All Stories

  1. Effectiveness of a gamified mobile health intervention for children and parents in pediatric day surgery: Randomized controlled trial

    Article • Finnish Journal of eHealth and eWelfare, September 2026, Finnish Journal of eHealth and eWelfare

    Otto Helve

  2. Parental Ability to Identify Severe Illnesses in Their Children

    Article • JAMA Network Open, February 2026, American Medical Association (AMA)

    Otto Helve

  3. Response to the Letter: Perioperative Interventions: A Critical Omission in Delivery Mode Research on Neonatal Gene Expression

    Article • Acta Paediatrica, February 2026, Wiley

    Otto Helve

  4. Evaluation of the Finnish exposure notification application “Koronavilkku” according to key performance indicators: lessons learned (Preprint)

    Article • December 2025, JMIR Publications Inc.

    Otto Helve

  5. Evaluation of the Finnish exposure notification application “Koronavilkku” according to key performance indicators: lessons learned (Preprint)

    Article • JMIR Public Health and Surveillance, December 2025, JMIR Publications Inc.

    Otto Helve

  6. Changes in Salivary Matrix Metalloproteinase-8 Concentrations Are Not Associated with Oral Health during Early Adolescence

    Article • Caries Research, November 2025, Karger Publishers

    Otto Helve

  7. Comparative Study Showed Significant Gene Expression Differences in Newborn Infants After Vaginal and Caesarean Deliveries

    Article • Acta Paediatrica, November 2025, Wiley

    Otto Helve

  8. Plasma fibrinogen level and severe bleeding in cardiac surgery: an observational post hoc study of the ALBICS trial

    Article • Canadian Journal of Anesthesia/Journal canadien d anesthésie, October 2025, Springer Science + Business Media

    Otto Helve

  9. Finnish Healthcare Professionals' Online Searches for Paediatric Oral Antibiotics: COVID‐19 Impact, 2017–2023

    Article • Acta Paediatrica, October 2025, Wiley

    Otto Helve

  10. Adenovirus type 7d outbreak associated with severe clinical presentation, Finland, February to June 2024

    Article • Eurosurveillance, February 2025, European Centre for Disease Control and Prevention (ECDC)

    Otto Helve

  11. One health, many interpretations: vaccinating risk groups against H5 avian influenza in Finland

    Article • Eurosurveillance, June 2024, European Centre for Disease Control and Prevention (ECDC)

    Otto Helve

  12. Paternal and induced gut microbiota seeding complement mother-to-infant transmission

    Article • Cell Host & Microbe, June 2024, Elsevier

    Otto Helve

  13. Detecting epinephrine auto-injector shortages in Finland 2016–2022: Log-data analysis of online information seeking

    Article • PLOS One, April 2024, PLOS

    Otto Helve

  14. Albumin and Cardioprotection in On-Pump Cardiac Surgery—A Post Hoc Analysis of a Randomized Trial

    Article • Journal of Cardiothoracic and Vascular Anesthesia, January 2024, Elsevier

    Otto Helve

  15. Albumin Infusion and Blood Loss After Cardiac Surgery

    Article • The Annals of Thoracic Surgery, August 2023, Elsevier

    Otto Helve

  16. Policies on children and schools during the SARS-CoV-2 pandemic in Western Europe

    Article • Frontiers in Public Health, July 2023, Frontiers

    Otto Helve

  17. Implementing and Maintaining a SARS-CoV-2 Exposure Notification Application for Mobile Phones: The Finnish Experience

    Article • JMIR Public Health and Surveillance, July 2023, JMIR Publications Inc.

    Otto Helve

  18. Implementing and Maintaining a SARS-CoV-2 Exposure Notification Application for Mobile Phones: The Finnish Experience (Preprint)

    Article • February 2023, JMIR Publications Inc.

