Paola Vergani

  30. Mutations in the pore regions of the yeast K+ channel YKC1 affect gating by extracellular K+

    Article • The EMBO Journal, December 1998, Wiley

    Dr Paola Vergani

  31. Extracellular K+and Ba2+mediate voltage-dependent inactivation of the outward-rectifying K+channel encoded by the yeast geneTOK1

    Article • FEBS Letters, April 1997, Wiley

    Dr Paola Vergani

  32. Complementation of a yeast Δpkc1mutant by theArabidopsisprotein ANT

    Article • FEBS Letters, January 1997, Wiley

    Dr Paola Vergani

  33. Relationship between fusaric acid uptake and its binding to cell structures by leaves of Egeria densa and its toxic effects on membrane permeability and respiration

    Article • Physiological and Molecular Plant Pathology, February 1993, Elsevier

    Dr Paola Vergani