    Otto Helve

  19. Transplantation of maternal intestinal flora to the newborn after elective cesarean section (SECFLOR): study protocol for a double blinded randomized controlled trial

    Article • BMC Pediatrics, September 2022, Springer Science + Business Media

    Otto Helve

  20. Decrease in paediatric emergency room visits during the COVID‐19 pandemic restrictions: A population‐based study

    Article • Acta Paediatrica, August 2022, Wiley

    Otto Helve

  21. Online searches of children’s oseltamivir in public primary and specialized care: Detecting influenza outbreaks in Finland using dedicated databases for health care professionals

    Article • PLOS One, August 2022, PLOS

    Otto Helve

  22. Election promises on children’s wellbeing and health 2015 to 2021 – a study of Finnish voting advice applications database

    Article • Scandinavian Journal of Public Health, July 2022, SAGE Publications

    Otto Helve

  23. Introduction and Rapid Spread of SARS-CoV-2 Omicron Variant and Dynamics of BA.1 and BA.1.1 Sublineages, Finland, December 2021

    Article • Emerging Infectious Diseases, June 2022, Centers for Disease Control and Prevention (CDC)

    Otto Helve

  24. Analyzing Citizens’ and Health Care Professionals’ Searches for Smell/Taste Disorders and Coronavirus in Finland During the COVID-19 Pandemic: Infodemiological Approach Using Database Logs

    Article • JMIR Public Health and Surveillance, December 2021, JMIR Publications Inc.

    Otto Helve

  25. A gamified mobile health intervention for children in day surgery care: Protocol for a randomized controlled trial

    Article • Nursing Open, December 2021, Wiley

    Otto Helve

  26. Incidence Trends for SARS-CoV-2 Alpha and Beta Variants, Finland, Spring 2021

    Article • Emerging Infectious Diseases, December 2021, Centers for Disease Control and Prevention (CDC)

    Otto Helve

  27. Closing lower secondary schools had no impact on COVID-19 incidence in 13-15-year-olds in Finland

    Article • Epidemiology and Infection, October 2021, Cambridge University Press

    Otto Helve

  28. Effect of High-Dose vs Standard-Dose Vitamin D Supplementation on Neurodevelopment of Healthy Term Infants

    Article • JAMA Network Open, September 2021, American Medical Association (AMA)

    Otto Helve

  29. Analyzing Citizens’ and Health Care Professionals’ Searches for Smell/Taste Disorders and Coronavirus in Finland During the COVID-19 Pandemic: Infodemiological Approach Using Database Logs (Preprint)

    Article • July 2021, JMIR Publications Inc.

    Otto Helve

  30. Early-life gut microbiota and its connection to metabolic health in children: Perspective on ecological drivers and need for quantitative approach

    Article • EBioMedicine, July 2021, Elsevier

    Otto Helve

  31. Nasal expression of SARS-CoV-2 entry receptors in newborns

    Article • Archives of Disease in Childhood Fetal & Neonatal, May 2021, BMJ

    Otto Helve

  32. Protocol for oral transplantation of maternal fecal microbiota to newborn infants born by cesarean section

    Article • STAR Protocols, March 2021, Elsevier

    Otto Helve

  33. Giving faecal transplants to infants born by Caesarean section produced similar gut microbiotica results to vaginal deliveries

    Article • Acta Paediatrica, January 2021, Wiley

    Otto Helve

  34. COVID-19 outbreak at a reception centre for asylum seekers in Espoo, Finland

    Article • Journal of Migration and Health, January 2021, Elsevier

    Otto Helve

  35. Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study

    Article • Cell, October 2020, Elsevier

    Otto Helve

  36. Parental Experiences of the Pediatric Day Surgery Pathway and the Needs for A Digital Gaming Solution: A Qualitative Study (Preprint)

    Article • August 2020, JMIR Publications Inc.

    Otto Helve

  37. Parental Experiences of the Pediatric Day Surgery Pathway and the Needs for A Digital Gaming Solution: A Qualitative Study (Preprint)

    Article • JMIR Medical Informatics, August 2020, JMIR Publications Inc.

    Otto Helve

  38. Glucocorticoids, sodium transport mediators, and respiratory distress syndrome in preterm infants

    Article • Pediatric Research, July 2020, Springer Science + Business Media

    Otto Helve

  39. Decreased airway epithelial ion transport was associated with the severity of the respiratory syncytial virus infection and complications in infants

    Article • Acta Paediatrica, May 2020, Wiley

    Otto Helve

  40. The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood

    Article • Mediators of Inflammation, November 2019, Hindawi Publishing Corporation

    Dr Irmeli Roine, Otto Helve, Tuula Pelkonen

  41. In Reply

    Article • The Pediatric Infectious Disease Journal, September 2019, Wolters Kluwer Health

    Otto Helve

  42. Genetic Variation of the Vitamin D Binding Protein Affects Vitamin D Status and Response to Supplementation in Infants

    Article • The Journal of Clinical Endocrinology & Metabolism, July 2019, Endocrine Society

    Otto Helve

  43. Refugee crisis in Finland: Challenges to safeguarding the right to health for asylum seekers

    Article • Health Policy, July 2019, Elsevier

    Otto Helve

  44. High-Dose Vitamin D Supplementation Does Not Prevent Allergic Sensitization of Infants

    Article • The Journal of Pediatrics, June 2019, Elsevier

    Otto Helve

  45. Postnatal decrease of cystic fibrosis transmembrane conductance regulator gene expression in nasal epithelium of healthy newborn infants

    Article • Acta Paediatrica, May 2019, Wiley

    Otto Helve

  46. Transient Tachypnea of the Newborn Is Associated With an Increased Risk of Hospitalization Due to Respiratory Syncytial Virus Bronchiolitis

    Article • The Pediatric Infectious Disease Journal, April 2019, Wolters Kluwer Health

    Otto Helve

  47. Postnatal gene expression of airway epithelial sodium transporters associated with birth stress in humans

    Article • Pediatric Pulmonology, March 2019, Wiley

    Otto Helve

  48. Healthcare professionals’ queries on oseltamivir and influenza in Finland 2011-2016-Can we detect influenza epidemics with specific online searches?

    Article • Influenza and Other Respiratory Viruses, March 2019, Wiley

    Otto Helve

  49. Pediatric Web-Based Chat Services for Caregivers of Children: Descriptive Study

    Article • Journal of Medical Internet Research, December 2018, JMIR Publications Inc.

    Otto Helve

  50. Public health response to large influx of asylum seekers: implementation and timing of infectious disease screening

    Article • BMC Public Health, September 2018, Springer Science + Business Media

    Otto Helve

  51. High Pregnancy, Cord Blood, and Infant Vitamin D Concentrations May Predict Slower Infant Growth

    Article • The Journal of Clinical Endocrinology & Metabolism, September 2018, Endocrine Society

    Otto Helve

  52. Effect of Higher vs Standard Dosage of Vitamin D3 Supplementation on Bone Strength and Infection in Healthy Infants

    Article • JAMA Pediatrics, July 2018, American Medical Association (AMA)

    Otto Helve

  53. Vitamin D was not associated with survival or cerebrospinal fluid cathelicidin levels in children with bacterial meningitis

    Article • Acta Paediatrica, May 2018, Wiley

    Otto Helve

  54. Pediatric Web-Based Chat Services for Caregivers of Children: Descriptive Study (Preprint)

    Article • February 2018, JMIR Publications Inc.

    Otto Helve

  55. Cerebrospinal Fluid Cathelicidin Correlates With the Bacterial Load and Outcomes in Childhood Bacterial Meningitis

    Article • The Pediatric Infectious Disease Journal, February 2018, Wolters Kluwer Health

    Otto Helve

  56. Population-based Borrelia burgdorferi sensu lato seroprevalence and associated risk factors in Finland

    Article • Ticks and Tick-borne Diseases, February 2018, Elsevier

    Otto Helve

  57. Maternal vitamin D status, gestational diabetes and infant birth size

    Article • BMC Pregnancy and Childbirth, December 2017, Springer Science + Business Media

    Otto Helve

  58. Food and Nutrient Intake and Nutrient Sources in 1-Year-Old Infants in Finland: A Cross-Sectional Analysis

    Article • Nutrients, December 2017, MDPI AG

    Otto Helve

  59. Health Information–Seeking Patterns of the General Public and Indications for Disease Surveillance: Register-Based Study Using Lyme Disease

    Article • JMIR Public Health and Surveillance, November 2017, JMIR Publications Inc.

    Otto Helve

  60. Sex and Iron Modify Fibroblast Growth Factor 23 (FGF23) Concentration in 1-Year-Old Children

    Article • The Journal of Clinical Endocrinology & Metabolism, October 2017, Endocrine Society

    Dr Heli T Viljakainen, Outi Makitie, Otto Helve

  61. Lyme Borreliosis in Finland, 1995–2014

    Article • Emerging Infectious Diseases, August 2017, Centers for Disease Control and Prevention (CDC)

    Otto Helve

  62. Age at onset of walking affects bone mineral content in early childhood

    Article • Bone Abstracts, July 2017, Bioscientifica

    Otto Helve

  63. Health Care Professionals’ Evidence-Based Medicine Internet Searches Closely Mimic the Known Seasonal Variation of Lyme Borreliosis: A Register-Based Study

    Article • JMIR Public Health and Surveillance, April 2017, JMIR Publications Inc.

    Otto Helve

  64. Towards evidence-based vitamin D supplementation in infants: vitamin D intervention in infants (VIDI) — study design and methods of a randomised controlled double-blinded intervention study

    Article • BMC Pediatrics, March 2017, Springer Science + Business Media

    Otto Helve

  65. Season, dietary factors, and physical activity modify 25-hydroxyvitamin D concentration during pregnancy

    Article • Zeitschrift für Ernährungswissenschaft, March 2017, Springer Science + Business Media

    Dr Heli T Viljakainen, Otto Helve

  66. 25-hydroxyvitamin D correlates with inflammatory markers in cord blood of healthy newborns

    Article • Pediatric Research, January 2017, Springer Science + Business Media

    Otto Helve

  67. No Severe Hypercalcemia with Daily Vitamin D3 Supplementation of up to 30 µg during the First Year of Life

    Article • Hormone Research in Paediatrics, January 2017, Karger Publishers

    Otto Helve

  68. Comparison of amniotic fluid matrix metalloproteinase-8 and cathelicidin in the diagnosis of intra-amniotic infection

    Article • Journal of Perinatology, September 2016, Springer Science + Business Media

    Otto Helve

  69. Swiftly Decreasing Cerebrospinal Fluid Cathelicidin Concentration Predicts Improved Outcome in Childhood Bacterial Meningitis: TABLE 1

    Article • Journal of Clinical Microbiology, March 2016, ASM Journals

    Otto Helve

  70. Chronic Hypoxemia in Children With Congenital Heart Defect Impairs Airway Epithelial Sodium Transport*

    Article • Pediatric Critical Care Medicine, January 2016, Wolters Kluwer Health

    Otto Helve

  71. Lung Ultrasound and Static Lung Compliance during Postnatal Adaptation in Healthy Term Infants

    Article • Neonatology, January 2015, Karger Publishers

    Otto Helve

  72. Decrease in Cerebrospinal Fluid Cathelicidin During Bacterial Meningitis in Children Correlates With Improved Outcome

    Article • Open Forum Infectious Diseases, January 2015, Oxford University Press (OUP)

    Otto Helve

  73. Duration of Gestation and Mode of Delivery Affect the Genes of Transepithelial Sodium Transport in Pulmonary Adaptation

    Article • Neonatology, October 2014, Karger Publishers

    Otto Helve

  74. A Medical Consultation Service on Facebook: Descriptive Analysis of Questions Answered

    Article • Journal of Medical Internet Research, September 2014, JMIR Publications Inc.

    Otto Helve

  75. Delayed Lung Liquid Absorption after Cesarean Section at Term

    Article • Neonatology, January 2013, Karger Publishers

    Otto Helve

  76. Airway Expression of the Epithelial Sodium Channel  -Subunit Correlates With Cortisol in Term Newborns

    Article • PEDIATRICS, July 2011, American Academy of Pediatrics (AAP)

    Otto Helve

  77. Expression of Airway Epithelial Sodium Channel in the Preterm Infant Is Related to Respiratory Distress Syndrome but Unaffected by Repeat Antenatal β-Methasone

    Article • Neonatology, January 2010, Karger Publishers

    Otto Helve

  78. Pulmonary Fluid Balance in the Human Newborn Infant

    Article • Neonatology, January 2009, Karger Publishers

    Otto Helve

  79. Effect of legislative changes in drug promotion on medical students: questionnaire survey

    Article • Academic Medicine, December 2008, Wiley

    Otto Helve

  80. Improvement of Lung Compliance during Postnatal Adaptation Correlates with Airway Sodium Transport

    Article • American Review of Respiratory Disease, February 2006, American Thoracic Society

    Otto Helve

  81. G protein‐coupled receptor for asthma susceptibility associates with respiratory distress syndrome

    Article • Annals of Medicine, January 2006, Taylor & Francis

    Otto Helve

  82. Sodium transport in airway epithelium correlates with lung compliance in healthy newborn infants

    Article • The Journal of Pediatrics, February 2005, Elsevier

    Otto Helve

  83. A national survey on the effect of pharmaceutical promotion on medical students

    Article • Medical Teacher, November 2004, Taylor & Francis

    Otto Helve